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Maria Aparecida Juliano
Bolsista de Produtividade em Pesquisa do CNPq - Nível 1A

Possui graduação em Engenharia Química pela Universidade de Mogi das Cruzes (1978), mestrado em Ciências Biológicas (Biologia Molecular) pela Universidade Federal de São Paulo (1983) e doutorado em Ciências Biológicas (Biologia Molecular) pela Universidade Federal de São Paulo (1992). Atualmente é professor adjunto- livre-docente da Universidade Federal de São Paulo e professora Titular da Universidade Federal de São Paulo. Tem experiência na área de Bioquímica, com ênfase em: - Sintese Quimica de Peptideos e Biblioteca de Peptideos de Inibidores e Substratos para Enzimas Proteoliticas - Estudo bioquimico de Enzimas Proteoliticas
(Texto informado pelo autor)

Última atualização do currículo em 21/11/2011
Endereço para acessar este CV:
http://lattes.cnpq.br/7909537302983812
Dados pessoais
NomeMaria Aparecida Juliano
Nome em citações bibliográficasJULIANO, M. A.
SexoFeminino
Endereço profissionalUniversidade Federal de São Paulo, Departamento de Biofísica.
Rua Tres de maio, 100
Vila Clementino
04044-020 - Sao Paulo, SP - Brasil
Telefone: (11) 55390809 Ramal: 212 Fax: (11) 55759617

Formação acadêmica/Titulação
2001Livre-docência.
Universidade Federal de São Paulo, UNIFESP, Brasil.
Título: , Ano de obtenção: 2001.
1996 - 1996Pós-Doutorado .
University of Copenhagen.
Bolsista do(a): Fundação de Amparo à Pesquisa do Estado de São Paulo ,FAPESP ,Brasil .
Grande área: Ciências Biológicas / Área: Bioquímica / Subárea: Química de Macromoléculas / Especialidade: Proteínas.
1988 - 1992Doutorado em Ciências Biológicas (Biologia Molecular) .
Universidade Federal de São Paulo, UNIFESP, Brasil.
Título: Estudo Comparativo da Especificidade entre Tonina, Calicreínas e Tripsina com Substratos Peptídicos Cromogênicos, Ano de Obtenção: 1992.
Orientador: Luiz Juliano Neto.
1979 - 1983Mestrado em Ciências Biológicas (Biologia Molecular) .
Universidade Federal de São Paulo, UNIFESP, Brasil.
Título: Síntese e Estudo Cinético de Novos Substratos Cromogênicos para algumas Serino-Proteases, Ano de Obtenção: 1983.
Orientador: Luiz Juliano Neto.
Bolsista do(a): Conselho Nacional de Desenvolvimento Científico e Tecnológico ,CNPq ,Brasil .
Palavras-chave: Serino-proteases; substratos cromogênicos.
Grande área: Ciências Biológicas / Área: Bioquímica / Subárea: Química de Macromoléculas / Especialidade: Proteínas.
1973 - 1978Graduação em Engenharia Química .
Universidade de Mogi das Cruzes, UMC, Brasil.

Atuação profissional
Universidade Federal de São Paulo, UNIFESP, Brasil.
Vínculo institucional
2004 - Atual Vínculo: Servidor Público, Enquadramento Funcional: Professor Titular, Carga horária: 40, Regime: Dedicação exclusiva.
Vínculo institucional
1982 - Atual Vínculo: Servidor Público, Enquadramento Funcional: Professor Adjunto- Livre-Docente, Carga horária: 40, Regime: Dedicação exclusiva.
Atividades
1995 - AtualEnsino, Ciências Biológicas (Biologia Molecular), Nível: Pós-Graduação.
Disciplinas ministradas
Síntese de peptídeos em Solução
Síntese de Peptídeos em Fase Sólida
2/1982 - AtualEnsino, Biofísica Sistema, Nível: Graduação.
Disciplinas ministradas
Biofísica
Fisico-Química

Áreas de atuação
1. Grande área: Ciências Biológicas / Área: Bioquímica.

Idiomas
Inglês Compreende Bem, Fala Bem, Lê Bem, Escreve Bem.

Prêmios e títulos
2007Scorpus-2007, .


Produção em C,T & A
Produção bibliográfica
Artigos completos publicados em periódicos
1. Watanabe RM ; TANAKA-AZEVEDO AM ; ARAUJO, M. ; JULIANO, M. A. ; TANAKA, A. S. . Characterization of thrombin inhibitory mechanism of rAaTI, a Kazal-type. Biochimie (Paris. Print), v. 93, p. 618-623, 2011.
2. CRUZ, LN ; Alves e ; Leal MT ; JULIANO, M. A. ; Rosenthal PJ ; JULIANO, L ; GARCIA C.R. . FRET peptides reveal differential proteolytic activation in intraerythrocytic. International Journal for Parasitology, v. 41, p. 363-372, 2011.
3. Andrade, Sheila S ; Silva-Lucca, R A ; Santana, LA ; Gouvea, I E ; JULIANO, M. A. ; CARMONA, A K ; ARAUJO, M S . Biochemical characterization of a cysteine proteinase from Bauhinia forficata leaves and its kininogenase activity. Process Biochemistry (1991), v. 46, p. 572-578, 2011.
4. Gesteira, T F ; Coulson-Thomas, V J ; Taunay R A ; OLIVEIRA, V. ; Thacker, B E ; JULIANO, M. A. ; Pasqualini, R ; Arap, W ; Tersariol, I L. S ; Pinhal, M A. S. . Inhibitory Peptides of the Sulfotransferase Domain of the Heparan Sulfate Enzyme, N-Deacetylase-N-sulfotransferase-1. The Journal of Biological Chemistry (Print), v. 286, p. 5338-5346, 2011.
5. Watanabe, R M. O ; Tanaka A A M ; ARAUJO, M S ; JULIANO, M. A. ; Tanaka, A S . Characterization of thrombin inhibitory mechanism of rAaTI, a Kazal-type inhibitor from Aedes aegypti with anticoagulant activity. Biochimie (Paris. Print), v. 93, p. 618-623, 2011.
6. Tonelli, R. R ; Torrecilhas, A. C ; Jacysyn, J. F ; JULIANO, M. A. ; COLLI, W. ; Alves, M. J. M. . In vivo infection by Trypanosoma cruzi: The conserved FLY domain of the gp85/trans-sialidase family potentiates host infection. Parasitology (London. Print), v. 138, p. 481-492, 2011.
7. Gouvea, I E ; Santos, J A. N ; Burlandy, F M ; Tersariol, I L. S ; da Silva, E E ; JULIANO, M. A. ; JULIANO, L ; Cunha, R LOR . Poliovirus 3C proteinase inhibition by organotelluranes. The Journal of Biological Chemistry (Print), v. 392, p. 587-591, 2011.
8. Kondo, M Y. ; Oliveira, L C. G ; Duarte dos Santos, C N ; JULIANO, M. A. ; JULIANO, L ; Gouvea, I E . Yellow fever virus NS2B/NS3 protease: Hydrolytic Properties and Substrate Specificity. Biochemical and Biophysical Research Communications (Print), v. 407, p. 640-644, 2011.
9. Pereira, I O ; Assis, D M ; JULIANO, M. A. ; Cunha, R L. O. R ; Barbieri, C L ; do Sacramento, L V. S ; Marques, M J . Natural Products from Garcinia brasiliensis as Leishmania Protease Inhibitors. Journal of Medicinal Food, v. 14, p. 557-562, 2011.
10. Ike, P T. L ; Assis, D M ; Icimoto, M Y ; JULIANO, M. A. ; JULIANO, L. ; PUZER, L. ; Henrique-Silva, F . Leviserpin: A Serine Peptidase Inhibitor (Serpin) from the Sugarcane Weevil Sphenophorus levis. Journal of Protein Chemistry (Print) (Cessou em 2003. Cont. ISSN 1572-3887 The Protein Journal), v. 30, p. 404-412, 2011.
11. ANDRADE, D. ; Assis, D M ; Santos, J A. N ; Alves, F M ; HIRATA, I Y ; ARAUJO, M S ; BLABER, S. I. ; Blaber, M . ; JULIANO, M. A. ; JULIANO, L. . Substrate specificity of kallikrein-related peptidase 13 activated by salts or glycosaminoglycans and a search for natural substrate candidates. Biochimie (Paris. Print), v. 93, p. 1701-1709, 2011.
12. Teixeira, T S. P ; Freitas, R F ; Abrahao, O Jr ; Devienne, K F ; de Souza, L R ; BLABER, S. I. ; Blaber, M . ; Kondo, M.Y ; JULIANO, M. A. ; JULIANO, L ; PUZER, L. . Biological evaluation and docking studies of natural isocoumarins as inhibitors for human kallikrein 5 and 7. Bioorganic & Medicinal Chemistry Letters (Print), v. 21, p. 6112-6115, 2011.
13. Fonseca FP ; Assis DM ; Icimoto MY ; JULIANO, M. A. ; JULIANO, L ; Puzer L ; Henrique-Silva F. . Leviserpin: a serine peptidase inhibitor (Serpin) from the. The Protein Journal, v. 30, p. 404-412, 2011.
14. Marcondes M F ; TORQUATO, R J ; Assis D M ; ASSIS, D. ; JULIANO, M. A. ; Hayashi A, M. ; OLIVEIRA, V. . Mitochondrial intermediate peptidase: Expression in Escherichia coli and improvement of its enzymatic activity detection with FRET substrates. Biochemical and Biophysical Research Communications (Print), v. 391, p. 123-128, 2010.
15. Staquicini DI ; MARTINS, R. M. ; Macedo S ; Sasso GR ; Atayde VD ; JULIANO, M. A. ; Yoshida N . Role of GP82 in the Selective Binding to Gastric Mucin during Oral Infection with Trypanosoma cruzi.. Plos Neglected Tropical Diseases, v. 4, p. 101371-101376, 2010.
16. Lorenzon RZ ; CUNHA, C. E. ; Marcondes M F ; Machado MF ; JULIANO, M. A. ; OLIVEIRA, V. ; TRAVASSSOS, L. ; PASCHOALIN, T. ; CARMONA, A. . Kinetic characterization of the Escherichia coli oligopeptidase A (OpdA) and the role of the Tyr(607) residue.. Archives of Biochemistry and Biophysics (Print), v. 2, p. 131-136, 2010.
17. KONDO, M. Y. ; OKAMOTO, D. N. ; SANTOS, J. A. ; JULIANO, M. A. ; ODA, K. ; Pillai B ; James MN ; LJULIANO ; GOUVEIA, I. E. . Studies on the catalytic mechanism of a glutamic peptidase.. The Journal of Biological Chemistry (Print), v. 285, p. 21437-21445, 2010.
18. Andrade D ; Assis DM ; LIMA, A. R. ; Oliveira JR ; ARAUJO, M. ; BLABER, S.I ; SCARISBRICK, I. A. ; JULIANO, M. A. ; JULIANO, L . Substrate specificity and inhibition of human kallikrein-related peptidase 3 (KLK3 or PSA) activated with sodium citrate andglycosaminoglycans. Archives of Biochemistry and Biophysics (Print), v. 498, p. 74-82, 2010.
19. Coppini LP ; BARROS, N. M. ; Oliveira M ; HIRATA, I Y ; ALVES, M F ; PASCHOALIN, T. ; Assis D M ; JULIANO, M. A. ; PUZER, L ; BROMME, D ; CARMONA, A K . Plasminogen hydrolysis by cathepsin S and identification of derived peptides as selective substrate for cathepsin V and cathepsin L inhibitor.. Biological Chemistry, v. 391, p. 561-570, 2010.
20. Machado MF ; Marcondes M F ; RIOLI, V ; FERRO, E. S. ; JULIANO, M. A. ; JULIANO, L ; OLIVEIRA, V. . Catalytic properties of thimet oligopeptidase H600A mutant. Biochemical and Biophysical Research Communications (Print), v. 394, p. 429-433, 2010.
21. OKAMOTO, D. N. ; KONDO, M. Y. ; HIRAGA, K. ; JULIANO, M. A. ; JULIANO, L ; Gouveia IE ; ODA, K. . Salt effect on substrate specificity of a subtilisin-like halophilic protease. Protein and Peptide Letters, v. 17, p. 796-802, 2010.
22. SCARISBRICK, I. A. ; YOON, H. ; JULIANO, M. A. ; Scarisbrick I A ; BLABER, S. I. . Functional intersection of the kallikrein-related peptidases (KLKs) and thrombostasis axis.. Biological Chemistry, v. 391, p. 311-320, 2010.
23. Oliveira M ; TORQUATO, R J ; ALVES, M F ; JULIANO, M. A. ; BROMME, D ; Barros NM ; CARMONA, A. . Improvement of cathepsin S detection using a designed FRET peptide based on putative natural substrates. Peptides (New York, N.Y. 1980), v. 31, p. 562-567, 2010.
24. OKAMOTO, D. N. ; Oliveira LC ; KONDO, M. Y. ; CEZARI, M H ; JULIANO, M. A. ; JULIANO, L ; GOUVEIA, I. E. . Increase of SARS-CoV 3CL peptidase activity due to macromolecular crowding effects in the milieu composition.. Biological Chemistry (Print), v. 391, p. 1461-1468, 2010.
25. Tonelli R R ; Torrecilhas A C ; JULIANO, M. A. ; COLLI, W. ; ALVES, M. J. . In vivo infection by Trypanosoma cruzi: The conserved FLY domain of the gp85/trans-sialidase family potentiates host infection. Parasitology (London. Print), v. 2, p. 1-12, 2010.
