Simon Gert Coetzee

  • Endereço para acessar este CV: http://lattes.cnpq.br/4092597580733088
  • Última atualização do currículo em 27/02/2014


Possui graduação em Biology pela University of California, Los Angeles(2008), especialização em Bioinformatics and Genomics pela University of Southern California(2013) e especialização em Bioinformatics and Genomics pela University of Southern California(2012). Tem experiência na área de Medicina, com ênfase em Clínica Médica. (Texto gerado automaticamente pela aplicação CVLattes)


Identificação


Nome
Simon Gert Coetzee
Nome em citações bibliográficas
COETZEE, S. G.;COETZEE, SIMON G.;COETZEE, S.


Formação acadêmica/titulação


2011 - 2013
Especialização em Bioinformatics and Genomics.
University of Southern California, USC, Estados Unidos.
Título: Annotation of GWAS Risk Regions in Colorectal Cancer.
Orientador: Graham Casey.
Bolsista do(a): National Institutes of Health.
2011 - 2012
Especialização em Bioinformatics and Genomics.
University of Southern California, USC, Estados Unidos.
Título: Opposing effects of Runx2 and estradiol on breast cancer cell proliferation: in vitro identification of reciprocally regulated gene signature related to clinical letrozole responsiveness.
Orientador: Baruch Frenkel.
Bolsista do(a): National Institutes of Health.
2005 - 2008
Graduação em Biology.
University of California, Los Angeles, UCLA, Estados Unidos.
Título: NA.
Orientador: NA.




Atuação Profissional



University of Southern California, USC, Estados Unidos.
Vínculo institucional

2011 - 2013
Vínculo: Bolsista, Enquadramento Funcional: Bioinformatic Technician/Analyst, Carga horária: 40

Atividades

1/2011 - 1/2013
Pesquisa e desenvolvimento , Department of Preventative Medicine, .

Linhas de pesquisa
Epigenomics and Genomics
1/2011 - 1/2013
Serviços técnicos especializados , Department of Preventative Medicine, .

Serviço realizado
Bioinformatic Technician/Analyst.


Linhas de pesquisa


1.
Epigenomics and Genomics

Objetivo: To characterize the interaction of the non coding genome with protein coding regions, thereby elucidating function, especially in the context of cancer..
Grande área: Ciências Biológicas / Área: Genética / Subárea: Genética Humana e Médica.
Grande Área: Ciências da Saúde / Área: Medicina / Subárea: Clínica Médica / Especialidade: Cancerologia.
Setores de atividade: Pesquisa e desenvolvimento científico.
Palavras-chave: bioinformatics; breast; cancer; colorectal; gwas; prostate.


