Paula Maria Garcia Agostinho

  • Endereço para acessar este CV: http://lattes.cnpq.br/9534916163820179
  • Última atualização do currículo em 17/10/2014


Possui graduação em Biologia (Bacharelado) - Center for Neuroscience and Cell Biology (1990) e doutorado em Biologia Celular - Center for Neuroscience and Cell Biology (1998). Atualmente é professor e líder de grupo de pesquisa - Center for Neuroscience and Cell Biology. Tem experiência na área de Biomedicina, Biologia Celular, Neurociências e Doenças Neurodegenerativas. (Texto informado pelo autor)


Identificação


Nome
Paula Maria Garcia Agostinho
Nome em citações bibliográficas
AGOSTINHO, P. M. G.;AGOSTINHO, PAULA;AGOSTINHO, P.;AGOSTINHO, P;AGOSTINHO, PAULA M.;AGOSTINHO, PAULA M;AGOSTINHO, PM

Endereço


Endereço Profissional
Center for Neuroscience and Cell Biology, Faculdade de Medicina.
Rua Larga
Faculdade de Medicina
3004504 - Coimbra, - Portugal
Telefone: (351) 239820190


Formação acadêmica/titulação


1994 - 1998
Doutorado em Biologia Celular.
Center for Neuroscience and Cell Biology.
Título: Efeito do "stress" oxidativo nos mecanismos que regulam a libertação de neurotransmissores nas células da retina em cultura, Ano de obtenção: 1998.
Orientador: Catarina Isabel Neno Resende de Oliveira.
1986 - 1990
Graduação em Biologia (Bacharelado).
Center for Neuroscience and Cell Biology.




Formação Complementar


2012 - 2012
Workshop on Advanced Fluorescence Microscopy. (Carga horária: 24h).
Center for Neuroscience and Cell Biology.
2008 - 2008
Carrying out Animal Experiments. (Carga horária: 40h).
Direção Geral de Veterinária, Ministério da Agricultura.


Atuação Profissional



Center for Neuroscience and Cell Biology, CNC, Portugal.
Vínculo institucional

1999 - Atual
Vínculo: Servidor Público, Enquadramento Funcional: Professor e Líder de Grupo de Pesquisa, Carga horária: 40, Regime: Dedicação exclusiva.

Atividades

01/1999 - Atual
Pesquisa e desenvolvimento , Faculdade de Medicina, .



Linhas de pesquisa


1.
Biomedicina
2.
Biologia Celular
3.
Neurociências
4.
Doenças Neurodegenerativas


Membro de corpo editorial


2014 - Atual
Periódico: Journal of Alzheimer's Disease


Revisor de periódico


2014 - Atual
Periódico: Brain Research Bulletin
2014 - Atual
Periódico: Neurobiology of Disease
2014 - Atual
Periódico: Journal of Neurochemistry
2014 - Atual
Periódico: Journal of Neuroscience Research
2014 - Atual
Periódico: Brain Research
2014 - Atual
Periódico: Journal of Alzheimer´s Disease
2014 - Atual
Periódico: BMC Neuroscience (Online)
2014 - Atual
Periódico: Journal of the Neurological Sciences
2014 - Atual
Periódico: British Journal of Pharmacology
2014 - Atual
Periódico: Neurotoxicity Research
2014 - Atual
Periódico: International Journal of Alzheimer's Disease
2014 - Atual
Periódico: Aging Cell
2014 - Atual
Periódico: FEBS Letters (Print)
2014 - Atual
Periódico: Glia (Online)
2014 - Atual
Periódico: Cell Death and Differentiation
2014 - Atual
Periódico: Journal of Cell Science


Revisor de projeto de fomento


2014 - Atual
Agência de fomento: Health Research Board
2014 - Atual
Agência de fomento: Alzheimer s Association/USA
2014 - Atual
Agência de fomento: Czech Science Foundation
2009 - Atual
Agência de fomento: ), Portuguese Foundation for Science and Technology (FCT) for Fellowships


Áreas de atuação


1.
Grande área: Outros.


Idiomas


Português
Compreende Bem, Fala Bem, Lê Bem, Escreve Bem.
Inglês
Compreende Bem, Fala Bem, Lê Bem, Escreve Bem.