26. MATSUO, A. L. ; TANAKA, A. S. ; JULIANO, M. A. ; Rodrigues EG ; TRAVASSOS, L R . A novel melanoma-targeting peptide screened by phage display exhibits antitumor activity.. Journal of Molecular Medicine (Berlin. Print), v. 88, p. 1255-1264, 2010.
27. Dobroff As ; Rodrigues EG ; JULIANO, M. A. ; Friaca DM ; NAKAYASU, E. ; POLONELLI, L. ; TRAVASSOS, L R . Differential Antitumor Effects of IgG and IgM Monoclonal Antibodies and Their Synthetic Complementarity-Determining Regions Directed to New Targetsof B16F10-Nex2 Melanoma Cells. Translational Oncology (Online), v. 3, p. 204-217, 2010.
28. Rezende-Soares FA ; CARVALHO-CAMPOS, C. ; Marques M J ; Porcino G N ; GIAROLA, N.l ; Costa BL ; JULIANO, M. A. ; JULIANO, L. ; Vasconcelos E G . Cytochemical localization of ATP diphosphohydrolase from Leishmania (Viannia) braziliensis promastigotes and identification of an antigenic and catalytically active isoform. Parasitology International (Print), v. 137, p. 773-783, 2010.
29. Izidoro MA ; Assis DM ; OLIVEIRA, V. ; SANTOS, J.A ; JULIANO, M. A. ; LINDBERG, I. ; JULIANO, L. . Effects of magnesium ions on recombinant human furin: selective activation of hydrolytic activity upon substrates derived from virus envelope glycoprotein. Biological Chemistry (Print), v. 391, p. 1105-1112, 2010.
30. Gesteira TF ; TAUNAY-RODRIGUES, A. ; OLIVEIRA, V. ; Thacker BE ; JULIANO, M. A. . Inhibitory peptides of the sulfotransferase domain of the heparan sulfate enzyme, N-deacetylase-N-sulfotransferase-1. Journal of Biological Chemistry (Online), v. 221, p. 1212-1220, 2010.
31. OKAMOTO, D. N. ; KONDO, M. Y. ; SANTOS, J. A. ; ODA, K. ; JULIANO, M. A. ; JULIANO, L ; GOUVEA, I. E. . Kinetic analysis of salting activation of a subtilisin-like halophilic protease. Biochimica et Biophysica Acta. G, General Subjects, v. 1794, p. 367-373, 2009.
32. SANTOS, J. A. ; GOUVEA, I. E. ; JUDICE, W A S ; ALVES, F. M. ; JULIANO, M. A. ; JULIANO, L. . Hydrolytic properties and substrate specificity of the foot and mouth disease leades protease. Biochemistry (Easton), v. 48, p. 7948-7958, 2009.
33. CUNHA, C. E. ; de FATIMA MAGLIARELLI, H. ; PASCHOALIN, T. ; NCHINDA, A. ; JULIANO, M. A. ; TRAVASSOS, L. R. ; CARMONA, A K . Catalytic properties of recombinant dipeptidyl carboxypeptidase from Escherichia coli: a comparative study with angiotensinI-converting enzyme. Biological Chemistry, v. 9, p. 931-940, 2009.
34. DALE, C S ; CENAC, N. ; GIORGI, R. ; JULIANO, M. A. ; JULIANO, L ; VERGNOLLE, N. . Analgesic properties of S100A9 c-terminal domin: a mecanism dependent on calcium channel inhibition.. Fundamental & Clinical Pharmacology, v. 4, p. 427-438, 2009.
35. Izidoro M ; GOUVEA, I. E. ; SANTOS, J. A. ; ASSIS, D. ; OLIVEIRA, V. ; JUDICE, W A S ; JULIANO, M. A. ; LINDBERG, I. ; JULIANO, L . A study of human firin specificity using synthetic peptides derived from natural substrates and effects of potassium ions. Biochemical and Biophysical Research Communications (Print), v. 487, p. 105-114, 2009.
36. Felegrini da Silva A ; JULIANO, M. A. ; PRADO, W A ; MARTINS, A R . Angiotensin III modulates the nociceptive control mediated by the periaqueductal gray matter. The Journal of Neuroscience, v. 1, p. 1263-1273, 2009.
37. CHOW, K. ; GAKH, O. ; JULIANO, M. A. ; JULIANO, L ; HERSH, L B . mammalian pitrilysin: substrate specificity and motochondrial targeting.. Biochemistry (New York), v. 48, p. 2868-2877, 2009.
38. Pegano R L ; SAMPAIO, S. C. ; JULIANO, M. A. ; JULIANO, L ; GIORGI, R. . Involvement of proteinase-activated receptors 1 and 2 in spreading and phagocytisis by murine adherent peritoneal cells: Modulation by the C-terminal of S100A9 protein. European Journal of Pharmacology, v. 628, p. 240-246, 2009.
39. Rezende-Soares FA ; Carvalho Campos C ; Marques M J ; Giarola G N ; Costa B L ; JULIANO, M. A. ; JULIANO, L ; Vasconcelos E G . Cytochemical localization of ATP diphosphohydrolase from Leishmania (Viannia) braziliensis promastigotes and identification of an antigenic and catalytically active isoform. Parasitology (London. Print), v. 7, p. 1-11, 2009.
40. CARMONA, A K ; JULIANO, M. A. ; LUIZJULIANO . The use of Fluorescence Resonance Energy Transfer (FRET) peptides for measurement of clinically important proteolytic enzymes. Anais da Academia Brasileira de Ciências (Impresso), v. 81, p. 381-392, 2009.
41. Sasaki SD ; LIMA, C. ; LOVATO, D. ; JULIANO, M. A. ; TORQUATO, R J ; TANAKA, A. S. . BmSI-7, a novel subtilisin inhibitor from Boophilus microplus, with activity toward Pr1 proteases from the fungus Metarhizium anisopliae. Experimental Parasitology, v. 118, p. 214-220, 2008.
42. SarzedasC G ; LIMA, Cs ; JULIANO, M. A. ; JULIANO, L. ; Valente A P ; POIAN, At da ; Almeida F C . A minor beta-structured confirmation is the active state of a fusion peptide of vesicular stomatitis virus glycoprotein. Journal of Peptide Science, v. 14, p. 429-435, 2008.
43. MARTINS, R. M. ; AMINO, R. ; Daghastanli K R ; Cuccovia I M ; JULIANO, M. A. ; SCHENKMAN, S. . A short proregion of trialysin, a pore-forming protein of Triatoma infestans salivary glands, controls activity by folding the N-terminal lytic motif. The FEBS Journal, v. 275, p. 994-1002, 2008.
44. STAUFFER, F ; Melo M N ; Carneiro F A ; Sousa F J ; JULIANO, M. A. ; JULIANO, L. ; MOHANA-BORGES, R. ; POIAN, At da ; Castanho M A . Interaction between dengue virus fusion peptide and lipid bilayers depends on peptide clustering. Molecular Membrane Biology, v. 25, p. 128-138, 2008.
45. MAGDESIAN, M. H. ; Carvalho MN ; Mendes F A ; Saraiva L M ; JULIANO, M. A. ; JULIANO, L. ; GARCIA-ABREU, J. ; FERREIRA, S. T. . Amyloid-beta binds to the extracellular cysteine-rich domain of Frizzled and inhibits Wnt/beta-catenin signaling. The Journal of Biological Chemistry, v. 283, p. 9359-9368, 2008.
46. Sato P M ; LOPES, A R ; JULIANO, L ; JULIANO, M. A. ; TERRA, W R . Subsite substrate specificity of midgut insect chymotrypsins. Insect Biochemistry and Molecular Biology, v. 38, p. 628-633, 2008.
47. Korkmaz B ; Attucci S ; JULIANO, M. A. ; Kalupov T ; Jourdan M L ; JULIANO, L ; GAUTHIER, F . Measuring elastase, proteinase 3 and cathepsin G activities at the surface of human neutrophils with fluorescence resonance energy transfer substrates. New Zealand Journal of Crop and Horticultural Science, v. 3, p. 991-1000, 2008.
48. LANFRANCO, M. F. ; Loayza-Muro R ; Clark D ; Nunez R ; Zavaleta A I ; Jimenez M ; MELDAL, M ; COOMBS, G H ; MOTTRAM, J. C. ; Izidoro M ; JULIANO, M. A. ; JULIANO, L ; AREVALO, J . Expression and substrate specificity of a recombinant cysteine proteinase B of Leishmania brasiliensis. Molecular and Biochemical Parasitology, v. 161, p. 91-100, 2008.
49. BARROS, N. M. ; NASCIMENTO, F. D. ; OLIVEIRA, V. ; JULIANO, M. A. ; JULIANO, L. ; LOISEL, T P ; NADER, H. B. ; BOILEAU, G ; CARMONA, A K . The critical interaction of the metallopeptidase PHEX with heparan sulfate proteoglycans. International Journal of Biochemistry & Cell Biology, v. 40, p. 2781-2792, 2008.
50. POLONELLI, L. ; PONTON, J. ; MORAGUES, M. D. ; ELGUEZABAL, N. ; CASOLI, C. ; PITOTTI, E. ; JULIANO, M. A. ; RONZI, P. ; TRAVASSOS, L R . Antibody complementarity-determining regions (CDRs) can display differential antimicrobial, antiviral and antitumor activities. PLoS ONE, v. 3, p. 2371-2378, 2008.
51. PACCOLO, C. C. ; GUTIERREZ, V. P. ; LONGO, I. ; JULIANO, L ; JULIANO, M. A. ; GIORGI, R. . Antinociceptive effect of the C-terminus of murine S100A9 protein on experimental neuropathic pain. Peptides (New York), v. 29, p. 1806-1814, 2008.
52. YOON, H. ; BLABER, S. I. ; Blaber M ; TRIM, J. ; JULIANO, M. A. ; Scarisbrick IA . Activation profiles of human kallikrein-related peptidases by proteases of the thrombostasis axis. Protein Science, v. 17, p. 1998-2007, 2008.
53. MARQUES, A. F. ; SILVA, M. B. ; JULIANO, M. A. ; TRAVASSOS, L. R. ; TABORDA, C. P. . Additive effect of P10 immunization and chemotherapy in anergic mice challenged interatracheally with virulent yeasts of Paracoccidioides brasiliensis. Microbes and Infection, v. 10, p. 1251-1258, 2008.
54. LIMA, A. R. ; ALVES, F. ; ANGELO JUNIOR, P. ; ANDRADE, D. ; Blaber M ; BLABER, S. I. ; JULIANO, L ; JULIANO, M. A. . S1 and S2 subsite specificities of human plasma kallikrein and tissue kallikrein1 for the hydrolysis of peptides derived from the bradykinin domain of human kininogen. Biological Chemistry, v. 389, p. 1787-1794, 2008.
55. PERPETUO, E. A. ; JULIANO, L ; JULIANO, M. A. ; FRATELLI, F. ; PRADO, S. M. ; PIMENTA, D C ; LEBRUM, I. . Enzymatic profiling of tetanus and botulinum neurotoxins based on vesicle-associated-membrane protein derived fluorogenic substrates. Protein and Peptide Letters, v. 15, p. 1100-1106, 2008.
56. IWAI, L K ; YOSHIDA, M ; GOLDBERG, A C ; JULIANO, M. A. ; LUIZJULIANO ; KALIL, J ; CUNHA NETO, e ; TRAVASSOS, L R . T-cell recognition of Paracoccidioides brasiliensis gp43-derived peptide patients with paracoccidioidomycosis and healthy individuals. Clin Vaccine Immunol, v. 14, p. 474-476, 2007.
57. MATSUO, A. L. ; CARMONA, A K ; CUNHA, C. E. ; NAKAYASU, E. S. ; JULIANO, M. A. ; PUCCIA, R. . C-Npys (S-3-nitro-2-pyridinesulfenyl) and petide derivatives can inhibition serine-thiol proteinase activity from paracoccidiodes brasiliensis. Biochemical and Biophysical Research Communications, v. 355, p. 1005, 2007.
58. SABATINI, R. ; BERSANETTI, P. A. ; FARIAS, S.L. ; JULIANO, L. ; JULIANO, M. A. ; CARMONA, A. ; Pesqueiro J.B. . Determination of angiotensinI converting enzyme activity in cell cul fluorescence resonance energy transfer peptrides. Analytical Biochemistry, v. 363, p. 255-262, 2007.
59. MACHADO, F ; RIOLI, V ; Castro LM ; JULIANO, M. A. ; TERSARIOL, I. L. S. ; JULIANO, L. ; OLIVEIRA, V. . The role of Tyr605 and Ala607 of thimet oligopeptidase and Tyr606 and neurolysin in substrate hydrolysis and inhibitor binding. Biochemical Journal (London), v. 404, p. 279-288, 2007.
60. GOUVEIA, I. E. ; JUDICE, W A S ; JULIANO, M. A. ; JULIANO, L. . Substrate specificity of recombinant dengue 2 virus NS2B-NS3 protease of natural and unnatural basic amino acids on hydrolysis of synthetic substrates. Archives of Biochemistry and Biophysics, v. 457, p. 187-196, 2007.
61. BARROS, N. M. ; CAMPOS, M. ; BERSANETTI, P. A. ; OLIVEIRA, V. ; JULIANO, M. A. ; BOILEAU, G ; CARMONA, A. . Neprilysin carboxydipeptidase specificity studies and improvement in detection with fluorescence energy trnsfer peptides. Biological Chemistry, v. 388, p. 447-455, 2007.
62. FREITAS, V. M. ; VILAS-BOAS, V. F. ; PIMENTA, C. D. ; LOUREIRO, V. ; JULIANO, M. A. ; PINHEIRO, J. ; MORISCOT, A. S. ; JAEGER, R. G. . SIKVAV, a laminin (alpha 1- derived peptide, interacts with integrins cell line through the ERK 1/2 signaling pathway. The American Journal of Pathology, v. 171, p. 124-138, 2007.
