Rede de Colaboração
Diretório de grupos de pesquisa
SciELO - artigos em texto completo

Luiz Juliano Neto
Bolsista de Produtividade em Pesquisa do CNPq - Nível 1A

possui graduação em Medicina pela Universidade Federal de São Paulo (1968) e doutorado em Ciências Biológicas (Biologia Molecular) pela Universidade Federal de São Paulo (1974). Atualmente é professor titular da Universidade Federal de São Paulo. Tem experiência na área de Bioquímica, com ênfase em Proteínas, atuando principalmente nos temas: peptideos e proteases.
(Texto informado pelo autor)

Última atualização do currículo em 07/02/2012
Endereço para acessar este CV:
http://lattes.cnpq.br/6593457386037361
Dados pessoais
NomeLuiz Juliano Neto
Nome em citações bibliográficasJULIANO L.;Juliano, Luiz;Juliano, L.
SexoMasculino
Endereço profissionalUniversidade Federal de São Paulo, Departamento de Biofísica.
Rua Tres de Maio, 100
Vila Clementino
04044-020 - Sao Paulo, SP - Brasil
Telefone: (11) 55764455 Ramal: 1 Fax: (11) 55759617
URL da Homepage: http://

Formação acadêmica/Titulação
1989Livre-docência.
Universidade Federal de São Paulo, UNIFESP, Brasil.
Título: , Ano de obtenção: 1989.
1969 - 1974Doutorado em Ciências Biológicas (Biologia Molecular) .
Universidade Federal de São Paulo, UNIFESP, Brasil.
Título: ANGIOTENSINA II, ANALOGOS E HOMOLOGOS: INTERACAO COM PROTON E COM ACETATO DE PARA-NITROFENILA., Ano de Obtenção: 1974.
Orientador: ANTONIO C. DE MATTOS PAIVA.
Palavras-chave: Angiotensinas; Estrutura Proteinas; peptideos.
Grande área: Ciências Biológicas / Área: Bioquímica / Subárea: Biologia Molecular.
1963 - 1968Graduação em Medicina .
Universidade Federal de São Paulo, UNIFESP, Brasil.

Atuação profissional
Universidade Federal de São Paulo, UNIFESP, Brasil.
Vínculo institucional
1989 - Atual Vínculo: Servidor público ou celetista, Enquadramento Funcional: PROFESSOR TITULAR, Carga horária: 48, Regime: Dedicação exclusiva.
Vínculo institucional
1974 - 1990 Vínculo: Servidor público ou celetista, Enquadramento Funcional: Prof. Adjunto, Carga horária: 0
Vínculo institucional
1971 - 1974 Vínculo: Servidor público ou celetista, Enquadramento Funcional: Assistente
Atividades
2007 - AtualAtividades de Participação em Projeto, Departamento de Biofísica, .
Projetos de pesquisa
Microbiologia Aplicada - Prospecção de proteases
1989 - AtualAtividades de Participação em Projeto, Departamento de Biofísica, .
Projetos de pesquisa
Substratos e inibidores de proteases - obtenção das proteases, sintese quimica dos peptidos e inibidores
1/1980 - AtualPesquisa e desenvolvimento Enzimas Proteolicas.
Linhas de pesquisa
Proteases
1/1975 - AtualEnsino, Ciências Biológicas (Biologia Molecular), Nível: Pós-Graduação.
Disciplinas ministradas
Estrutura e função de proteinas
1/1971 - AtualPesquisa e desenvolvimento Sintese de Peptideos.
Linhas de pesquisa
Peptideos
Proteases
1/1971 - AtualEnsino, Medicina, Nível: Graduação.
Disciplinas ministradas
Biofisica
00/1986 - 00/1987Direção e administração, .
Cargo ou função
CHEFE DO DEPARTAMENTO.
00/1986 - 00/1987Direção e administração, .
Cargo ou função
COORDENADOR DO CURSO DE POS-GRADUACAO: BIOLOGIA MOLECULAR.

Linhas de Pesquisa
1. Peptideos
2. Proteases
3. Proteases

Projetos de Pesquisa
2007 - AtualMicrobiologia Aplicada - Prospecção de proteases
Descrição: Prospecção de proteases em microorganismos da flora dos sistemas de compostagens do Zoologico de São Paulo.
Situação: Em andamento; Natureza: Pesquisa.
Alunos envolvidos: Graduação ( 5) / Mestrado acadêmico ( 2) / Doutorado ( 1) .
Integrantes: Luiz Juliano Neto - Coordenador.
.
1989 - AtualSubstratos e inibidores de proteases - obtenção das proteases, sintese quimica dos peptidos e inibidores
Descrição: Proteases humanas, de parasitas e virais sõa obtidas por isolamento de fontes naturais e/ou por tecnologia recombinante e ensaiadas com substratos fluorescentes desenvolvidas por nós desde 1989.Evoluimos para bibliotecas combinatoria o que nos permte criteriosa analise da especificidade de substrato e geração de inibidores orientando a sintese de aminoácidos não naturais assim como de peptideomiméticos..
Situação: Em andamento; Natureza: Pesquisa.
Alunos envolvidos: Graduação ( 4) / Mestrado acadêmico ( 4) / Doutorado ( 8) .
Integrantes: M. H. S. CEZARI - Integrante / A. K. CARMONA - Integrante / I Y Hirata - Integrante / M A JULIANO - Integrante / Luiz Juliano Neto - Coordenador.
.

Membro de corpo editorial
2000 - Atual Periódico: Brazilian Journal of Medical and Biological Research

Revisor de periódico
2003 - Atual Periódico: The Journal of Biological Chemistry
2001 - Atual Periódico: Analytical Biochemistry
2001 - Atual Periódico: Biological Chemistry
2006 - Atual Periódico: Peptides (New York)
2004 - Atual Periódico: Biochimie (Paris)

Áreas de atuação
1. Grande área: Ciências Biológicas / Área: Bioquímica / Subárea: Química de Macromoléculas / Especialidade: Proteínas.
2. Grande área: Ciências Biológicas / Área: Bioquímica / Subárea: Biologia Molecular.
3. Grande área: Ciências Biológicas / Área: Bioquímica / Subárea: Enzimologia.
4. Grande área: Ciências Biológicas / Área: Biofísica / Subárea: Biofísica Molecular.
5. Grande área: Ciências Exatas e da Terra / Área: Química / Subárea: Química Orgânica.
6. Grande área: Ciências Biológicas / Área: Biofísica / Subárea: Biofísica Molecular.

Idiomas
Inglês Compreende Bem, Fala Bem, Lê Bem, Escreve Bem.
Espanhol Fala Razoavelmente, Lê Razoavelmente, Escreve Pouco.

Prêmios e títulos
2008Scopus-Elsevier, CAPES - Elsevier.
2007Ordem Nacional do Merito Cientifico - Classe Comendador, Ministerio da Ciencia e Tecnologia - Brasil.
2002Membro Titular da Academia Brasileira de Ciencias, Academia Brasileira de Ciencias.
1973PREMIO LAFI, FUNDACAO LAFI.


Produção em C,T & A
Produção bibliográfica
Citações
Web of Science
Total de trabalhos343Total de citações5019Fator H37
Juliano L  Data: 07/02/2012
Artigos completos publicados em periódicos
1. Oliveira, Lilian C.G. ; Silva, Vinícius O. ; Okamoto, Debora N. ; Kondo, Marcia Y. ; Santos, Saara M.B. ; Hirata, Isaura Y. ; Vallim, Marcelo A. ; Pascon, Renata C. ; Gouvea, Iuri E. ; Juliano, Maria A. ; Juliano, Luiz . Internally quenched fluorescent peptide libraries with randomized sequences designed to detect endopeptidases. Analytical Biochemistry (Print), v. 421, p. 299-307, 2012.
