Valder Roberval Arruda

  • Endereço para acessar este CV: http://lattes.cnpq.br/1706206665225855
  • Última atualização do currículo em 30/06/2015


Possui graduação em Medicina pela Universidade Federal do Triângulo Mineiro (1987) e doutorado em Ciências Médicas pela Universidade Estadual de Campinas (1995). , atuando principalmente nos seguintes temas: myelodysplasia, hemofilia, leucemia, teleangiectsia hemorragica hereditaria e b-thalassemia. Atualmente é professor Associado em Pediatria , na escola de Medicina Parelman, Universidade da Pensilvânia e Pesquisador no "The Children`s Hospital of Philadelphia". (Texto informado pelo autor)


Identificação


Nome
Valder Roberval Arruda
Nome em citações bibliográficas
ARRUDA, V. R.;ARRUDA, VALDER R;ARRUDA, VALDER R.

Endereço


Endereço Profissional
University of Pennsylvania, The Chidren´s hospital of Philadelphia.
3501 Civic Center Blvd 5056 Colket Translational Research Center
Center Blvd
Philadelphia, - Estados Unidos
Telefone: (215) 5904907
URL da Homepage: http://www.philau.edu/


Formação acadêmica/titulação


1991 - 1995
Doutorado em Ciências Médicas.
Universidade Estadual de Campinas, UNICAMP, Brasil.
Título: Detecção de portadoras e caracterização molecular na hemofilia A em uma população brasileira, Ano de obtenção: 1995.
Orientador: Fernando Ferreira Costa.
Bolsista do(a): Fundação de Amparo à Pesquisa do Estado de São Paulo, FAPESP, Brasil.
Grande área: Ciências da Saúde
1981 - 1987
Graduação em Medicina.
Universidade Federal do Triângulo Mineiro, UFTM, Brasil.


Pós-doutorado


1997 - 1999
Pós-Doutorado.
University of Pennsylvania, UPENN, Estados Unidos.
Grande área: Ciências da Saúde


Atuação Profissional



University of Pennsylvania, UPENN, Estados Unidos.
Vínculo institucional

1997 - Atual
Vínculo: Servidor Público, Enquadramento Funcional: Professor titular, Carga horária: 40
Outras informações
Dr. Arruda has been a full-time member of the Division of Hematology at The Children?s Hospital of Philadelphia since 1997. He join us as a Post-Doctoral Fellow and in 2000 was appointed as Faculty of the University of Pennsylvania Medical School and became an Associate Professor of Pediatrics at the University of Pennsylvania with Tenure since 2007. Dr. Arruda has many ongoing hospital and administrative appointments: He is a lecturer for University graduate courses, and is a member of the Admissions Committee for MD, PhD Students at the University of Pennsylvania School of Medicine. He has trained several post-doctoral fellows, graduate students and pre-med students over the last decades while at The Children's Hospital of Philadelphia/University of Pennsylvania.


Universidade Estadual de Campinas, UNICAMP, Brasil.
Vínculo institucional

1991 - 1997
Vínculo: Servidor Público, Enquadramento Funcional: Professor titular, Carga horária: 40



Membro de corpo editorial


2008 - Atual
Periódico: Molecular Therapy (Print)


Revisor de periódico


2003 - Atual
Periódico: Expert Review of Cardiovascular Therapy
2006 - Atual
Periódico: Journal of Thrombosis and Haemostasis (Print)
2007 - Atual
Periódico: Molecular Therapy (Print)
2007 - Atual
Periódico: Current Gene Therapy
2008 - Atual
Periódico: Neuromuscular Disorders
2009 - Atual
Periódico: ILAR Journal
2010 - Atual
Periódico: Haemophilia (Oxford. Print)
2005 - Atual
Periódico: Blood (Philadelphia, PA)
2005 - Atual
Periódico: Nature Biotechnology (Print)
2005 - Atual
Periódico: The Journal of Clinical Investigation
2005 - Atual
Periódico: Proceedings of the National Academy of Sciences of the United States of Ame
2005 - Atual
Periódico: Human Mutation
2005 - Atual
Periódico: American Journal of Hematology (Print)
2005 - Atual
Periódico: Thrombosis and Haemostasis
2005 - Atual
Periódico: Clinical Genetics
2005 - Atual
Periódico: The Journal of Gene Medicine
2005 - Atual
Periódico: FABEB Journal
2005 - Atual
Periódico: Human Gene Therapy


Prêmios e títulos


2009
American Society for Clinical Investigation Award, American Society for Clinical Investigation.
1999
Young Investigator Award, American Society of Hematology.
1998
II Prêmio do simpósio Internacional Rio de Janeiro 1998 do Grupo Claht, Grupo Claht.
1998
Prêmio de Melhor Tema Livre com o trabalho intitulado Mutação Ala-677-Val no gene da metilenotetrahidrofolatoreductase: um fator de risco para acidente vascular cerebral ischemico em jovens, XVIII Congresso Brasileiro de Neurologia.
1998
1998 ASH Travel Award, American Society of Hematology.


Produções



Produção bibliográfica
Artigos completos publicados em periódicos

1.
NICHOLS, TIMOTHY C.2015NICHOLS, TIMOTHY C. ; WHITFORD, MARGARET H. ; ARRUDA, VALDER R. ; STEDMAN, HANSELL H. ; KAY, MARK A. ; High, Katherine A. . Translational Data from Adeno-Associated Virus-Mediated Gene Therapy of Hemophilia B in Dogs. Human Gene Therapy Clinical Development, v. 26, p. 5-14, 2015.

2.
Crudele, J. M.2015Crudele, J. M. ; Finn, J. D. ; SINER, J. I. ; MARTIN, N. B. ; Niemeyer, G. P. ; Zhou, S. ; Mingozzi, F. ; Lothrop, C. D. ; ARRUDA, V. R. . AAV liver expression of FIX-Padua prevents and eradicates FIX inhibitor without increasing thrombogenicity in hemophilia B dogs and mice. Blood (Philadelphia, PA), v. 125, p. 1553-1561, 2015.

3.
Ozelo, M. C.2014Ozelo, M. C. ; VIDAL, B. ; BROWN, C. ; NOTLEY, C. ; HEGADORN, C. ; WEBSTER, S. ; HARPELL, L. ; AHLIN, J. ; WINTERBORN, A. ; HANDFORTH, J. ; ARRUDA, V. R. ; HOUGH, C. ; Lillicrap, D. . Omental implantation of BOECs in hemophilia dogs results in circulating FVIII antigen and a complex immune response. Blood (Philadelphia. Online), v. 123, p. 4045-4053, 2014.

4.
BALESTRA, D.2014BALESTRA, D. ; FAELLA, A. ; MARGARITIS, P. ; CAVALLARI, N. ; PAGANI, F. ; BERNARDI, F. ; ARRUDA, V. R. ; PINOTTI, M. . An engineered U1 small nuclear RNA rescues splicing-defective coagulation gene expression in mice. Journal of Thrombosis and Haemostasis (Print), v. 12, p. 177-185, 2014.

5.
SINER, J. I.2013SINER, J. I. ; IACOBELLI, N. P. ; Sabatino, D. E. ; IVANCIU, L. ; Zhou, S. ; Poncz, M. ; Camire, R. M. ; ARRUDA, V. R. . Minimal modification in the factor VIII B-domain sequence ameliorates the murine hemophilia A phenotype. Blood (Philadelphia. Online), v. 121, p. 4396-4403, 2013.

6.
TELLEZ, JOSEPH2013TELLEZ, JOSEPH ; VAN VLIET, KIM ; TSENG, YU-SHAN ; Finn, Jonathan D. ; TSCHERNIA, NICK ; ALMEIDA-PORADA, GRAÇA ; ARRUDA, VALDER R. ; AGBANDJE-MCKENNA, MAVIS ; PORADA, CHRISTOPHER D. ; QIU, JIANMING . Characterization of Naturally-Occurring Humoral Immunity to AAV in Sheep. Plos One, v. 8, p. e75142, 2013.

7.
Finn, J. D.2012Finn, J. D. ; Nichols, T. C. ; SVORONOS, N. ; Merricks, E. P. ; BELLENGER, D. A. ; Zhou, S. ; Simioni, P. ; High, K. A. ; ARRUDA, V. R. . The efficacy and the risk of immunogenicity of FIX Padua (R338L) in hemophilia B dogs treated by AAV muscle gene therapy. Blood (Philadelphia. Online), v. 120, p. 4521-4523, 2012.

8.
FABRI, D. R.2011FABRI, D. R. ; DE PAULA, E. V. ; COSTA, D. S. P. ; ANNICHINO-BIZZACCHI, J. M. ; ARRUDA, V. R. . Novel insights into the development of atherosclerosis in hemophilia A mouse models. Journal of Thrombosis and Haemostasis (Print), v. 9, p. 1556-1561, 2011.

9.
Favaro, Patricia2011Favaro, Patricia ; Finn, Jonathan D. ; Siner, Joshua I. ; Wright, J. Fraser ; High, Katherine A. ; ARRUDA, V. R. . Safety of Liver Gene Transfer Following Peripheral Intravascular Delivery of Adeno-Associated Virus (AAV)-5 and AAV-6 in a Large Animal Model. Human Gene Therapy, v. 22, p. 843-852, 2011.

10.
Li, H.2011Li, H. ; Malani, N. ; Hamilton, S. R. ; Schlachterman, A. ; Bussadori, G. ; Edmonson, S. E. ; Shah, R. ; ARRUDA, V. R. ; Mingozzi, F. ; Fraser Wright, J. ; Bushman, F. D. ; High, K. A. . Assessing the potential for AAV vector genotoxicity in a murine model. Blood (Philadelphia, PA), v. 117, p. 3311-3319, 2011.

11.
IVANCIU, LACRAMIOARA2011IVANCIU, LACRAMIOARA ; TOSO, RAFFAELLA ; MARGARITIS, PARIS ; PAVANI, GIULIA ; KIM, HAEIN ; SCHLACHTERMAN, ALEXANDER ; LIU, JIAN-HUA ; CLERIN, VALERIE ; PITTMAN, DEBRA D ; ROSE-MIRANDA, ROSALIND ; SHIELDS, KATHLEEN M ; ERBE, DAVID V ; TOBIN, JAMES F ; ARRUDA, VALDER R ; Camire, Rodney M . A zymogen-like factor Xa variant corrects the coagulation defect in hemophilia. Nature Biotechnology, v. 29, p. 1028-1033, 2011.

12.
Sabatino, Denise E2010Sabatino, Denise E ; Lange, Amy M ; Altynova, Ekaterina S ; Sarkar, Rita ; Zhou, Shangzhen ; Merricks, Elizabeth P ; Franck, Helen G ; Nichols, Timothy C ; ARRUDA, V. R. ; Kazazian Jr, Haig H . Efficacy and Safety of Long-term Prophylaxis in Severe Hemophilia A Dogs Following Liver Gene Therapy Using AAV Vectors. Molecular Therapy (Print), v. 19, p. 442-449, 2010.

13.
Finn, J. D.2010Finn, J. D. ; Ozelo, M. C. ; Sabatino, D. E. ; Franck, H. W. G. ; Merricks, E. P. ; Crudele, J. M. ; Zhou, S. ; Kazazian, H. H. ; Lillicrap, D. ; Nichols, T. C. ; ARRUDA, V. R. . Eradication of neutralizing antibodies to factor VIII in canine hemophilia A after liver gene therapy. Blood (Philadelphia, PA), v. 116, p. 5842-5848, 2010.

14.
Greene, T. K.2010Greene, T. K. ; Wang, C. ; Hirsch, J. D. ; Zhai, L. ; Gewirtz, J. ; Thornton, M. A. ; Miao, H. Z. ; Pipe, S. W. ; Kaufman, R. J. ; Camire, R. M. ; ARRUDA, V. R. ; Kowalska, M. A. ; Poncz, M. . In vivo efficacy of platelet-delivered, high specific activity factor VIII variants. Blood (Philadelphia, PA), v. 116, p. 6114-6122, 2010.

15.
Nichols, T. C.2010Nichols, T. C. ; RAYMER, R. A. ; Franck, H. W. G. ; Merricks, E. P. ; BELLINGER, D. A. ; DeFRIESS, N. ; MARGARITIS, P. ; ARRUDA, V. R. ; KAY, M. A. ; High, K. A. . Prevention of spontaneous bleeding in dogs with haemophilia A and haemophilia B. Haemophilia (Oxford. Print), v. 16, p. 19-23, 2010.

16.
Haurigot, Virginia2010Haurigot, Virginia ; Mingozzi, Federico ; Buchlis, George ; Hui, Daniel J ; Chen, Yifeng ; Basner-Tschakarjan, Etiena ; ARRUDA, V. R. ; Radu, Antoneta ; Franck, Helen G ; Wright, J Fraser ; Zhou, Shangzhen ; Stedman, Hansell H ; Bellinger, Dwight A ; Nichols, Timothy C ; HIGH, Katherine A . Safety of AAV Factor IX Peripheral Transvenular Gene Delivery to Muscle in Hemophilia B Dogs. Molecular Therapy (Print), v. 18, p. 1318-1329, 2010.

17.
ARRUDA, V. R.;ARRUDA, VALDER R;ARRUDA, VALDER R.2010ARRUDA, V. R.; Stedman, H. H. ; Haurigot, V. ; Buchlis, G. ; Baila, S. ; Favaro, P. ; Chen, Y. ; Franck, H. G. ; Zhou, S. ; Wright, J. F. ; Couto, L. B. ; Jiang, H. ; Pierce, G. F. ; BELLINGER, D. A. ; Mingozzi, F. ; Nichols, T. C. ; High, K. A. . Peripheral transvenular delivery of adeno-associated viral vectors to skeletal muscle as a novel therapy for hemophilia B. Blood (Philadelphia, PA), v. 115, p. 4678-4688, 2010.