63. HAJJ, G. N. ; LOPES, M. H. ; MERCADANTE, A. F. ; VEIGA, S. S. ; JULIANO, M. A. ; ZANATA, S. M. ; MARTINS, V. R. . Cellular prion protein interaction with vitronectin supports axonal compensated by integrins. Journal of Cell Science, v. 120, p. 1915-1926, 2007.
64. PERPETUO, E. A. ; LEBRUN, I. ; JULIANO, L ; JULIANO, M. A. ; SAKAUCHI, M. A. . Analysis of Secreted Protein Profile and Enzymatic Activities from Corynebacterium diphtheriae and Bordetella pertussis on Production Bat using Peptide Quenched Fluorescent Substrates. Bioscience, Biotechnology, and Biochemistry, v. 37, p. 353-367, 2007.
65. PASCHOALIN, T. ; CARMONA, A. ; RODRIGUES, E. ; OLIVEIRA, V. ; JULIANO, M. A. ; JULIANO, L ; TRAVASSSOS, L. . Characterization of thimet oligoeptidase and neurolysin activities B16F10-Nex2 tumor cells and their involvement in angiogenesis and tumur. Molecular Cancer Research, v. 9, p. 44-50, 2007.
66. ALVES, F. ; HIRATA, I Y ; GOUVEIA, I. E. ; ALVES, M F ; MEDAL, M. ; MELDAL, M ; BROMME, D ; JULIANO, L ; JULIANO, M. A. . Controlled peptide solvation in portion-mixing libraries of FRET peptide improved specificity determination for Dengue 2 virus NS2B-NS3 protease cathepsin S. Journal of Combinatorial Chemistry, v. 9, p. 627-634, 2007.
67. Blaber SI ; YOON, H. ; SCARISBRICK, I. A. ; JULIANO, M. A. ; Blaber M . The autolytic regulation of human kallikrein peptidase 6. Biochemistry (Easton), v. 46, p. 5209-5217, 2007.
68. LIU, Y. ; GUAN, H. ; BECKETT, T. L. ; JULIANO, M. A. ; JULIANO, L ; SONG, Es ; CHOW, K. ; HERSH, L B . In vitro and in vivo degradation of Abeta peptide by peptidases coupl erythrocytes. Peptides (New York), v. 28, p. 2348-2355, 2007.
69. GORRAO, S. S. ; HEMERLY, J. P. ; LIMA, A. R. ; MELO, R L ; SZELTNER, Z. ; JULIANO, M. A. ; JULIANO, L. . Fluorescence resonance energy transfer (FRET) eptides and cycloretro peptides derived from bradykinin as substrates and inhibitors of proly oligopeptidase. Peptide Research, v. 28, p. 2146-2154, 2007.
70. Cencic R ; Mayer C ; JULIANO, M. A. ; JULIANO, L. ; KONRAT, R. ; Kontaxis G . Investigating the substrate specificity and oligomerisation of the protease of foot and mouth disease bvirus using NMR. Journal of Molecular Biology, v. 373, p. 1071-1087, 2007.
71. ANGELO, P. F. ; LIMA, A. R. DE ; ALVES, F. M. ; Blaber SI ; SCARISBRICK, I. A. ; Blaber M ; JULIANO, L. ; JULIANO, M. A. . Substrate secificity of human kallikrein 6: Salt and glycosaminoglycan activation effects. J Biol Chem, v. 281, p. 3116-3126, 2006.
72. CARNEIRO, Fa ; LAPIDO-LOUREIRO, P. A. ; CORDO, S. M. ; STAUFFER, F ; WEISSMULLER, G. ; BIANCONI, G. ; JULIANO, M. A. ; LJULIANO ; BISCH, P. M. ; POIAN, At da . Probing the interaction between vesicular stomatitis virus and phoshatidylserine. Eur Biophys J, v. 35, p. 145-154, 2006.
73. LOPES, A.R. ; JULIANO, M. A. ; MARANA, S.R. ; JULIANO, L ; TERRA, W R . Substrate specificity of insect trypsins and the role of their subsites in catalysis. Insect Biochem Mol Biol, v. 36, p. 130-140, 2006.
74. MARTINS, R. M. ; SFORCA, M. ; AMINO, R. ; JULIANO, M. A. ; OYAMA, S. ; JULIANO, L. ; PERTINHEZ, T. A. ; SCHENKMAN, S. . Lytic activity and strutural differences of amphipathic eptides from trialysin. Biochem, v. 45, p. 1765-1774, 2006.
75. PUZER, L ; COTRIN, S. S. ; CEZARI, M H ; HIRATA, I. ; JULIANO, M. A. ; STEFE, I. ; TU, B. ; JULIANO, L ; CARMONA, A. . Recombinant human cathepsin X is a carboxymonopeptidase only: a comparaction cathepsins B and L. Biological Chemistry, v. 386, p. 1191-1195, 2006.
76. REIS, F. ; JUDICE, W A S ; JULIANO, M. A. ; JULIANO, L. ; SCHARFSTEIN, J. . The Substrate specificity of cruzipain2, a cysteine rotease isoform Trypanosoma cruzi. FEMS Microbiology Letters, v. 259, p. 215-220, 2006.
77. FARIAS, S.L. ; SABATINI, R. ; SAMPAIO, T. ; HIRATA, Y. ; CEZARI, M H ; JULIANO, M. A. ; CARMONA, A. ; JULIANO, L. . Angiotensin I-converting enzyme inhibitor peptides derived from the endostatin-containing NC1 fragment of human Collagen XVIII. Biological Chemistry, v. 387, p. 611-616, 2006.
78. MARES-GUIA, M. L. ; MAIGRET, B. ; MARTINS, N. F. ; MAIA, A. L. ; VILELA, L. ; RAMOS, C. H. ; JULIANO, M. A. ; MARES-GUIA, T. R. ; SANTORO, M. M. . Molecular dynamics and circular dichroism studies of human and rat C-peptides. Journal of Molecular Graphics & Modelling, v. 25, p. 532-542, 2006.
79. MARQUES, A. F. ; SILVA, M. B. ; JULIANO, M. A. ; TRAVASSOS, L. R. ; TABORDA, C. P. . peptide immunization as an adjuvant to chemotherapy in mice challenge intratracheally with virulent yeast cells of paracoccidiodes brasiliense. Antimicrobial Agents and Chemotherapy, v. 50, p. 2814-2819, 2006.
80. DALE, C S ; PAGANO, R. L. ; PACCOLA, C. C. ; PINOTTI-GUIRAO, T. ; JULIANO, M. A. ; GIORGE, R . Effect of the C-terminus of murine S100A9 protein on experimental noception. Regulatory Peptides, v. 27, p. 2794-2802, 2006.
81. DALE, C S ; CENAC, N. ; BRITTO, L. R. ; JULIANO, M. A. ; JULIANO, L. ; VERGNOLLE, N. . The C-terminus of murine S100A9 protein inhibits hyperalgesia induced agonist peptide of protease-activated receptor 2 (PAR2). British Journal of Pharmacology, v. 149, p. 374-384, 2006.
82. GOUVEA, I. E. ; JUDICE, W A S ; CEZARI, M. H. ; JUHASZ, T. ; JULIANO, M. A. ; SZELTNER, Z. ; JULIANO, L. . Kosmotropic salt activation and subnstrate specificity of poliovirus protease 3C. Biochemistry (Easton), v. 45, p. 12083-12089, 2006.
83. CARNEIRO, Fa ; VANDENBUSSCHE, G. ; JULIANO, M. A. ; JULIANO, L ; RUYSSCHAERT, J. . Charged residues are involved in menbrane fusion mediated by a hydrophilic peptide located in vesicular stomatitis virus G protein. Mol Menbr Biol, v. 23, p. 396-406, 2006.
84. FAE, K. C. ; HIGA, F. ; CHAVES, L. ; OSHIRO, S. E. ; PUSCHEL, C. ; JULIANO, M. A. ; TANAKA, A. S. ; SPINA, G. ; KALIL, J . Towards a vaccine against rheumatic fever. Clin Dev Immunol, v. 13, p. 125-132, 2006.
85. CARMONA, A K ; JULIANO, M. A. ; JULIANO, L ; STRURROCK, E. . A continuous fluorescence resonance energy transfer angiotensin I converting enzyme assay. Nat Protoc, v. 1, p. 1971-1976, 2006.
86. BLABER, S. I. ; YOON, H. ; Scarisbrick IA ; JULIANO, M. A. ; Blaber M . The autolytic regulation of human kallirein-related petidase 6. Biochemistry (Easton), v. 46, p. 5209-5217, 2006.
87. BERSANETTI, P. A. ; JULIANO, M. A. ; HIRATA, I Y ; LJULIANO ; CARMONA, A K . Characterization of arazyme, an exocelklular metalloprotease isolated from Serratia proteamaculans culture medium. Enzyme and microbial technology, v. 37, p. 574-581, 2005.
88. IWAI, L K ; JULIANO, M. A. ; JULIANO, L. ; KALIL, J ; CUNHANETO, E. . T-cell molecular mimicry in Chaqgas disease: identification and partial structuralanalysis of multiple cross-reactive epitopes between Trypanosoma cruzi B13 and cardiac myosin heavy chain. J Autoimmun, v. 24, p. 111-117, 2005.
89. FARIAS, S.L. ; Gazarini M.L. ; MELO, R. L. DE ; HIRATA, I. Y. ; JULIANO, M. A. ; LJULIANO ; GARCIA C.R. . Cysteine-protease activity elicited by Ca+2 stimulus in Plasmodium. Mol Biochem Parasitol, v. 141, p. 71-79, 2005.
90. SONG, Es ; Daily A. ; Fried MG ; JULIANO, M. A. ; LJULIANO ; HERSH, L B . Mutation of active site residues of insulin-degrading enzyme alters allosteric interactions. J Biol Chem, v. 280, p. 17701-17706, 2005.
91. Gioli-Pereira L. ; Nascimento E.A. ; Santos EL ; Bracht A. ; JULIANO, M. A. ; Pesqueiro J.B. ; Borges D.R. ; Kouyoumdjian M . Fate of bradykinin on the rat liver when administered by the venous or arterial route. J gastroenterol Hepatol, v. 20, p. 463-473, 2005.
92. PUZER, L ; Barros NM ; OLIVEIRA, V. ; JULIANO, M. A. ; Lu G ; Hassanein M ; JULIANO, L ; Mason RW ; CARMONA, A. . Defining the substrate specificity of mouse cathepsin P. Arch Biochem Biophys, v. 435, p. 190-196, 2005.
93. Laxmikanthan G ; Blaber SI ; Bernett MJ ; Scarisbrick IA ; JULIANO, M. A. ; Blaber M . 1.70 a x-ray structure of human apo kallikrein 1: structural changes upon peptide inhibitor/substrate binding. Proteins, v. 58, p. 802-814, 2005.
94. OLIVEIRA, V. ; Garrido PAG ; Rodrigues CC ; Colquhoun A ; Castro LM ; ALMEIDA, P. C. ; JULIANO, M. A. ; JULIANO, L ; CAMARGO, A. C. ; FERRO, E. S. . Calcium modulates endopeptidase 24.15 (EC 3.4.24.15) membrane association, secondary structure and substrate specificity. Eu J Biochem, v. 272, p. 2978-2992, 2005.
95. PAGANO, R. L. ; SAMPAIO, S. C. ; LJULIANO ; JULIANO, M. A. ; GIORGE, R . The C-terminal of murine S100A9 inhibits spreading and phagocytic activity of adherent peritoneal cells. Inflamm Res, v. 5, p. 204-210, 2005.
96. ABEL, L. C. J. ; IWAI, L K ; JULIANO, M. A. ; JULIANO, L ; KALIL, J ; CUNHANETO, E. . T-cell epitope characterization in tandemly reetitive Trypanosoma cruzi B 13 rotein. Microbes Infect, 2005.
97. ALVES, M F ; ARAUJO, M. C. ; JULIANO, M. A. ; JULIANO, L ; CASARINI ; CARMONA, A. . A continuous fluorescent assay for the determination of plasma and tissue angiotensin I-converting enzyme activity. Braz J Med Biol res, v. 6, p. 861-868, 2005.
98. AZZALINI, S. ; SASAKI, S. D. ; CAMPOS, I. T. ; TORQUATO, R J ; JULIANO, M. A. ; TANAKA, A. S. . The role of HiTI, a serine rotease inhibitor from Haematobia irritans (Diptera: Muscidae) in the control of fly and bacterial proteases. Exp Parasitol, v. 111, p. 30-36, 2005.
99. NUNES, V A ; GOZZO, A J ; CRUZ-SILVA, I. ; JULIANO, M. A. ; VIEL, T. A. ; GODINHO, R. O. ; SAMPAIO, C. A. M. ; SAMPAIO, M. U. ; ARAUJO, M S . Vitamin E prevents cell death induced by mild oxidative stress in chicken skeletal muscle cells.. Biochem Physiol Toxicol Pharmacol, 2005.
100. KACRZAK, M. M. ; THAN, M. E. ; LJULIANO ; JULIANO, M. A. ; BODE, W. ; LINDBERG, I. . Mutations of the PC2 substrate binding pocket alter enzyme specificity. J Biol Chem, v. 208, p. 31850-31858, 2005.
101. MAGDESIAN, M. H. ; NERY, A. A. ; MARTINS, A. H. ; JULIANO, M. A. ; JULIANO, L ; ULRICH, H. ; FERREIRA, S. T. . Petide blockers of the inhibition of neuronal nicotinic acetylcholine receptors by Abeta. J Biol Chem, v. 208, p. 31085-31090, 2005.