2. da Cruz, Laura Nogueira ; Alves, Eduardo ; Leal, Mônica Teixeira ; Juliano, Maria A. ; Rosenthal, Philip J. ; Juliano, Luiz ; Garcia, Celia R.S. . FRET peptides reveal differential proteolytic activation in intraerythrocytic stages of the malaria parasites Plasmodium berghei and Plasmodium yoelii. International Journal for Parasitology, v. 41, p. 363-372, 2011.
3. Piovan, Leandro ; Alves, Márcio F.M. ; Juliano, Luiz ; Brömme, Dieter ; Cunha, Rodrigo L.O.R. ; Andrade, Leandro H. . Structure activity relationships of hypervalent organochalcogenanes as inhibitors of cysteine cathepsins V and S. Bioorganic & Medicinal Chemistry (Print), v. 19, p. 2009-2014, 2011.
4. Kondo, Marcia Y. ; Oliveira, Lilian C.G. ; Okamoto, Debora N. ; de Araujo, Marina R.T. ; Duarte dos Santos, Claudia N. ; Juliano, Maria A. ; Juliano, Luiz ; Gouvea, Iuri E. . Yellow fever virus NS2B/NS3 protease: Hydrolytic Properties and Substrate Specificity. Biochemical and Biophysical Research Communications (Print), v. 407, p. 640-644, 2011.
5. Gouvea, Iuri E. ; Santos, Jorge A.N. ; Burlandy, Fernanda M. ; Tersariol, Ivarne L.S. ; da Silva, Edson E. ; Juliano, Maria A. ; Juliano, Luiz ; Cunha, Rodrigo L.O.R. . Poliovirus 3C proteinase inhibition by organotelluranes. Biological Chemistry (Print), v. 392, p. 587-591, 2011.
6. Korkmaz, Brice ; Jégot, Gwenhael ; Lau, Laurie C. ; Thorpe, Michael ; Pitois, Elodie ; Juliano, Luiz ; Walls, Andrew F. ; Hellman, Lars ; Gauthier, Francis . Discriminating between the activities of human cathepsin G and chymase using fluorogenic substrates. The FEBS Journal (Print), v. 278, p. 2635-2646, 2011.
7. Noinaj, Nicholas ; Bhasin, Sonia K. ; Song, Eun Suk ; Scoggin, Kirsten E. ; Juliano, Maria A. ; Juliano, Luiz ; Hersh, Louis B. ; Rodgers, David W. ; Gerrard, Juliet Ann . Identification of the Allosteric Regulatory Site of Insulysin. Plos One, v. 6, p. e20864, 2011.
8. Nunes, Gabriel L. C. ; Simões, Alyne ; Dyszy, Fábio H. ; Shida, Claudio S. ; Juliano, Maria A. ; Juliano, Luiz ; Gesteira, Tarsis F. ; Nader, Helena B. ; Murphy, Gillian ; Chaffotte, Alain F. ; Goldberg, Michel E. ; Tersariol, Ivarne L. S. ; Almeida, Paulo C. ; Pastore, Annalisa . Mechanism of Heparin Acceleration of Tissue Inhibitor of Metalloproteases-1 (TIMP-1) Degradation by the Human Neutrophil Elastase. Plos One, v. 6, p. e21525, 2011.
9. Andrade, Douglas ; Assis, Diego M. ; Santos, Jorge A.N. ; Alves, Fabiana M. ; Hirata, Izaura Y. ; Araujo, Mariana S. ; Blaber, Sachiko I. ; Blaber, Michael ; Juliano, Maria A. ; Juliano, Luiz . Substrate specificity of kallikrein-related peptidase 13 activated by salts or glycosaminoglycans and a search for natural substrate candidates. Biochimie (Paris. Print), v. 93, p. 1701-1709, 2011.
10. Nunes, Gabriel L. C. ; Simà es, Alyne ; Dyszy, Fà bio H. ; Shida, Claudio S. ; Juliano, Maria A. ; Juliano, Luiz ; Gesteira, Tarsis F. ; Nader, Helena B. ; Murphy, Gillian ; Chaffotte, Alain F. ; Goldberg, Michel E. ; Tersariol, Ivarne L. S. ; Almeida, Paulo C. ; Pastore, Annalisa . Mechanism of Heparin Acceleration of Tissue Inhibitor of Metalloproteases-1 (TIMP-1) Degradation by the Human Neutrophil Elastase. Plos One, v. 6, p. e21525, 2011.
11. Fonseca, Fernando P. P. ; Ike, Priscila T. L. ; Assis, Diego M. ; Icimoto, Marcelo Y. ; Juliano, Maria A. ; Juliano, Luiz ; Puzer, Luciano ; Henrique-Silva, Flavio . Leviserpin: A Serine Peptidase Inhibitor (Serpin) from the Sugarcane Weevil Sphenophorus levis. The Protein Journal, v. 30, p. 404-412, 2011.
12. Pascon, Renata C. ; Bergamo, Rogério Faria ; Spinelli, Rafael Xavier ; de Souza, Elisangela Dutra ; Assis, Diego Magno ; Juliano, Luiz ; Vallim, Marcelo Afonso . Amylolytic Microorganism from São Paulo Zoo Composting: Isolation, Identification, and Amylase Production. Enzyme Research, v. 2011, p. 1-8, 2011.
13. Teixeira, Thiago S.P. ; Freitas, Renato F. ; Abrahão, Odonírio ; Devienne, Karina F. ; de Souza, Lucas R. ; Blaber, Sachico I. ; Blaber, Michael ; Kondo, Marcia Y. ; Juliano, Maria A. ; Juliano, Luiz ; Puzer, Luciano . Biological evaluation and docking studies of natural isocoumarins as inhibitors for human kallikrein 5 and 7. Bioorganic & Medicinal Chemistry Letters (Print), v. 21, p. 6112-6115, 2011.
14. Icimoto, Marcelo Y. ; Barros, Nilana M. ; Ferreira, Juliana C. ; Marcondes, Marcelo F. ; Andrade, Douglas ; Machado, Mauricio F. ; Juliano, Maria A. ; Júdice, Wagner A. ; Juliano, Luiz ; Oliveira, Vitor ; Uversky, Vladimir N. . Hysteretic Behavior of Proprotein Convertase 1/3 (PC1/3). Plos One, v. 6, p. e24545, 2011.
15. Proto, W. R. ; Castanys-Munoz, E. ; Black, A. ; Tetley, L. ; Moss, C. X. ; Juliano, L. ; Coombs, G. H. ; Mottram, J. C. . Trypanosoma brucei Metacaspase 4 Is a Pseudopeptidase and a Virulence Factor. The Journal of Biological Chemistry (Print), v. 286, p. 39914-39925, 2011.
16. Nogueira Santos, Jorge Alexandre ; Assis, Diego M. ; Gouvea, Iuri Estrada ; Júdice, Wagner A.S. ; Izidoro, Mario Augusto ; Juliano, Maria Aparecida ; Skern, Tim ; Juliano, Luiz . Foot and mouth disease leader protease (Lbpro): Investigation of prime side specificity allows the synthesis of a potent inhibitor. Biochimie (Paris. Print), v. 94, p. 711-718, 2011.
17. Souza, Tatiana A.C.B. ; Okamoto, Débora N. ; Ruiz, Diego M. ; Oliveira, Lilian C.G. ; Kondo, Márcia Y. ; Tersario, Ivarne L.S. ; Juliano, Luiz ; De Castro, Rosana E. ; Gouvea, Iuri E. ; Murakami, Mário T. . Correlation between catalysis and tertiary structure arrangement in an archaeal halophilic subtilase. Biochimie (Paris. Print), v. 94, p. 798-805, 2011.