18.
Simioni, P.2009Simioni, P. ; Tormene, D. ; Tognin, G. ; Gavasso, S. ; Bulato, C. ; Iacobelli, N.P. ; Finn, J.D. ; Spiezia, L. ; Radu, I. ; ARRUDA, V. R. . X-Linked Thrombophilia with a Mutant Factor IX (Factor IX Padua). The New England Journal of Medicine, v. 361, p. 1671-1675, 2009.

19.
Sabatino, D. E.2009Sabatino, D. E. ; Freguia, C. F. ; Toso, R. ; Santos, A. ; Merricks, E. P. ; Kazazian, H. H. ; Nichols, T. C. ; Camire, R. M. ; ARRUDA, V. R. . Recombinant canine B-domain-deleted FVIII exhibits high specific activity and is safe in the canine hemophilia A model. Blood (Philadelphia, PA), v. 114, p. 4562-4565, 2009.

20.
ARRUDA, V. R.;ARRUDA, VALDER R;ARRUDA, VALDER R.2009ARRUDA, V. R.; Favaro, Patricia ; Finn, Jonathan D . Strategies to Modulate Immune Responses: A New Frontier for Gene Therapy. Molecular Therapy (Print), v. 17, p. 1492-1503, 2009.

21.
de Paula, Erich V.2009de Paula, Erich V. ; Flores-Nascimento, Mariane Cristina ; ARRUDA, V. R. ; Garcia, Rosana A. ; Ramos, Celso D. ; Guillaumon, Ana T. ; Annichino-Bizzacchi, Joyce M. . Dual gene transfer of fibroblast growth factor-2 and platelet derived growth factor-BB using plasmid deoxyribonucleic acid promotes effective angiogenesis and arteriogenesis in a rodent model of hindlimb ischemia. Translational Research, v. 153, p. 232-239, 2009.

22.
Favaro, Patricia2009Favaro, Patricia ; Downey, Harre D ; Zhou, J Shangzhen ; Wright, J Fraser ; Hauck, Bernd ; Mingozzi, Federico ; HIGH, Katherine A ; Arruda, Valder R ; ARRUDA, V. R. . Host and Vector-dependent Effects on the Risk of Germline Transmission of AAV Vectors. Molecular Therapy (Print), v. 17, p. 1022-1030, 2009.

23.
Nichols, T.C.2009Nichols, T.C. ; Dillow, A.M. ; Franck, H.W.G. ; Merricks, E.P. ; Raymer, R.A. ; Bellinger, D.A. ; ARRUDA, V. R. ; High, K.A. . Protein Replacement Therapy and Gene Transfer in Canine Models of Hemophilia A, Hemophilia B, von Willebrand Disease, and Factor VII Deficiency. ILAR Journal, v. 50, p. 144-167, 2009.

24.
Niemeyer, G. P.2009Niemeyer, G. P. ; Herzog, R. W. ; Mount, J. ; ARRUDA, V. R. ; Tillson, D. M. ; Hathcock, J. ; van Ginkel, F. W. ; High, K. A. ; Lothrop, C. D. . Long-term correction of inhibitor-prone hemophilia B dogs treated with liver-directed AAV2-mediated factor IX gene therapy. Blood (Philadelphia, PA), v. 113, p. 797-806, 2009.

25.
Toromanoff, Alice2008Toromanoff, Alice ; Chérel, Yan ; Guilbaud, Mickaël ; Penaud-Budloo, Magalie ; Snyder, Richard O ; Haskins, Mark E ; Deschamps, Jack-Yves ; Guigand, Lydie ; Podevin, Guillaume ; ARRUDA, V. R. ; HIGH, Katherine A ; Stedman, Hansell H ; Rolling, Fabienne ; Anegon, Ignacio ; Moullier, Philippe ; Le Guiner, Caroline . Safety and Efficacy of Regional Intravenous (RI) Versus Intramuscular (IM) Delivery of rAAV1 and rAAV8 to Nonhuman Primate Skeletal Muscle. Molecular Therapy (Print), v. 16, p. 1291-1299, 2008.

26.
Maguire, Albert M.2008Maguire, Albert M. Simonelli, Francesca Pierce, Eric A. Pugh, Edward N. Mingozzi, Federico Bennicelli, Jeannette Banfi, Sandro Marshall, Kathleen A. Testa, Francesco Surace, Enrico M. Rossi, Settimio Lyubarsky, Arkady Arruda, Valder R. Konkle, Barbara Stone, Edwin Sun, Junwei Jacobs, Jonathan Dell'Osso, Lou Hertle, Richard Ma, Jian-xing Redmond, T. Michael Zhu, Xiaosong Hauck, Bernd Zelenaia, Olga Shindler, Kenneth S. , et al.Maguire, Maureen G. Wright, J. Fraser Volpe, Nicholas J. McDonnell, Jennifer Wellman Auricchio, Alberto High, Katherine A. Bennett, Jean ARRUDA, V. R. ; Safety and Efficacy of Gene Transfer for Leber's Congenital Amaurosis. The New England Journal of Medicine, v. 358, p. 2240-2248, 2008.

27.
Bennicelli, Jeannette2008Bennicelli, Jeannette ; Wright, John Fraser ; Komaromy, Andras ; Jacobs, Jonathan B ; Hauck, Bernd ; Zelenaia, Olga ; Mingozzi, Federico ; Hui, Daniel ; Chung, Daniel ; Rex, Tonia S ; Wei, Zhangyong ; Qu, Guang ; Zhou, Shangzhen ; Zeiss, Caroline ; ARRUDA, V. R. ; Acland, Gregory M ; Dell'Osso, Lou F ; HIGH, Katherine A ; Maguire, Albert M ; Bennett, Jean . Reversal of Blindness in Animal Models of Leber Congenital Amaurosis Using Optimized AAV2-mediated Gene Transfer. Molecular Therapy (Print), v. 16, p. 458-465, 2008.

28.
TAI, S. J.2008TAI, S. J. ; Herzog, R. W. ; MARGARITIS, P. ; ARRUDA, V. R. ; CHU, K. ; GOLDEN, J. A. ; LABOSKY, P. A. ; High, K. A. . A viable mouse model of factor X deficiency provides evidence for maternal transfer of factor X. Journal of Thrombosis and Haemostasis (Print), v. 6, p. 339-345, 2008.

29.
CAO, O.2007CAO, O. ; FURLAN-FREGUIA, C. ; ARRUDA, V. R. ; Herzog, R. W. . Emerging role of regulatory T cells in gene transfer.. Current Gene Therapy, v. 7, p. 381-390, 2007.

30.
Chen, Lingxia2007Chen, Lingxia ; Zhu, Fuxiang ; Li, Juan ; Lu, Hui ; Jiang, Haiyan ; Sarkar, Rita ; ARRUDA, V. R. ; Wang, Jinhui ; Zhao, Jennifer ; Pierce, Glenn F ; Ding, Qiulan ; Wang, Xuefeng ; Wang, Hongli ; Pipe, Steven W ; Liu, Xiang-Qin ; Xiao, Xiao ; Camire, Rodney M ; Xiao, Weidong . The Enhancing Effects of the Light Chain on Heavy Chain Secretion in Split Delivery of Factor VIII Gene. Molecular Therapy (Print), v. 15, p. 1856-1862, 2007.

31.
Mingozzi, F.2007Mingozzi, F. ; Hasbrouck, N. C. ; Basner-Tschakarjan, E. ; Edmonson, S. A. ; Hui, D. J. ; Sabatino, D. E. ; Zhou, S. ; Wright, J. F. ; Jiang, H. ; Pierce, G. F. ; ARRUDA, V. R. ; High, K. A. . Modulation of tolerance to the transgene product in a nonhuman primate model of AAV-mediated gene transfer to liver. Blood (Philadelphia, PA), v. 110, p. 2334-2341, 2007.

32.
ARRUDA, V. R.;ARRUDA, VALDER R;ARRUDA, VALDER R.2007ARRUDA, V. R.. The Role of Immunosuppression in Gene- and Cell-Based Treatments for Duchenne Muscular Dystrophy. Molecular Therapy (Print), v. 15, p. 1040-1041, 2007.

33.
ARRUDA, V. R.;ARRUDA, VALDER R;ARRUDA, VALDER R.2007ARRUDA, V. R.; XIAO, W. . It's all about the clothing: capsid domination in the adeno-associated viral vector world. Journal of Thrombosis and Haemostasis (Print), v. 5, p. 12-15, 2007.

34.
Assis, A. M.2007Assis, A. M. ; Costa, F. F. ; ARRUDA, V. R. ; ANNICHINO-BIZZACCHI, J. M. ; Bertuzzo, C. S. . Three novel mutations in the activin receptor-like kinase 1 (ALK-1) gene in hereditary hemorrhagic telangiectasia type 2 in Brazilian patients. Journal of Human Genetics (Print), v. 52, p. 237-243, 2007.

35.
CASTRO, Vagner2007CASTRO, Vagner ; Kroll, Hartmut ; Origa, Andréa  ; Falconi, Mônica  ; Marques, Sílvia  ; Marba, Sérgio  ; Passini, Renato ; Annichino-Bizzacchi, Joyce  ; Costa, Fernando  ; Santoso, Sentot ; ARRUDA, V. R. . A prospective study on the prevalence and risk factors for neonatal thrombocytopenia and platelet alloimmunization among 9332 unselected Brazilian newborns. Transfusion (Arlington, Va.), v. 47, p. 59-66, 2007.

36.
JIANG, H2006JIANG, H ; PIERCE, G ; OZELO, M ; DEPAULA, E ; VARGAS, J ; SMITH, P ; SOMMER, J ; LUK, A ; MANNO, C ; HIGH, K ; ARRUDA, V. R. . Evidence of Multiyear Factor IX Expression by AAV-Mediated Gene Transfer to Skeletal Muscle in an Individual with Severe Hemophilia B. Molecular Therapy (Print), v. 14, p. 452-455, 2006.

37.
de Paula, Erich V.2006de Paula, Erich V. ; Nascimento, Mariane C. F. ; Ramos, Celso D. ; Ozelo, Margareth C. ; Machado, Tânia F. ; Guillaumon, Ana T. ; ARRUDA, V. R. ; Annichino-Bizzacchi, Joyce M. . Early in vivo anticoagulation inhibits the angiogenic response following hindlimb ischemia in a rodent model. Thrombosis and Haemostasis, v. 96, p. 68-72, 2006.

38.
ARRUDA, V. R.;ARRUDA, VALDER R;ARRUDA, VALDER R.2006ARRUDA, V. R.. Toward gene therapy for hemophilia A with novel adenoviral vectors: successes and limitations in canine models. Journal of Thrombosis and Haemostasis (Print), v. 4, p. 1215-1217, 2006.

39.
SCHUETTRUMPF, J2006SCHUETTRUMPF, J ; LIU, J ; COUTO, L ; ADDYA, K ; LEONARD, D ; ZHEN, Z ; SUMMER, J ; ARRUDA, V. R. . Inadvertent Germline Transmission of AAV2 Vector: Findings in a Rabbit Model Correlate with Those in a Human Clinical Trial. Molecular Therapy (Print), v. 13, p. 1064-1073, 2006.

40.
Manno, Catherine S2006Manno, Catherine S ARRUDA, V. R. Pierce, Glenn F Glader, Bertil Ragni, Margaret Rasko, John Ozelo, Margareth C Hoots, Keith Blatt, Philip Konkle, Barbara Dake, Michael Kaye, Robin Razavi, Mahmood Zajko, Albert Zehnder, James Nakai, Hiroyuki Chew, Amy Leonard, Debra Wright, J Fraser Lessard, Ruth R Sommer, Jürg M Tigges, Michael Sabatino, Denise Luk, Alvin Jiang, Haiyan , et al.Mingozzi, Federico Couto, Linda Ertl, Hildegund C HIGH, Katherine A Kay, Mark A ; Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response. Nature Medicine (Print), v. 12, p. 342-347, 2006.

41.
SCHUETTRUMPF, J2006SCHUETTRUMPF, J ; ZOU, J ; ZHANG, Y ; SCHLACHTERMAN, A ; LIU, Y ; EDMONSON, S ; XIAO, W ; ARRUDA, V. R. . The inhibitory effects of anticoagulation on in vivo gene transfer by adeno-associated viral or adenoviral vectors. Molecular Therapy (Print), v. 13, p. 88-97, 2006.

42.
Schlachterman, A.2005Schlachterman, A. ; SCHUETTRUMPF, J. ; LIU, J.-H. ; Freguia, C. F. ; Toso, R. ; Poncz, M. ; Camire, R. M. ; ARRUDA, V. R. . Factor V Leiden improves in vivo hemostasis in murine hemophilia models. Journal of Thrombosis and Haemostasis (Print), v. 3, p. 2730-2737, 2005.

43.
SCHUETTRUMPF, J.2005SCHUETTRUMPF, J. ; Herzog, R. W. ; Schlachterman, A. ; KAUFHOLD, A ; STAFFORD, D W ; ARRUDA, V. R. . Factor IX variants improve gene therapy efficacy for hemophilia B. Blood (Philadelphia, PA), v. 105, p. 2316-2323, 2005.

44.
ARRUDA, V. R.;ARRUDA, VALDER R;ARRUDA, VALDER R.2005ARRUDA, V. R.; Stedman, H. H. ; Nichols, T.C. ; Haskins, Mark E ; NICHOLSON, M. ; HERZOG, R W ; COUTO, L B ; High, K.A. . Regional intravascular delivery of AAV-2-F.IX to skeletal muscle achieves long-term correction of hemophilia B in a large animal model. Blood (Philadelphia, PA), v. 105, p. 3458-3464, 2005.

45.
SCHUETTRUMPF, J2004SCHUETTRUMPF, J ; ZOU, J ; HERZOG, Rw ; KAUFHOLD, A ; STAFFORD, Dw ; HIGH, Katherine A ; ARRUDA, V. R. . The use of Factor IX variants imporves AAV-mediated gene therapy for hemophilia B. Blood (Philadelphia), 2004.