Projetos de pesquisa


2012 - Atual
Annotation of GWAS Risk Regions in Various Cancers
Descrição: We seek to provide a complete summary annotation of functional hypotheses relating to risk identified by genome wide association studies of various cancers, and in addition seek to characterize enhancer regulatory networks among the cell lines to elucidate dysregulation in cancer..
Situação: Em andamento; Natureza: Pesquisa.
2011 - 2012
Opposing effects of Runx2 and estradiol on breast cancer cell proliferation: in vitro identification of reciprocally regulated gene signature related to clinical letrozole responsiveness
Descrição: This work provides clinical evidence for the importance of antagonism between Runx2 and E2 signaling in breast cancer. Likely sensing the tension between them, letrozole responsiveness of a genomic node, positively regulated by estradiol and negatively regulated by Runx2 in vitro, best correlated with the clinical efficacy of letrozole treatment..
Situação: Concluído; Natureza: Pesquisa.
2011 - Atual
FunciSNP: An R/Bioconductor tool integrating functional non-coding datasets with genetic association studies to identify candidate regulatory
Descrição: Single nucleotide polymorphisms (SNPs) are increasingly used to tag genetic loci associated with phenotypes such as risk of complex diseases. Technically, this is done genome-wide without prior restriction or knowledge of biological feasibility in scans referred to as genome-wide association studies (GWAS). Depending on the linkage disequilibrium (LD) structure at a particular locus, such tagSNPs may be surrogates for many thousands of other SNPs, and it is difficult to distinguish those that may play a functional role in the phenotype from those simply genetically linked. Because a large proportion of tagSNPs have been identified within non-coding regions of the genome, distinguishing functional from non-functional SNPs has been an even greater challenge. A strategy was recently proposed that prioritizes surrogate SNPs based on non-coding chromatin and epigenomic mapping techniques that have become feasible with the advent of massively parallel sequencing. Here, we introduce an R/Bioconductor software package that enables the identification of candidate functional SNPs by integrating information from tagSNP locations, lists of linked SNPs from the 1000 genomes project and locations of chromatin features which may have functional significance. Availability: FunciSNP is available from Bioconductor (bioconductor.org)..
Situação: Em andamento; Natureza: Pesquisa.
2005 - 2006
Interleukin-6-Related Genotypes, Body Mass Index, and Risk of Multiple Myeloma and Plasmacytoma
Descrição: Interleukin-6 (IL-6) promotes normal plasma cell development and proliferation of myeloma cells in culture. We evaluated IL-6 genotypes and body mass index (BMI) in a case-control study of multiple myeloma and plasmacytoma. DNA samples and questionnaires were obtained from incident cases of multiple myeloma (n = 134) and plasmacytoma (n = 16; plasma cell neoplasms) ascertained from the Los Angeles County population-based cancer registry and from siblings or cousins of cases (family controls, n = 112) and population controls (n = 126). Genotypes evaluated included IL-6 promoter gene single nucleotide polymorphisms (SNP) at positions -174, -572, and -597; one variable number of tandem repeats (-373 A(n)T(n)); and one SNP in the IL-6 receptor (IL-6ralpha) gene at position -358. The variant allele of the IL-6 promoter SNP -572 was associated with a roughly 2-fold increased risk of plasma cell neoplasms when cases were compared with family [odds ratio (OR), 1.8; 95% confidence interval (95% CI), 0.7-4.7] or population controls (OR, 2.4; 95% CI, 1.2-4.7). The -373 9A/9A genotype was associated with a decreased risk compared with the most common genotype (OR for cases versus family controls, 0.4; 95% CI, 0.1-1.7; OR for cases versus population controls, 0.3; 95% CI, 0.1-0.9). No other SNPs were associated with risk. Obesity (BMI >or= 30 kg/m(2)) increased risk nonsignificantly by 40% and 80% when cases were compared with family controls or population controls, respectively, relative to persons with a BMI of <25 kg/m(2). These results suggest that IL-6 promoter genotypes may be associated with increased risk of plasma cell neoplasms..
Situação: Concluído; Natureza: Pesquisa.


Áreas de atuação


1.
Grande área: Ciências da Saúde / Área: Medicina / Subárea: Clínica Médica/Especialidade: Cancerologia.
2.
Grande área: Ciências Biológicas / Área: Genética / Subárea: Genética Humana e Médica.


Idiomas


Inglês
Compreende Bem, Fala Bem, Lê Bem, Escreve Bem.
Afrikaans
Compreende Razoavelmente, Fala Razoavelmente, Lê Pouco, Escreve Pouco.
Português
Compreende Pouco, Fala Pouco, Lê Pouco, Escreve Pouco.


Produções



Produção bibliográfica
Citações

Web of Science
Total de trabalhos:6
Total de citações:52
Fator H:4
Coetzee, Simon G  Data: 27/02/2014

Outras
Total de trabalhos:14
Total de citações:90
Coetzee, Simon G  Data: 27/02/2014

Artigos completos publicados em periódicos

1.
HAZELETT, DENNIS J.2014 HAZELETT, DENNIS J. ; RHIE, SUHN KYONG ; GADDIS, MALAINA ; YAN, CHUNLI ; LAKELAND, DANIEL L. ; COETZEE, SIMON G. ; HENDERSON, BRIAN E. ; NOUSHMEHR, HOUTAN ; COZEN, WENDY ; KOTE-JARAI, ZSOFIA ; EELES, ROSALIND A. ; EASTON, DOUGLAS F. ; HAIMAN, CHRISTOPHER A. ; LU, WANGE ; FARNHAM, PEGGY J. ; COETZEE, GERHARD A. . Comprehensive Functional Annotation of 77 Prostate Cancer Risk Loci. PLOS Genetics (Online), v. 10, p. e1004102, 2014.

2.
RHIE, SUHN KYONG2013RHIE, SUHN KYONG ; COETZEE, SIMON G. ; NOUSHMEHR, HOUTAN ; YAN, CHUNLI ; KIM, JAE MUN ; HAIMAN, CHRISTOPHER A. ; COETZEE, GERHARD A. . Comprehensive Functional Annotation of Seventy-One Breast Cancer Risk Loci. Plos One, v. 8, p. e63925, 2013.