18. Costa, Robson ; Manjavachi, Marianne N ; Motta, Emerson M ; Marotta, Denise M ; Juliano, Luiz ; Torres, Hugo A ; Pesquero, Joà o B ; Calixto, Joà o B. . The role of kinin B and B receptors in the scratching behaviour induced by proteinase-activated receptor-2 agonists in mice. British Journal of Pharmacology, p. 1-1, 2010.
19. Trossini, Gustavo H. G. ; Malvezzi, Alberto ; T.-do Amaral, Antonia ; Rangel-Yagui, Carlota Oliveira ; Izidoro, Mario A. ; Cezari, Maria Helena S. ; Juliano, Luiz ; Chin, Chung Man ; Menezes, Carla M. S. ; Ferreira, Elizabeth Igne . Cruzain inhibition by hydroxymethylnitrofurazone and nitrofurazone: investigation of a new target in. Journal of Enzyme Inhibition and Medicinal Chemistry (Print), v. 25, p. 62-67, 2010.
20. Pagano, Rosana L. ; Sampaio, Sandra C. ; Juliano, Maria A. ; Juliano, Luiz ; Giorgi, Renata . Involvement of proteinase-activated receptors 1 and 2 in spreading and phagocytosis by murine adherent peritoneal cells: Modulation by the C-terminal of S100A9 protein. European Journal of Pharmacology, v. 628, p. 240-246, 2010.
21. OKAMOTO, D ; KONDO, M ; Hiraga K ; JULIANO, M. A. ; JULIANO, L ; Gouveia IE ; ODA, K . Salt effect on substrate specificity of a subtilisin-like halophilic protease.. Protein and Peptide Letters, v. 17, p. 796-802, 2010.
22. Machado, Maurício F.M. ; Marcondes, Marcelo F. ; Rioli, Vanessa ; Ferro, Emer S. ; Juliano, Maria A. ; Juliano, Luiz ; Oliveira, Vitor . Catalytic properties of thimet oligopeptidase H600A mutant. Biochemical and Biophysical Research Communications (Print), v. 394, p. 429-433, 2010.
23. Andrade, Douglas ; Assis, Diego M. ; Lima, Aurelio Resende ; Oliveira, Juliana R. ; Araujo, Mariana S. ; Blaber, Sachiko I. ; Blaber, Michael ; Juliano, Maria A. ; Juliano, Luiz . Substrate specificity and inhibition of human kallikrein-related peptidase 3 (KLK3 or PSA) activated with sodium citrate and glycosaminoglycans. Archives of Biochemistry and Biophysics (Print), v. 498, p. 74-82, 2010.
24. Kondo, M. Y. ; Okamoto, D. N. ; Santos, J. A. N. ; JULIANO, M. A. ; Oda, K. ; Pillai, B. ; James, M. N. G. ; Juliano, L. ; Gouvea, I. E. . Studies on the Catalytic Mechanism of a Glutamic Peptidase. The Journal of Biological Chemistry (Print), v. 285, p. 21437-21445, 2010.
25. Izidoro, Mario A. ; Assis, Diego M. ; Oliveira, Vitor ; Santos, Jorge A.N. ; Juliano, Maria A. ; Lindberg, Iris ; Juliano, Luiz . Effects of magnesium ions on recombinant human furin: selective activation of hydrolytic activity upon substrates derived from virus envelope glycoprotein. Biological Chemistry (Print), v. 391, p. 1105-1112, 2010.
26. Okamoto, Debora N. ; Oliveira, Lilian C.G. ; Kondo, Marcia Y. ; Cezari, Maria H.S. ; Szeltner, Zoltán ; Juhász, Tünde ; Juliano, Maria A. ; Polgár, László ; Juliano, Luiz ; Gouvea, Iuri E. . Increase of SARS-CoV 3CL peptidase activity due to macromolecular crowding effects in the milieu composition. Biological Chemistry (Print), v. 391, p. 1461-1468, 2010.
27. OKAMOTO, D ; KONDO, M ; SANTOS, J ; NAKAJIMA, S ; HIRAGA, K ; ODA, K ; JULIANO, M ; JULIANO, L ; GOUVEA, I . Kinetic analysis of salting activation of a subtilisin-like halophilic protease. BBA. Proteins and Proteomics, v. 1794, p. 367-373, 2009.
28. Koussis, Konstantinos ; Withers-Martinez, Chrislaine ; Yeoh, Sharon ; Child, Matthew ; Hackett, Fiona ; Knuepfer, Ellen ; Juliano, Luiz ; Woehlbier, Ute ; Bujard, Hermann ; Blackman, Michael J . A multifunctional serine protease primes the malaria parasite for red blood cell invasion. EMBO Journal, v. 28, p. 725-735, 2009.
29. Izidoro, Mario A. ; Gouvea, Iuri E. ; Santos, Jorge A.N. ; Assis, Diego M. ; Oliveira, Vitor ; Judice, Wagner A.S. ; Juliano, Maria A. ; Lindberg, Iris ; Juliano, Luiz . A study of human furin specificity using synthetic peptides derived from natural substrates, and effects of potassium ions. Archives of Biochemistry and Biophysics, v. 487, p. 105-114, 2009.
30. Santos, Jorge A. N. ; Gouvea, Iuri E. ; Ju?dice, Wagner A. S. ; Izidoro, Mario A. ; Alves, Fabiana M. ; Melo, Robson L. ; Juliano, Maria A. ; Skern, Tim ; Juliano, Luiz . Hydrolytic Properties and Substrate Specificity of the Foot-and-Mouth Disease Leader Protease. Biochemistry (Easton), v. 48, p. 7948-7958, 2009.
31. Cunha, Rodrigo L.O.R. ; Gouvêa, Iuri E. ; Feitosa, Geovana P.V. ; Alves, Márcio F.M. ; Brömme, Dieter ; Comasseto, João V. ; Tersariol, Ivarne L.S. ; Juliano, Luiz . Irreversible inhibition of human cathepsins B, L, S and K by hypervalent tellurium compounds. Biological Chemistry, v. 390, p. 1205-1212, 2009.
32. Takara, Marcelo ; Eisenhut, Jéssica Karoline ; Hirata, Izaura Yoshico ; Juliano, Luiz ; Ito, Amando Siuiti . Solvent Effects in Optical Spectra of ortho-Aminobenzoic Acid Derivatives. Journal of Fluorescence, v. 19, p. 1053-1060, 2009.
33. Kalupov, T. ; BRILLARD-BOURDET, M. ; Dade, S. ; Serrano, H. ; Wartelle, J. ; Guyot, N. ; Juliano, L. ; MOREAU, T. ; Belaaouaj, A. ; GAUTHIER, F. . Structural Characterization of Mouse Neutrophil Serine Proteases and Identification of Their Substrate Specificities: RELEVANCE TO MOUSE MODELS OF HUMAN INFLAMMATORY DISEASES. The Journal of Biological Chemistry (Print), v. 284, p. 34084-34091, 2009.
34. REZENDE-SOARES, F. A. ; CARVALHO-CAMPOS, C. ; MARQUES, M. J. ; PORCINO, G. N. ; GIAROLA, N. L. L. ; COSTA, B. L. S. ; TAUNAY-RODRIGUES, A. ; FARIA-PINTO, P. ; SOUZA, M. A. ; DINIZ, V. A. ; CORTE-REAL, S. ; JULIANO, M. A. ; Juliano, L. ; VASCONCELOS, E. G. . Cytochemical localization of ATP diphosphohydrolase from Leishmania (Viannia) braziliensis promastigotes and identification of an antigenic and catalytically active isoform. Parasitology (London. Print), p. 1-1, 2009.