46.
SCHUETTRUMPF, J2004SCHUETTRUMPF, J ; ZOU, J ; ZHANG, Y ; SCHLACHTERMAN, A ; LIU, Ly ; HERZOG, Rw ; HIGH, Katherine A ; ARRUDA, V. R. . Effects of inhibitors to thrombin or Factor Xa on viral vector-mediated gene transfer. Molecular Therapy, 2004.

47.
MARGARITAS, P2004MARGARITAS, P ; ARRUDA, V. R. ; ALIJAMALI, M ; CAMIRE, R ; SCHLACHTERMAN, A ; HIGH, Katherine A . Novel therapeutic approach for hemophilia using gene delivery of an engineered secreted activated FVII. The Journal of Clinical Investigation, v. 113, p. 1025-1031, 2004.

48.
ARRUDA, V. R.;ARRUDA, VALDER R;ARRUDA, VALDER R.2004ARRUDA, V. R.; SCHEUTTRUMPF, J ; HERZOG, Rw ; NICHOLS, Tc ; ROBINSON, N ; LOFTI, Y ; MINGOZZI, F ; XIAO, W ; COUTO, Lb ; HIGH, Katherine A . Safetly and efficacy of factor IX gene transfer to skeletal muscle in murine and canine hemophilia B models by adeno-associated viral vector serotype 1. Blood (Philadelphia, PA), v. 103, p. 85-92, 2004.

49.
FURLAN-FREGUIA, C.2004FURLAN-FREGUIA, C. ; TOSO, R ; POLLAK, e S ; ARRUDA, V. R. ; PINOTTI, M. ; BERNARDI, F. W. H. . Characterization of mild coagulation factor VII deficiency: activity and clearance of the Arg315Trp and Arg315Lys variants in the Cys310-Cys329 loop (c170s).. Haematologica (Roma), v. 89, p. 1504-1509, 2004.

50.
Ozelo, Margareth C.2004Ozelo, Margareth C. ; Costa, Devanira S.P. ; Siqueira, Lucia H. ; Machado, Tania M.F. ; CASTRO, Vagner ; Gon alves, Marilda S. ; Menezes, Raimundo C. ; Soares, Manoel ; Annichino-Bizzacchi, Joyce M. ; Costa, Fernando F. ; ARRUDA, V. R. . Genetic variability of platelet glycoprotein Ib? gene. American Journal of Hematology (Print), v. 77, p. 107-116, 2004.

51.
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ARRUDA, V. R.;ARRUDA, VALDER R;ARRUDA, VALDER R.1996ARRUDA, V. R.; SALLES, T. ; Costa, F. F. ; Saad, S.T.O. . Glutathione Peroxidase, Reduced Glutathione, Superoxide Dismutase And Catalase In Red Cell Of Patients With Hairy Cell Leukemia. Neoplasma, Journal of Experimental and Clinical Oncology, Polônia, v. 43, p. 99-102, 1996.

120.
ARRUDA, V. R.;ARRUDA, VALDER R;ARRUDA, VALDER R.1996ARRUDA, V. R.; von Zuben P.M. ; Soares, M.C. ; Menezes, R. C. ; ANNICHINO-BIZZACCHI, J. M. ; Costa, F. F. . Very Low Incidence Of Arg506-Gln Mutation In The Factor V Gene Among Amazonian Indians And Brazilian Black Population. Thrombosis and Haemostasis, Bélgica, v. 75, p. 860-861, 1996.

121.
DIAS-DA-MOTTA, P.1996DIAS-DA-MOTTA, P. ; ARRUDA, V. R. ; MUSCARA, M. ; Saad, S.T.O. ; NUCCI, G. ; Costa, F.F. ; CONDINO-NETO, A. . The Release Of Nitric Oxide And Superoxide Anion By Neutrophils And Mononuclear Cells From Patients With Sickle Cell Anemia. British Journal of Haematology, Inglaterra, v. 93, p. 333-340, 1996.

122.
KERBAUY, J.1996KERBAUY, J. ; Goncalves, M. S. ; ARRUDA, V. R. ; Saad, S.T.O. ; Sonati, M.F. ; STOMING, T. ; Costa, F.F. . Effect of A-Thalassemia And B-Globin Gene Cluster Haplotypes on The Hematological And Clinical Features Of Sickle Cell Anemia In Brazil. American Journal of Hematology, Estados Unidos da América, v. 53, p. 72, 1996.

123.
ARRUDA, V. R.;ARRUDA, VALDER R;ARRUDA, VALDER R.1996ARRUDA, V. R.; ANNICHINO-BIZZACCHI, J. M. . High-Dose Dexamethasone Therapy In Chronic Idiopathic Thrombocytopenic Purpura. Annals of Hematology, Alemanha, v. 73, p. 175-177, 1996.

124.
ARRUDA, V. R.;ARRUDA, VALDER R;ARRUDA, VALDER R.1996ARRUDA, V. R.; von Zuben P.M. ; ANNICHINO-BIZZACCHI, J. M. ; Costa, F.F. . Rapid Detection Of Factor V Leiden (Fvq506) By Non-Radioactive Single Strand Conformation Polymorphism (Sscp). Sangre, Espanha, v. 41, p. 379-381, 1996.

125.
ARRUDA, V. R.;ARRUDA, VALDER R;ARRUDA, VALDER R.1995 ARRUDA, V. R.; PIENEMANN, W. ; REITSMA, P. ; DEUTZ-TERLOUW, P. ; ANNICHINO-BIZZACCHI, J. M. ; BRIET, E. ; Costa, F.F. . Eleven Novel Mutations In The Factor Viii Gene From Brazilian Hemophilia A Patients. Blood, Estados Unidos da América, v. 86, p. 3015-3020, 1995.

126.
ARRUDA, V. R.;ARRUDA, VALDER R;ARRUDA, VALDER R.1995 ARRUDA, V. R.; ANNICHINO-BIZZACCHI, J. M. ; Costa, F. F. ; REITSMA, P. . Factor V Leiden (Fvq 506) Is Common In A Brazilian Population. American Journal of Hematology, Estados Unidos da América, v. 49, p. 242-243, 1995.

127.
Gon alves, Marilda S.1995Gon alves, Marilda S. ; FAHEL, S. ; FIGUEIREDO, M. S. ; Kimura, E.M. ; NECHTMAN, F. ; STOMING, T. ; ARRUDA, V. R. ; Saad, S.T.O. ; Costa, F. F. . Molecular Identification Of Hereditary Persistence Of Fetal Hemoglobin Type 2 (HPFH Type 2) In Patients From Brazil. Annals of Hematology, Alemanha, v. 70, p. 159-161, 1995.

128.
Saad, S.T.O.1994Saad, S.T.O. ; VASALLO, J. ; ARRUDA, V. R. ; LORAND-METZE, I. G. . The Role Of Bone Marrow Study In Diagnosis And Prognosis Of Myelodysplastic Syndrome. Pathologica, Italia, v. 86, p. 47-51, 1994.

129.
ARRUDA, V. R.;ARRUDA, VALDER R;ARRUDA, VALDER R.1994ARRUDA, V. R.; Saad, S.T.O. ; Costa, F. F. . Hairy Cell Leukemia And Glucose-6-Phosphate Dehydrogenase. Acta Oncologica, Suiça, v. 33, p. 574-574, 1994.

130.
Costa, F. F.1994Costa, F. F. ; ARRUDA, V. R. ; Goncalves, M. S. ; MIRANDA, S. R. ; Carvalho, M.H. ; Sonati, M.F. ; Saad, S.T.O. ; GESTEIRA, F. ; FERNANDES, D. ; NASCIMENTO, M. . Beta S - Gene Cluster Haplotypes In Sickle Cell Anemia Patients From Two Regions Of Brasil. American Journal of Hematology, Estados Unidos da América, v. 45, p. 96-97, 1994.

131.
Goncalves, M. S.1994Goncalves, M. S. ; Sonati, M.F. ; Kimura, E.M. ; ARRUDA, V. R. ; Costa, F. F. ; NECHTMAN, J. ; STOMING, T. . Association Of Hb Santa Ana [A2b288(F4)Leu-Pro] And Hemoglobin Porto Alegre [A2b29(A6)Ser-Cys] In A Brazilian Female. Hemoglobin, Estados Unidos da América, v. 18, p. 235-239, 1994.

132.
Goncalves, M. S.1994Goncalves, M. S. ; NECHTMAN, J. ; FIGUEIREDO, M. S. ; KERBAUY, J. ; ARRUDA, V. R. ; Sonati, M.F. ; Saad, S.T.O. ; Costa, F.F. ; STOMING, T. . Sickle Cell Disease In A Brazilian Population From São Paulo: A Study Of The Bs Haplotypes. Human Heredity, Estados Unidos da América, v. 44, p. 322-327, 1994.

133.
ANNICHINO-BIZZACCHI, J. M.1993ANNICHINO-BIZZACCHI, J. M. ; MACHADO, T F ; ARRUDA, V. R. . Successful immunosuppressive treatment of high-tier postpartum factor VII inhibitor. Annals of Internal Medicine, v. 119, p. 1149-1150, 1993.

134.
ARRUDA, V. R.;ARRUDA, VALDER R;ARRUDA, VALDER R.1993ARRUDA, V. R.; ANNICHINO-BIZZACCHI, J. M. ; Sonati, M.F. ; Costa, F. F. . Factor VIII and IX genes polymorphisms in a Brazilian black population. Thrombosis and Haemostasis, v. 70, p. 371-371, 1993.

135.
ARRUDA, V. R.;ARRUDA, VALDER R;ARRUDA, VALDER R.1993ARRUDA, V. R.; ANNICHINO-BIZZACCHI, J. M. ; Costa, F. F. . Detection of hemophilia A gene carriers in a Brazilian population. Revista da Associação Médica Brasileira (1992. Impresso), v. 39, p. 126-130, 1993.

136.
ARRUDA, V. R.;ARRUDA, VALDER R;ARRUDA, VALDER R.1993ARRUDA, V. R.; ANNICHINO-BIZZACCHI, J. M. ; LORAND-METZE, I. G. . Hairy cell leukemia and multiple autoimmune manifestations in a human immunodeficiency virus-infected patient. Annals of Hematology (Print), v. 66, p. 325-327, 1993.

137.
ARRUDA, V. R.;ARRUDA, VALDER R;ARRUDA, VALDER R.1993ARRUDA, V. R.; EID, K. A. ; ZEN, G. C. ; Goncalves, M. S. ; Saad, S.T.O. ; Costa, F. F. . Hepatitis C antibody (anti-HCV) prevalence in Brazilian patients with sickle cell diseases. Vox Sanguinis (Basel. 1956), v. 65, p. 247-247, 1993.

138.
Saad, S.T.O.1990Saad, S.T.O. ; ARRUDA, V. R. ; JUNQUEIRA, O. ; SCHELINI, F. A. ; COELHO, O. R. . Acute myocardial infarction in sickle cell anaemia associated with severe hypoxia. Postgraduate Medical Journal, v. 66, p. 10681-1070, 1990.

Capítulos de livros publicados
1.
ARRUDA, V. R.. Modulating Immune Response in Muscle Gene Therapy. In: Duan D. (Org.). Muscle Gene Therapy. 1ed.: Springer Science, 2010, v. 01, p. 181-204.

2.
ARRUDA, V. R.; High, K.A. . Coagulation Disorders. In: Fauci AS; Kasper DL; Braunwald E; Hauser SL; Longo DL; Jamson JL; Loscalzo J. (Org.). Harrison?s Principles of Internal Medicine. 17ed.: The McGraw-Hill Companies, Inc., 2008, v. 02, p. 725-730.

3.
ARRUDA, V. R.. Immune Modulation and Transient Suppression Strategies.. In: Herzog RW. (Org.). In Gene Therapy Immunology. 1ed.: John Wiley & Sons, Inc, 2008, v. 1, p. 311-329.

4.
ARRUDA, V. R.; VR, A. ; Coagulação Intravascular Disseminada. Anais de Atualização Médica. Campinas: Unième Editora, 1995, v. 1995, p. -.

5.
ARRUDA, V. R.; FF, L. C. A. V. C. ; Hemopatias: Anemias. Obstetrícia Básica. São Paulo: Sarvier, 1994, v. 1994, p. -.

6.
ARRUDA, V. R.; CA, A. V. S. ; Tromboembolismo: Alterações da Coagulação. Obstetrícia Básica. São Paulo: Sarvier, 1994, v. 1994, p. -.

Trabalhos completos publicados em anais de congressos
1.
ARRUDA, V. R.; FF, A. V. V. Z. P. C. L. A. J. C. ; The Mutation Ala677-Val In The Methylene Tetrahydrofolate Reductase Gene: A Risk Factor For Premature Arterial Disease And Venous Thrombosis. In: XVIth Congress of the International Society on Thrombosis and Haemostasis, 1997. Thrombosis and Haemostasis. Itália.

2.
ARRUDA, V. R.; CASTRO, V. ; VR, A. J. C. F. A. . Hpa-1b Platelet Glycoprotein Iiia As A Risk Factor For Arterial Disease. In: XVIth Congress of the International Society on Thrombosis and Haemostasis, 1997. Itália.

3.
ARRUDA, V. R.; JM, S. L. A. V. A. ; A Nonsense Mutation In A Brazilian Patient With Protein S Deficiency. In: XVIth Congress of the International Society on Thrombosis and Haemostasis, 1997. Thrombosis and Haemostasis. Itália.

4.
ARRUDA, V. R.; HESSEL, G. S. C. ; JM, R. C. A. . Factor F Leiden (Fvq 506) Is Not Commom In Children With Portal Vein Thrombosis. In: Second Meeting of the European Haematology Association, 1996. França.