Prêmios e títulos


2005
Short-term grants from the Fundação Calouste Gulbenkian for participation in the 35th Annual Meetings of the Society for Neuroscience (SfN), held at Washington DC, and New Orleans, LA,, Fundação Calouste Gulbenkian.
2003
Short-term grants from the Fundação Calouste Gulbenkian for participation in the 33rd Annual Meetings of the Society for Neuroscience (SfN), held at Washington DC, and New Orleans, LA,, Fundação Calouste Gulbenkian.
2000
Short-term grants from the Fundação Calouste Gulbenkian for participation in the 30th Annual Meetings of the Society for Neuroscience (SfN), held at Washington DC, and New Orleans, LA,, Fundação Calouste Gulbenkian.


Produções



Produção bibliográfica
Citações

Web of Science
Total de trabalhos:62
Total de citações:1111
Fator H:23
Agostinho, Paula M  Data: 17/10/2014

Artigos completos publicados em periódicos

1.
RIAL, DANIEL2014RIAL, DANIEL ; PAMPLONA, FABRÍCIO A. ; MOREIRA, EDUARDO L. G. ; MOREIRA, KARIN M. ; HIPOLIDE, DÉBORA ; RODRIGUES, DIANA I. ; DOMBROWSKI, PATRÍCIA A. ; DA CUNHA, CLAUDIO ; AGOSTINHO, PAULA ; TAKAHASHI, REINALDO N. ; WALZ, ROGER ; CUNHA, RODRIGO A. ; PREDIGER, RUI D. . Cellular prion protein is present in dopaminergic neurons and modulates the dopaminergic system. European Journal of Neuroscience (Print), v. 40, p. 2479-2486, 2014.

2.
GARÇÃO, PEDRO2014GARÇÃO, PEDRO ; OLIVEIRA, CATARINA R. ; CUNHA, RODRIGO A. ; AGOSTINHO, PAULA . Subsynaptic localization of nicotinic acetylcholine receptor subunits: A comparative study in the mouse and rat striatum. Neuroscience Letters (Print), v. 566, p. 106-110, 2014.

3.
Rodrigues, D.I.2014Rodrigues, D.I. ; GUTIERRES, J.M. ; Pliássova, A. ; Oliveira, C.R. ; Cunha, R.A. ; AGOSTINHO, P. M. G. . Synaptic and sub-synaptic localization of amyloid-β protein precursor in the rat hippocampus. Journal of Alzheimer's Disease, v. 40, p. 981-992, 2014.

4.
GUTIERRES, JESSIÉ M.2014GUTIERRES, JESSIÉ M. ; CARVALHO, FABIANO B. ; SCHETINGER, MARIA ROSA C. ; AGOSTINHO, PAULA ; MARISCO, PATRICIA C. ; VIEIRA, JULIANO M. ; ROSA, MICHELE M. ; BOHNERT, CRYSTIANI ; RUBIN, MARIBEL A. ; MORSCH, VERA M. ; SPANEVELLO, ROSELIA ; MAZZANTI, CINTHIA M. . Neuroprotective effect of anthocyanins on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia in rats. International Journal of Developmental Neuroscience, v. 33, p. 88-97, 2014.

5.
SALAMONE, ALESSIA2014SALAMONE, ALESSIA ; ZAPPETTINI, STEFANIA ; GRILLI, MASSIMO ; OLIVERO, GUENDALINA ; AGOSTINHO, PAULA ; TOMÉ, ANGELO R. ; CHEN, JIAYANG ; PITTALUGA, ANNA ; CUNHA, RODRIGO A. ; MARCHI, MARIO . Prolonged nicotine exposure down-regulates presynaptic NMDA receptors in dopaminergic terminals of the rat nucleus accumbens. Neuropharmacology, v. 79, p. 488-497, 2014.