35. Cunha, Rodrigo L. O. R. ; Gouvea, Iuri E. ; Juliano, Luiz . A glimpse on biological activities of tellurium compounds. Anais da Academia Brasileira de Ciências (Impresso), v. 81, p. 1-1, 2009.
36. Carmona, Adriana K. ; Juliano, Maria Aparecida ; Juliano, Luiz . The use of Fluorescence Resonance Energy Transfer (FRET) peptidesfor measurement of clinically important proteolytic enzymes. Anais da Academia Brasileira de Ciências (Impresso), v. 81, p. 1, 2009.
37. Merheb-Dini, Carolina ; Cabral, Hamilton ; Leite, Rodrigo S. R. ; Zanphorlin, Leti?cia M. ; Okamoto, De?bora N. ; Rodriguez, Gustavo O. Bonilla ; Juliano, Luiz ; Arantes, Eliane C. ; Gomes, Eleni ; da Silva, Roberto . Biochemical and Functional Characterization of a Metalloprotease from the Thermophilic Fungus. Journal of Agricultural and Food Chemistry, v. 57, p. 9210-9217, 2009.
38. Dale, Camila Squarzoni ; Altier, Christophe ; Cenac, Nicolas ; Giorgi, Renata ; Juliano, Maria Aparecida ; Juliano, Luiz ; Zamponi, Gerald W. ; Vergnolle, Nathalie . Analgesic properties of S100A9 C-terminal domain: a mechanism dependent on calcium channel inhibition. Fundamental & Clinical Pharmacology, v. 23, p. 427-438, 2009.
39. Chow, K. Martin ; Gakh, O. ; Payne, I. C. ; Juliano, Maria Aparecida ; Juliano, Luiz ; Isaya, G. ; Hersh, Louis B. . Mammalian Pitrilysin: Substrate Specificity and Mitochondrial Targeting. Biochemistry (Easton), v. 48, p. 2868-2877, 2009.
40. Williams, Roderick A.M. ; Woods, Kerry L. ; Juliano, Luiz ; Mottram, Jeremy C. ; Coombs, Graham H. . Characterization of unusual families of ATG8-like proteins and ATG12 in the protozoan parasite. Autophagy (Georgetown, TX), v. 5, p. 159-172, 2009.
41. Nunes SS ; Outeiro-Bernstein MA ; JULIANO L. ; Vardiero F ; NADER, H B ; Woods A ; Legrand C ; MORANDI, V. . Syndecan-4 contributes to endothelial tubulogenesis through interactions with two motifs inside the pro-angiogenic N-terminal domain of thrombospondin. Journal of Cellular Physiology, v. 214, p. 828-837, 2008.
42. Sarzedas, Carolina G. ; Lima, Carla S. ; Juliano, Maria A. ; Juliano, Luiz ; Valente, Ana Paula ; Da Poian, Andrea T. ; Almeida, Fabio C. L. . A minor ?-structured conformation is the active state of a fusion peptide of vesicular stomatitis virus glycoprotein. Journal of Peptide Science, v. 14, p. 429-435, 2008.
43. MAGDESIAN, M H ; Carvalho MMVF ; Mendes FA ; JULIANO, M. A. ; JULIANO L. ; Abreu JG ; FERREIRA, S T . Amyloid-beta binds to the extracellular cysteine-rich domain of Frizzled and inhibits Wnt/beta-catenin signaling.. The Journal of Biological Chemistry, v. 283, p. 9359-9368, 2008.
44. Paszcuk AF ; Quintão NLM ; Fernandes ES ; JULIANO L. ; Chapman K ; Gordon AG ; Campos MM ; Vergnolle N ; Calixto JB . Mechanisms underlying the nociceptive and inflammatory responses induced by trypsin in the mouse paw.. European Journal of Pharmacology, v. 581, p. 204-215, 2008.
45. Nascimento-Silva MC ; Leal AT ; Daffre S ; JULIANO L. ; Silva Vaz I Jr ; Paiva-Siva Gde O ; OLIVEIRA, P. L. ; SORGINE, M. H. . BYC, an atypical aspartic endopeptidase from Rhipicephalus (Boophilus) microplus eggs.. Comparative Biochemistry and Physiology. B, Biochemistry & Molecular Biology, v. 149, p. 599-607, 2008.
46. STAUFFER, F ; Melo MN ; Carneiro FA ; Sousa FJ ; JULIANO, M. A. ; JULIANO L. ; Mohana-Borges R ; POIAN, A T da ; Castanho MA . Interaction between dengue virus fusion peptide and lipid bilayers depends on peptide clustering.. Molecular Membrane Biology, v. 2008, p. 128-138, 2008.
47. MALVEZZI, A ; DEREZENDE, L ; IZIDORO, M ; CEZARI, M ; JULIANO L. ; AMARAL, A . Uncovering false positives on a virtual screening search for cruzain inhibitors. Bioorganic & Medicinal Chemistry Letters, v. 18, p. 350-354, 2008.
48. Costa, R ; Marotta, D M ; Manjavachi, M N ; Fernandes, E S ; Lima-Garcia, J F ; Paszcuk, A F ; Quintão, N L M ; JULIANO L. ; Brain, S D ; Calixto, J B . Evidence for the role of neurogenic inflammation components in trypsin-elicited scratching behaviour in mice. British Journal of Pharmacology, v. 154, p. 1094-1103, 2008.
49. SATO, P ; LOPES, A ; JULIANO L. ; JULIANO, M ; TERRA, W . Subsite substrate specificity of midgut insect chymotrypsins. Insect Biochemistry and Molecular Biology, v. 38, p. 628-633, 2008.
50. PERSIKE, D ; CUNHA, R ; JULIANO, L ; SILVA, I ; ROSIM, F ; VIGNOLI, T ; DONA, F ; CAVALHEIRO, E ; FERNANDES, M . Protective effect of the organotelluroxetane RF-07 in pilocarpine-induced status epilepticus. Neurobiology of Disease, v. 31, p. 120-126, 2008.
51. PACCOLA, C ; GUTIERREZ, V ; LONGO, I ; JULIANO, L ; JULIANO, M ; GIORGI, R . Antinociceptive effect of the C-terminus of murine S100A9 protein on experimental neuropathic pain. Peptides (New York), v. 29, p. 1806-1814, 2008.
52. BARROS, N ; NASCIMENTO, F ; OLIVEIRA, V ; JULIANO, M ; JULIANO, L ; LOISEL, T ; NADER, H ; BOILEAU, G ; TERSARIOL, I ; CARMONA, A . The critical interaction of the metallopeptidase PHEX with heparan sulfate proteoglycans. International Journal of Biochemistry & Cell Biology, v. 40, p. 2781-2792, 2008.
53. LANFRANCO, M ; LOAYZAMURO, R ; CLARK, D ; NUNEZ, R ; ZAVALETA, A ; JIMENEZ, M ; MELDAL, M ; COOMBS, G ; MOTTRAM, J ; IZIDORO, M ; JULIANO L. . Expression and substrate specificity of a recombinant cysteine proteinase B of Leishmania braziliensis?. Molecular and Biochemical Parasitology, v. 161, p. 91-100, 2008.
54. Moro L.P. ; Murakami M.T. ; Cabral H. ; Vidotto A. ; Tajara E.H. ; Arni R.K. ; JULIANO, L ; Bonilla-Rodrigues G.O. . Purification, biochemical and functional characterization of miliin, a new thiol-dependent serine protease isolated from the latex of Euphorbia milii.. Protein and Peptide Letters, v. 15, p. 724-730, 2008.