5.
ARRUDA, V. R.; CASTRO, V. ; FF, S. L. A. V. A. J. C. . The Frequency Of Platelet-Specific Alloantigens Hpa-1 And 5 Among Amazonian Indians And Brazilian Black Population. In: Second Meeting of the European Haematology Association, 1996. França.

6.
ARRUDA, V. R.; JORGE, J. C. M. A. V. ; JM, Annichino-bizzacchi . The Efficacy Of Autologous Fibrin Glue In Patients With Hereditary Hemorrhagic Disorders. In: XXII International Congress of the World Federation of Hemophilia, 1996. Irlanda.

7.
ARRUDA, V. R.; SZAJNER, P. ; FF, A. V. A. J. C. . The Molecular Basis Of Brazilian Hemophiliacs B Patients. In: XXII International Congress of the World Federation of Hemophilia, 1996. Irlanda.

8.
ARRUDA, V. R.; NOGUEIRA, E. ; FF, C. S. B. S. A. J. C. . Detection Of Cytomegalovirus Infection By The Polymerase Chain Reaction In Hemophiliacs Patients. In: XXII International Congress of the World Federation of Hemophilia, 1996. Irlanda.

9.
ARRUDA, V. R.; SZAJNER, P. ; FF, A. V. A. J. C. . Molecular Basis Of Brazilian Hemophiliacs B Patients. In: 9th International Congress of Human Genetics, 1996. Brasil.

10.
ARRUDA, V. R.; CASTRO, V. ; VR, S. L. A. J. C. F. A. . Frequência de Aloantígenos Plaquetários Específicos Hpa 1 e 5 Em Populações Brasileiras. In: XXII Congresso Brasileiro de Hematologia e Hemoterapia - Hemo-96, 1996. Brasil.

11.
ARRUDA, V. R.; FF, A. V. V. Z. P. C. L. A. J. C. ; The Mutation Ala677-Val In The Methylene Tetrahydrofolate Reductase Gene: A Risk Factor For Premature Arterial Disease And Venous Thrombosis. In: Thirty-Eighth Annual Meeting of the American Society of Hematology, 1996. EUA.

12.
ARRUDA, V. R.; CASTRO, V. ; VR, A. J. C. F. A. . Hpa-1b Platelet Glycoprotein Iiia As A Risk Factor For Arterial Disease. In: Thirty-Eighth Annual Meeting of the American Society of Hematology, 1996. EUA.

13.
ARRUDA, V. R.; FF, G. A. A. V. S. S. C. ; Treatment Of Leg Ulcers Of Sickle Cell Anemia By Physioterapy And Electric Stimulation. In: 20th Annual Meeting of the National Sickle Cell Disease Program, 1995. EUA.

14.
ARRUDA, V. R.; DIAS-DA-MOTTA, P. ; NUCCI, G. A. V. M. M. S. S. ; CONDINO-NETO, A. C. F. . The Release Of Nitric Oxide And Superoxide Anion By Neutrophils And Mononuclear Cells From Patients With Sickle Cell Anemia. In: 20th Annual Meeting of the National Sickle Cell Disease Program, 1995. EUA.

15.
ARRUDA, V. R.; MAZZALI, M. A. V. ; ALVES FILHO, G. O. E. ; JM, Annichino-bizzacchi . Ativação da Fase de Contato da Coagulação Na Rejeição Aguda do Transplante Renal. In: IV Congresso da Associação Brasileira de Transplante de Órgãos (ABTO), III Encontro de Enfermagem para Transplante, 1995. Brasil.

16.
ARRUDA, V. R.; NOGUEIRA, E. ; BORDIN, S. C. S. ; FF, A. V. A. J. C. . High Prevalence Of Cytomegalovirus Infection Detected By The Polymerase Chain Reaction In Hemophilia Patients. In: 5th International Cytomegalovirus Conference, 1995. Suécia.

17.
ARRUDA, V. R.; BORDIN, I. ; LS, A. V. A. J. L. . Evaluation Of The Splenectomy In Chronic Immunologic Thrombocytopenia Purpura (Ipt). In: European I.H.P.B.A. Congress, 1995. Grécia. p. 955-958.

18.
ARRUDA, V. R.; PH, A. V. A. J. C. F. R. ; Factor V Leiden (Fvq506) Is Common In A Brazilian Population. In: XVth Congress of the International Society on Thrombosis and Haemostasis, 1995. Israel.

19.
ARRUDA, V. R.; JM, C. L. A. V. C. O. R. C. A. ; Primary Hypercoagulability In Young Patients With Myocardial Infarction. In: XVth Congress of the International Society on Thrombosis and Haemostasis, 1995. Israel. v. 73. p. 1386-1386.

20.
ARRUDA, V. R.; MAZZALI, M. A. V. ; ALVES FILHO, G. O. E. ; JM, Annichino-bizzacchi . Activation Of Contact Phase Of Coagulation During Acute Rejection Episodes. In: XIII International Congress of Nephrology, 1995. Espanha.

21.
ARRUDA, V. R.; NOGUEIRA, E. ; BORDIN, S. C. S. ; FF, A. V. A. J. C. . High Prevalence Of Cytomegalovirus Infection Detected By The Polymerase Chain Reaction (Pcr) In Hemophilia Patients. In: X Reunião Anual da Federeção de Sociedades de Biologia Experimental, 1995. Brasil.

22.
ARRUDA, V. R.; SZAJNER, P. A. V. V. Z. P. ; FF, A. J. C. . Rápida Detecção da Transição G®A No Gene do Fator V (Fv Leiden) Pela Técnica de Single Strand Conformation Polymorphism (Sscp) Não-Radioativo. In: X Reunião Anual da Federeção de Sociedades de Biologia Experimental, 1995. Brasil.

23.
ARRUDA, V. R.; SZAJNER, P. ; FF, A. V. A. J. C. . Caracterização das Alterações Moleculares No Gene do Fator Ix. In: X Reunião Anual da Federeção de Sociedades de Biologia Experimental, 1995. Brasil.

24.
ARRUDA, V. R.; FF, A. V. L. C. S. S. C. ; Utilização da Hidroxiuréia Em Pacientes Com B-Talassemia Intermediária. In: XV Congresso Nacional do Colégio Brasileiro de Hematologia, 1995. Brasil.

25.
ARRUDA, V. R.; RIBEIRO, N. M. C. ; JM, A. V. A. . Determinação do Polimorfismo (A/T-1476) Na Região Promotora do Gene da Proteína C, Em Uma População Brasileira. In: XV Congresso Nacional do Colégio Brasileiro de Hematologia, 1995. Brasil.

26.
ARRUDA, V. R.; JORGE, J. C. M. ; JM, A. V. A. . Lesão Radiolúcida Expansiva Em Paciente Hemofílico. In: XV Congresso Nacional do Colégio Brasileiro de Hematologia, 1995. Brasil.

27.
ARRUDA, V. R.; VR, P. N. J. G. A. M. T. A. J. A. ; Manifestações Clínicas e Laboratoriais Associadas À Presença de Anticorpos Antifosfolipídeos. In: XV Congresso Nacional do Colégio Brasileiro de Hematologia, 1995. Brasil.

28.
ARRUDA, V. R.; JM, F. R. A. V. A. ; Avaliação da Indicação Clínica e Laboratorial do Teste de Agregação Plaquetária e dos Seus Resultados. In: XV Congresso Nacional do Colégio Brasileiro de Hematologia, 1995. Brasil.

29.
ARRUDA, V. R.; VR, R. J. A. M. A. J. A. ; O Uso de Minidose de Vitamina K1 No Controle da Intoxicação Com Anticoagulante Oral. In: XV Congresso Nacional do Colégio Brasileiro de Hematologia, 1995. Brasil.

30.
ARRUDA, V. R.; JM, F. R. A. V. A. ; O Uso do Antifibrinolítico (Ácido Aminocapróico) Para A Teleangiectasia Hemorrágica Hereditária. In: XV Congresso Nacional do Colégio Brasileiro de Hematologia, 1995. Brasil.

31.
ARRUDA, V. R.; SZAJNER, P. ; FF, A. V. A. J. C. . Caracterização das Alterações Moleculares No Gene do Fator Ix. In: XV Congresso Nacional do Colégio Brasileiro de Hematologia, 1995. Brasil.

32.
ARRUDA, V. R.; FF, V. Z. P. S. M. M. R. A. J. C. . Mutação No Codon 506 Arg-Gln do Fator V (Fator V Leiden) Em Populações Brasileiras Normais e Com Trombose Venosa. In: Congresso Nacional do Colégio Brasileiro de Hematologia, 1995. Brasil.

33.
ARRUDA, V. R.; CASTRO, V. ; VR, F. M. M. S. C. F. A. . Trombocitopenia Neonatal: Estudo Restropectivo de 1681 Nascimentos. In: XV Congresso Nacional do Colégio Brasileiro de Hematologia, 1995. Brasil.

34.
ARRUDA, V. R.; NOGUEIRA, E. ; BORDIN, S. ; SCB, A. V. A. J. C. F. C. . Detection Of Cytomegalovirus Infection By The Polimerase Chain Reaction In Hemophilia Patients. In: XV Congresso Nacional do Colégio Brasileiro de Hematologia, 1995. Brasil.

35.
ARRUDA, V. R.; FF, L. C. A. V. S. S. C. ; Utilização da Hidroxiuréia Em Pacientes Com Doença Falciforme. In: XV Congresso Nacional do Colégio Brasileiro de Hematologia, 1995. Brasil.

36.
ARRUDA, V. R.; JM, S. L. C. L. A. V. A. ; Determinação do Polimorfismo No Fator Vii Em Uma População Com Infarto Agudo do Miocárdio. In: XV Congresso Nacional do Colégio Brasileiro de Hematologia, 1995. Brasil.

37.
ARRUDA, V. R.; JM, S. L. A. V. S. L. A. ; Fvii Coagulant Activity And Factor Vii Polymorphism In Patients With Myocardial Infarction. In: XIV Congreso International de Hemostasis y Trombosis del Grupo CLAHT, 1995. Uruguai.

38.
ARRUDA, V. R.; JM, S. L. A. V. A. ; Frequency Of Genetic Polymorphism (Arg353-Gln) Of The Factor Vii Gene In Amazonian Indians. In: XIV Congreso International de Hemostasis y Trombosis del Grupo CLAHT, 1995. Uruguai.

39.
ARRUDA, V. R.; JM, M. C. R. C. A. V. A. ; Prevalence Of Polymorphism A/T At Position -1476 Of The Protein C Promoter Region In A Brazilian Population. In: XIV Congreso International de Hemostasis y Trombosis del Grupo CLAHT, 1995. Uruguai.

40.
ARRUDA, V. R.; FF, A. V. V. Z. P. S. M. M. R. A. J. C. ; Low Incidence Of Arg506-Gln Mutation In The Factor V Gene Among Amazonian Indians And Brazilian Black Population. In: Thirty-Seventh Annual Meeting of the American Society of Hematology, 1995. EUA. v. 86. p. 204a-204a.

41.
NOGUEIRA, E. ; BORDIN, S. ; ARRUDA, V. R. ; SCB, A. J. C. F. C. . Detection Of Cytomegalovirus Infection By Polymerase Chain Reaction In Hemophilia. In: Thirty-Seventh Annual Meeting of the American Society of Hematology, 1995. EUA. v. 86. p. 855a-855a.

42.
ARRUDA, V. R.; ROVERI, E. M. J. J. ; PELLEGRINO JR, J. ; CA, S. S. A. V. C. F. S. . Erythrocytapheresis In The Treatment Of Sickle Cell Anemia In Brazilian Patients, 1994. Estados Unidos da América. v. 9. p. 98-98.

43.
ARRUDA, V. R.; DEUTZ-TERLOUW, P. A. V. P. W. ; BRIËT, E. A. J. ; FF, R. P. C. . Twelve Novel Mutation In Factor Viii Gene From Brazilian Hemophilia A Patients, 1994. Estados Unidos da América. v. 84. p. 61-61.

44.
ARRUDA, V. R.; BORDIN, S. A. M. ; FF, A. V. S. S. C. . Haplótipos do Complexo do Gene da Globina Beta Na Hemoglobinopatia Sc No Brasil. In: XXI Congresso Brasileiro de Hematologia e Hemoterapia, VII Simpósio Nacional sobre Transplante de Medula Óssea, VI Congresso Brasileiro de Hemostasia e Trombose, 1994. Brasil. v. 16. p. 83-83.

45.
ARRUDA, V. R.; FF, G. M. A. V. S. S. N. J. S. T. C. ; Novo Caso da Persistência Hereditária da Hemoglobina Fetal Por Mutação de Ponto do Tipo Brasileiro - B + Ga (C-G) - 195. In: XXI Congresso Brasileiro de Hematologia e Hemoterapia, VII Simpósio Nacional sobre Transplante de Medula Óssea, VI Congresso Brasileiro de Hemostasia e Trombose, 1994. Brasil. v. 16. p. 83-83.

46.
ARRUDA, V. R.; NOGUEIRA, E. A. J. G. N. P. V. A. V. ; FF, C. L. A. S. L. C. C. . Utilização de Pcr Para Detecção do Vírus da Hepatite C Em Pacientes Hemofílicos. In: XXI Congresso Brasileiro de Hematologia e Hemoterapia, VII Simpósio Nacional sobre Transplante de Medula Óssea, VI Congresso Brasileiro de Hemostasia e Trombose, 1994. Brasil. v. 16. p. 84-84.

47.
ARRUDA, V. R.; DEUTZ-TERLOUW, P. A. V. P. W. ; PH, A. J. C. F. B. R. . Caracterização Molecular da Hemofilia A Em Uma População Brasileira. In: XXI Congresso Brasileiro de Hematologia e Hemoterapia, VII Simpósio Nacional sobre Transplante de Medula Óssea, VI Congresso Brasileiro de Hemostasia e Trombose, 1994. Brasil. v. 16. p. 84-84.