102. JUDICE, W A S ; MOTTRAM, J. C. ; COOMBS, G. H. ; JULIANO, M. A. ; JULIANO, L. . Specific negativ charges in cysteine rotease isoforms of Leishmaniamexicana are highly influential on the substrate binding and hydrolysis. Mol Biochem Parasitol, v. 144, n. 1, p. 36-43, 2005.
103. CARNEIRO, Fa ; LAPIDO-LOUREIRO, P. A. ; CORDO, S. M. ; STAUFFER, F ; WEISSMULLER, G. ; BIANCONI, M. L. ; JULIANO, M. A. ; JULIANO, L. ; BISCH, P. M. ; POIAN, At da . Probing the interaction between vesicular stomatitis virus and phosphatidylserine. Eur Biophys J, v. 24, p. 1-10, 2005.
104. PUZER, L ; COTRIN, S S ; MHSCESARI ; HIRATA, I Y ; JULIANO, M. A. ; STEFE, I. ; TURK, D. ; TURK, B. ; JULIANO, L. ; CARMONA, A. . Recombinant human cathepsin X is a carboxymonopeptidase only: a comparison with cathepsins B and L. Biol Chem, v. 386, p. 1191-1195, 2005.
105. PEREIRA, N. G. ; JULIANO, M. A. ; CARMONA, A K ; STRURROCK, E. ; KOTWAL, G. . Cloning and expression of a functionally active truncated N-glycosylated KSHV ORF4/Kaposica in the methylotrophic yeast pichia pastoris. Ann NY Acad Sci, v. 1056, p. 388-404, 2005.
106. MORAES, R M ; SILVA, D L D ; RUMJANEK, F D ; JULIANO, L ; JULIANO, M. A. ; FANTAPPIE, M R . Schitosoma mansoni histone acetyltransferase GCN5: linking histone acetylation to gene activation. Mol Biochem Parasitol, v. 133, p. 131-135, 2004.
107. LOPES, A R ; JULIANO, M. A. ; JULIANO, L ; TERRA, W R . Coevolution of insect trypsins and inhibitors. Archives of Insect Biochemistry and Physiology, v. 55, p. 140-152, 2004.
108. JUDICE, W A S ; PEZER, L ; COTRIN, S S ; CARMONA, A K ; COOMBS, G H ; JULIANO, L ; JULIANO, M. A. . Carboxipeptidase activities of recombinant cystein peptidases Cruzain of Trypanosoma cruzi and CPB of Leishmania mexicana. European Journal of Biochemistry, v. 271, p. 1046-1053, 2004.
109. DALE, C S ; CAMARGO, L R G ; JULIANO, L ; SILVA, A M ; JULIANO, M. A. ; GIORGE, R . The C-terminus of murine S100A9 inhibits hyperalgesia and edema induced by jararhagin. Peptides (New York), v. 1, p. 81-89, 2004.
110. FOGACA, S e ; MELO, R L ; PIMENTA, D C ; HOSOI, K ; JULIANO, L ; JULIANO, M. A. . Diferences in substrate and inhibitor sequence specifity of human, mouse and rat tissue kallikreins. Biochemical Journal (London), v. 380, p. 775-781, 2004.
111. QUITO, B M R ; JULIANO, M. A. ; HIRATA, I Y ; CARMONA, A K ; JULIANO, L ; CASARINI, D e . Specificity comparisom of a serine endopeptidase (SH1) and a serine thiol endopeptidase (STH2) purified from human urine. International Journal of Biochemistry & Cell Biology, 2004.
112. LIMA, R A ; JULIANO, L ; JULIANO, M. A. . Cyclic linear, cycloretro-isomer and cycloretro-inverso peptides derived from the C-terminal sequence of Bradykinin as substrate or inhibitors of serine and cysteine proteases. Journal of Protein Chemistry, v. 23, p. 287-294, 2004.
113. SONG, Es ; JULIANO, M. A. ; LJULIANO ; FRIED, M. ; WAGNER, S. ; HERSH, L B . ATP affects on insulin degrading enzyme are mediated primarily through its triphosphste moiety. J Biol Chem, v. 279, p. 54216-54220, 2004.
114. PUZER, L ; COTRIN, S. ; ALVES, M. ; EGBORGE, T. ; ARAUJO, M. ; JULIANO, M. A. ; JULIANO, L ; BROMME, D ; CARMONA, A K . Comparative substrate specificity analysis of recombinant human cathepsin V and cathepsin L. Arch Biochem Biophys, v. 430, p. 274-283, 2004.
115. JULIANO, M. A. ; BROOKS, D. ; SELZER, P. ; PANDOLFO, H. ; JUDICE, W A S ; JULIANO, L ; MEDAL, M. ; SANDERSON, S J ; MOTTRAM, J. C. ; COOMBS, G. H. . Differences in substrate specificities between cysteine protease CPB isoformas of Leishmania mexicana are mediated by a few amino acid changes. Eur J Biochem, v. 271, p. 3704-3714, 2004.
116. MOLINARO, G. ; CARMONA, A K ; JULIANO, M. A. ; JULIANO, L ; MALITSKAYA, E. ; YESSINE, M. ; CHAGNON, M. ; LEPAGE, Y. ; BOILEAU, G ; ADAM, A. . Human recombinant membrane-bound aminopeptidase P: production of a soluble form and characterization using novel, internally-quenched fluorescent substrate. Biochem J, v. 385, p. 389-397, 2004.
117. MARROQUIN-QUELOPANA, M. ; OYAMA, S. J. ; PERTINHEZ, T. A. ; SPISNI, A ; JULIANO, M. A. ; JULIANO, L. ; COLLI, W. ; ALVES, M. J. . Modeling the Trypanosoma cruzi Tc85-11 protein and mapping the laminin-binding site. Biochem Biophys Res Commun, v. 2, p. 612-618, 2004.
118. LEBRUN, I. ; CAVALLARO, V. ; JULIANO, M. A. ; LJULIANO ; SOUSA, E. ; SILVA, M. C. . Effects of casoparan, a peptide isolated from casein hydrolysates with mastoparan-like properties. Mediators Inflamm, v. 4, p. 263-268, 2004.
119. Caires AC ; Oliveira CR ; Smith MC ; Hemerly JP ; JULIANO, M. A. ; Bincoletto C . Effects of palldacycle complex on hematopoietic progenitor cells proliferation in vivo and in vitro and its relation with the inhibitory properties of this coumpond on the angiotensin-I converting enzyme activity. Immunotoxicol, v. 26, p. 487-500, 2004.
120. BERSANETTI, P. A. ; ANDRADE, M. ; CASARINI ; JULIANO, M. A. ; NCHINDA, A. ; STRURROCK, E. ; CARMONA, A. . Positional-sacanning combinatorial libraries of fluorescence resonance energy transfer peptides for defining substrate specificity of the angiotensin I converting enzyme and development of selective C-domain substrates. Biochem, v. 43, p. 15729-15736, 2004.
121. CARNEIRO, Fa ; STAUFFER, F ; LIMA, Cs ; JULIANO, M. A. ; JULIANO, L ; POIAN, At da . Membrane fusion induced by vesicular stomatitis virus dependes on histidine protonation. The Journal of Biological Chemistry, v. 278, p. 13789-13794, 2003.
122. PIMENTA, D. C. ; FOGACA, S e ; MELO, R L ; JULIANO, M. A. ; JULIANO, L . Specificity of S'1 and S'2 subsites of human tissue kallikrein using the reactive-centre loop of kallistatin: the importante of P'1 and P'2 positions in desing of inibitors. Biochemical Journal (London), v. 371, p. 1021-1025, 2003.
123. SCHWINDT, T T ; FORTI, F L ; JULIANO, M. A. ; JULIANO, L ; ARMELIN, H A . Arginine vasopresin inhibition of cyclic D1 gene espression blocks the cell cycle and cell proliferation in the mouse Y1 adrenocortical tumor cell line. Biochemistry (Easton), v. 42, p. 2116-2121, 2003.
124. CHOW, K.M. ; OAKLEY, O ; GOODMAN, J ; MA, Z ; JULIANO, M. A. ; JULIANO, L ; HERSH, L B . Nardilysin cleaves peptides at monobasic sites. Biochemistry (Easton), v. 42, p. 2239-2244, 2003.
125. LUNDEQUIST, A ; JULIANO, M. A. ; JULIANO, L ; PEJLER, G . Polycationic peptides as inhibitors of mast cell serine proteases. Biochemical Pharmacology, v. 65, p. 1171-1180, 2003.
126. OLIVA, M. L. V. ; ANDRADE, S A ; JULIANO, M. A. ; SALLAI, R C ; TORQUATO, R J ; SAMPAIO, M. U. ; POTT, V. J. ; SAMPAIO, C A . Kinetic characterization os factor Xa binding using a quenched fluorescent substrate based on the reactive site of Factor Xa inhibitor from Bauhinia ungulata Seeds. Curr Med Chem, v. 10, p. 1085-1093, 2003.
127. CAMPOS, M. ; COUTURE, C ; HIRATA, I. Y. ; JULIANO, M. A. ; LOISEL, T P ; CRINE, P ; JULIANO, L ; BOILEAU, G ; CARMONA, A K . Human recombinant PHEX has a strict S'1 specificity for acidic residues and cleaves peptides derived from FGF-23 and MEPE. Biochemical Journal (London), 2003.
128. OLIVEIRA, V. ; ARAUJO, M. C. ; RIOLI, V ; CAMARGO, A. C. ; TERSARIOL, I L ; JULIANO, M. A. ; JULIANO, L ; FERRO, E. S. . A structure-based site-directed mutagenesis study on the neurolysin (EC 3.4.24.16) and thimet oligopetidase (EC 3.4.24.15) catalysis. FEBS Letters, v. 541, p. 89-92, 2003.
129. ANDRADE, S A ; SANTOMAUROVAZ, E. M. ; LOPES, A R ; CHUDZINSKITAVASSI, A M ; TERRA, W R ; JULIANO, M. A. ; SAMPAIO, M. U. ; SAMPAIO, C A ; OLIVA, M. L. V. . Bauhinia proteinase inhibitor-based synthetic fluorogenic substrates for enzymes isolated from insect midgut and caterpillar bristles. Biological Chemistry, v. 384, p. 489-492, 2003.
130. ALVES, M F ; PUZER, L ; COTRIN, S S ; JULIANO, M. A. ; JULIANO, L ; BROMME, D ; CARMONA, A K . S3 to S'3 subsite specificity of recombinant human cathpesin K and development of selective internally quenched fluorescent substrates. Biochemical Journal (London), v. 373, p. 981-986, 2003.
131. HEMERLY, J. P. ; OLIVEIRA, V. ; NERY, e Del ; MORTY, R e ; ANDREWS, N W ; JULIANO, M. A. ; JULIANO, L . Subsite specificity (S3, S2, S1, S'2 and S'3) of oligopetidase B from Trypanosoma cruzi and Trypanosoma brucei using fluorescent-quenched peptides: a comparative study and identification of specific carboxypeptidase activity. Biochemical Journal (London), v. 373, p. 933-939, 2003.
132. MACIEL, R M ; DUTRA, D L S ; RUMJANEK, F D ; JULIANO, L ; JULIANO, M. A. ; FANTAPPIE, M R . Schistosoma mansoni histone acetyltransferase GCN5: linking histone acetylation to Gene activation. Biol Biochem Parasitol, 2003.
133. NUNES, V A ; GOZZO, A J ; JULIANO, M. A. ; CESAR, M.C. ; SAMPAIO, M. U. ; SAMPAIO, C A ; ARAUJO, M S . Antioxidant dietary deficiency induces caspase activation in chick skeletal muscle cells. Braz. J Med Biol Res, v. 36, p. 1047-1053, 2003.
134. LECAILLE, F. ; WEIDAUER, E. ; JULIANO, M. A. ; BROMME, D ; LALMANACH, G. . Probing cathepsin K activity with a selective substrate spanning its active site. Biochem J, v. 375, p. 307-312, 2003.
135. SONG, Es ; JULIANO, M. A. ; LUIZJULIANO ; HERSH, L B . Substrate activation of insulin-degrading enzyme (insulysin). A potencial target for drug development. The Journal of Biological Chemistry, v. 278, p. 49789-49794, 2003.
136. EBIHARA, F ; MARCO, Gs Di ; JULIANO, M. A. ; CASARINI, D e . Neutral endopeptidase expression in mesangial cells.. J Renin Angiotensin Aldosterone Syst, v. 4, p. 228-233, 2003.
137. NUNES, V A ; GOZZO, A J ; SAMPAIO, M A ; JULIANO, M. A. ; SAMPAIO, C A ; ARAUJO, M S . Mapping of human plasma kallikrein active site by desing of peptides based on modifications of a Kazal-type inhibitor reactive site. Journal of Protein Chemistry, v. 22, p. 533-541, 2003.
138. IWAI, L K ; YOSHIDA, M ; SHIKANAIYASUDA, M A ; GOLDBERG, A C ; JULIANO, M. A. ; HAMMER, J ; JULIANO, L ; SETTE, A ; KALIL, J ; TRAVASSOS, L R ; CUNHA NETO, e . In silico prediction of peptides binding to multiple HLAA-Dr Molecules accurately identifies immunodominant epitoopes from gp43 of paracoccidiodes brasiliensis frequently recognized in primary periipheral blood mononuclear cell responses from sensitized individuais. Molecular Medicine (Cambridge), v. 9, p. 9-12, 2003.
139. MARANA, S.R. ; LOPES, A.R. ; JULIANO, L ; JULIANO, M. A. ; FERREIRA, C. ; TERRA, W R . Subsites of Tripsin active site favor catalysis or substrate binding. Biochemical and Biophysical Research Communications, USP, v. 290, p. 494-497, 2002.