3.
PETERS, ULRIKE2013PETERS, ULRIKE JIAO, SHUO SCHUMACHER, FREDRICK R. HUTTER, CAROLYN M. ARAGAKI, AARON K. BARON, JOHN A. BERNDT, SONJA I. BÉZIEAU, STÉPHANE BRENNER, HERMANN BUTTERBACH, KATJA CAAN, BETTE J. CAMPBELL, PETER T. CARLSON, CHRISTOPHER S. CASEY, GRAHAM CHAN, ANDREW T. CHANG-CLAUDE, JENNY CHANOCK, STEPHEN J. CHEN, LIN S. COETZEE, GERHARD A. COETZEE, SIMON G. CONTI, DAVID V. CURTIS, KEITH R. DUGGAN, DAVID EDWARDS, TODD FUCHS, CHARLES S. , et al.GALLINGER, STEVEN GIOVANNUCCI, EDWARD L. GOGARTEN, STEPHANIE M. GRUBER, STEPHEN B. HAILE, ROBERT W. HARRISON, TABITHA A. HAYES, RICHARD B. HENDERSON, BRIAN E. HOFFMEISTER, MICHAEL HOPPER, JOHN L. HUDSON, THOMAS J. HUNTER, DAVID J. JACKSON, REBECCA D. JEE, SUN HA JENKINS, MARK A. JIA, WEI-HUA KOLONEL, LAURENCE N. KOOPERBERG, CHARLES KÜRY, SÉBASTIEN LACROIX, ANDREA Z. LAURIE, CATHY C. LAURIE, CECELIA A. LE MARCHAND, LOIC LEMIRE, MATHIEU LEVINE, DAVID LINDOR, NORALANE M. LIU, YAN MA, JING MAKAR, KAREN W. MATSUO, KEITARO NEWCOMB, POLLY A. POTTER, JOHN D. PRENTICE, ROSS L. QU, CONGHUI ROHAN, THOMAS ROSSE, STEPHANIE A. SCHOEN, ROBERT E. SEMINARA, DANIELA SHRUBSOLE, MARTHA SHU, XIAO-OU SLATTERY, MARTHA L. TAVERNA, DARIN THIBODEAU, STEPHEN N. ULRICH, CORNELIA M. WHITE, EMILY XIANG, YONGBING ZANKE, BRENT W. ZENG, YI-XIN ZHANG, BEN ZHENG, WEI HSU, LI ; Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis. Gastroenterology (New York, N.Y. 1943), v. 144, p. 799-807.e24, 2013.

4.
BIANCOLELLA, M.2013BIANCOLELLA, M. ; FORTINI, B. K. ; TRING, S. ; PLUMMER, S. J. ; MENDOZA-FANDINO, G. A. ; HARTIALA, J. ; HITCHLER, M. J. ; YAN, C. ; SCHUMACHER, F. R. ; CONTI, D. V. ; EDLUND, C. K. ; NOUSHMEHR, H. ; COETZEE, S. G. ; BRESALIER, R. S. ; AHNEN, D. J. ; BARRY, E. L. ; BURMAN, B. P. ; RICE, J. C. ; COETZEE, G. A. ; CASEY, G. . Identification and Characterization of Functional Risk Variants for Colorectal Cancer Mapping to Chromosome 11q23.1. Human Molecular Genetics, v. online, p. 1-12, 2013.

5.
HAZELETT, DENNIS J.2013 HAZELETT, DENNIS J. ; COETZEE, SIMON G. ; COETZEE, GERHARD A. . A rare variant, which destroys a FoxA1 site at 8q24, is associated with prostate cancer risk. Cell Cycle (Georgetown, Tex.), v. 12, p. 379-380, 2013.

6.
COETZEE, S. G.2012 COETZEE, S. G.; RHIE, S. K. ; BERMAN, B. P. ; COETZEE, G. A. ; NOUSHMEHR, H. . FunciSNP: an R/bioconductor tool integrating functional non-coding data sets with genetic association studies to identify candidate regulatory SNPs. Nucleic Acids Research (Online), v. 40, p. e139-e139, 2012.

7.
CHIMGE, N.-O.2012CHIMGE, N.-O. ; BANIWAL, S. K. ; LUO, J. ; COETZEE, S. ; KHALID, O. ; BERMAN, B. P. ; TRIPATHY, D. ; ELLIS, M. J. ; FRENKEL, B. . Opposing Effects of Runx2 and Estradiol on Breast Cancer Cell Proliferation: In Vitro Identification of Reciprocally Regulated Gene Signature Related to Clinical Letrozole Responsiveness. Clinical Cancer Research (Print), v. 18, p. 901-911, 2012.

8.
COZEN, W.2006COZEN, W. ; GEBREGZIABHER, M. ; CONTI, D. V. ; VAN DEN BERG, D. J. ; COETZEE, G. A. ; WANG, S. S. ; ROTHMAN, N. ; BERNSTEIN, L. ; HARTGE, P. ; MORHBACHER, A. ; COETZEE, S. G. ; SALAM, M. T. ; WANG, W. ; ZADNICK, J. ; INGLES, S. A. . Interleukin-6-Related Genotypes, Body Mass Index, and Risk of Multiple Myeloma and Plasmacytoma. Cancer Epidemiology, Biomarkers & Prevention, v. 15, p. 2285-2291, 2006.