55. Lima, Aurelio Resende ; Alves, Fabiana M. ; Ângelo, Pedro Francisco ; Andrade, Douglas ; Blaber, Sachiko I. ; Blaber, Michael ; Juliano, Luiz ; Juliano, Maria Aparecida . S ? and S ? subsite specificities of human plasma kallikrein and tissue kallikrein 1 for the hydrolysis of peptides derived from the bradykinin domain of human kininogen. Biological Chemistry, v. 389, p. 1487-1494, 2008.
56. Dos Santos, Adriana C ; Roffê, Ester ; Arantes, Rosa ME ; Juliano, Luiz ; Pesquero, Jorge L ; Pesquero, João B ; Bader, Michael ; Teixeira, Mauro M ; Carvalho-Tavares, Juliana . Kinin B2 receptor regulates chemokines CCL2 and CCL5 expression and modulates leukocyte recruitment and pathology in experimental autoimmune encephalomyelitis (EAE) in mice, v. 5, p. 49, 2008.
57. PERPETUO, e A ; JULIANO, L ; JULIANO, M. A. ; FRATELLI, F ; PRADO, S M ; PIMENTA, D. C. ; LEBRUN, I . Enzymatic profiling of tetanus and botulinum neurotoxins based on vesicle-associated-membrane protein derived fluorogenic substrates. Protein and Peptide Letters, v. 15, p. 1100-1106, 2008.
58. Korkmaz, Brice ; Attucci, Sylvie ; Juliano, Maria Aparecida ; Kalupov, Timofey ; Jourdan, Marie-Lise ; Juliano, Luiz ; Gauthier, Francis . Measuring elastase, proteinase 3 and cathepsin G activities at the surface of human neutrophils with fluorescence resonance energy transfer substrates, v. 3, p. 991-1000, 2008.
59. Korkmaz B ; Hajjar E ; Kalupov T ; BRILLARBOURDET, M ; MOREAU, T ; JULIANO L. ; GAUTHIER, F. . Influence of charge distribution at the active site surface on the substrate specificity of human neutrophil protease 3 and elastase: A kinetic and molecular modeling analysis. The Journal of Biological Chemistry, v. 282, p. 1989-1997, 2007.
60. Gouveia IE ; Izidoro MA ; JUDICE, W. A. S. ; CEZARI, M. H. S. ; CALIENDO, G ; SANTAGADA, V ; Santos CND ; Queiroz MH ; JULIANO, M. A. ; Young PR ; Fairlie DP ; JULIANO L. . Substrate specificity of recombinant dengue 2 virus NS2B-NS3 protease: Influence of natural and unnatural basic amino acids on hydrolysis of synthetic fluorescent substrates. Archives of Biochemistry and Biophysics, v. 457, p. 187-196, 2007.
61. BARROS, N M ; CAMPOS, M ; BERSANETTI, P. A. ; OLIVEIRA, V ; JULIANO, M. A. ; BOILEAU, G ; JULIANO L. ; CARMONA, A. K. . Neprilysin carboxydipeptidase specificity studies and improvement in its detection with fluorescence energy transfer peptides.. Biological Chemistry, v. 388, p. 447-455, 2007.
62. IWAI, L. K. ; YOSHIDA, M ; Sadahiro A ; da Silva WR ; Marin ML ; GOLDBERG, A C ; JULIANO, M. A. ; JULIANO L. ; YASUDA, M A S ; KALIL, J ; CUNHA NETO, e ; TRAVASSOS, L R . T-cell recognition of Paracoccidioides brasiliensis gp43-derived peptides in patients with paracoccidioidomycosis and healthy individuals.. Clinical and Diagnostic Laboratory Immunology, v. 14, p. 474-476, 2007.
63. Sabatini RA ; Bersatini PA ; FARIAS, S L ; JULIANO L. ; JULIANO, M. A. ; CASARINI, D. E. ; CARMONA, A. K. ; PAIVA, A. C. M. ; Pesquero JB . Determination of angiotensin I-converting enzyme activity in cell culture using fluorescence resonance energy transfer peptides.. Analytical Biochemistry, v. 363, p. 255-262, 2007.
64. Machado MM ; RIOLI, V ; Dalio FM ; CASTRO, L M ; JULIANO, M. A. ; TERSARIOL, I. L. S. ; FERRO, E. S. ; JULIANO L. ; OLIVEIRA, V. . The role of Tyr605 and Ala607 of thimet oligopeptidase and Tyr606 and Gly608 of neurolysin in substrate hydrolysis and inhibitor binding. Biochemical Journal (London), v. 404, p. 279-288, 2007.
65. CARMONA, A. K. ; Schwager SL ; JULIANO, M. A. ; JULIANO L. ; Sturrock ED . A continuous fluorescence resonance energy transfer angiotensin I-converting enzyme assay.. Nature Protocols, v. 1, p. 1971-1976, 2007.
66. FM Alves ; HIRATA, I. Y. ; GOUVEIA, Iuri Estrada ; MFM Alves ; MELDAL, M. ; D Brömme ; JULIANO L. ; JULIANO, M. A. . Controlled peptide solvation in portion-mixing libraries of FRET peptides: improved specificity determination for Dengue 2 virus NS2B-NS3 protease and human cathepsin S.. Journal of Combinatorial Chemistry, v. 9, p. 627-634, 2007.
67. PASCHOALIN, T ; CARMONA, A. K. ; RODRIGUES, E. G. ; OLIVEIRA, V. M. B. B. ; HP Monteiro ; JULIANO, M. A. ; JULIANO L. ; TRAVASOS, L. R. . Characterization of thimet oligopeptidase and neurolysin activities in B16F10-Nex2 tumor cells and their involvement in angiogenesis and tumor growth.. Molecular Cancer, v. 6, p. 44-58, 2007.
68. EA Perpetuo ; LEBRUN, I. ; JULIANO L. ; JULIANO, M. A. ; MA Sakaushi ; SM Prado . Analysis of Secreted Protein Profile and Enzymatic Activities from Corynebacterium diphtheriae and Bordetella pertussis on Production Batch Media using Peptide Quenched Fluorescent Substrates.. Preparative Biochemistry & Biotechnology, v. 37, p. 353-367, 2007.
69. Cencic R ; Mayer C ; JULIANO, M A ; JULIANO L. ; Konrat R ; Skern T . Investigating the substrate specificity and oligomerisation of the leader protease of foot and mouth disease virus using NMR.. Journal of Molecular Biology, v. 373, p. 1071-087, 2007.
70. GORRÃO, Silvia dos Santod ; HEMERLY, J P ; LIMA, A R ; MELO, R L ; SZELTNER, Z ; POLGAR, L ; JULIANO, M. A. ; JULIANO L. . Fluorescence resonance energy transfer (FRET) peptides and cycloretro-inverso peptides derived from bradykinin as substrates and inhibitors of prolyl oligopeptidase.. Peptides (New York), v. 28, p. 2146-2154, 2007.
71. Malvezzi A ; Resende L ; Izidore MA ; CEZARI, M. H. S. ; JULIANO L. ; Amaral A . Uncovering false positives on a virtual screening search for cruzain inhibitors.. Bioorganic & Medicinal Chemistry Letters, v. 18, p. 350-354, 2007.
72. Liu Y ; Guan H ; Beckett TL ; JULIANO, A. M. ; JULIANO L. ; Song ES ; Chow KM ; Murphy MP ; HERSH, L. B. . In vitro and in vivo degradation of Abeta peptide by peptidases coupled to erythrocytes.. Peptides (New York), v. 28, p. 2548-2355, 2007.
73. Moss CX ; Westrop GD ; JULIANO L. ; COOMBS, G H ; Mottram JC . Metacaspase 2 of Trypanosoma brucei is a calcium-dependent cysteine peptidase active without processing.. FEBS Letters, v. 581, p. 5635-5639, 2007.