48.
ARRUDA, V. R.; PH, A. V. A. J. C. F. R. ; Mutação No Codon 506 do Fator V (Fator V Leiden) É Comum Em Pacientes Brasileiros Com Trombose Venosa. In: XXI Congresso Brasileiro de Hematologia e Hemoterapia, VII Simpósio Nacional sobre Transplante de Medula Óssea, VI Congresso Brasileiro de Hemostasia e Trombose, 1994. Brasil. v. 16. p. 84-84.

49.
ARRUDA, V. R.; JORGE, J. C. M. ; VR, A. J. A. . O Uso da Cola de Fibrina Autóloga Em Cirurgias Orais de Pacientes Com Doenças Hemorrágicas. In: XXI Congresso Brasileiro de Hematologia e Hemoterapia, VII Simpósio Nacional sobre Transplante de Medula Óssea, VI Congresso Brasileiro de Hemostasia e Trombose, 1994. Brasil. v. 16. p. 91-91.

50.
ARRUDA, V. R.; KB, A. J. A. V. B. ; Uso de Dapsona Em Pti Refratária. In: XXI Congresso Brasileiro de Hematologia e Hemoterapia, VII Simpósio Nacional sobre Transplante de Medula Óssea, VI Congresso Brasileiro de Hemostasia e Trombose, 1994. Brasil. v. 16. p. 91-91.

51.
ARRUDA, V. R.; JM, B. K. A. V. A. ; Púrpura Trombocitopênica Imunológica: Observação Clínica e Resposta À Terapia. In: XXI Congresso Brasileiro de Hematologia e Hemoterapia, VII Simpósio Nacional sobre Transplante de Medula Óssea, VI Congresso Brasileiro de Hemostasia e Trombose, 1994. Brasil. v. 16. p. 94-94.

52.
ARRUDA, V. R.; IS, A. J. B. K. A. V. B. ; Análise de Parâmetros Clínicos Pré-Esplenectomia Preditivos da Resposta Cirúrgica. In: XXI Congresso Brasileiro de Hematologia e Hemoterapia, VII Simpósio Nacional sobre Transplante de Medula Óssea, VI Congresso Brasileiro de Hemostasia e Trombose, 1994. Brasil. v. 16. p. 94-94.

53.
ARRUDA, V. R.; PH, A. V. P. W. D. P. A. J. C. F. B. R. ; Molecular Characterization Of Brazilian Patients With Hemophilia A. In: First Meeting of the European Haematology Association, 1994. Bélgica.

54.
ARRUDA, V. R.; FAHEL, S. G. M. F. M. ; NECHTMAN, J. ; STOMMING, T. ; KERBAUY, J. ; FF, A. V. S. S. C. . Rapid Molecular Identification Of Deletional Hereditary Persistence Of Fetal Hemoglobin Type 2 (Phhf-Type 2). In: IX Reunião Anual da Federação das Sociedades de Biologia Experimental, 1994. Brasil.

55.
ARRUDA, V. R.; DEUTZ-TERLOUW, P. A. V. P. W. ; BRIËT, E. A. J. ; FF, R. P. C. . Twelve Novel Mutations In Factor Viii Gene From Brazilian Hemophilia A Patients. In: Thirty-Sixth Annual Meeting of the American Society of Hematology, 1994. Estados Unidos da América. v. 84. p. 61-61.

Resumos publicados em anais de congressos
1.
ARRUDA, V. R.; HACKEL, C. T. E. G. C. A. V. ; HB, B. . Genotipos Nulos Para Glutationa S-Transferases Mu (Gstm1) Em Pacientes Com Cancer de Mama. In: 44 Congresso Nacional de Genetica, 1998. Genetics and Molecular Biology. Aguas de Lindoia, SP. v. 21. p. 316-316.

2.
ARRUDA, V. R.; VOETSCH, B. ; VR, D. B. A. J. A. . The Prothrombin 20210 G To A Mutation In Young Patients With Ischemic Stroke. In: 50th Annual Meeting Program of the American Academy of Neurology, 1998. Anais de Congresso. Minneapolis - USA.

3.
ARRUDA, V. R.; JM, C. M. A. V. A. ; Gengival Evaluation In Sickle Cell Anemia, Hemohilia And Talassemic Patients. In: XXIII International Congress of the World Federation of Hemophilia, 1998. Hemophilia. The Hague, Holanda. v. 04. p. 303-303.

4.
ARRUDA, V. R.; HEIMAN-PATTERSON, T. H. J. A. V. L. P. ; CHU, K. ; KA, C. L. K. G. H. R. H. . Biochemical Characterization Of Human Factor Ix Synthesized In Human Myotubes Following Transduction With An Aav Vector. In: 1ST ANNUAL MEETING OF THE AMERICAN SOCIETY OF GENE THERAPY, 1998. ANAIS DE CONGRESSO. WASHINGTON - USA.

5.
ARRUDA, V. R.; STO, S. E. A. V. C. F. S. ; Cytoplasmic Overexpression Of P53 And P21 Ras In Megaloblastic Anemia. In: ISH-EHA Combined Haematology Congress, 1998. British Journal of Haematology. Amsterdam, Holanda. v. 102. p. 153-153.

6.
ARRUDA, V. R.; BORDIN, S. A. M. A. V. B. D. ; STO, C. F. S. . Low Frequency Of The Hemochromatosis C282y Mutation In Four Brazilian Populations. In: ISH-EHA Combined Haematology Congress, 1998. British Journal of Haematology. Amsterdam - Holanda. v. 102. p. 37-37.

7.
ARRUDA, V. R.; FF, G. C. C. M. K. E. S. M. A. V. S. S. C. ; Beta Thalassemia Resulting From A Novel Mutation: Beta 6 Glu To Stop Codon. In: ISH-EHA COMBINED HAEMATOLOGY CONGRESS, 1998. bRITISH JOURNAL OF HAEMATOLOGY. AMSTERDAM, HOLANDA. v. 102. p. 46-46.

8.
ARRUDA, V. R.; BORDIN, S. A. F. ; FF, B. A. A. M. A. V. F. M. S. S. C. . Beta Globin Gene Haplotypes Among Brazilian Patients With Hemoglobin Sc Disease. In: ISH-EHA COMBINED HAEMATOLOGY CONGRESS, 1998. British Journal of Haematology. Amsterdam, Holanda. v. 102. p. 48-48.

9.
ARRUDA, V. R.; FF, G. C. W. M. S. M. K. E. A. V. S. S. C. ; Hb Rio Claro [Beta 34 (B16) Val To Met]: A New Silent Variant Associated With Hb Hasharon (Alpha 47 Asp To His) And Alpha Thalassemia 2. In: ISH-EHA COMBINED HAEMATOLOGY CONGRESS, 1998. British Journal of Haematology. Amsterdam, Holanda. v. 102. p. 177-177.

10.
ARRUDA, V. R.; CASTRO, V. ; VR, A. J. C. F. A. . Genic Polymorphism Of Human Plateler Antigen-1 System In Patients With Venous Thrombosis. In: ISH-EHA COMBINED HAEMATOLOGY CONGRESS, 1998. British Journal of Haematology. Amsterdam, Holanda. v. 102. p. 255-255.

11.
ARRUDA, V. R.; CASTRO, V. ; VR, O. G. A. J. C. F. A. . Human Platelet Antigen-5 System Polymorphism In Patients With Idiopathic Throbocytopenic Purpura. In: ISH-EHA COMBINED HAEMATOLOGY CONGRESS, 1998. British Journal of Haematology. Amsterdam, Holanda. v. 102. p. 362-362.

12.
ARRUDA, V. R.; JM, S. C. S. L. P. D. A. V. A. ; Inhereted Risk Factors For Thrombophilia In Children With Portal Vein Disease. In: Simposio Internacional Rio de Janeiro 1998 do Grupo Claht, Grupo Cooperativo latinoamericano de Hemostasis y Thrombosis, 1998. Livro de Anais. Rio de Janeiro.

13.
ARRUDA, V. R.; VOETSCH, B. ; VR, D. B. S. L. A. J. A. . Amutação Ala677 A Val No Gene do Metilenotetrahidro Folato Reductase: Um Fator de Risco Para Acidente Vascular Cerebral Isquemico Em Jovens. In: XVIII Congresso Brasileiro de Neurologia, 1998. Arquivos de Neuro-Psquiatria. São Paulo. v. 56. p. 13-13.

14.
ARRUDA, V. R.; VOETSCH, B. ; VR, D. B. S. L. A. J. A. . Prevalencia da Mutacao 20210 G A A No Gene da Protrombina Em Acidente Vascular Cerebral Isquemico Em Jovens. In: XVIII Congresso Brasileiro de Neurologia, 1998. Arquivos de Neuro-Psquiatria. São Paulo. v. 56. p. 15-15.

15.
ARRUDA, V. R.; VOETSCH, B. ; VR, A. J. A. . Associação de Homozigose Para Fator V Leiden, Heterozigose Para Variante 20.210 da Protrombina e Deficiência de Proteina S Causando Avc de Repetição. In: XVIII Congresso Brasileiro de Neurologia, 1998. Arquivos de Neuro-Psquiatria. São Paulo. v. 56. p. 260-260.

16.
ARRUDA, V. R.; STO, A. M. B. D. A. V. C. F. S. ; Associação Entre As Mutações C282y e H63d No Gene Hfe Em Amostras da População Brasileira e Pacientes Com Hemocromatose Hereditária. In: XIII Reunião Anual da Federação de Sociedades de Biologia Experimental, 1998. Brazilian Journal of Medical and Biological Research. Caxambu, MG. p. 180-180.

17.
ARRUDA, V. R.; CASTRO, V. ; MAZZALI, M. O. A. A. J. ; ALVES FILHO, G. . Platelet-Specific Alloantigens In Renal Transplants. In: XXIII Congresso Brasileiro de Hematologia e Hemoterapia, 1998. Boletim da Sociedade Brasileiro de Hematologia e Hemoterapia. São Paulo. v. 20. p. 22-22.

18.
ARRUDA, V. R.; CASTRO, V. ; SOARES, M. O. A. A. J. ; MENEZES, R. ; VR, C. F. A. . Parakana (Amazonian) Indians: Frequencies Of Platelet Specific Alloantigens. In: XXIII Congresso Brasileiro de Hematologia e Hemoterapia, 1998. Boletim da Sociedade Brasileiro de Hematologia e Hemoterapia. Sao Paulo. v. 20. p. 44-44.

19.
ARRUDA, V. R.; TFG, S. Y. A. V. A. J. M. ; Hereditary Type I Protein C Deficiency Due To A Nonsense Mutation In Exon Vi Of The Protein C Gene. In: XXIII Congresso Brasileira de Hematologia e Hemoterapia, 1998. Boletim da Sociedade Brasileira de Hematologia e Hemoterapia. Sao Paulo. v. 20. p. 84-84.

20.
ARRUDA, V. R.; VOETSCH, B. ; TFG, D. B. A. J. M. . Hereditary Hypercoagulability Among Young Patients With Cerebral Thrombosis. In: XXIII Congresso Brasileiro de Hematologia e Hemoterapia, 1998. Boletim da Sociedade Brasileira de Hematologia e Hemoterapia. Sao Paulo. v. 20. p. 93-93.

21.
ARRUDA, V. R.; JM, T. M. A. V. S. L. M. T. A. ; Associação Entre Trombofilia Hereditaria e Anticoagulante Lupico. In: XXIII Congresso Brasileiro de Hematologia e Hemoterapia, 1998. Boletim da Sociedade Brasileira de Hematologia e Hemoterapia. Sao Paulo. v. 20. p. 107-107.

22.
ARRUDA, V. R.; VR, C. L. A. J. A. ; Frequencia das Mutacoes 20210 C466 A T No Gene da Mthfr e do Gln605 - Fator V Em Pacientes Com Infarto Agudo No Miocardio. In: XXIII Congresso Brasileiro de Hematologia e Hemoterapia, 1998. Boletim da Sociedade Brasileira de Hematologia e Hemoterapia. Sao Paulo. v. 20. p. 154-154.

23.
ARRUDA, V. R.; CASTRO, V. M. J. T. M. ; VR, L. A. T. A. S. C. A. . Thrombotic Thrombocytopenic Purpura (Ttp): A Case Report Of Remission Combined Therapy. In: XXIII Congresso Brasileiro de Hematologia e Hemoterapia, 1998. Boletim da Sociedade Brasileira de Hematologia e Hemoterapia. Sao Paulo. v. 20. p. 186-186.

24.
ARRUDA, V. R.; HACKEL, C. T. E. G. C. A. V. ; HB, B. . Genótipos Nulos Para Glutanina S-Transferases Um (Gstm1) e Theta (Gstt1) Em Pacientes Com Cancer de Mama. In: 44 Congresso Nacional de Genetica, 1998. Genetics and Molecular Biology. Aguas de Lindoia - SP. v. 21. p. 316-316.

25.
ARRUDA, V. R.; CASTRO, V. ; SOARES, M. A. J. ; MENEZES, R. ; VR, C. F. A. . Frequencies Of Platelet-Specific Alloantigens In Amazonian Indians. In: 51 Annual Meeting of the American Association of Blood Banks, 1998. Transfusion. Philadelpia - USA. v. 38. p. 39-39.

26.
ARRUDA, V. R.; CASTRO, V. ; VR, O. A. F. M. M. S. A. J. C. F. A. . Thrombocytopenia In 3347 Unselected Newborns: Prevalence, Ethiology, And Impact Of Genotyping For The Hpa Systems. In: 40th Annual Meeting of the American Society of Hematology, 1998. Blood. Florida - USA. v. 92. p. 179-179.

27.
ARRUDA, V. R.; VOETSCT, B. ; CASTRO, V. D. B. ; VR, C. F. A. J. A. . Increased Prevalence Of Risk Factors For Inherited Thrombophilia Among Young Adults With Ischemic Stroke. In: 40th Annual Meeting of the American Society of Hematology, 1998. Blood. Florida - USA. v. 92. p. 560-560.