6.
GUTIERRES, JESSIÉ M.2014GUTIERRES, JESSIÉ M. ; CARVALHO, FABIANO B. ; SCHETINGER, MARIA ROSA C. ; MARISCO, PATRÍCIA ; AGOSTINHO, PAULA ; RODRIGUES, MARÍLIA ; RUBIN, MARIBEL A. ; SCHMATZ, ROBERTA ; DA SILVA, CASSIA R. ; DE P. COGNATO, GIANA ; FARIAS, JULIA G. ; SIGNOR, CRISTIANE ; MORSCH, VERA M. ; MAZZANTI, CINTHIA M. ; BOGO, MAURICIO ; BONAN, CARLA D. ; SPANEVELLO, ROSELIA . Anthocyanins restore behavioral and biochemical changes caused by streptozotocin-induced sporadic dementia of Alzheimer's type. Life Sciences (1973), v. 96, p. 7-17, 2014.

7.
MATOS, M.2013MATOS, M. ; AUGUSTO, E. ; AGOSTINHO, P. ; CUNHA, R. A. ; CHEN, J.-F. . Antagonistic Interaction between Adenosine A2A Receptors and Na+/K+-ATPase- 2 Controlling Glutamate Uptake in Astrocytes. The Journal of Neuroscience, v. 33, p. 18492-18502, 2013.

8.
SOARES, E.2013SOARES, E. ; PREDIGER, R.D. ; NUNES, S. ; CASTRO, A.A. ; VIANA, S.D. ; LEMOS, C. ; DE SOUZA, C.M. ; AGOSTINHO, P. ; Cunha, R.A. ; CARVALHO, E. ; FONTES RIBEIRO, C.A. ; REIS, F. ; PEREIRA, F.C. . Spatial memory impairments in a prediabetic rat model. Neuroscience, v. 250, p. 565-577, 2013.

9.
GARÇÃO, P2013GARÇÃO, P ; SZABÓ, E C ; WOPEREIS, S ; CASTRO, A A ; TOMÉ, Â R ; PREDIGER, R D ; CUNHA, R A ; AGOSTINHO, P ; KÖFALVI, A . Functional interaction between presynaptic α6β2-containing nicotinic and adenosine A 2A receptors in the control of dopamine release in the rat striatum. British Journal of Pharmacology, v. 250, p. n/a-n/a, 2013.

10.
SILVA, DANIEL2013SILVA, DANIEL ; CHIOUA, MOURAD ; SAMADI, ABDELOUAHID ; AGOSTINHO, PAULA ; GARÇÃO, PEDRO ; LAJARÍN-CUESTA, ROCÍO ; DE LOS RÍOS, CRISTOBAL ; IRIEPA, ISABEL ; MORALEDA, IGNACIO ; GONZALEZ-LAFUENTE, LAURA ; MENDES, EDUARDA ; PÉREZ, CONCEPCIÓN ; RODRÍGUEZ-FRANCO, MARÍA ISABEL ; MARCO-CONTELLES, JOSÉ ; CARMO CARREIRAS, M. . Synthesis, Pharmacological Assessment, and Molecular Modeling of Acetylcholinesterase/Butyrylcholinesterase Inhibitors: Effect against Amyloid-β-Induced Neurotoxicity. ACS CHEM NEUROSCI, v. 4, p. 547-565, 2013.

11.
SIMÕES, ANA2012SIMÕES, ANA ; DUARTE, JOÃO A ; AGASSE, FABIENNE ; CANAS, PAULA ; TOMÉ, ANGELO R ; AGOSTINHO, PAULA ; CUNHA, RODRIGO A . Blockade of adenosine A2A receptors prevents interleukin-1β-induced exacerbation of neuronal toxicity through a p38 mitogen-activated protein kinase pathway. Journal of Neuroinflammation, v. 9, p. 204, 2012.

12.
FERREIRA, SAMIRA G.2012FERREIRA, SAMIRA G. ; TEIXEIRA, FILIPE M. ; GARÇÃO, PEDRO ; AGOSTINHO, PAULA ; LEDENT, CATHERINE ; CORTES, LUÍSA ; MACKIE, KEN ; KÖFALVI, ATTILA . Presynaptic CB1 cannabinoid receptors control frontocortical serotonin and glutamate release - Species differences. Neurochemistry International, v. 61, p. 219-226, 2012.