140. SILVA JR, A. ; KAWAZOE, U. ; FREITAS, F. T. F. ; GATTI, M. S. V. ; DOLDER, H. ; SCHUMACHER, R. I. ; JULIANO, M. A. ; SILVA, M. J. ; LEITE, A. . Avian anticoccidial activity of a novel membrane-interactive peptide selected from phage display libraries. Molecular and Biochemical Parasitology, v. 120, p. 53-60, 2002.
141. BOURGUIGNON, S C ; PAES, F S ; CALHEIROS, e B ; JULIANO, M. A. ; AGUIAR, A S ; MELGAREJO, A R ; DESIMONE, G. . S.Bothrops moojeni venom peptides containing bradykinin potentaiting peptides sequence. Protein and Peptide Letters, v. 1, p. 21-24, 2002.
142. AMINO, R. ; MARTINS, R. M. ; PROCOPIO, J. ; HIRATA, I Y ; JULIANO, M. A. ; SCHENKMAN, S. . Trialysin, a Novel Pore-forming protein from Saliva of Hematophagous insects activated by limited proteolysis. The Journal of Biological Chemistry, v. 277, p. 6207-6213, 2002.
143. ZANATA, S. M. ; LOPES, M. H. ; MERCADANTE, A. F. ; HAJI, G. N. M. ; CHIARINI, L. B. ; NOMIZO, R. ; FREITAS, A. R. O. ; JULIANO, M. A. ; BRENTANI, R. R. ; MARTINS, V. R. . Stress-inducible protein 1 is a cell surface ligand for cellular prion that triggers neuroprotection. The EMBO Journal, v. 21, p. 3307-3316, 2002.
144. PIMENTA, D C ; MELO, R L ; CALIENDO, G. ; SANTAGADA, V. ; FIORINO, F. ; NUCCI, G. ; LJULIANO ; JULIANO, M. A. . Design of inhibitors for human tissue kallikrein using non-natural aromatic and basic amino acids. Biol. Chem., v. 383, p. 853-857, 2002.
145. OLIVEIRA, V. ; GATTI, R ; RIOLI, V ; FERRO, E. S. ; SPISNI, A ; CAMARGO, A. C. ; JULIANO, M. A. ; JULIANO, L . Temperature and salts effects on the peptidase activities of the recombinant metallooligopeptidases neurolysin and thimet oligopeptidase. European Journal of Biochemistry, v. 269, p. 4326-4334, 2002.
146. BIANCHINI, e P ; LOUVAIN, V B ; MARQUE, e P ; JULIANO, M. A. ; JULIANO, L ; BONNIEC, B F . Mapping of the catalytic groove preferences of factor Xa reveals an inadequate selectivity for its macromolecule substrates. The Journal of Biological Chemistry, v. 277, p. 20527-20534, 2002.
147. KONNO, K. ; PALMA, M. S. ; HIRATA, I Y ; JULIANO, M. A. ; YASUHARA, T. . Identification of bradykinins in solitary wasp venoms. Toxicon, v. 40, p. 309-312, 2002.
148. PIMENTA, D. C. ; NANTES, I L ; BONIEC, B Le ; ITO, A S ; TERSARIOL, I L ; OLIVEIRA, V. ; JULIANO, M. A. ; JULIANO, L . Interaction of heparin with internally quenched fluorogenic peptides derived from heparin-binding consensus sequences, kallistatin and anti-thrombin III. Biochemical Journal (London), v. 366, p. 435-446, 2002.
149. STHILAIRE, P. M. ; ALVES, L C ; HERRERA, F ; RENIL, M ; SANDERSON, S J ; MOTTRAM, J C ; COOMBS, G H ; JULIANO, M. A. ; JULIANO, L ; AREVALO, J ; MELDAL, M . Solid-phase library synthesis, screening, and selection of tight-binding reduced peptide bond inhibitors of a recombinant leishmania mexicana cysteine protease. B J Med Chem, v. 45, p. 1971-1982, 2002.
150. CEZARI, M H ; PUZER, L ; JULIANO, M. A. ; CARMONA, A K ; JULIANO, L . Cathepesin B carboxydipetidase specificity analysis using internally quenched fluorescent peptides. Biochemical Journal (London), v. 15, p. 365-369, 2002.
151. Pelegrini-da-Silva A ; PRADO, W A ; JULIANO, M. A. ; WILK, S ; MARTINS, A R . High-performance liquid chromatographic separation of renin-angiotensin system peptides and most of their metabolic fragments. J Cromatogr B Analyt Technol Biomed Life Sci, v. 780, p. 301-307, 2002.
152. MELO, R L ; POZZO, R. ; PIMENTA, D. C. ; E.PERISSUTI, ; CALIENDO, G. ; SANTAGADA, V. ; LJULIANO ; JULIANO, M. A. . Human tissue kallikrein S1 subsite recognition of non natural basic amino acids. Biochemistry (Easton), USA, v. 40, p. 5226-5232, 2001.
153. KONNO, K. ; HISADA, M. ; NAOKI, H. ; ITAGAKI, Y. ; YASUHARA, T. ; JULIANO, M. A. ; LJULIANO ; PALMA, M.S. ; YAMANE, T. ; NAKAJIMA, T. . Isolation and sequence determination of peptides in the venom of the spider wasp (Cyphonoyx dorsalis) guide by matrix-assisted laser desorption time of flight (MALDI-TOF) mass spectrometry. Toxicon, USA, v. 39, p. 1257-1260, 2001.
154. ALVES, L. C. ; HILAIRE, P. M. S. ; SANDERSON, S.J. ; MOTTRAM, J. C. ; COOMBS, G. H. ; MEDAL, M. ; LJULIANO ; JULIANO, M. A. . Identification peptides inhibitory to recombinant cysteine proteinase, CPB, of Leishmania mexican. Mol Biochem Parasitol, v. 114, p. 81-88, 2001.
155. ALVES, L. C. ; MELO, R L ; SANDERSON, S.J. ; MOTTRAM, J. C. ; COOMBS, G. H. ; CALIENDO, G. ; SANTAGADA, V. ; LUIZJULIANO ; JULIANO, M. A. . S1 subsite specificity of a recombinant cysteien proteinase, CPB, of Leishmania mexicana compared with cruzain, human cathepsin L and papain using substrates containing non natural basic amino acids. Eur J Biochem, v. 268, p. 1206-1212, 2001.
156. MELO, R L ; POZZO, R. ; ALVES, L. C. ; E.PERISSUTI, ; CALIENDO, G. ; SANTAGADA, V. ; JULIANO, L ; JULIANO, M. A. . Synthesis and hydrilysis by cathepsin B fluorogenic substrates with the general sctruture Benzoil-X-Arg-MCA containing non-natural basic aminoacids at X position. Biochem Biophys Acta, v. 1547, p. 82-94, 2001.
157. CORDOVA, M. ; NERY, e Del ; HIRATA, I Y ; ARAUJO, M S ; CARMONA, A K ; JULIANO, M. A. ; JULIANO, L . Characterization of two cysteine proteinases secreted by Fasciola hepatica and demonstration of their kininogenase activity. Molecular and Biochemical Parasitology, UNIFESP, v. 116, p. 109-115, 2001.
158. OLIVA, M. L. V. ; MENDES, C. R. ; SANTOMAUROVAZ, E. M. ; JULIANO, M. A. ; MENTELE, R. ; AUERSWALD, E. A. ; SAMPAIO, U. M. ; SAMPAIO, C. A. M. . Bauhinia bauhinoides plasma kallikrein inhibitor: interaction with synthetic peptides and fluorogenic peptide substrates related to the reactive site sequence. Current Medicinal Chemistry, UNIFESP, v. 8, p. 977-987, 2001.
159. OLIVEIRA, V. ; CAMPOS, M. ; HEMERLY, J. P. ; FERRO, E. S. ; CAMARGO, A. C. ; JULIANO, M. A. ; JULIANO, L . Selective neurotensin-derived internally quenched fluorogenic substrates for neurolysin (EC 3.4.24.16): comparison with thimet oligopeptidase. Analytical Biochemistry, v. 292, p. 257-265, 2001.
160. MAGDESIAN, M. H. ; GIORDANO, R. ; ULRICH, H. ; JULIANO, M. A. ; JULIANO, L ; SCHUMACHER, R. I. ; COLLI, W. ; ALVES, M. J. . Infection by Trypanosoma cruzi: identification of a pasite ligant and its host-cell receptor. The Journal of Biological Chemistry, v. 276, p. 19382-19389, 2001.
161. IWAI, L K ; DURANTI, M. A. ; ABEL, L. C. J. ; JULIANO, M. A. ; JULIANO, L ; CUNHANETO, E. . Retro-inverso peptide analogues of Trypanosoma cruzi B 13 protein epitopes fail to be recognized by human sera and peripheral blood mononuclear cells. Peptides (New York), v. 22, p. 853-860, 2001.
162. OLIVA, M. L. V. ; SANTOMAUROVAZ, E. M. ; ANDRADE, S. ; JULIANO, M. A. ; POTT, V. J. ; SAMPAIO, M. U. ; SAMPAIO, C. A. M. . Synthetic peptides and fluorogenic substartes related to the reactive site sequence of kunitz type inhibitors isolated from bauhinia: Interaction with human plasma kallkrein. Biological Chemistry, v. 382, p. 109-113, 2001.
163. OLIVEIRA, V. ; CAMPOS, M. ; MELO, R L ; FERRO, E. S. ; CAMARGO, A. M. C. ; JULIANO, M. A. ; JULIANO, L . Substrate Specificity Caracterization of recombinant metallo oligo-petidases Thimet Oligopeptidase and neurolysin. Biochemistry (Easton), v. 40, p. 4417-4425, 2001.
164. ALVES, L. C. ; JUDICE, W A S ; STHILAIRE, P. M. ; MELDAL, M ; SANDERSON, S J ; MOTTRAM, J C ; COOMBS, G H ; JULIANO, L ; JULIANO, M. A. . Substrate specificity of recombinant cysteine proteinase, CPB, of Leishania mexicana. Molecular and Biochemical Parasitology, v. 116, p. 1-9, 2001.
165. JUDICE, W A S ; CEZARI, M. H. ; LIMA, A. P. C. A. ; SCHARFSTEIN, J. ; CHAGAS, J R ; TERSARIOL, I. L. S. ; JULIANO, M. A. ; JULIANO, L . Comparison of the specificity, stability and individual rate constants with respective activation parameters for the peptidase activity of cruzipain and its recombinant form, cruzain, from trypanosoma cruzi. European Journal of Biochemistry, v. 268, p. 6578-6586, 2001.
166. ALVES, L C ; MELO, R L ; CEZARI, M H ; SANDERSON, S J ; MOTTRAM, J C ; COOMBS, G H ; JULIANO, L ; JULIANO, M. A. . Analysis of the s2 subsite specificities of the recombinant cysteine proteases CPB of leishmania mexicana and cruzain of Trypanosoma cruzi, using fluorescent substrates containing non-natural basic amino acids. Molecular and Biochemical Parasitology, v. 117, p. 137-143, 2001.
167. NAGHETTINI, A V ; NOGUEIRA, P C ; JULIANO, M. A. ; BUENO, A A ; CASARINI, D e ; CARVAHLAES, J T . Tubular urinary enzymes in acute post-infectious glomerulonephritis. Pediatric Nephrology (Berlin, West), v. 16, p. 719-722, 2001.
168. CORDEIRO, Y ; MACHADO, F ; JULIANO, L ; JULIANO, M. A. ; BRENTANI, R R ; FOGUEL, D ; SILVA, J L . DNA converts cellular prion protein into the beta-sheet conformation and inhibits prion peptide aggregation. The Journal of Biological Chemistry, v. 276, p. 49400-49409, 2001.
169. MELO, R L ; ALVES, L C ; NERY, e Del ; JULIANO, L ; JULIANO, M. A. . Synthesis and hydrolysis by cysteine and serine proteases of short internally quenched fluorogenic peptides. Analytical Biochemistry, v. 293, p. 71-77, 2001.
170. PIMENTA, D C ; OLIVEIRA, A ; JULIANO, M. A. ; JULIANO, L . Substrate specificity of human cathepsin D using internally quenched fluorescent peptides derived from reactive site loop of kallistatin. Biochimica and Biophysica Acta, v. 1544, p. 133-122, 2001.
171. MANQUE, P. M. ; EICHINGER, D. ; JULIANO, M. A. ; JULIANO, L. ; ARAYA, J. E. ; YOSHIDA, N. . Characterization of the Cell Adhesion Site of Trypanosoma cruzi metacyclic stage surfacs glycoprotein gp82. Infection and Immunity, USA, v. 68, n. 2, p. 478-484, 2000.
172. OLIVEIRA, V. ; FERRO, E. S. ; GOMES, M. D. ; OSHIRO, M. E. M. ; ALMEIDA, P. C. ; JULIANO, M. A. ; JULIANO, L. . Characterization of thiol, aspartyl and thiol-metallo-peptidase activities in madin-darby kidney cells. J Cell Biochem, USA, v. 76, p. 478-488, 2000.
173. GRANER, E. ; MERCADANTE, A. F. ; ZANATA, S. M. ; FORLENZA, O. V. ; CABRAL, A. L. B. ; VEIGA, S. S. ; JULIANO, M. A. ; ROESLER, R. ; WALZ, R. ; MINETTI, A. ; IZQUIERDO, I. ; MARTINS, V. R. ; BRENTANI, R. R. . Cellular prion protein binds laminin and mediates neuritogenisis. Mol Brain Res, v. 76, p. 85-92, 2000.