Capítulos de livros publicados
1.
COETZEE, S. G.; Noushmehr, H . The Functionality of Prostate Cancer Predisposition Risk Regions Is Revealed by AR Enhancers. In: Zhou Wang. (Org.). Androgen-Responsive Genes in Prostate Cancer. 1ed.New York, New York: Springer New York, 2013, v. 1, p. 59-84.

Resumos publicados em anais de congressos
1.
COZEN, WENDY ; GEBREGZIABHER, M. ; VAN DEN BERG, D. J. ; CONTI, D. V. ; COETZEE, G. A. ; BERNSTEIN, L. ; WANG, S. S. ; ROTHMAN, N. ; HARTGE, P. ; WANG, W. ; COETZEE, S. G. ; INGLES, S. A. . IL-6 promoter and receptor polymorphisms, body mass index, and risk of multiple myeloma. In: American Association of Cancer Research Meeting, 2006, Washington DC. Proc Amer Assoc Cancer Res, 2006. v. 47.

Apresentações de Trabalho
1.
COETZEE, S. G.. biOMICs+: Easily Integrate Public OMICS data for Functional Study. 2013. (Apresentação de Trabalho/Congresso).

2.
COETZEE, S. G.. Funci{SNP} An R/Bioconductor Tool - Integrating SNPs, biofeatures, and 1000 genomes data. 2012. (Apresentação de Trabalho/Outra).

3.
COETZEE, S. G.. Funci{SNP}: Integrating Functional Non-coding Data sets with Genetic Association Studies to Identify Candidate Regulatory SNPs. 2012. (Apresentação de Trabalho/Simpósio).


Produção técnica
Programas de computador sem registro
1.
COETZEE, S. G.; NOUSHMEHR, H. ; NOUSHMEHR, H. . Funci{SNP}. 2012.


Demais tipos de produção técnica
1.
COETZEE, S. G.. X Summer Course for Bioinformatics (Instructor). 2014. (Curso de curta duração ministrado/Outra).

2.
COETZEE, S. G.. X Summer Course for Bioinformatics (Organizer). 2014. (Curso de curta duração ministrado/Outra).

3.
COETZEE, S. G.. X Summer Course for Bioinformatics (Monitor). 2014. (Curso de curta duração ministrado/Outra).

4.
COETZEE, S. G.. IX Curso de Verão em Bioinformática (Organizer). 2013. (Curso de curta duração ministrado/Outra).

5.
COETZEE, S. G.. IX Curso de Verão em Bioinformática (Instructor). 2013. (Curso de curta duração ministrado/Outra).



Eventos



Participação em eventos, congressos, exposições e feiras
1.
São Paulo school of advanced sciences on oncogenesis and translational medicine school + bioinformatcs mini-course. Genomic regulatory maps define cell of origin and risk regions for epithelial ovarian cancer. 2014. (Congresso).

2.
BioC2013 Annual Conference. Funci{SNP}: Integrating Functional Non-coding Data sets with Genetic Association Studies to Identify Candidate Regulatory SNPs / biOMICs+: Easily Integrate Public OMICS data for Functional Study. 2013. (Congresso).

3.
Escola de estudos avancados em Genomica. 2013. (Congresso).



Inovação



Programa de computador sem registro
1.
COETZEE, S. G.; NOUSHMEHR, H. ; NOUSHMEHR, H. . Funci{SNP}. 2012.



Outras informações relevantes


Skills:
Computers: Office Suite, Adobe Photoshop and Illustrator, Programming (Python and R), Gadget friendly. GNU/Linux, Mac OS X, and Windows proficient.
Organization: I am detail oriented and have the ability to multitask, while quickly picking up new skills. I also have office related organizational skills.
Managerial: I worked as a field manager, supervising training and new hires, throughout most of my political action fundraising work.
Leadership: While working as a field manager, provisional hires/trainees assigned to me would consistently outperform expectations in meeting fundraising requirements (raising more money than required to transition to full employment).
Biology: I have mastered in various wet-lab techniques in molecular and cell biology, in the context of both a formal classroom setting and on the job training.
 
Work Experience Outside of science:.
Donor Services Group   Fundraiser
March 2009   June 2009
Engaged in telephone fundraising on behalf of non-profit organizations.

Grassroots Campaigns Inc.   Field Manager
August 2008   January 2009
Responsible for the training and performance of new fundraisers, while raising money and educating the public on behalf of non-profit organizations, primarily for the 2008 Obama Campaign for president and the ACLU.



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