13.
DUARTE, JOÃO M. N.2012DUARTE, JOÃO M. N. ; AGOSTINHO, PAULA M. ; CARVALHO, RUI A. ; CUNHA, RODRIGO A. . Caffeine Consumption Prevents Diabetes-Induced Memory Impairment and Synaptotoxicity in the Hippocampus of NONcZNO10/LTJ Mice. Plos One, v. 7, p. e21899, 2012.

14.
MATOS, MARCO2012MATOS, MARCO ; AUGUSTO, ELISABETE ; SANTOS-RODRIGUES, ALEXANDRE DOS ; SCHWARZSCHILD, MICHAEL A. ; CHEN, JIANG-FAN ; CUNHA, RODRIGO A. ; AGOSTINHO, PAULA . Adenosine A2A receptors modulate glutamate uptake in cultured astrocytes and gliosomes. GLIA (New York, N.Y. : Print), v. 60, p. 702-716, 2012.

15.
MATOS, M.2012MATOS, M. ; AUGUSTO, ELISABETE ; NJ, M. ; DOS SANTOS-RODRUIGUES, A ; A. CUNHA, RODRIGO ; AGOSTINHO, PAULA . Astrocytic adenosine A2A receptors control the amyloid-β peptide-induced decrease of glutamate uptake. Journal of Alzheimer's Disease, v. 31, p. 555-567, 2012.

16.
COSTENLA, ANA R.2011COSTENLA, ANA R. ; DIÓGENES, MARIA J. ; CANAS, PAULA M. ; RODRIGUES, RICARDO J. ; NOGUEIRA, CÉLIA ; MAROCO, JOÃO ; AGOSTINHO, PAULA M. ; RIBEIRO, JOAQUIM A. ; CUNHA, RODRIGO A. ; DE MENDONÇA, ALEXANDRE . Enhanced role of adenosine A2A receptors in the modulation of LTP in the rat hippocampus upon ageing. European Journal of Neuroscience (Print), v. 34, p. 12-21, 2011.

17.
LOPES, JOAO P.2011LOPES, JOAO P. ; AGOSTINHO, PAULA . Cdk5: Multitasking between physiological and pathological conditions. Progress in Neurobiology, v. 94, p. 49-63, 2011.

18.
REBOLA, NELSON2011REBOLA, NELSON ; SIMÕES, ANA PATRÍCIA ; CANAS, PAULA M. ; TOMÉ, ANGELO R. ; ANDRADE, GEANNE M. ; BARRY, CLAIRE E. ; AGOSTINHO, PAULA M. ; LYNCH, MARINA A. ; CUNHA, RODRIGO A. . Adenosine A2A receptors control neuroinflammation and consequent hippocampal neuronal dysfunction. Journal of Neurochemistry, v. 117, p. 100-111, 2011.

19.
GOMES, CATARINA V.2011GOMES, CATARINA V. ; KASTER, MANUELLA P. ; TOMÉ, ANGELO R. ; AGOSTINHO, PAULA M. ; CUNHA, RODRIGO A. . Adenosine receptors and brain diseases: Neuroprotection and neurodegeneration. Biochimica et Biophysica Acta. Biomembranes, v. 1808, p. 1380-1399, 2011.

20.
AGOSTINHO, PAULA2010AGOSTINHO, PAULA; A. CUNHA, RODRIGO ; OLIVEIRA, CATARINA . Neuroinflammation, Oxidative Stress and the Pathogenesis of Alzheimers Disease. Current Pharmaceutical Design (Print), v. 16, p. 2766-2778, 2010.

21.
Cunha, R.A.2010Cunha, R.A. ; AGOSTINHO, PAULA M. . Chronic caffeine consumption prevents memory disturbance in different animal models of memory decline. Journal of Alzheimer's Disease, v. 20, p. 95-116, 2010.