28.
ARRUDA, V. R.; BORDIN, S. A. F. A. V. L. C. ; MARTINS, J. ; FF, S. S. C. . Long-Term Hydroxyurea Therapy In Thalassemia Intermedia And Thalassemia Major Patients. In: 40th Annual Meeting of the American Society of Hematology, 1998. Blood. Florida - USA. v. 92. p. 36-36.

29.
ARRUDA, V. R.; KA, F. P. H. R. A. V. H. J. P. K. H. ; Immune Response To A Secreted Protein Following Gene Transfer Into Muscle By Plasmid-Based, Adenoviral Or Adeno-Associated Viral Vectors. In: 40th Annual Meeting of the American Society of Hematology, 1998. Blood. Florida - USA. v. 92. p. 147-147.

30.
ARRUDA, V. R.; ELWELL, D. H. R. F. P. A. V. ; KA, N. T. C. L. H. J. H. . Characterization Of Immune Reponses To Factor Ix In Small And Large Animal Models For Gene Therapy. In: 40th Annual Meeting of the American Society of Hematology, 1998. Blood. Florida - USA. v. 92. p. 689-689.

31.
ARRUDA, V. R.; VR, C. M. A. J. C. L. A. ; Cirurgias Bucais Em Pacientes Em Uso de Anticoagulantes. In: XVI Congresso Nacional do Colegio Brasileiro de Hematologia, 1998. Anais de Congresso. Belo Horizonte - MG.

32.
ARRUDA, V. R.; JM, A. L. P. N. P. F. Z. J. A. V. A. ; Two Novel Splice Site Mutations And A "De Novo" Spontaneous Point Mutation Responsible For Antithrombin Deficiency. In: XXIII Congresso Brasileiro de Hematologia e Hemoterapia, 1998. Boletim da Sociedade Brasileira de Hematologia e Hemoterapia. Sao Paulo. v. 20. p. 84-84.

33.
ARRUDA, V. R.; NOGUEIRA, E. ; BORDIN, S. C. S. ; FF, A. V. A. J. C. . High Prevalence Of Gastrointestinal Symptoms In Hemophiliacs Infected By Cytomegalovirus (Cmv). In: XII Reuniao Anual da Federacao de Sociedades de Biologia Experimental, 1997. Brazilian Journal of Medical and Biological Research. Caxambu - MG. p. 138-138.

34.
ARRUDA, V. R.; DURANTE, P. C. S. O. G. ; NOGUEIRA, E. ; VR, A. J. A. . Cmv-Dna Detection Among Patients With Chronic Autoimmune Thrombocytopenic Purpura (Aitp). In: XII Reuniao Anual da Federacao de Sociedades de Biologia Experimental, 1997. Brazilain Journal of Medical and Biological Research. Caxambu - MG. p. 138-138.

35.
ARRUDA, V. R.; NOGUEIRA, E. C. S. ; BORDIN, S. ; FF, A. V. A. J. C. . High Prevalence Of Gastrointestinal Symptoms In Hemophiliacs Infected By Cytomegalovirus (Cmv). In: XIVth meeting of the International Society of Haematology, 1997. Abstract Book. Estocolmo - Suecia. p. 150-150.

36.
ARRUDA, V. R.; SCHREIBER, R. ; FF, J. M. A. V. S. S. K. J. C. . Mapping Of Regulatory Regions Of The Gamma A Promoter Using The Luciferase Reporter Gene Approach. In: XVI Congresso Nacional do Colegio Brasileiro de Hematologia, 1997. Livro de Anais. Belo Horizonte - MG.

37.
ARRUDA, V. R.; FF, G. C. C. M. K. E. S. M. A. V. S. S. C. ; Beta Tal Resultante de Uma Nova Mutacao Beta 6 Glu A Stop Codon. In: XVI Congresso Nacional do Colegio Brasileiro de Hematologia, 1997. Anais do Congresso. Belo Horizonte.

38.
ARRUDA, V. R.; AP, A. J. S. S. A. V. S. L. C. L. M. ; Mutacao Cys282tyr,Relacionada A Hemocromatose Em Pacientes Com Infarto Agudo No Miocardio. In: XVI Congresso Nacional do Colegio Brasileiro de Hematologia, 1997. Anais do Congresso. Belo Horizonte.

39.
ARRUDA, V. R.; LORAND-METZE, I. A. V. G. C. M. M. ; FF, S. S. C. . High Prevalence Of The Glutathione S-Transferase (Gst) Null Genotype In Acute Myeloblastic Leukemia. In: XVI Congresso Nacional do Colegio Brasileiro de Hematologia, 1997. Anais do Congresso. Belo Horizonte MG.

40.
ARRUDA, V. R.; STO, S. E. A. V. C. F. S. ; Super Expressao Citoplasmatica de P53 e P21ras Em Anemia Megaloblastica. In: XVI Congresso Nacional do Colegio Brasileiro de Hematologia, 1997. Anais do Congresso. Belo Horizonte.

41.
ARRUDA, V. R.; FF, G. C. W. M. K. E. S. M. A. V. S. S. C. ; Hb Rio Claro [Beta 34(B16) Val A Met]: Uma Nova Variante da Beta Globina Em Associação Com Alpha Talassemia-2 (-3,7 Kb) e Hb Hasharon [Alpha 47 (Ce5) Asp A His]. In: XVI Congresso Nacional do Colegio Brasileiro de Hematologia, 1997. Anais do Congresso. Belo Horizonte - MG.

42.
ARRUDA, V. R.; VR, S. L. A. J. A. ; Caracterizacao Molecular da Deficiencia de Proteinas. In: XVI Congresso Nacional do Colegio Brasileiro de Hematologia, 1997. Anais do Congresso. Belo Horizonte.

43.
ARRUDA, V. R.; RAMIRES, A. A. V. S. L. C. L. C. O. M. A. ; JM, C. F. A. . Prevalence Of The Prothrombin Gene Variant 20210 G To A Among Patients With Venous Thrombosis And Arterial Disease. In: XVI Congresso Nacional do Colegio Brasileiro de Hematologia, 1997. Anais de Congresso. Belo Horizonte - MG.

44.
ARRUDA, V. R.; VR, C. M. A. J. C. L. A. M. A. ; Cirurgias Bucais Empacientes Em Uso de Anticoagulantes. In: XVI Congresso Nacional do Colegio Brasileiro de Hematologia, 1997. Anais de Congresso. Belo Horizonte - BH.

45.
ARRUDA, V. R.; CASTRO, V. ; VR, A. J. C. F. A. . Hpa-1b Pf Platelet Glycoprotein Iiia As A Risk Factor For Arterial Disease V. In: XVI Congresso Nacional do Colegio Brasileiro de Hematologia, 1997. Anais de Congresso. Belo Horizonte.

46.
ARRUDA, V. R.; CASTRO, V. ; JM, O. A. A. . Polimorfismo Genico do Sistema Hpa-5em Pacientes Com Pti. In: XVI Congresso Nacional do Colegio Brasileiro de Hematologia, 1997. Anais de Congresso. Belo Horizonte - MG.

47.
ARRUDA, V. R.; VR, A. L. A. J. A. ; Caracterizacao Molecular da Deficiencia de Antitrombina Iii. In: XVI Congresso Nacional do Colegio Brasileiro de Hematologia, 1997. Anais de Congresso. Belo Horizonte - MG.

48.
ARRUDA, V. R.; CASTRO, V. ; VR, A. J. C. F. A. . Gene Frequencies Of The Human Platelet Alloantigens Hpa-1 And 5 In Three Distinct Ethnic Groups From Brazil. In: XVI Congresso Nacional do Colegio Brasileiro de Hematologia, 1997. Anais de Congresso. Belo Horizonte - MG.

49.
ARRUDA, V. R.; LORAND-METZE, I. A. V. G. C. M. M. ; FF, S. S. C. . High Prevalence Of The Glutathione S-Transferase (Gst) Null Genotype In Acute Myeloblastic Leukemia. In: XVI Congresso Nacional do Colegio Brasileiro de Hematologia, 1997. Anais de Congresso. Belo Horizonte.

50.
ARRUDA, V. R.; BORDIN, S. ; FF, C. V. B. D. D. A. M. M. G. C. S. S. C. . Different Rates Of Recombination Among Polymorphic Short Tandem Repeats Of The Beta Globin Gene Cluster In Beta S Chromossomes. In: XVI Congresso Nacional do Colegio Brasileiro de Hematologia, 1997. Anais de Congresso. Belo Horizonte.

Resumos publicados em anais de congressos (artigos)
1.
ZHOU, J2003ZHOU, J ; SCHUETTRUMPF, J ; ZHANG, Y ; SCHLACHTERMAN, A ; LIU, A Y ; HERZOG, R W ; HIGH, Katherine A ; ARRUDA, V. R. . Effects of inhibitors to thrombin or factor Xa on viral vector-mediated gene transfer. Blood: Journal Of The American Society Of Hematology, v. 102, p. 794-794, 2003.

2.
TAI, S J2003TAI, S J ; HERZOG, R W ; ARRUDA, V. R. ; SCHLACHTERMAN, A ; CAMIRE, R M ; LABOSKY, P A ; HIGH, Katherine A . Expression of factor X-Friuli (Pro343 to Ser) rescues factor x-deficient mice from embryonic lethality and fatal perinatal bleeding. Blood: Journal Of The American Society Of Hematology, v. 102, p. 302-302, 2003.

3.
HIGH, Katherine A2003HIGH, Katherine A MANNO, C S SABATINO, D e HUTCHISON, S DAKE, M RAZAVI, M KAYE, R ARRUDA, V. R. HERZOG, R W RUSTAGI, P K RAKSO, J e J HOOTS, K BLATT, P SOMMER, J LEONARD, D B ADDYA, K RAGNI, M V OZELO, Margareth Castro KONKLE, B A LESSARD, R AXSOM, K M CHEW, A J GLADER, B PIERCE, G COUTO, L B , et al.KAY, M A ; Immune responses to AAV and to factor IX in a phase I study of AAV-mediated, liver directed gene transfer for hemophilia. Blood: Journal Of The American Society Of Hematology, v. 102, p. 154-154, 2003.

4.
ARRUDA, V. R.;ARRUDA, VALDER R;ARRUDA, VALDER R.2003ARRUDA, V. R.; SCHUETTRUMPF, J ; LIU, J H ; ADDYA, K ; LEONARD, D ; COUTO, L ; ZHEN, Z ; SOMMER, J ; HERZOG, R W ; KAY, M A ; GLADER, B ; MANNO, C S ; HIGH, Katherine A . Assessing the risk of inadvertent germline transmission of recombinant AAV-2 vector. Molecular Therapy, v. 07, p. 161-161, 2003.

5.
MARGARITIS, P2003MARGARITIS, P ; ARRUDA, V. R. ; HIGH, Katherine A . Gene therapy for hemophilia with inhibitors using secreted activated FVII (FVIIa). Molecular Therapy, v. 07, p. 27-27, 2003.

6.
ARRUDA, V. R.;ARRUDA, VALDER R;ARRUDA, VALDER R.2002ARRUDA, V. R.; SCHUETTRUMPF, J ; COUTO, L ; LEONARD, D ; ADDYA, K ; LIU, J H ; SOMMER, S ; HERZOG, R W ; KAY, M A ; GLADER, B ; MANNO, C S ; CHEW, A ; HIGH, Katherine . Assessing the risk of inadvertent germline transmission of vector DNA following intravascular delivery of rAAV vector. Blood: Journal Of The American Society Of Hematology, v. 100, p. 869-869, 2002.

7.
COUTO, L2002COUTO, L ; SCALLAN, C ; JIANG, H ; QIAN, X ; PATARROYOWHITE, S ; PARKER, A ; LIU, T ; CHEN, H ; POWELL, S ; WRIGHT, F ; TINLIN, S ; WEBSTER, S ; LILLICRAP, D ; ARRUDA, V. R. ; HIGH, Katherine A ; KAY, M ; MCCLELLAND, A . Hemophilia A gene therapy in mouse and dog models using an AAV-FVIII vector. Blood: Journal Of The American Society Of Hematology, v. 100, p. 117-117, 2002.

8.
MINGOZZI, F2002MINGOZZI, F ; LIU, Y L ; DOBRZYNSKI, e ; ARRUDA, V. R. ; HIGH, Katherine A ; HERZOG, R W . AAV-Mediated hepatic gene transfer induces regulatory CD4+ T cells promoting tolerance to the coagulation factor IX transgene product. Blood: Journal Of The American Society Of Hematology, v. 100, p. 116-116, 2002.

9.
KAY, M A2002KAY, M A ; HIGH, Katherine A ; GLADER, B ; MANNO, C S ; HUTCHISON, S ; DAKE, M ; RAZAVI, M ; KAYE, R ; ARRUDA, V. R. ; HERZOG, R ; MCCLELLAND, A ; RUSTAGI, P ; JOHNSON, F ; RASKO, J e J ; HOOTS, K ; BLATT, P ; LEONARD, D G B ; ADDYA, K ; KONKLE, B ; CHEW, A ; COUTO, L . A phase I/II clinical trial for liver directed AAV-mediated gene transfer for severe hemophilia B. Blood: Journal Of The American Society Of Hematology, v. 100, p. 115-115, 2002.

10.
ARMSTRONG, e2002ARMSTRONG, e ; SABATINO, D e ; PLEIMES, M ; SCHEUTTRUMPF, J ; DOBRZYNSKI, e ; HERZOG, R W ; ARRUDA, V. R. ; HIGH, Katherine A . Inhibitor formation as a function of undelying factor mutation in AAV-mediated muscle directed gene therapy using novel transgenic mouse models of hemophilia B. Blood: Journal Of The American Society Of Hematology, v. 100, p. 19-19, 2002.