74.   ANGELO, P F ; LIMA, A R ; ALVES, F M ; BLABER, S I ; SCARISBRICK, I A ; BLABER, M ; JULIANO L. ; JULIANO, M A . Substrate specificity of human kallikrein 6: Salt and glycosaminoglycan activation effects. The Journal of Biological Chemistry, Estados Unidos, v. 281, p. 3116-3126, 2006.
75. LOPES, A R ; JULIANO, M A ; MARANA, S R ; JULIANO L. ; TERRA, W R . Substrate specificity of insect trypsins and the role of their subsites in catalysis. Insect Biochemistry and Molecular Biology, Estados Unidos, v. 36, p. 130-140, 2006.
76. MARTINS, R M ; SFORÇA, M L ; AMINO, R ; JULIANO, M A ; OYAMA JR, S ; JULIANO L. ; PERTINHEZ, T A ; SPISNI, A ; SCHENKMAN, S . Lytic Activity and Structural Differences of Amphipathic Peptides Derived from Trialysin. Biochemistry (Easton), USA, v. 45, n. 6, p. 1765-1774, 2006.
77. MAGALHÃES, H P ; MAGALHÃES, A ; JULIANO L. ; NELSON, D L ; ROGANA, e . Mechanism of action and determination of the best substrate for a thrombin-like enzyme from Lachesis muta muta venom by regression analysis of the kinetic parameters determined with peptidyl p-nitroanilide substrates.. Toxicon, USA, v. 47, p. 453-458, 2006.
78. REIS, F C ; JUDICE, W A ; JULIANO, M A ; JULIANO L. ; SCHARFSTEIN, J ; LIMA, A P . The substrate specificity of cruzipain 2, a cysteine protease isoform from Trypanosoma cruzi.. FEMS Microbiology Letters, USA, v. 259, p. 215-220, 2006.
79. FARIAS, S L ; SABATINI, S A ; SAMPAIO, T C ; HIRATA, I Y ; CEZARI, M H ; JULIANO, M A ; STURROCK, e D ; CARMONA, A K ; JULIANO L. . Angiotensin I-converting enzyme inhibitor peptides derived from the endostatin-containing NC1 fragment of human collagen XVIII.. Biological Chemistry, Alemanha, v. 387, p. 611-616, 2006.
80. MARQUESIN, C A ; HIRATA, I Y ; JULIANO L. ; ITO, A S . Spectroscopic characterization of 2-amino-N-hexadecyl-benzamide (AHBA), a new fluorescence probe for membranes. Biophysical Chemistry, USA, v. 124, p. 125-133, 2006.
81. DALE, C S ; PAGANO, R D ; PACCOLA, C C ; PINOTTIGUIRAO, T ; JULIANO, M A ; JULIANO L. ; GIORGI, R . Effect of the C-terminus of murine S100A9 protein on experimental nociception. Peptides (New York), USA, v. 27, p. 2794-2802, 2006.
82. DALE, C S ; CENAC, N ; BRITO, L R ; JULIANO, M A ; JULIANO L. ; VERGNOE, N ; GIORGI, R . The C-terminus of murine S100A9 protein inhibits hyperalgesia induced by the agonist peptide of protease-activated receptor 2 (PAR2).. British Journal of Pharmacology, Inglaterra, v. 149, p. 374-384, 2006.
83. GOUVEA, I e ; JUDICE, W A ; CEZARI, M H ; JULIANO, M A ; JUHASZ, T ; SZELTNER, Z ; POLGAR, L ; JULIANO L. . Kosmotropic salt activation and substrate specificity of poliovirus protease 3C.. Biochemistry (Easton), USA, v. 45, p. 12083-12089, 2006.
84. CARNEIRO, F A ; VANDENBUSSCHE, G ; JULIANO, M A ; JULIANO L. ; RUYSSCHAERT, J M ; POIAN, A T da . Charged residues are involved in membrane fusion mediated by a hydrophilic peptide located in vesicular stomatitis virus G protein.. Molecular Membrane Biology, USA, v. 23, p. 396-406, 2006.
85. KORKMAZ, B ; HAIJAR, e ; KALUPOV, T ; REUTER, N ; BOUDET, M Brillard ; MOREAU, M ; JULIANO L. ; GAUTHIER, F . Influence of charge distribution at the active site surface on the substrate specificity of human neutrophil protease 3 and elastase: A kinetic and molecular modeling analysis.. The Journal of Biological Chemistry, USA, v. 282, p. 1989-1997, 2006.
86. L, Puzer ; BARROS, N M ; OLIVEIRA, V ; JULIANO, M A ; LU, G ; HASSANEIN, M ; JULIANO, L ; CARMONA, A K . Defining the substrate specificity of mouse cathepsin P. Archives of Biochemistry and Biophysics, USA, v. 435, p. 190-196, 2005.
87. FARIAS, S L ; GAZARINI, L M ; MELO, R L ; HIRATA, I Y ; JULIANO, M A ; JULIANO, L ; GARCIA, C R S . Cysteine-protease activity elicited by Ca2+ stimulus in Plasmodium. . Molecular and Biochemical Parasitology, Holanda, v. 141, p. 71-79, 2005.
88. SONG, S ; DAILY, A ; FRIED, M G ; JULIANO, M A ; JULIANO, L ; HERSH, L B . Mutation of active site residues of insulin degrading enzyme alters allosteric interactions. The Journal of Biological Chemistry, Estados Unidos, v. 280, p. 17701-17706, 2005.
89. FIALHO, e ; NAKAMURA, A ; JULIANO, L ; MASUDA, H ; SILVANETO, Ma . Cathepsin D-mediated yolk protein degradation is blocked by acid phosphatase inhibitors. Archives of Biochemistry and Biophysics, USA, v. 436, p. 246-253, 2005.
90. NASCIMENTO, F D ; RIZZI, C C ; NANTES, I L ; STEFE, I ; TURK, B ; CARMONA, A K ; NADER, H B ; JULIANO, L ; TERSARIOL, I L . Cathepsin X binds to cell surface heparan sulfate proteoglycans. . Archives of Biochemistry and Biophysics, USA, v. 436, p. 323-332, 2005.
91. IWAI, L K ; JULIANO, M A ; JULIANO, L ; KALIL, J ; CUNHA NETO, e . T-cell molecular mimicry in Chagas disease: identification and partial structural analysis of multiple cross-reactive epitopes between Trypanosoma cruzi B13 and cardiac myosin heavy chain. Journal of Autoimmunity, USA, v. 24, p. 111-117, 2005.
92. ALVES, M F ; ARAUJO, M C ; JULIANO, M A ; OLIVEIRA, e M ; KRIEGER, J e ; CASARINI, D e ; JULIANO L. ; CARMONA, A K . A continuous fluorescent assay for the determination of plasma and tissue angiotensin I-converting enzyme activity.. Brazilian Journal of Medical and Biological Research, Brasil, v. 38, p. 861-868, 2005.
93. ABEL, L C ; IWAI, L K ; VIVIANI, W ; BILATE, A M ; FAE, K C ; FERREIRA, R C ; GOLDBERG, A C ; JULIANO, L ; JULIANO, M A ; IANNI, B ; MADY, C ; GRUBER, A ; HAMMER, J ; SINIGAGLIA, F ; KALIL, J ; CUNHANETO, e . T cell epitope characterization in tandemly repetitive Trypanosoma cruzi B13 protein. Microbes and Infection, USA, v. 7, p. 1184-1195, 2005.
94. PAGANO, R L ; SAMPAIO, S C ; JULIANO, L ; JULIANO, M A ; GIORGI, R . The C-terminus of murine S100A9 inhibits spreading and phagocytic activity of adherent peritoneal cells.. Inflammation Research, USA, v. 54, p. 204-210, 2005.