22.
COGNATO, GIANA P.2010COGNATO, GIANA P. ; AGOSTINHO, PAULA M. ; HOCKEMEYER, JÃ RG ; MÃ LLER, CHRISTA E. ; SOUZA, DIOGO O. ; CUNHA, RODRIGO A. . Caffeine and an adenosine A 2A receptor antagonist prevent memory impairment and synaptotoxicity in adult rats triggered by a convulsive episode in early life. Journal of Neurochemistry, v. 112, p. 453-462, 2010.

23.
LOPES, JOAO P.2010LOPES, JOAO P. ; OLIVEIRA, CATARINA R. ; AGOSTINHO, PAULA . Neurodegeneration in an Aβ-induced model of Alzheimer-s disease: the role of Cdk5. Aging Cell (Print), v. 9, p. 64-77, 2010.

24.
LOPES, J.2009LOPES, J. ; OLIVEIRA, C. ; AGOSTINHO, P. . Cell Cycle Re-Entry in Alzheimers Disease: A Major Neuropathological Characteristic?. Current Alzheimer Research, v. 6, p. 205-212, 2009.

25.
LOPE, J. P.2009LOPE, J. P. ; Blurton-Jones, M ; Yamasaki, T.R. ; AGOSTINHO, PAULA M. ; LaFerla, F.M. . Activation of cell cycle proteins in transgenic mice in response to neuronal loss but not Amyloid-β and tau pathology. Journal of Alzheimer's Disease, v. 16, p. 541-549, 2009.

26.
MELO, JOANA B.2009MELO, JOANA B. ; SOUSA, CARLA ; GARÇÃO, PEDRO ; OLIVEIRA, CATARINA R. ; AGOSTINHO, PAULA . Galantamine protects against oxidative stress induced by amyloid-beta peptide in cortical neurons. European Journal of Neuroscience (Print), v. 29, p. 455-464, 2009.

27.
LOPES, JOÃO P.2009LOPES, JOÃO P. ; OLIVEIRA, CATARINA R. ; AGOSTINHO, PAULA . Cdk5 acts as a mediator of neuronal cell cycle re-entry triggered by amyloid-β and prion peptides. Cell Cycle (Georgetown, Tex.), v. 8, p. 97-104, 2009.

28.
MATOS, M.2008MATOS, M. ; AUGUSTO, E. ; Oliveira, C.R. ; AGOSTINHO, P. . Amyloid-beta peptide decreases glutamate uptake in cultured astrocytes: Involvement of oxidative stress and mitogen-activated protein kinase cascades. Neuroscience, v. 156, p. 898-910, 2008.

29.
AGOSTINHO, PAULA2008AGOSTINHO, PAULA; LOPES, JOÃO P. ; VELEZ, ZÉLIA ; OLIVEIRA, CATARINA R. . Overactivation of calcineurin induced by amyloid-beta and prion proteins. Neurochemistry International, v. 52, p. 1226-1233, 2008.

30.
LOPES, JOAO P.2007LOPES, JOAO P. ; OLIVEIRA, CATARINA R. ; AGOSTINHO, PAULA . Role of Cyclin-Dependent Kinase 5 in the Neurodegenerative Process Triggered by Amyloid-Beta and Prion Peptides: Implications for Alzheimer-s Disease and Prion-Related Encephalopathies. Cellular and Molecular Neurobiology, v. 27, p. 943-957, 2007.

31.
SANTOS, S. C. R.2007SANTOS, S. C. R. ; VALA, I. ; MIGUEL, C. ; BARATA, J. T. ; GARCAO, P. ; AGOSTINHO, P. ; MENDES, M. ; COELHO, A. V. ; CALADO, A. ; OLIVEIRA, C. R. ; E SILVA, J. M. ; SALDANHA, C. . Expression and Subcellular Localization of a Novel Nuclear Acetylcholinesterase Protein. The Journal of Biological Chemistry (Print), v. 282, p. 25597-25603, 2007.

32.
RESENDE, R.2007RESENDE, R. ; PEREIRA, C. ; AGOSTINHO, P. ; VIEIRA, A.P. ; MALVA, J.O. ; Oliveira, C.R. . Susceptibility of hippocampal neurons to Aβ peptide toxicity is associated with perturbation of Ca2+ homeostasis. Brain Research, v. 1143, p. 11-21, 2007.