174. PORTARO, F. C. V. ; SANTOS, A. B. F. ; CEZARI, M. H. ; JULIANO, M. A. ; JULIANO, L ; CARMONA, E. . Probing the specificity of cysteine proteinases at subsites remote from the active site: analysis of P4, P3, P'2, and P'3 variations in extended substrates. Biochemical Journal (London), v. 347, p. 123-129, 2000.
175. APLETALINA, E. ; JULIANO, M. A. ; JULIANO, L ; LINDBERG, I. . Structure-Funtion analysis of the 7b2 CT peptide. Biochemical and Biophysical Research Communications, usa, v. 267, p. 940-942, 2000.
176. NERY, E. ; ALVES, L. C. ; MELO, R L ; MHSCESARI ; JULIANO, L ; JULIANO, M. A. . Specificity of cathepsin B to fluorescent substrates containing benzyl side-chain substituted amino acids at P1 subsite. Journal of Protein Chemistry, v. 19, p. 33-38, 2000.
177. ALMEIDA, A. ; OLIVEIRA, V. ; CHAGAS, J. R. ; MEDAL, M. ; JULIANO, M. A. ; LJULIANO . Hydrolysis by cathepsin B of fluorescent peptides derived from human prorenin. Hypertension, USA, p. 1278-1283, 2000.
178. ARAUJO, M. C. ; MELO, R L ; MHSCESARI ; JULIANO, M. A. ; LJULIANO ; CARMONA, A. . Peptidase specificity characterization of C-and N-terminal catalytic sites of angiotensin I converting enzyme. Biochemistry, USA, v. 39, p. 8519-8525, 2000.
179. CHOW, K.M. ; CSUHAI, E. ; JULIANO, M. A. ; PYREK, J. ; JULIANO, L ; HERSH, L B . Studies on the subsite specificity of rat nardilysin (N-arginine dibasic convertase). J.Biol. Chem., USA, v. 26, p. 1945-1951, 2000.
180. SANDERSON, S.J. ; POLLOCK, K. G. J. ; MELDAL, M ; MEDAL, M. ; HILAIRE, P. M. S. ; JULIANO, M. A. ; JULIANO, L. ; MOTTRAM, J. C. ; COOMBS, G. H. . Expression and characterization of a recombinant cysteine proetinase of Leishmania mexcana. Biochem. J., USA, v. 347, p. 383-388, 2000.
181. DAVY, A. ; THOMSEN, K. K. ; JULIANO, M. A. ; ALVES, L. C. ; SVENDSEN, I. ; SIMPSON, D.J. . Purification and characterization of Barley dipeptidyl peptidase IV. Plant Physiology, USA, v. 122, p. 425-431, 2000.
182. HILAIRE, P. M. S. ; WILLERT, M. ; JULIANO, M. A. ; LJULIANO ; MELDAL, M. . Fluorescence quenched solid phase combinatorial libraries in the characterization of cysteine protease substrate specificity. J. Comb. Chem., USA, v. 1, p. 509-523, 2000.
183. ALMEIDA, P. C. ; CHAGAS, J. R. ; CEZARI, M. H. S. ; JULIANO, M. A. ; JULIANO, L. . Hydrolisis by plasma kallikrein of fluorogenic peptides derived from prorenin processing site. Bioch. Biophys. Acta, USA, v. 1479, p. 83-90, 2000.
184. FERNANDES, B.L. ; JULIANO, M. A. ; LJULIANO ; PALMA, M.S. ; LEBRUN, I. ; PORTARO, F. C. V. . Development of an operational substrate for ZapA, a metalloprotease secreted by the bacterium Proteus mirabilis. Braz J Med Biol Res, Brasil, v. 33, p. 765-770, 2000.
185. KLEMENCIC, I. ; CARMONA, A K ; MHSCESARI ; JULIANO, M. A. ; LJULIANO ; GUNCAR, G. ; TURK, D. ; KRIZAJ, I. ; TURK, V. ; TURK, B. . Biochemical characterization of human cathepsin X revealed that the enzyme is an exopeptidase, acting as carboxymonopeptidase or carboxydipeptidase. Eur J Biochem, v. 267, p. 5404-5412, 2000.
186. PIMENTA, D C ; CHEN, V. C. ; CHAO, J. ; JULIANO, M. A. ; JULIANO, L . Alpha(1)-antichymotrypsin and kallistatin by human cathepsin D. J Prot Chem, v. 19, p. 411-418, 2000.
187. QUINTO, B. ; JULIANO, M. A. ; HIRATA, I. Y. ; CARMONA, A. ; JULIANO, L ; CASARINI, D e . Characterization of a prolyl endopeptidase from human urine using fluorogenic quenched substrates. Int J Biochem Cell, v. 32, p. 1161-1172, 2000.
188. SONG, Es ; MUKHERJEE, A. ; JULIANO, M. A. ; St PYREK, J. ; GOODMAN, J. P. ; JULIANO, L ; HERSH, L B . Analysis of the subsite specificity of rat insulysin using fluorogenic peptide substrates. J Biol Chem, v. 276, p. 1152-1155, 2000.
189. HILAIRE, P M ; ALVES, L C ; SANDERSON, S J ; MOTTRAM, J C ; JULIANO, M. A. ; JULIANO, L ; COOMBS, G H ; MELDAL, M . The substrate specificity of a recombinant cysteine protease from Leishmania mexicana: application of a combinatorial peptide library approach. ChemBioChem, v. 1, p. 115-122, 2000.
190. PIMENTA, D. C. ; CHAO, J. ; CHEN, V. C. ; JULIANO, M. A. ; JULIANO, L. . Hydrolysis Of Peptides By Human Tissue Kallikrein Based On The Reactive Loop Sequences Of Kallistatin, Protein C Inhibitor And Anti-Thrombin Iii.. Biochemical Journal (London), Inglaterra, v. 339, p. 473-479, 1999.
191. JULIANO, M. A. ; FILIRA, F. ; GOBBO, M. ; ROCCHI, R. ; NERY, e Del ; JULIANO, L. . Chromogenic and fluorogenic glycosylated and acetylglycosylated peptides as substrates for serine, thiol and aspartyl proteases J. Peptide Research . J Peptide Research, v. 53, p. 109-119, 1999.
192. PIMENTA, D C ; CHAO, J. ; CHAO, L. ; JULIANO, M. A. ; JULIANO, L . Specificity of human tissue kallikrein towards substrates containing Phe-Phe pair of amino acids Biochemical J.. Biochemical Journal (London), Estados Unidos, v. 327, p. 473-479, 1999.
193. ARAUJO, M. C. ; MELO, M. C. ; NERY, e Del ; ALVES, M. F. M. ; JULIANO, M. A. ; CASARINI, D e ; JULIANO, L ; CARMONA, A K . Internally quenched fluorogenic substrates for angiotensin I-converting enzyme. . Journal of Hypertension, Estados Unidos, v. 17, p. 665-672, 1999.
194. CSUHAI, E. ; JULIANO, M. A. ; HARMS, J. ; JULIANO, L ; HERSH, L B . New fluorogenic substrates for N-arginine dibasic convertase. Analytical Biochemistry, Estados Unidos, v. 269, p. 149-154, 1999.
195. REHAULT, S. ; BRILLARDBOURDET, M ; JULIANO, M. A. ; JULIANO, L ; GAUTHIER, F ; MOREAU, T . New, sensitive fluorogenic substrates for human cathepsin G based on the sequence of serpin reactive site loops. The Journal of Biological Chemistry, v. 274, p. 13810-13817, 1999.
196. CSUHAI, E. ; JULIANO, M. A. ; JULIANO, L ; HERSH, L B . Kinetic analysis of spermine binding to NRD Convertase.. Arch Biochem Biophys, Estados Unidos, v. 362, p. 291-300, 1999.
197. MULLER, L. ; ZHU, P. ; JULIANO, M. A. ; JULIANO, L ; LINDBERG, I. . A 36-Residue Peptide contains all of the Information Required for 7B2-Mediated activation of Prohormone Convertase 2. The Journal of Biological Chemistry, v. 23, p. 21471-21477, 1999.
198. SERVEAU, C. ; LALMANACH, G. ; HIRATA, I. ; SCHARFSTEIN, J. ; JULIANO, M. A. ; GAUTHIER, F . Discrimination of cruzipain, the major cysteine protease of Trypanosoma cruzi , and mammalian cathepsins B and L, by a pH-inducible fluorogenic substrate of trypanosomal cysteine proteinases . Eur. J. Biochem., Ingalterra, v. 259, p. 275-280, 1999.
199. PUCCIA, R. ; JULIANO, M. A. ; TRAVASSOS, L R ; CARMONA, A K . Detection of the basement menbrane-degrading proteolytic activity of Paracoccioioides brasiliensis after SDS -PAGE using agarose overlays containing Abz-MKALTLQ-EDDnp. Bras J Med And Biol Res, Brasil, v. 32, p. 645-649, 1999.
200. HILAIRE, P. M. S. ; WILLERT, M. ; JULIANO, M. A. ; JULIANO, L. ; MELDAL, M. . Fluorescence-Quenched solid pfase combinatorial libraries in the characterization of cysteine protease substrate specificity. J Combinatorial Chemistry, USA, v. 1, n. 6, p. 509-523, 1999.
201. OLIVA, M. L. V. ; MENDES, C. R. ; JULIANO, M. A. ; CHAGAS, J. R. ; ROSA, J. C. ; GREENE, L. J. ; SAMPAIO, M. U. ; SAMPAIO, C. A. M. . Characterization of a tissue kallikrein inhibitor isolated from Bauhinia bauhinioides seeds: inihibition of the hydrolysis of kininogen related substrates. Immunopharmacology, USA, v. 45, p. 163-169, 1999.
202. OLIVA, M. L. V. ; ANDRADE, S. ; BATISTA, I. F. C. ; SAMPAIO, M. U. ; JULIANO, M. A. ; FRITZ, H. ; AUERSWALD, E. A. ; SAMPAIO, C. A. M. . Human plasma kallikrein and tissue kallikrein binding to a substrate based on the reactive site of a factor Xa inhibitor isolated from Bauhinia ungulata seeds. Immunopharmacology, v. 45, p. 145-149, 1999.
203. QUINTO, B. ; JULIANO, L ; JULIANO, M. A. ; CARMONA, A. ; CASARINI, D e . Characterization of a kinin inactivating serine endopeptidase H2 (kininase) from human urine ising fluorogenic substrate. Immunopharmacology, USA, v. 45, p. 223-228, 1999.
204. NERY, E. ; CHAGAS, J. R. ; JULIANO, M. A. ; JULIANO, L. ; PRADO, E. S. . Comparison of human and porcine tissue kallikrein substrate specificities. Immunopharmacology, USA, v. 45, p. 151-157, 1999.
205. TABORDA, C. P. ; JULIANO, M. A. ; PUCCIA, R. ; FRANCO, M. ; TRAVASSOS, L. R. . Mapping Of The T-Cell Epitope In The Major 43-Kilodalton Glycoprotein Of Paracoccioides Brasiliensis Which Induces A Th1 Response Protective Against Fungal Infection In Balb/C Mice.. Infection and Immunity, England, v. 66, p. 786-793, 1998.
206.   JOHANNING, K. ; JULIANO, M. A. ; LAZURE, C. ; LAMANGO, N. S. ; STEINER, D. F. ; LINDBERG, I. . Specificity Of Prohormone Convertase 2 On Proenkephalin And Proenkephalin-Related Substrates.. J. Biol. Chem., England, v. 35, p. 22672-22680, 1998.
207. JULIANO, M. A. ; FILERA, F. ; GOBBO, M. ; ROCCHI, R. ; NERY, E. . Hydrolysis Of Chromogenic And Fluorogenc Glycosylated And Acetylglycosylated Peptides By Serine, Thiol And Aspartyl Proteases.. Peptide Research, v. 53, p. 109-119, 1998.
208.   LALMANACH, G. ; LECAILLE, F. ; CHAGAS, J. R. ; AUTHIE, E. ; SCHARFSTEIN, J. ; JULIANO, M. A. ; GAUTHIER, F. . Inhibition Of Trypanosomal Cysteine Proteinase By Their Propeptides.. J. Biol. Chem., Estados Unidos, v. 39, p. 25112-25116, 1998.
209. JULIANO, M. A. ; MEDAL, M. ; SVENDSEN, I. ; JULIANO, L. ; NERY, e Del ; SCHARFSTEIN, J. . Inhibition of cruzipain visualized in a fluorescence quenched solid-phase inhibitor library assay. D-amino acid inhibitors for cruzipain, cathepsin B and cathepesin L . J Peptide Science, Inglaterra, v. 4, p. 83-91, 1998.
210. MARCO, Gs Di ; QUINTO, B. ; JULIANO, M. A. ; CARMONA, A. ; STELLA, R. ; PLAVNIK, F. ; CASARINI . Purification and characterization of a neutral endopeptidase-like enzyme from fuman urine. Journal of Hypertension, Estados Unidos, v. 16, p. 1971-1978, 1998.
211. PORTARO, F. C. V. ; CEZARI, M. H. S. ; JULIANO, M. A. ; PRADO, E. S. ; JULIANO, L. . The Design Of Kallidin-Releasing Tissue Kallikrein Inhibitors Based On The Specificities Of The Enzymes Extended Binding-Site.. Biochemical J., England, v. 323, p. 167-171, 1997.
212.   NERY, E. ; JULIANO, M. A. ; MELDAL, M. ; SVENDSEN, I. ; SCHARFSTEIN, J. ; WALMSLEY, A. ; JULIANO, L. . Characteization Of The Substrate Specificity Of The Major Cysteine Proease (Cruzipain) From Trypanosoma Cruzi Using A Portion-Mixing Combinatorial Library And Fluorogenic Peptides.. Biochemical Journal (London), v. 323, p. 427-433, 1997.