11.
SCHUETTRUMPF, J2002SCHUETTRUMPF, J ; HERZOG, R W ; KAUFOLD, A ; STAFFORD, D W ; HIGH, Katherine A ; ARRUDA, V. R. . The use of Factor IX variants improves AAV-mediated gene therapy for hemophilia B. Blood: Journal Of The American Society Of Hematology, v. 100, p. 17-17, 2002.

12.
SCHUETTRUMPF, J2002SCHUETTRUMPF, J ; HIGH, Katherine A ; ARRUDA, V. R. . Molecular response to AAV or plasmid-DNA transduction of human skeletal muscle. Molecular Therapy, v. 05, p. 184-184, 2002.

13.
ARRUDA, V. R.;ARRUDA, VALDER R;ARRUDA, VALDER R.2002ARRUDA, V. R.; COUTO, L ; LEONARD, D ; ADDYA, D ; SOMMER, J ; HERZOG, R W ; KAY, M A ; GLADER, B ; MANNO, C ; CHEW, A ; HIGH, Katherine A . Risk of inadvertent germline transmission of vector DNA following intravascular delivery of recombinant AAV vector. Molecular Therapy, v. 05, p. 159-159, 2002.

14.
MINGOZZI, F2002MINGOZZI, F ; ARRUDA, V. R. ; LIU, Y L ; KAUFHOLD, A ; WANG, Y Q ; LIU, J H ; DOBRYNSKI, e ; HIGH, Katherine A ; HERZOG, R W . Induction of immune tolerance to a secreted protein antigen by hepatic gene transfer. Molecular Therapy, v. 05, p. 158-158, 2002.

15.
ARRUDA, V. R.;ARRUDA, VALDER R;ARRUDA, VALDER R.2002ARRUDA, V. R.; STEDMAN, H ; NICHOLS, T C ; HASKINS, M ; SCHUETTRUMPF, J ; HERZOG, R W ; LIU, Y L ; WAGNER, K ; COUTO, L ; HIGH, Katherine A . sustained correcton of hemophilia B phenotype following intravascular delivery of AAV vector to skeletal muscle. Molecular Therapy, v. 05, p. 157-157, 2002.

16.
SABATINO, D e2002SABATINO, D e ; ARRUDA, V. R. ; LIU, Y L ; VELANDER, W H ; ALPAN, O ; MATZINGER, P ; HIGH, Katherine A . Induction of oral tolerance to human factor IX in neonatal hemophilia B mice. Molecular Therapy, v. 05, p. 89-89, 2002.

17.
SCALLAN, C2002SCALLAN, C ; LIU, T ; PARKER, A ; WHITE, S Patarroyo ; CHEN, H ; MCCLELLAND, A ; POWELL, S ; WRIGHT, F ; SARKER, R ; KAZAZIAN, H ; ARRUDA, V. R. ; HIGH, Katherine A ; MEUSE, L ; OHASHI, K ; KAY, M ; COUTO, L . Phenotypic correction of hemophilia A using a dual AAV vector aproach. Molecular Therapy, v. 05, p. 86-86, 2002.

18.
COUTO, L2002COUTO, L ; JIAN, H ; SCALLAN, C I ; QIAN, X ; PATARROYOWHITE, S ; PARKER, A ; LIU, T ; CHEN, H ; POWELL, S ; WRIGHT, F ; TINLIN, S ; WEBSTER, S ; LILLICRAP, D ; SARKAR, R ; KAZAZIAN, H ; ARRUDA, V. R. ; HIGH, Katherine A ; MEUSE, L ; OHASHI, K ; KAY, M ; MCCLELLAND, A . A gene therapy in mouse and dog models using an AAV-FVIII vector. Molecular Therapy, v. 05, p. 84-84, 2002.

19.
SCHEUTTRUMPF, J2002SCHEUTTRUMPF, J ; LIU, Y L ; HERZOG, R W ; HIGH, Katherine A ; ARRUDA, V. R. . Effects of anticoagulant drugs IN VIVO AAV-mediated liver-directed gene transfer. Molecular Therapy, v. 05, p. 40-40, 2002.

20.
HERZOG, R W2002HERZOG, R W ; MINGOZZI, F ; ARRUDA, V. R. ; LIU, Y L ; HIGH, Katherine A . Improved efficacy of hepatic gene transfer by use of an AAV serotype-5 vector. Molecular Therapy, v. 05, p. 39-39, 2002.

21.
SABATINO, D e2001SABATINO, D e ; ARRUDA, V. R. ; LIU, Y L ; VELANDER, W H ; HIGH, Katherine A . Generation of whey acidic protein promoter human factor IX transgenic mice for studies of oral tolerance to human factor IX in neonatal hemophilia B mice. Blood: Journal Of The American Society Of Hematology, v. 98, p. 825-825, 2001.

22.
ARRUDA, V. R.;ARRUDA, VALDER R;ARRUDA, VALDER R.2001ARRUDA, V. R.; SCHUETTRUMPF, J ; NICHOLS, T C ; HERZOG, R W ; HASKINS, M ; COUTO, L B ; STEDMAN, H ; HIGH, Katherine A . Correction of canine hemophilia B phenotype by intravascular delivery of AAV vector to skeletal muscle. Blood: Journal Of The American Society Of Hematology, v. 98, p. 781-781, 2001.

23.
ARRUDA, V. R.;ARRUDA, VALDER R;ARRUDA, VALDER R.2001ARRUDA, V. R.; SCHUETTRUMPF, J ; XIAO, W ; NICHOLS, T C ; ROBINSON, N ; NI, D ; POWELL, S ; ALLEN, J ; HERZOG, R W ; HIGH, Katherine A . Alternative AAV serotypes result in enhanced factor IX expression in murine and canine models of hemophilia B. Blood: Journal Of The American Society Of Hematology, v. 98, p. 745-745, 2001.

24.
L, Liu Y2001L, Liu Y ; MINGOZZI, F ; ARRUDA, V. R. ; WANG, Y ; JOSEPH, S ; SCHEUTTRUMPF, J ; SUZUKI, T ; HIGH, Katherine A ; HERZOG, R W . high levels of muscle-derived factor IX expression using a combnation of AAV-1 vector and a myocyte-specific promoter. Blood: Journal Of The American Society Of Hematology, v. 98, p. 697-697, 2001.

25.
MARGARITIS, P2001MARGARITIS, P ; ARRUDA, V. R. ; HIGH, Katherine A . Long term expression of activated FVII IN VIVO following AAV mediated liver gene transfer: implications for treatment with conitnuous infusion of recombinant activated FVII. Blood: Journal Of The American Society Of Hematology, v. 98, p. 696-696, 2001.

26.
MINGOZZI, F2001MINGOZZI, F ; ARRUDA, V. R. ; LIU, Y L ; WANG, Y ; LIU, J H ; KAUFHOLD, A ; HIGH, Katherine A ; HERZOG, R W . Induction of immunological tolerance to a coagulation factor antigen by hepatic gene transfer. Blood: Journal Of The American Society Of Hematology, v. 98, p. 694-694, 2001.

27.
TOSO, R2001TOSO, R ; TIDD, T ; ARRUDA, V. R. ; HIGH, Katherine A ; POLLAK, e S . The absence of N-linked glycosylation in factor VII (FVIII) does not impair FVII activation or FVIIa activity. Thrombosis And Haemostasis, v. 0, p. 1398-1398, 2001.

28.
MANNO, C S2001MANNO, C S ; GLADER, B ; RAGNI, M V ; THOMPSON, A ; FOGLIO, Fernando Ferreira ; CHEW, A J ; HERZOG, R W ; ARRUDA, V. R. ; OZELO, Margareth Castro ; COUTO, L B ; MCCLELLAND, A ; JOHNSON, F ; FLAKE, A ; SKARSGARD, e ; ARMSTRONG, e ; KAY, M ; HIGH, Katherine A . A phase I trial of AAV mediated muscle directed gene transfer for hemophilia B. Thrombosis And Haemostasis, v. 0, p. 2488-2488, 2001.

29.
ARRUDA, V. R.;ARRUDA, VALDER R;ARRUDA, VALDER R.2001ARRUDA, V. R.; SCHUTTRUMPF, J ; ROBINSON, N ; NI, D ; XIAO, W ; COUTO, L B ; HERZOG, R W ; HIGH, Katherine A . Improved muscle-directed gene transfer of factor IX for treatment of hemophilia by use of novel AAV serotype vectors. Thrombosis And Haemostasis, v. 0, p. 2492-2492, 2001.

30.
KAY, M A2001KAY, M A ; NAKAI, H ; COUTO, L ; NICHOLS, T ; LOTHROP, C D ; GLADER, B ; MANNO, C S ; ARRUDA, V. R. ; HERZOG, R W ; HIGH, Katherine A . Safety and efficacy studies of AAV-mediated, liver-directed gene transfer for hemophilia B. Thrombosis And Haemostasis, v. 0, p. 2491-2491, 2001.

31.
ARRUDA, V. R.;ARRUDA, VALDER R;ARRUDA, VALDER R.2001ARRUDA, V. R.; SCHUTTRUMPF, J ; ROBINSON, N ; POWELL, S ; ALLEN, J ; NI, D ; XIAO, W ; NICHOLS, T ; HERZOG, R ; HIGH, Katherine A . Improved muscle directed gene transfer of factor IX for treatment of hemophilia B by use of novel AAV serotypes. Molecular Therapy, v. 03, p. 218-218, 2001.

32.
QIAN, X2001QIAN, X ; SCALLAN, C ; CHEN, H ; PARKER, A ; WHITE, S Patarroyo ; COLOSI, P ; CLELLAND, A Mc ; MEUSE, L ; KAY, M ; ARRUDA, V. R. ; HIGH, Katherine A ; SARKER, R ; KAZAZIAN, H ; COUTO, L . Optimization of AAV vectors for liver-directed gene therapy of hemophilia B. Molecular Therapy, v. 03, p. 187-187, 2001.

33.
KAY, Ma2001KAY, Ma ; MIAO, C H ; OHASHI, K ; ARRUDA, V. R. ; MCCLELLAND, A ; COUTO, L B ; MEUSE, L ; STORM, T A ; DAKE, M D ; RAZAVI, M ; MANNO, C S ; GLADE, B ; HIGH, Katherine A ; NAKAI, H . A proposed rAAV-liver directed clinical trial for hemophilia B. Molecular Therapy, v. 03, p. 33-33, 2001.

34.
MARGARITIS, P2001MARGARITIS, P ; ARRUDA, V. R. ; TOSO, R ; CAMIRE, R M ; KAUFHOLD, A ; POLLAK, e S ; HIGH, Katherine A . Gene therapy for hemophilia with inhibitors: generation of secreted activated FVII (FVIIa). Molecular Therapy, v. 03, p. 32-32, 2001.

35.
KAUFHOLD, A2001KAUFHOLD, A ; MPLEIMES ; HERZOG, R W ; FAKHARZADE, S S ; ARRUDA, V. R. ; ARMSTRONG, e ; MARGARITIS, P ; HIGH, Katherine A . Partial correction of hemophilia B by keratinocyte-derived expression of human factor IX variants in a transgenic mouse model. Molecular Therapy, v. 03, p. 32-32, 2001.

36.
ARRUDA, V. R.;ARRUDA, VALDER R;ARRUDA, VALDER R.2001ARRUDA, V. R.; SCHUTTRUMPF, J ; ROBINSON, N ; POWELL, S ; ALLEN, J ; NI, D ; XIAO, W ; NICHOLS, T ; HERZOG, R ; HIGH, Katherine A . Improved muscle derived gene transfer of factor IX for treatment of hemophilia B by use of novel AAv serotypes. Molecular Therapy, v. 03, p. 218-218, 2001.

37.
QIAN, X2001QIAN, X ; SCALLAN, C ; CHEN, H ; PARKER, A ; WHITE, S Patarroyo ; COLOSI, P ; MCCLELLAND, A ; MEUSE, L ; KAY, M ; ARRUDA, V. R. ; HIGH, Katherine A ; SARKER, R ; KAZAZIAN, H ; COUTO, L . Optimization of AAV vectors for liver-directed gene therapy of hemophilia B. Molecular Therapy, v. 03, p. 187-187, 2001.

38.
MARGARITIS, P2001MARGARITIS, P ; ARRUDA, V. R. ; TOSO, R ; CAMIRE, R M ; KAUFOLD, A ; POLLAK, e S ; HIGH, Katherine A . Gene therapy for hemophilia with inhibitors: generation of secreted activated FVII (FVIIa). Molecular Therapy, v. 03, p. 32-32, 2001.

39.
KAUFOLD, A2001KAUFOLD, A ; PLEIMES, M ; HERZOG, R W ; FAKHARZADEH, S S ; ARRUDA, V. R. ; ARMSTRONG, e ; MARGARITIS, P ; HIGH, Katherine A . Partial correction of hemophilia B by keratinocyte-derived expression of human factor IX variants in a transgenic mouse model. Molecular Therapy, v. 03, p. 32-32, 2001.

40.
TOSO, R2000TOSO, R ; TISS, T ; ARRUDA, V. R. ; HIGH, Katherine A ; POLLAK, e S . Lack of heavy chain glycocosylaton in patient with factor VII deficiency not responsible for mutant FVIIa activity. Blood: Journal Of The American Society Of Hematology, v. 96, p. 79-79, 2000.

41.
ARRUDA, V. R.;ARRUDA, VALDER R;ARRUDA, VALDER R.2000ARRUDA, V. R.; MOUNT, M J ; HERZOG, R W ; LOTHROP, C D ; HIGH, Katherine A . Systemic expression of factor IX and partial correction of canine hemophilia B by muscle directed gene therapy in a null mutation background. Blood: Journal Of The American Society Of Hematology, v. 96, p. 803-803, 2000.

42.
NAKAI, H2000NAKAI, H ; OHASHI, K ; ARRUDA, V. R. ; MCCLELLAND, A ; COUTO, L B ; MEUSE, L ; STORM, T ; DAKE, M D ; MANNO, C S ; GLADER, B ; HIGH, Katherine A ; KAY, M A . A proposed rAAV-liver directed clinical trial for hemophilia A. Blood: Journal Of The American Society Of Hematology, v. 96, p. 798-798, 2000.