33.
MELO, J. B.2007MELO, J. B. ; AGOSTINHO, P. ; OLIVEIRA, C. R. . Prion Protein Aggregation and Neurotoxicity in Cortical Neurons. Annals of the New York Academy of Sciences, v. 1096, p. 220-229, 2007.

34.
GARÇÃO, PEDRO2006GARÇÃO, PEDRO ; OLIVEIRA, CATARINA R. ; AGOSTINHO, PAULA . Comparative study of microglia activation induced by amyloid-beta and prion peptides: Role in neurodegeneration. Journal of Neuroscience Research, v. 84, p. 182-193, 2006.

35.
PEREIRA, C.2005PEREIRA, C. ; AGOSTINHO, P. ; MOREIRA, P. ; CARDOSO, S. ; OLIVEIRA, C. . Alzheimers Disease-Associated Neurotoxic Mechanisms and Neuroprotective Strategies. Current Drug Targets. CNS & Neurological Disorders (Cessou em 2005. Cont. ISSN 1871-5273 CNS & Neurological Disorders. Drug Targets), v. 4, p. 383-403, 2005.

36.
CARDOSO, S.2005CARDOSO, S. ; MOREIRA, P. ; AGOSTINHO, P. ; PEREIRA, C. ; OLIVEIRA, C. . Neurodegenerative Pathways in Parkinsons Disease: Therapeutic Strategies. Current Drug Targets. CNS & Neurological Disorders (Cessou em 2005. Cont. ISSN 1871-5273 CNS & Neurological Disorders. Drug Targets), v. 4, p. 405-419, 2005.

37.
Pereira, C.2003Pereira, C. ; AGOSTINHO, PAULA M. ; MOREIRA, P.I. ; DUARTE, A.L. ; SANTOS, M.S. ; OLIVEIR, C.R. . Neuroprotection strategies: effect of vinpocetine in vitro oxidative stress models. Acta Med Port, v. 16, p. 401-406, 2003.

38.
AGOSTINHO, PAULA2003AGOSTINHO, PAULA; OLIVEIRA, CATARINA RESENDE . Involvement of calcineurin in the neurotoxic effects induced by amyloid-beta and prion peptides. European Journal of Neuroscience (Print), v. 17, p. 1189-1196, 2003.

39.
MELO, JOANA BARBOSA2003MELO, JOANA BARBOSA ; AGOSTINHO, PAULA ; OLIVEIRA, CATARINA RESENDE . Involvement of oxidative stress in the enhancement of acetylcholinesterase activity induced by amyloid beta-peptide. Neuroscience Research, v. 45, p. 117-127, 2003.

40.
MELO, JOANA BARBOSA2002MELO, JOANA BARBOSA ; AGOSTINHO, PAULA ; OLIVEIRA, CATARINA RESENDE . Amyloid beta-peptide 25-35 reduces [ H] acetylcholine release in retinal neurons. Involvement of metabolic dysfunction. Amyloid (Carnforth), v. 9, p. 221-228, 2002.

41.
PEREIRA, CLÁUDIA2000PEREIRA, CLÁUDIA ; AGOSTINHO, PAULA ; OLIVEIRA, CATARINA R. . Vinpocetine attenuates the metabolic dysfunction induced by amyloid β-peptides in PC12 cells. Free Radical Research, v. 33, p. 497-506, 2000.

42.
REGO, ANA CRISTINA2000REGO, ANA CRISTINA ; AGOSTINHO, PAULA ; MELO, JOANA ; CUNHA, RODRIGO A ; OLIVEIRA, CATARINA R . Adenosine A2AReceptors Regulate the Extracellular Accumulation of Excitatory Amino Acids upon Metabolic Dysfunction in Chick Cultured Retinal Cells. Experimental Eye Research, v. 70, p. 577-587, 2000.