213.   MELDAL, M. ; JULIANO, M. A. ; JANSSON, A. M. . Azido Acids In A Novel Method Of Solid Peptide Synthesis .. Tetrahedron Letters, England, v. 38, p. 2531-2534, 1997.
214. MELDAL, M. ; SVENDSEN, I. ; JULIANO, M. A. ; NERY, E. ; SCHARFSTEIN, J. ; LUIZJULIANO . Inhibition Of Cruzipain Visualized In A Fluorescence Quenched Solid-Phase Inhibitor Library Assay. D-Amino Acid Inhibitors For Cruzipain, Cathepsin B And Cathepesin L.. Biochemical Journal (London), England, v. 3, p. 1-10, 1997.
215. PIMENTA, C. D. ; JULIANO, M. A. ; JULIANO, L. . Hydrolysis Of Somatostatin By Human Tissue Kallikrein After The Amino Acido Pair Phe-Phe.. Biochemical Journal (London), Estados Unidos, v. 327, p. 27-30, 1997.
216. NERY, E. M. A. ; SCHARFSTEIN, J. ; JULIANO, M. A. ; JULIANO, L. ; APCALIMA . Kininogenase Activity By Major Cysteinyl Proteinase (Cruzipain) From Trypanosoma Cruzi.. The Journal of Biological Chemistry, Estados Unidos, v. 272, p. 25713-25718, 1997.
217. BOURGEOIS, L. ; BOURDET, M. ; DEPERTHES, D. ; JULIANO, M. A. ; TREMBLAY, R. R. ; DUBE, J. Y. ; GAUTHIER, F. . Serpin-Derived Peptide Substrate For Investigating The Substrate Specificity Of Human Tissue Kallikreins Hk1 And Hk2.. J. Biol. Chem., England, v. 47, p. 29590-29595, 1997.
218. VANHOOF, G. ; GOOSSENS, F. ; JULIANO, M. A. ; LJULIANO ; HENDRIKS, I. ; SCHATTEMAN, K. ; SCHARPE, S. . Isolation and sequence analysis of a human cDNA clone (XPNPEPL) homologous to X-prolyl aminopeptidase (aminopeptidase P) . Cytogenetics and Cell Genetics, Inglaterra, v. 421, p. 25-29, 1997.
219. VANHOOF, G. ; GOOSSENS, F. ; JULIANO, M. A. ; JULIANO, L ; HENDRIKS, I. D. ; SCHATTEMAN, K. ; SCHARP, S. . Human lymphocyte X-Prolyl aminopeptidase (aminopeptidaseP)-like protein. A new member of the proline peptidase family?. Adv Exp Med Biol, Inglaterra, v. 421, p. 25-29, 1997.
220. MOUJAHED, A El ; BRILLARDBOURDET, M ; JULIANO, M. A. ; MOREAU, T ; CHAGAS, J R ; GUTMAN, N ; PRADO, e S ; GAUTHIER, F . Kininogen-derived fluorogenic substartes for investigating the vasoactive properties of rat tissue kallikreins identification of a T-kinin releasing rat kallikrein. European Journal of Biochemistry, v. 247, p. 652-658, 1997.
221. SERVEAU, C. ; LALMANACH, G. ; JULIANO, M. A. ; SCHARFSTEIN, J. ; GAUTHIER, F. ; JULIANO, L. . Investigation Ofthe Substrate Specificity Of Cruzipain, The Major Cysteine Proteinase Of Trypanosoma Cruzi Through The Use Of Cystatin Derived Substrates And Inhibitors.. Biochemical J., Estados Unidos, v. 313, p. 951-956, 1996.
222. ALVES, L. C. ; ALMEIDA, P. C. ; JULIANO, M. A. ; JULIANO, L. . Improved Synthesis Of Na-Protected Aminoacyl 7-Amino-4-Methylcoumarin Amide And Preparation Of Specific Substrates For Papain.. Peptide Research 9, 92-96., Inglaterra, v. 9, p. 92-96, 1996.
223. SANTORI, F. R. ; DORTA, M. L. ; JULIANO, M. A. ; SILVEIRA, J. S. ; CRUZ, R. C. ; YOSHIDA, N. ; JULIANO, L. . Identification Of A Domain Of Trypanosoma Cruzi Metacyclic Trypomastigote Surface Molecule Gp82 Required For Attachment And Invasion Of Mammalian Cells.. Molecular and Biochemical Parasitology., Estados Unidos, v. 78, p. 209-216, 1996.
224. SOUZA, M. O. ; RODRIGUES, C. V. ; PENA, H. B. ; ALVARENGA, M. G. ; MACHADO-COELHO, G. L. L. ; SANTORO, M. M. ; JULIANO, M. A. ; FIGUEREDO, A. F. S. ; JULIANO, L. . Kinetic Characterization Of Rat Tissue Kallikrein Using Na Substituted Arginine 4-Nitroanilides And Na -Benzoyl-L-Arginine Ethyl Ester As Substrates.. Brazilian Journal of Medical and Biological Research., Brasil, v. 29, p. 327-334, 1996.
225. BIZETO, L. ; ANTUNES, E. ; PORTARO, F. C. V. ; JULIANO, M. A. ; PRADO, E. S. ; NUCCI, G. ; JULIANO, L. . Pharmacological Characterization Of Novel Tissue Kallikrein Inhibitors In Vivo.. Immunopharmacology., Estados Unidos, v. 32, p. 111-114, 1996.
226. MELDAL, M. ; RENIL, M. ; JULIANO, M. A. ; JANSSON, A. M. ; MEINJOHANNS, E. ; BUCHARDT, J. ; SCHLEYER, A. . Novel Peg-Based Resins And Synthetic Methods: Azido Acids In Spps And Direct Solid-Phase Peptide Glycosylations.. Peptides (in press), p. 141-151, 1996.
227. JULIANO, M. A. ; NERY, E. ; SCHARFSTEIN, J. ; MELDAL, M. ; SVENDSEN, I. ; WALMSLEYD, A. ; JULIANO, L. . Characterization Of Substrate Specificity Of The Major Cysteine Protease (Cruzipain) From Trypanosoma Cruzi. Comparison To Human Cathepsin B And L.. Peptides (New York), Inglaterra, p. 511-512, 1996.
228. ALVES, L C ; ALMEIDA, P C ; FRANZONI, L ; JULIANO, L ; JULIANO, M. A. . Synthesis of N-alfa protected aminoacyl 7-amino-4-methyl coumarin amide by phosphous oxychloride and preparation of specific fluorogenic substartes for papain. Peptide Research, v. 9, p. 92-96, 1996.
229. CHAGAS, J. R. ; PORTARO, F. C. V. ; HIRATA, I. Y. ; ALMEIDA, P. C. ; JULIANO, M. A. ; PRADO, E. S. ; JULIANO, L. . Determinant Of The Usual Specificity Of Lysylbradykinin Releasing Kallikreins.. Biochemical Journal, Estados Unidos, v. 306, p. 63-69, 1995.
230. HIRATA, Y. ; CEZARI, M. H. S. ; NAKAIE, C. R. ; BOSCHOV, P. ; ITO, A. S. ; JULIANO, M. A. ; JULIANO, L. . Internally Quenched Fluorogenic Proteases: Solid-Phase Synthesis And Fluorescence Spectroscopy Of Peptides Containing Ortho-Aminobenzoyl-Dinitrophenyl Groups As Donor-Aceptor Pairs.. Letters in Peptide Science, Inglaterra, v. 1, p. 299-308, 1995.
231. NERY, E. ; CHAGAS, J. R. ; JULIANO, M. A. ; PRADO, E. S. ; JULIANO, L. . The Extent Of The Human Tissue Kallikrein Binding Site Evaluated Byosynthetic Substrates Having The Sequences Of Human Kininogen Fragments.. Biochemical Journal, Estados Unidos, v. 312, p. 233-237, 1995.
232. JULIANO, M. A. ; OLIVEIRA, M. C. F. ; FILIRA, F. ; SCOLARO, B. ; ROCCHI, R. ; JULIANO, L. . Glyco-Peptides As Substrates For Proteases.. Peptides - ESCOM Science Publishers B.V., Inglaterra, p. 731-732, 1994.
233. JULIANO, M. A. ; PORTARO, F. C. V. ; CHAGAS, J. R. ; HIRATA, I. Y. ; NUCCI, G. ; PRADO, E. S. ; JULIANO, L. . Design Of Inhibitors For Human Tissue Kallikrein Based On Its Extended Binding Site Specificities.. Peptides - ESCOM Science Publishers B.V., Inglaterra, p. 885-886, 1994.
234. CHAGAS, J R ; HIRATA, I. ; JULIANO, M. A. ; XIONG, W. ; CHAO, J. ; JULIANO, L . Substrate specificities to tissue kallikrein and T-kininogenase: Their possible role in kininogen processing. Biochemistry (Easton), v. 31, p. 4969-4974, 1992.
235. PADRO, E. S. ; CHAO, J. ; CHAGAS, J R ; JULIANO, M. A. ; JULIANO, L . Determinants of tissue kallikrein clevage specificity in the limited proteolysis of kininogens. Agents And Actions, v. 38, p. 78-81, 1992.
236. HIRATA, I. ; BOSCHCOV, P. ; OLIVEIRA, M. C. F. ; JULIANO, M. A. ; MIRANDA, A. ; CHAGAS, J R ; TSUBOI, S. ; OKADA, Y. ; JULIANO, L . Synthesis of human angiotensinogen (1-17) containing one of the putative glycosylation binding sites and its hydrolysis by human renin and porcine pepsin. . Int J Pept Prot Res, v. 38, p. 298-307, 1991.
237. JULIANO, M. A. ; JULIANO, L ; BIONDI, L. ; ROCCHI, R. . Synthesis and hydrolysis by arginyl-hydrolases of p-nitroanilide chromogenic substrates containing polyethylene glycol and D-gluconyl moieties. Peptide Research, v. 4, p. 334-339, 1991.
238. JULIANO, L ; HIRATA, I. ; BOSCHOV, P. ; JULIANO, M. A. ; MIRANDA, A. ; OKADA, Y. . Synthesis of human (1-17)-angiotensinogen renin substrate and side reactions on arginine and histidine couplings.. Peptides (New York), p. 100-101, 1990.
239. ARAUJO, M S ; JULIANO, M. A. ; OLIVEIRA, L. ; PADRO, E. S. . Horse Urinary Kallikrein. II: Effect of subsite interactions on its catalytic activity. . Biological Chemistry, v. 369, p. 197-206, 1988.
240. OKADA, Y. ; TSUBOI, S. ; MIRANDA, A. ; JULIANO, M. A. ; JULIANO, L . Formation and degradation of lactam derivatives of NG-Tosyl-arginine during peptide synthesis.. Anais da Academia Brasileira de Ciências, v. 60, p. 281-286, 1988.
241. JULIANO, L ; JULIANO, M. A. ; MIRANDA, A. ; TSUBOI, S. ; OKADA, Y. . Synthesis of NG-Tosyl-arginyl peptide derivatives - Observation of lactam formation of arginyl residue.. Chemical and Pharmaceutical Bulletin, Japao, v. 35, p. 2550-2553, 1987.
242. PRADO, e S ; ARAUJO, M S ; JULIANO, M. A. ; JULIANO, L ; STELLA, R. C. R. ; SAMPAIO, C. M. A. . Tetrapeptide e substrates for discrimination amongkallikreins and trypsin-like serine proteinases. . Biological Chemistry, v. 367, p. 199-205, 1986.
243. PADRO, E. S. ; JULIANO, L ; ARAUJO, M. ; JULIANO, M. A. . Tissue kallikreins and related enzymes: characterization by model oligopeptides.. Kinins IV, Estados Unidos, p. 241-246, 1986.
244. JULIANO, M. A. ; JULIANO, L . Synthesis and kinetic parameters of hydrolysis by trypsin of some acyl-arginyl-p-nitroanilides and peptides containing argingy-p-nitroanilide. . Brazilian Journal of Medical and Biological Research, Brasil, v. 18, p. 435-445, 1985.

Bancas
Participação em bancas examinadoras
Dissertações
1. JULIANO, M. A.. Participação em banca de Isabela Cabral Cavichioli pereira. Atividade da catpsina D, gastricsina, pepsina e uropepsina humanas sobre substratos sinteticos relacionados a calistatina humana. 2009. Dissertação (Mestrado em Patologia) - Universidade Federal do Triângulo Mineiro.
2. JULIANO, M. A.. Participação em banca de Carolina H Thome. Eluicao passiva de proteinas de geis de poliacrilamida e caracterizacao por MALDI-TOF. 2007. Dissertação (Mestrado em biologia molecular) - Universidade Federal de São Paulo.
3. JULIANO, M. A.. Participação em banca de Elizabete Rosa. Efeito antinociceptivo das angiotensinas III e IV microinjetadas na substancia cinzenta periaquedutal do rato. 2007 - Universidade de Ribeirão Preto.
4. JULIANO, M. A.. Participação em banca de Patricia Nogueira Amorim de Assis. Efeitos de frações peptidicas isoladas dos meios de cultura extrato de levedura, lactoalbumina e NZcase sobre culturas bacterianas e celulares, em bioensaios. 2003. Dissertação (Mestrado em Biotecnologia) - Universidade de São Paulo.
5. JULIANO, M. A.. Participação em banca de Luciana Juncioni de Arauz. Caracterização da atividade proteolitica da Hsp65 de mycobacterium laprae. 2002. Dissertação (Mestrado em biologia molecular) - Universidade Federal de São Paulo.