95. OLIVEIRA, V ; GARRIDO, P A ; RODRIGUES, C C ; COLQUHOUN, A ; CASTRO, L M ; ALMEIDA, P C ; SHIDA, C S ; JULIANO, M A ; JULIANO, L ; CAMARGO, A C ; HYSLOP, S ; ROBERTS, J L ; GRUMTOKARS, V ; GLUCKSMAN, M J ; FERRO, e S . Calcium modulates endopeptidase 24.15 (EC 3.4.24.15) membrane association, secondary structure and substrate specificity. The FEBS Journal, Holanda, v. 272, p. 2978-2992, 2005.
96. MAGDESIAN, M H ; NERY, A A ; MARTINS, A H ; JULIANO, M A ; JULIANO, L ; ULRICH, H ; FERREIRA, S T . Peptide Blockers of the Inhibition of Neuronal Nicotinic Acetylcholine Receptors by Amyloid {beta} . The Journal of Biological Chemistry, USA, v. 280, p. 31085-31090, 2005.
97. KACPRZAK, M M ; THAN, M e ; JULIANO, L ; JULIANO, M A ; BODE, W ; LINDBERG, I . Mutations of the PC2 substrate binding pocket alter enzyme specificity.. The Journal of Biological Chemistry, USA, v. 280, p. 31850-31858, 2005.
98. MAGALHÃES, G S ; FERREIRA, M L ; AZEVEDO, I L J ; SPENCER, P J ; ARAUJO, M S ; PORTARO, F C ; MA, L ; VALENTE, R H ; JULIANO, L ; FOX, J W ; HO, P L ; SILVA, A M M . Natterins, a new class of proteins with kininogenase activity characterized from Thalassophryne nattereri fish venom.. Biochimie (Paris), França, v. 87, p. 687-699, 2005.
99. PASCHOALIN, T ; CARMONA, A K ; OLIVEIRA, V ; JULIANO, L ; TRAVASSOS, L R . Characterization of thimet- and neurolysin-like activities in Escherichia coli M3A peptidases and description of a specific substrate.. Archives of Biochemistry and Biophysics, USA, v. 441, p. 25-34, 2005.
100. KORKMAZ, B ; ATTUCCI, S ; JOURDAN, M L ; JULIANO, L ; GAUTHIER, F . Inhibition of Neutrophil Elastase by {alpha}1-Protease Inhibitor at the Surface of Human Polymorphonuclear Neutrophils. Journal of Immunology (Baltimore), USA, v. 175, p. 3329-3338, 2005.
101. BERSANETTI, P A ; PARK, H Y ; BAE, K S ; SHIN, K H ; HIRATA, I Y ; JULIANO, M A ; CARMONA, A K ; JULIANO, L . Characterization of arazyme, an exocellular metalloprotease isolated from Serratia proteamaculans culture medium.. Enzyme and Microbial Technology, USA, v. 37, p. 574-581, 2005.
102. JUDICE, W A ; MOTTRAM, J C ; COOMBS, C H ; JULIANO, M A ; JULIANO, L . Specific negative charges in cysteine protease isoforms of Leishmania mexicana are highly influential on the substrate binding and hydrolysis.. Molecular and Biochemical Parasitology, USA, v. 144, p. 36-43, 2005.
103. CARNEIRO, F A ; LAPIDOLOUREIRO, P A ; CORDO, S M ; STAUFFER, F ; WEISSMULLER, G ; BIANCONE, M L ; JULIANO, M A ; JULIANO, L ; BISH, P M ; POIAN, A T . Probing the interaction between vesicular stomatitis virus and phosphatidylserine.. European Biophysics Journal, Inglaterra, v. 35, p. 145-154, 2005.
104. PUZER, L ; VERCESI, J ; ALVES, M F ; BARROS, N M ; ARAUJO, M S ; JULIANO, M A ; REIS, M L ; JULIANO, L ; CARMONA, A K . A possible alternative mechanism of kinin generation in vivo by cathepsin L. Biological Chemistry, Alemanha, v. 386, p. 699-704, 2005.
105. MORTY, R ; VADASZ, I ; BULAU, P ; DIVE, V ; OLIVEIRA, V ; SEEGER, W ; JULIANO, L . Tropolysin, a new oligopeptidase from African trypanosomes. Biochemistry (Easton), Estados Unidos, v. 44, p. 14658-14669, 2005.
106. PUZER, L ; COTRIN, S S ; CEZARI, M H ; HIRATA, I Y ; JULIANO, M A ; STEFE, I ; TURK, D ; TURK, B ; JULIANO, L ; CARMONA, A K . Recombinant human cathepsin X is a carboxymonopeptidase only: a comparison with cathepsins B and L.. Biological Chemistry, Alemanha, v. 386, p. 1191-1195, 2005.
107. GONZALES, A D F ; ROBBS, B K ; MOREAU, V H ; FERREIRA, A ; JULIANO, L ; VALENTE, A P ; VALENTE, F C ; SILVA, J L ; FOGUEL, D . Controlling {beta}-amyloid oligomerization by the use of naphthalene sulfonates: trapping low molecular weight oligomeric species. The Journal of Biological Chemistry, USA, v. 280, p. 34747-34754, 2005.
108. MACIEL, R Moraes ; SILVA, D L ; RUMJANEK, D ; JULIANO, L ; JULIANO, M A ; FANTAPPIE, M R . Schistosoma mansoni histone acetyltransferase GCN5: linking histone acetylation to gene activation. Molecular and Biochemical Parasitology, USA, v. 133, p. 131-135, 2004.
109. KORKOMAZ, B ; ATTUCCI, S ; MOREAU, T ; GODAT, e ; JULIANO, L ; GAUTHIER, F . Design and use of highly specific substrates of neutrophil elastase and proteinase 3. American Journal of Respiratory Cell and Molecular Biology, USA, v. 30, p. 801-807, 2004.
110.   RICHER, M J ; HASHIMOTO, C ; JULIANO, L ; JEAN, F . Serpin mechanism of hepatitis C virus NS3 protease inhibition: Induced-fit as a mechanism for narrow specificity.. The Journal of Biological Chemistry, USA, v. 279, p. 10222-10227, 2004.
111. LOPES, A R ; JULIANO, M A ; JULIANO, L ; TERRA, W R . Coevolution of insect trypsins and inhibitors. . Archives of Insect Biochemistry and Physiology, USA, v. 55, p. 140-152, 2004.
112.   JUDICE, W A ; PUZER, L ; COTRIN, S S ; CARMONA, A K ; COOMBS, G H ; JULIANO, L ; JULIANO, M A . Carboxydipeptidase activities of recombinant cysteine peptidases. European Journal of Biochemistry, USA, v. 271, p. 1046-1053, 2004.
113. FOGAÇA, S e ; MELO, R L ; PIMENTA, D C ; HOSOI, K ; JULIANO, L ; JULIANO, M A . Differences in substrate and inhibitor sequence specificity of human, mouse and rat tissue kallikreins. . Biochemical Journal (London), Inglaterra, v. 380, p. 775-781, 2004.
114. LIMA, A R ; JULIANO, L ; JULIANO, M A . Cyclic, linear, cycloretro-isomer and cycloretro-inverso peptides derived from the C-terminal sequence of bradykinin as substrates or inhibitors of serine and cysteine proteases . Journal of Protein Chemistry, USA, v. 23, p. 287-294, 2004.
115. DALE, C S ; GONÇALVES, L R ; JULIANO, L ; JULIANO, M A ; SILVA, A M ; GIORGI, R . The C-terminus of murine S100A9 inhibits hyperalgesia and edema induced by jararhagin. Peptides (New York), USA, v. 25, p. 81-89, 2004.