43.
AGOSTINHO, PAULA2000AGOSTINHO, PAULA; CASEIRO, PAULA ; REGO, ANA CRISTINA ; DUARTE, EM''LIA P. ; CUNHA, RODRIGO A. ; OLIVEIRA, CATARINA R. . Adenosine modulation of d-[3H]aspartate release in cultured retina cells exposed to oxidative stress. Neurochemistry International, v. 36, p. 255-265, 2000.

44.
DUARTE, CARLOS B1998DUARTE, CARLOS B ; FERREIRA, ILDETE L ; SANTOS, PAULO F ; CARVALHO, ANA L ; AGOSTINHO, PAULA M ; CARVALHO, ARSÉLIO P . Glutamate in Life and Death of Retinal Amacrine Cells*. General Pharmacology (Cessou em 2001. Cont. ISSN 1537-1891 Vascular Pharmacology), v. 30, p. 289-295, 1998.

45.
AGOSTINHO, PAULA M.1997AGOSTINHO, PAULA M.; DUARTE, C.B. ; OLIVEIRA, CATARINA R. . Impairment of excitatory amino acid transporter activity by oxidative stress conditions in retinal cells: effect of antioxidants.. The FASEB Journal (Online), v. 11, p. 154-163, 1997.

46.
AGOSTINHO, PAULA1997AGOSTINHO, PAULA; DUARTE, CARLOS B ; CARVALHO, ARSÉLIO P ; OLIVEIRA, CATARINA R . Oxidative stress affects the selective ion permeability of voltage-sensitive Ca2+ channels in cultured retinal cells. Neuroscience Research, v. 27, p. 323-334, 1997.

47.
AGOSTINHO, PAULA1996AGOSTINHO, PAULA; DUARTE, CARLOS B. ; OLIVEIRA, CATARINA R. . Activity of Ionotropic Glutamate Receptors in Retinal Cells: Effect of Ascorbate/Fe2+-Induced Oxidative Stress. Journal of Neurochemistry, v. 67, p. 1153-1163, 1996.

48.
AGOSTINHO, PAULA1995AGOSTINHO, PAULA; DUARTE, CARLOS B. ; OLIVEIRA, CATARINA R. . Influence of oxidative stress on membrane potential and on K+ channels in neuronal cells. Bioelectrochemistry and Bioenergetics (Print) (Cessou em 2000. Cont.1567-5394 Bioelectrochemistry (Amsterdam), v. 38, p. 297-305, 1995.

49.
AGOSTINHO, PAULA1995AGOSTINHO, PAULA; DUARTE, CARLOS B. ; CARVALHO, ARSÉLIO P. ; OLIVEIRA, CATARINA R. . Modulation of N-methyl-d-aspartate receptor activity by oxidative stress conditions in chick retinal cells. Neuroscience Letters (Print), v. 198, p. 193-196, 1995.

50.
OLIVEIRA, C. R.1994OLIVEIRA, C. R. ; AGOSTINHO, P. ; CASEIRO, P. ; DUARTE, C. B. ; CARVALHO, A. P. . Reactive Oxygen Species on GABA Releasea. New York Academy of Sciences. Annals, v. 738, p. 130-140, 1994.

51.
AGOSTINHO, PAULA1994AGOSTINHO, PAULA; DUARTE, CARLOS B. ; CARVALHO, ARSÉLIO P. ; OLIVEIRA, CATARINA R. . Effect of oxidative stress on the release of [3H]GABA in cultured chick retina cells. Brain Research, v. 655, p. 213-221, 1994.

52.
MOREIRA, LEONILDE1994MOREIRA, LEONILDE ; AGOSTINHO, PAULA ; MORALS, PAULA VASCONCELLOS ; DA COSTA, M. S. . Survival of allochthonous bacteria in still mineral water bottled in polyvinyl chloride (PVC) and glass. Journal of Applied Bacteriology, v. 77, p. 334-339, 1994.

Livros publicados/organizados ou edições
1.
AGOSTINHO, P. M. G.; OLIVEIRA, CATARINA . Neuroinflammation and mitochondrial dysfunction in Alzheimer´s and Prion´s diseases. In: "Interaction Between neurons and glia in aging and disease". 14. ed. New York: Springer Publishers, 2007.