6. JULIANO, M. A.. Participação em banca de Chandler Tahan. Receptores ativados por serino\proteases em musculo liso ileo de cobaia. 2002. Dissertação (Mestrado em biologia molecular) - Universidade Federal de São Paulo.
7. JULIANO, M. A.. Participação em banca de Marcio fritzen. Caracterzação funcional do Lopap. 2002. Dissertação (Mestrado em biologia molecular) - Universidade Federal de São Paulo.
8. HEMERLY, J. P.; JULIANO, M. A.. Participação em banca de Jefferson Pessôa Hemerly. Estudo da Especificidade da prolil oligopeptidase (EC 3.4.21.26) através de peptídeos sintéticos de flurescência apagada. 2001. Dissertação (Mestrado em Ciências Biológicas (Biologia Molecular)) - Universidade Federal de São Paulo.
9. QUITO, B. M. R.; JULIANO, M. A.. Participação em banca de Beata Marie Redublo Quito. Caracterização de Cininases purificadas a partir de urina humana utilizando substartos com apagamento intramolecular de fluorescência. 2000. Dissertação (Mestrado em Ciências Biológicas (Biologia Molecular)) - Universidade Federal de São Paulo.
10. FRUTUOSO, C. R. DA S.; JULIANO, M. A.. Participação em banca de Claudia Regina da Silva Frutuoso. Atenuação da Toxicidade do metotrexato em ratos através da dieta. 2000. Dissertação (Mestrado em Ciências Biológicas (Biologia Molecular)) - Universidade Federal de São Paulo.
11. ANDRADE, S. A. DE; JULIANO, M. A.. Participação em banca de Sonia Aparecida de Andrade. Hidrolise enzimatica de substratos peptídicos de fluorescência apagada e estruturalmente relacionada com BuXI, inibidor do fator Xa isolado da Bauhinia ungulata. 1999. Dissertação (Mestrado em Ciências Biológicas (Biologia Molecular)) - Universidade Federal de São Paulo.
12. ANDRADE, M. C. C. DE; JULIANO, M. A.. Participação em banca de Maria Claudina Camargo de Andrade. PurificaçÃo e Caracterização das enzimas conversoras de angiotensina-I de células mesangiais em cultura. 1998. Dissertação (Mestrado em Ciências Biológicas (Biologia Molecular)) - Universidade Federal de São Paulo.
13. MENDES, C. R.; JULIANO, M. A.. Participação em banca de Catarina Ruas mendes. Proteínas de Linques: purificação e caracterização de inibidores de tripsina, calicreinas tissular e papaína, de Collema leptosporum malme. 1994. Dissertação (Mestrado em Ciências Biológicas (Biologia Molecular)) - Universidade Federal de São Paulo.
Teses de doutorado
1. JULIANO, M. A.. Participação em banca de Fabiana M Alves. biblioteca combinatoria de peptideos no estudo de proteases. 2007. Tese (Doutorado em Biologia Molecular) - Universidade Federal de São Paulo.
2. LAURE, H. J.; JULIANO, M. A.. Participação em banca de Helen Julie Laure. Soro featl bovino induz a migração de neutrófilos na cavidade peritoneal de camundongos pre-tratados com dexametasona. 2002. Tese (Doutorado em Ciências Biológicas (Biologia Molecular)) - Universidade Federal de São Paulo.
3. JULIANO, M. A.. Participação em banca de Jose Cezar Borges. KM uma lectina de aArtocarpus integrifolia ligante de D-manose: sequencia de aminoacidos, predicao da estrutura terciaria e sitio de reconhecimento de carboidrato. 1998 - Universidade de Ribeirão Preto.
Participação em bancas de comissões julgadoras
Concurso público
1. JULIANO, M. A.. Prof. Adjunto Ciencias de alimentos. 2009. Universidade Federal de Sao Paulo.
2. JULIANO, M. A.. Prof. Adjunto -equipamentos e processos de troca termica. 2009. Universidade Federal de Sao Paulo- Campus Diadema.
3. JULIANO, M. A.. Prof Adjunto- Resistencia dos Materiais. 2009.
4. JULIANO, M. A.. Prof. Adjunto matematica computacional. 2009. Universidade Federal de Sao Paulo.
5. JULIANO, M. A.. Prof Adjunto Micro/Imuno e Parasit. 2008. Universidade Federal de São Paulo.
6. JULIANO, M. A.. Prof. Adjunto Quimica Biorganica. 2008. Universidade Federal de Sao Paulo.
7. JULIANO, M. A.. Prof. adjunto Zoologia de Vertebrados. 2008. Universidade Federal de Sao Paulo.
8. JULIANO, L; JULIANO, M. A.. Prof. Adjunto-Bioquimica. 2005. Universidade de São Paulo.

Orientações
Orientações em andamento
Dissertação de mestrado
1. Alyne Marem Silva Barbosa. Estudo de especificidade de proteases providas de microorganismos da Unidade de produção de compostos organicos da Fundação Parque Zoologico de São Paulo. Início: 2011. Dissertação (Mestrado em biologia molecular) - Universidade Federal de São Paulo, Conselho Nacional de Desenvolvimento Científico e Tecnológico. (Orientador).
2. Thiago Bertiline. Estudo Bioquimico da calicreina tecidual 7. Início: 2010. Dissertação (Mestrado em biologia molecular) - Universidade Federal de São Paulo, Conselho Nacional de Desenvolvimento Científico e Tecnológico. (Orientador).
3. Vinicius Otavio da Silva. Desenho de biblioteca combinatoria para uso em estudo da especificidade de proteases. Início: 2010. Dissertação (Mestrado em biologia molecular) - Universidade Federal de São Paulo, Conselho Nacional de Desenvolvimento Científico e Tecnológico. (Orientador).
4. Rafaela Quintanilha Abrahão. Avaliação do efeito antirociceptivo induzido por oligopeptidases B de trypanosoma cruzi e trypanosoma brecei em camundongos. Início: 2009. Dissertação (Mestrado em biologia molecular) - Universidade Federal de São Paulo, Conselho Nacional de Desenvolvimento Científico e Tecnológico. (Orientador).
Tese de doutorado
1. Juliana Rodrigues de Oliveira. Estudo da Especificidade da calicreina tecidual 5. Início: 2010. Tese (Doutorado em Biologia Molecular) - Universidade Federal de São Paulo, Conselho Nacional de Desenvolvimento Científico e Tecnológico. (Orientador).
2. Diego M Assis. Sintese e ensaio de inibidores pra KhKL 1. Início: 2009. Tese (Doutorado em Ciências Biológicas (Biologia Molecular)) - Universidade Federal de São Paulo. (Orientador).
3. Douglas de Andrade. Estudo especificidade da calicreina 8 humana. Início: 2008. Tese (Doutorado em Biologia Molecular) - Universidade Federal de São Paulo, Conselho Nacional de Desenvolvimento Científico e Tecnológico. (Orientador).
Supervisão de pós-doutorado
1. Rafael Costa Santos Rocha. Isolamento de bacterias provenientes do processo de compostagem da Fundação Parque Zoologico de São Paulo para avaliar a capacidade de produção de polihidroxialcanoatos. Início: 2010. Universidade Federal de São Paulo, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior.
2. Jorge Alexandre Nogueira Santos. Início: 2009. Universidade Federal de São Paulo, Fundação de Amparo à Pesquisa do Estado de São Paulo.
Iniciação científica
1. Mariana Barbosa dos Santos. Desenho e sintese de biblioteca de peptideos para estudo de proteases. Início: 2008. Iniciação científica (Graduando em Biofísica Sistema) - Universidade Federal de São Paulo, Conselho Nacional de Desenvolvimento Científico e Tecnológico. (Orientador).
Supervisões e orientações concluídas
Dissertação de mestrado
1. Juliana de Oliveira. Estudo Bioquimico da calicreina tecidual 2 humana. 2010. Dissertação (Mestrado em Ciências Biológicas (Biologia Molecular)) - Universidade Federal de São Paulo, Conselho Nacional de Desenvolvimento Científico e Tecnológico. Orientador: Maria Aparecida Juliano.
2. Diego M Assis. Estudos bioquimicos e farmaclogicos da Bradicinina fosforilada. 2009. Dissertação (Mestrado em Ciências Biológicas (Biologia Molecular)) - Universidade Federal de São Paulo, . Orientador: Maria Aparecida Juliano.
3. Douglas de Andrade. Estudo Bioquimico da Calicreina 13 Humana. 2008. Dissertação (Mestrado em biologia molecular) - Universidade Federal de São Paulo, Conselho Nacional de Desenvolvimento Científico e Tecnológico. Orientador: Maria Aparecida Juliano.
4. Sandro Eurico Fogaça. Estudo cininogenásico das calicreinas tissulares de rato e camundongo e dos subsítios S'1, e S'2 da calicreinatissilar humana. 2003. 82 f. Dissertação (Mestrado em Ciências Biológicas (Biologia Molecular)) - Universidade Federal de São Paulo, Conselho Nacional de Desenvolvimento Científico e Tecnológico. Orientador: Maria Aparecida Juliano.
5. Fabiana Madureira Alves. Ligação de peptídeos à resina de alta porosidade e escolha de sondas apagadoras de fluorescência na construção de substratos para protases. 2003. 95 f. Dissertação (Mestrado em Ciências Biológicas (Biologia Molecular)) - Universidade Federal de São Paulo, Conselho Nacional de Desenvolvimento Científico e Tecnológico. Orientador: Maria Aparecida Juliano.
6. Aurelio Resende lima. Síntese e caracterização de peptideos ciclicos com potencial uso na inibição de proteases. 2002. Dissertação (Mestrado em Ciências Biológicas (Biologia Molecular)) - Universidade Federal de São Paulo, Conselho Nacional de Desenvolvimento Científico e Tecnológico. Orientador: Maria Aparecida Juliano.
7. Roseli Cristina barboza Pozzo. Síntese e Catarcterização dos Aminoácidos Modificados N-Dimetil Histidina e sua Incorporação em substatos e Inibidores de Proteinases. 2001. Dissertação - Universidade Federal de São Paulo, . Orientador: Maria Aparecida Juliano.
8. Rosangela Simões. Peptideos Ciclicos Contendo A Sequencia Hpfh Como Inibidor da Enzima Conversora de Angiotensina e Catepsina B.. 1998. Dissertação (Mestrado em Ciências Biológicas (Biologia Molecular)) - Universidade Federal de São Paulo, Conselho Nacional de Desenvolvimento Científico e Tecnológico. Orientador: Maria Aparecida Juliano.
9. Mauricio de Campos Araujo. Desenvolvimento de Substratos de Fluorescencia Apagada Para Enzima Conversora da Angiotensina-I.. 1998. Dissertação (Mestrado em Ciências Biológicas (Biologia Molecular)) - Universidade Federal de São Paulo, Conselho Nacional de Desenvolvimento Científico e Tecnológico. Orientador: Maria Aparecida Juliano.
10. Lira Celeste Alves. Sintese e Estudo Cinetico da Hidrolise de Substratos Fluorescentes Para Proteases.. 1994. Dissertação (Mestrado em Ciências Biológicas (Biologia Molecular)) - Universidade Federal de São Paulo, . Orientador: Maria Aparecida Juliano.
Tese de doutorado
1. Aurelio Resende Lima. Sintese de peptideos para o estudo da especificidade da calicreina tecidual 3 humana. 2009. Tese (Doutorado em Biologia Molecular) - Universidade Federal de São Paulo, Conselho Nacional de Desenvolvimento Científico e Tecnológico. Orientador: Maria Aparecida Juliano.
2. Fabiana Alves Madureira. Desenvolvimento de biblioteca combinatoria de peptideos para estudo da especificidasde de proteases. 2007. Tese (Doutorado em Biologia Molecular) - Universidade Federal de São Paulo, Conselho Nacional de Desenvolvimento Científico e Tecnológico. Orientador: Maria Aparecida Juliano.
3. Pedro Francisco Angelo Junior. Estudo da especificidade da calicreina 6 humana. 2006. Tese (Doutorado em Biologia Molecular) - Universidade Federal de São Paulo, Conselho Nacional de Desenvolvimento Científico e Tecnológico. Orientador: Maria Aparecida Juliano.
4. Robson Lopes de Melo. Substratos e inibidores peptídeos contendo aminoácidos básicos não naturais para o estudo de especificidade de enzim. 2002. Tese (Doutorado em Biologia Molecular) - Universidade Federal de São Paulo, Conselho Nacional de Desenvolvimento Científico e Tecnológico. Orientador: Maria Aparecida Juliano.
5. Lira Celeste Alves. Estudo da Especificidade de uma cisteino-peptidase recombinante da Leishmania mexicana. 2001. Tese - Universidade Federal de São Paulo, Conselho Nacional de Desenvolvimento Científico e Tecnológico. Orientador: Maria Aparecida Juliano.
Supervisão de pós-doutorado
1. Fabiana Madureira Alves. 2009. Universidade Federal de São Paulo, Fundação de Amparo à Pesquisa do Estado de São Paulo. Maria Aparecida Juliano.
Iniciação Científica
1. Mariana Barbosa dos Santos. Desenho e sintese de biblioteca de peptideos para estudo de proteases. 2009. Iniciação Científica. (Graduando em Biofísica Sistema) - Universidade Federal de São Paulo, Conselho Nacional de Desenvolvimento Científico e Tecnológico. Orientador: Maria Aparecida Juliano.
2. Mariana Barbosa dos Santos. Desenho e sintese de biblioteca de peptideos para estudo de proteases. 2008. Iniciação Científica - Universidade Federal de São Paulo, Conselho Nacional de Desenvolvimento Científico e Tecnológico. Orientador: Maria Aparecida Juliano.
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