43.
KAUFHOLD, A2000KAUFHOLD, A ; PLEIMES, M ; HERZOG, R W ; FAKHARZADEH, S S ; ARRUDA, V. R. ; ARMSTRONG, e ; MARGARITIS, P ; HIGH, Katherine A . Human factor IX expression in skin in a transgenic mouse model and indication for an advantage in using the collagen IV binding lacking factor IX mutantK5A. Blood: Journal Of The American Society Of Hematology, v. 96, p. 213-213, 2000.

44.
ARRUDA, V. R.;ARRUDA, VALDER R;ARRUDA, VALDER R.2000ARRUDA, V. R.; HERZOG, R W ; MOORE, K L ; HIGH, Katherine A . Improvement of tyrosine sulfation of myotube synthesized FIX following co-expression of AAV vector encoding tyrosylprotein sulfotransferase. Blood: Journal Of The American Society Of Hematology, v. 96, p. 212-212, 2000.

45.
HERZOG, R W2000HERZOG, R W ; FIELDS, P A ; ARRUDA, V. R. ; HAGSTROM, J N ; ARMSTRONG, e ; HIGH, Katherine A . Immune tolerance to factor IX in C57BL/6 mice following intravenous administration of first generation adenovirus vector. Molecular Therapy, v. 01, p. 288-288, 2000.

46.
ARRUDA, V. R.;ARRUDA, VALDER R;ARRUDA, VALDER R.2000ARRUDA, V. R.; FIELDS, P A ; MILNER, R ; WAINWRIGHT, L ; LIU, J ; HUFF, D ; HERZOG, R W ; COUTO, L B ; HIGH, Katherine A . Risk of inadvertent germ line transmission of AAV vector sequences in muscle directed gene transfer. Molecular Therapy, v. 01, p. 239-239, 2000.

47.
ARMSTRONG, e2000ARMSTRONG, e ; FIELDS, P A ; ARRUDA, V. R. ; HAGSTROM, J N ; KOWALCYZK, D W ; ERTL, H C J ; HIGH, Katherine A . Immune responses in hemophilia B mice expressing a species specific transgene. Molecular Therapy, v. 01, p. 29-29, 2000.

48.
MANNO, C S2000MANNO, C S ; GLADER, B ; RAGNI, M V ; THOMPSON, A ; COSTA, Fernando Ferreira ; CHEW, A J ; HERZOG, R W ; ARRUDA, V. R. ; TAI, S J ; COUTO, L B ; JOHNSON, F ; MCCLELLAND, A ; FLAKE, A W ; FIELDS, P A ; ARMSTRONG, e ; LEONARD, D ; SKARSGARD, e ; LARSON, P J ; KAY, M A ; HIGH, Katherine A . A phase I trial of AAV-mediated muscle directed gene therapy for hemophilia B. Molecular Therapy, v. 01, p. 128-128, 2000.

Artigos aceitos para publicação
1.
IVANCU, L. ; TOSO, R ; MARGARITIS, P ; PAVANI, G. ; KIM, H. ; Schlachterman, A. ; LIU, J H ; CLERIN, V. ; PITTMAN, D. ; ROSE-MIRANDA, R. ; SHIELDS, K. M. ; ERBE, D. V. ; TOBIN, J. F. ; ARRUDA, V. R. ; CAMIRE, R M . Correction of the coagulation defect in hemophilia using a Factor Xa variant with novel engineered protease function.. Nature Biotechnology (Print), 2011.

Apresentações de Trabalho
1.
ARRUDA, V. R.. Gene therapy for hemophilia, new insights into coagulation. 2003. (Apresentação de Trabalho/Conferência ou palestra).

2.
ARRUDA, V. R.. Gene therapy for hematological disorders. 2003. (Apresentação de Trabalho/Conferência ou palestra).

3.
ARRUDA, V. R.. Improving gene therapy for hemophilia B by AAV vectors. 2002. (Apresentação de Trabalho/Conferência ou palestra).

4.
ARRUDA, V. R.. Genetic counseling for hemophilia. 2002. (Apresentação de Trabalho/Conferência ou palestra).

5.
ARRUDA, V. R.. Assessinf the risk of germline transmission of AAV in a rabbit model biological response modifiers. 2002. (Apresentação de Trabalho/Conferência ou palestra).

6.
ARRUDA, V. R.. Gene therapy for hemophilia. 2002. (Apresentação de Trabalho/Comunicação).

7.
ARRUDA, V. R.. Vascular delivery of AAV to skeletal muscle in hemophila B dogs. 2002. (Apresentação de Trabalho/Comunicação).

8.
ARRUDA, V. R.. Gene therapy for bleeding disorders. 2001. (Apresentação de Trabalho/Conferência ou palestra).

9.
ARRUDA, V. R.. Adeno-associated virus muscle-directed gene therapy for hemophilia B. 1999. (Apresentação de Trabalho/Conferência ou palestra).


Produção técnica
Assessoria e consultoria
1.
ARRUDA, V. R.. International Advisory Committee. 2007.

Produtos tecnológicos
1.
ARRUDA, V. R.. Protein C zymogen and methods of use thereof to prevent cancer metastases. 2011.

Processos ou técnicas
1.
ARRUDA, V. R.. Compositions and methods for enhancing coagulation factor VIII function?. Patent Pending, October, 2009. 2009.

2.
ARRUDA, V. R.. Compositions and Methods for Modulating Hemostasis Using Variant Forms of Activated Factor V.? Patent Pending, Filed March 2006. 2006.

3.
ARRUDA, V. R.; HIGH, Katherine A . Supressão da formação do inibidor na hemofilia B. 1999.

Trabalhos técnicos
1.
ARRUDA, V. R.. Diretor: Gene and Cell Therapy for Genetic and Metabolic Diseases.. 2010.


Demais tipos de produção técnica
1.
ARRUDA, V. R.. Critical issuers in Gl-Liver disease in the aging hemophilia patient. 2010. (Curso de curta duração ministrado/Outra).

2.
ARRUDA, V. R.. Gene Therapy for Hemophilia, New Insights into Coagulation. 2007. (Curso de curta duração ministrado/Outra).

3.
ARRUDA, V. R.. Gene Therapy Genetic Diseases Committee. 2007. (Membro de Comitê).

4.
ARRUDA, V. R.. Hemophilia B Trials: Problems and Prospects. 2006. (Curso de curta duração ministrado/Outra).

5.
ARRUDA, V. R.. Biodistribution of recombinant AAV vector sequences in phase I studies of hemophilia B. 2004. (Curso de curta duração ministrado/Extensão).

6.
ARRUDA, V. R.. Pediatrics aplications of gene therapy. 2002. (Curso de curta duração ministrado/Outra).

7.
ARRUDA, V. R.. Gene therapy for hemophilia B by adeno-associated virus vector. 2002. (Curso de curta duração ministrado/Extensão).

8.
ARRUDA, V. R.. Assessing the Risk of Germline Transmission of AAV in a Rabbit Model. 2002. (Curso de curta duração ministrado/Outra).

9.
ARRUDA, V. R.. Adeno associated virus vector muscle-directed gene therapy for hemophilia B. 1999. (Curso de curta duração ministrado/Extensão).

10.
ARRUDA, V. R.. Ministrou a Aula: Métodos de Biologia Molecular Aplicadas ao Diagnóstico de Doenças Hemorrágicas, da Disciplina BB103 Bioquímica Básica. 1997. (Curso de curta duração ministrado/Outra).

11.
ARRUDA, V. R.. Ministrou a Aula: Diagnóstico Moleuclar das Doenças Hereditárias, na Disciplina BB103 Bioquimica Básica. 1997. (Curso de curta duração ministrado/Outra).

12.
ARRUDA, V. R.. Curso de Hematologia. 1997. (Curso de curta duração ministrado/Extensão).

13.
ARRUDA, V. R.. Ministrou a aula: Purpuras - Diagnostico Diferencial, para os residentes da Disciplina de Medicina Interna. 1995. (Curso de curta duração ministrado/Outra).

14.
ARRUDA, V. R.. Ministrou a palestra: Alterações Moleculares na Hemofilia, na reunião cientifica do Departamento de Clínica Médica. 1995. (Curso de curta duração ministrado/Outra).

15.
ARRUDA, V. R.. Ministrou a aula: Trombofiia, para a Disciplina de Moléstias Vasculares Perifericas do Departamento de Cirurgia, FCM/UNICAMP. 1995. (Curso de curta duração ministrado/Outra).

16.
ARRUDA, V. R.. Proferiu a palestra: Diagnóstico de Trombofilia, para residentes do Departamento de Neurologia da FCM/UNICAMP. 1995. (Curso de curta duração ministrado/Outra).



Patentes e registros



Patente

A Confirmação do status de um pedido de patentes poderá ser solicitada à Diretoria de Patentes (DIRPA) por meio de uma Certidão de atos relativos aos processos
1.
 ARRUDA, V. R.. Compositions and Methods for Modulating Hemostasis Using Variant Forms of Activated Factor V.? Patent Pending, Filed March 2006. 2006, Brasil.
Patente: Patente no Exterior. Número do registro: 01/03/2006, título: "Compositions and Methods for Modulating Hemostasis Using Variant Forms of Activated Factor V.? Patent Pending, Filed March 2006" .



Bancas



Participação em bancas de trabalhos de conclusão
Mestrado
1.
ARRUDA, V. R.. Participação em banca de Andrea Cristina Fernandes. Diagnóstico de portadores do gene da hemofilia A através dos polimorfismos de restrição Hind III e Bcl I. 1998. Dissertação (Mestrado em Medicina (Hematologia)) - Universidade Federal de São Paulo.

2.
ARRUDA, V. R.. Participação em banca de Carlos Augusto Seixas. Estudo de componentes da hemostasia em crianças portadoras de trombose de veia porta. 1996. Dissertação (Mestrado em Clínica Médica) - Universidade Estadual de Campinas.

Qualificações de Doutorado
1.
ARRUDA, V. R.. Participação em banca de Neiva Sellan Lopes gonçalves. Exame de qualificação na Anatomia Patológica. 1997. Exame de qualificação (Doutorando em Clínica Médica) - Universidade Estadual de Campinas.




Eventos



Participação em eventos, congressos, exposições e feiras
1.
2nd Advances in Bleeding Disorders: Understanding Today; Planning for Tomorrow.Advances in Bleeding Disorders. 2004. (Encontro).

2.
The Annual Combined Congress of Hematology Society and Blood and Marrow Transplantation. Gene Transfer as an Approach to Treating Hemophilia: Problems and Prospects. 2004. (Congresso).

3.
Second International Symposium of Hemoglobinopathies.Gene Therapy for Hematological Disorders. 2003. (Simpósio).

4.
25 Congresso Brasileiro de Hematologa e Hemoterapia. Gene Therapy for hemophilia. 2002. (Congresso).

5.
American Association of Blood Banks Annual Meeting.Gene Therapy for Bleeding Disorders. 2002. (Outra).

6.
Region III Meeting for Hemophilia Treatments.Genetic Counseling for Hemophilia. 2002. (Encontro).

7.
The National Hemophilia' s Foundation Fifth Workshop on Gene Therapies for Hemophilia.Vascular Delivery of AAV to Skeletal Muscle in hemophilia B Dogs. 2002. (Oficina).

8.
Thrombosis Research Center Seminar Series.Improving Gene Therapy for Hemophilia B by AAV Vectors. 2002. (Seminário).

9.
Molecular Biology in Modern Medicine - Visons for the Next Millenium.Adeno-associated virus muscle-directed gene therapy for hemophilia B. 1999. (Outra).

10.
XVI Congresso Nacional do Colégio Brasieliro de Hematologia. Coordenador da Mesa Redonda: Hipercoafulabilidade. 1997. (Congresso).

11.
XVI Congresso Nacional do Colégio Brasileiro de Hematologia. Apresentou a Sessão Educacional: Biologia Moleuclar para o Hematologista Clínico. 1997. (Congresso).

12.
XVI Congresso Nacional do Colégio Brasileiro de Hematologia. Relator da Mesa Redonda : Avanços no diagnostico e Tratamento das hemofilias e Doença de von Willebrand com o tema : Fisiologia molecular no diagnóstico pré natal. 1997. (Congresso).


Organização de eventos, congressos, exposições e feiras
1.
ARRUDA, V. R.. Scientific Symposium:Genetic Diseases: Protein Modifications to Enhance Therapy of Genetic Disease no Annual Meeting ASGT. 2005. (Outro).

2.
ARRUDA, V. R.. International Symposium in Hemophilia in the Context of a Latin American European Network. 2004. (Outro).

3.
ARRUDA, V. R.. New Insights in Coagulation - 1 day CME Course. 2003. (Outro).

4.
ARRUDA, V. R.. Gene Therapy-Clinical Results durante o American Society of Hematology Annual Meeting. 2001. (Congresso).



Orientações



Orientações e supervisões concluídas
Dissertação de mestrado
1.
Barbara Voetsch. Trombofilias hereditárias em paceintes jovens com acidente vascular cerebral isquemico. 2002. 0 f. Dissertação (Mestrado em Clínica Médica) - Universidade Estadual de Campinas, . Coorientador: Valder Roberval Arruda.

2.
Margareth Castro Ozelo. Caracterização genotipica e fenotipica das trombopatias. 1998. 0 f. Dissertação (Mestrado em Clínica Médica) - Universidade Estadual de Campinas, . Coorientador: Valder Roberval Arruda.

Tese de doutorado
1.
Vagner de Castro. Determinação da frequencia dos aloantigenos plaquetarios em populações brasileiras. 2000. 0 f. Tese (Doutorado em Clínica Médica) - Universidade Estadual de Campinas, . Orientador: Valder Roberval Arruda.




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