Orientações



Orientações e supervisões concluídas
Dissertação de mestrado
1.
Anna Vladímirovna Pliássova. Localization of secretases involved in the processing of β-amyloid precursor protein related to Alzheimer´s disease. 2013. Dissertação (Mestrado em Bioquímica) - Faculty of Sciences and Technology, University of Coimbra., . Orientador: Paula Maria Garcia Agostinho.

2.
Tiago Soares Silva. Interaction between ecto-5´- nucleotidase and adenosine A2A receptors in mice nerve terminals of mice prefrontal cortex. 2013. Dissertação (Mestrado em Bioquímica) - Faculty of Sciences and Technology, University of Coimbra., . Orientador: Paula Maria Garcia Agostinho.

3.
Diana Isabel Queirós Guedes Rodrigues. Synaptic localization of amyloid precursor protein in the rat hippocampus. 2011. Dissertação (Mestrado em Biologia) - Faculty of Sciences and Technology, University of Coimbra, . Orientador: Paula Maria Garcia Agostinho.

4.
Marco António Paisana de Matos. The effect of amyloid-beta peptide on the glutamate uptake by astrocytes. 2008. Dissertação (Mestrado em Biologia) - Faculty of Sciences and Technology, University of Coimbra., . Orientador: Paula Maria Garcia Agostinho.

5.
Maria Joana Barbosa de Melo. The effect of amyloid-beta peptide in cholinergic system. The role of oxidative stress and metabolic dysfunction. 2001. Dissertação (Mestrado em Biologia) - Faculty of Sciences and Technology, University of Coimbra, . Orientador: Paula Maria Garcia Agostinho.

Tese de doutorado
1.
Elisabete Oliveira Augusto. Reactive Astrocytes in Alzheimer s Disease and the Protective Effect of Galantamine. 2008. Tese (Doutorado em Biologia Celular) - Faculty of Sciences, University of Porto, . Orientador: Paula Maria Garcia Agostinho.

2.
Carla Jesus Cardoso de Sousa. Potencial efeito antioxidante da galantamina. Relevância na terapêutica da doença de Alzheimer. 2006. Tese (Doutorado em Biologia) - Faculdade de Ciências e Tecnologia da Universidade de Coimbra, . Orientador: Paula Maria Garcia Agostinho.

3.
Pedro Manuel Venâncio Garção. The role of microglia in neurodegeneration induced amyloid-beta and prion petides. 2004. Tese (Doutorado em Biologia) - Faculty of Sciences and Technology, University of Coimbra., . Orientador: Paula Maria Garcia Agostinho.

4.
Zélia Cristina Pereira Velez. Neurodegeneration induced by amyloid-beta and prion peptides: The role of kinases and phosphatases. 2002. Tese (Doutorado em Biologia) - Faculty of Sciences and Technology, University of Coimbra., . Orientador: Paula Maria Garcia Agostinho.

Supervisão de pós-doutorado
1.
Marco António Paisana de Matos. Role of adenosine A2A receptors in astrocytes: implications for glutamatergic activity. 2013. Faculty of Sciences and Technology, University of Coimbra, . Paula Maria Garcia Agostinho.

2.
Pedro Manuel Venâncio Garção. Functional interaction between presynaptic nicotinic and adenosine receptors in the control of dopamine release in the striatum. 2013. Faculty of Sciences and Technology, University of Coimbra, . Paula Maria Garcia Agostinho.

3.
João Pedro Oliveira da Silva Paulino Lopes. Neurodegeneration in Alzheimer´s disease and Prion-related encephalopathies: the role of cyclin-dependent kinase 5 and cell cycle regulators. 2009. Faculty of Sciences and Technology, University of Coimbra, . Paula Maria Garcia Agostinho.

4.
Elisabete Oliveira Augusto. Role of A2A receptors in glutamatergic synapses in the control of synaptic plasticity and memory. 2009. Faculty of Sciences and Technology, University of Coimbra, . Paula Maria Garcia Agostinho.




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