116. QUINTINO, B M ; JULIANO, M A ; HIRATA, I Y ; CARMONA, A K ; JULIANO, L ; CASARINI, D e . Specificity comparison of a serine endopeptidase (SH1) and a serine thiol endopeptidase (STH2) purified from human urine. International Journal of Biochemistry & Cell Biology, USA, v. 36, p. 1943-1954, 2004.
117. BARROS, N M ; TERSARIOL, I L ; OLIVA, M L ; ARAUJO, M S ; SAMPAIO, C A M ; JULIANO, L ; MOTTA, G . High molecular weight kininogen as substrate for cathepsin B. . Biological Chemistry, Alemanha, v. 385, p. 551-555, 2004.
118. JULIANO, M A ; BROOKS, D R ; SELZER, P M ; PANDOLFO, H L ; JUDICE, W A ; JULIANO, L ; MELDAL, M ; SANDERSON, Sj ; MOTTRAM, J C ; COOMBS, G H . Differences in substrate specificities between cysteine protease CPB isoforms of Leishmania mexicana are mediated by a few amino acid changes. European Journal of Biochemistry, Inglaterra, v. 271, p. 3704-3714, 2004.
119. MOLINARO, G ; CARMONA, A K ; JULIANO, M A ; JULIANO, L ; MALITSKAYA, e ; YESSINE, M A ; CHAGNON, M ; LEPAGE, Y ; SIMMONS, W H ; BOILEAU, G ; ADAM, A . Human recombinant membrane-bound aminopeptidase P: production of a soluble form and characterization using novel, internally quenched fluorescent substrates. Biochemical Journal (London), Inglaterra, v. 385, p. 389-397, 2004.
120. PUZER, L ; COTRIN, S S ; ALVES, M F ; RGBORGE, T ; ARAUJO, M S ; JULIANO, M A ; JULIANO, L ; BROMME, D ; CARMONA, A K . Comparative substrate specificity analysis of recombinant human cathepsin V and cathepsin L . Archives of Biochemistry and Biophysics, USA, v. 430, p. 274-283, 2004.
121. SONG, e S ; JULIANO, M A ; JULIANO, L ; FRIED, M G ; WAGNER, S L ; HERSH, L B . ATP effects on insulin-degrading enzyme are mediated primarily through its triphosphate moiety. The Journal of Biological Chemistry, USA, v. 279, p. 54216-54220, 2004.
122. FERREIRA, M Lopes ; EMIN, J A ; OLIVEIRA, V ; PUZER, L ; CESARI, M H S ; ARAUJO, M S ; JULIANO, L ; LAPA, A J ; SOUCCAR, C ; SILVA, A M M . Kininogenase activity of Thalassophryne nattereri fish venom. . Biochemical Pharmacology, USA, v. 68, p. 2151-2157, 2004.
123. MARROQUIN, M Q ; OYAMA, S ; AGUIAR, T P ; SPISNI, A ; JULIANO, M A ; JULIANO, L ; COLLI, W ; ALVES, M J . Modeling the Trypanosoma cruzi Tc85-11 protein and mapping the laminin-binding site. Biochemical and Biophysical Research Communications, USA, v. 325, p. 612-618, 2004.
124. LEBRUN, I ; CAVALLARO, V ; JULIANO, L ; JULIANO, M A ; SOUSA, M C S . Effects of 'casoparan', a peptide isolated from casein hydrolysates with mastoparan-like properties. Mediators of Inflammation, USA, v. 13, p. 263-268, 2004.
125. COTRIN, S S ; PUZER, L ; JUDICE, W A ; CARMONA, A K ; JULIANO, L ; JULIANO, M A . Positional-scanning combinatorial libraries of fluorescence resonance energy transfer peptides to define substrate specificity of carboxydipeptidases: assays with human cathepsin B. Analytical Biochemistry, USA, v. 335, p. 244-252, 2004.
126. BERSANETTI, P A ; ANDRADE, M C ; CASARINI, D e ; JULIANO, M A ; NCHINDA, A T ; STURROCK, e D ; JULIANO, L ; CARMONA, A K . Positional-scanning combinatorial libraries of fluorescence resonance energy transfer peptides for defining substrate specificity of the angiotensin I-converting enzyme and development of selective C-domain substrates. Biochemistry (Easton), USA, v. 43, p. 15729-15736, 2004.
127. CARNEIRO, F A ; STAUFFER, F ; LIMA, C S ; JULIANO, M A ; JULIANO, L ; POIAN, A T . Membrane fusion induced by vesicular stomatitis virus depends on histidine protonation. The Journal of Biological Chemistry, Estados Unidos, v. 278, p. 13789-13794, 2003.
128. PIMENTA, D C ; FOGAÇA, S e ; MELO, R L ; JULIANO, L ; JULIANO, M A . Specificity of S'1 and S'2 subsites of human tissue Kallikrein using the reactive center loop of Kallistatin: the importance of P'1 and P'2 positions in design of inhibitors.. Biochemical Journal (London), Inglaterra, v. 371, p. 1021-1025, 2003.
129. SCHWINDT, T T ; FORTI, F L ; JULIANO, M A ; JULIANO, L ; ARMELIN, H A . Arginine vasopressin inhibition of cyclin d1 gene expression blocks the cell cycle and cell proliferation in the mouse y1 adrenocortical tumor cell line. . Biochemistry (Easton), Estados Unidos, v. 42, p. 2116-2121, 2003.
130. CHOW, K M ; OAKLEY, O ; GOODMAN, J ; MA, Z ; JULIANO, M A ; JULIANO, L ; HERSH, L B . Nardilysin cleaves peptides at monobasic sites. Biochemistry (Easton), Estados Unidos, v. 42, p. 2239-2244, 2003.
131. LUNDEQUIST, A ; JULIANO, M A ; JULIANO, L ; PEJLER, G . Polycationic peptides as inhibitors of mast cell serine proteases.. Biochemical Pharmacology, Inglaterra, v. 65, p. 1171-1180, 2003.
132. CAMPOS, M ; COUTURE, C ; HIRATA, Iy ; JULIANO, M A ; LOISEL, T P ; CRINE, P ; JULIANO L. ; BOILEAU, G ; CARMONA, A K . Human recombinant PHEX has a strict S1'specificity for acidic residues and cleaves peptides derived from FGF-23 and MEPE.. Biochemical Journal (London), Inglaterra, v. 373, p. 271-279, 2003.
133. GOMES, R A S ; BATISTA, R P ; ALMEIDA, A C ; FONSECA, D N ; JULIANO, L ; HIAL, V . A fluorimetric method for the determination of pepsin activity.. Analytical Biochemistry, Estados Unidos, v. 316, p. 11-14, 2003.
134. OLIVEIRA, V ; ARAUJO, M C ; RIOLI, V ; CAMARGO, A C M ; TERSARIOL, I L ; JULIANO, M A ; JULIANO, L ; FERRO, e S . A structure-based site-directed mutagenesis study on the neurolysin (EC 3.4.24.16) and thimet oligopeptidase (EC 3.4.24.15) catalysis. . FEBS Letters, Inglaterra, v. 541, p. 89-92, 2003.
135. ALVES, M F ; PUZER, L ; COTRIN, S S ; JULIANO, M A ; JULIANO, L ; BROMME, D ; CARMONA, A K . S3 to S3'subsite specificity of recombinant human cathepsin K and development of selective internally quenched fluorescent substrates. Biochemical Journal (London), Inglaterra, v. 373, p. 981-986, 2003.
136. HEMERLY, J P ; OLIVEIRA, V ; NERY, e ; MORTY, R e ; ANDREWS, N W ; JULIANO, M A ; JULIANO, L . Subsite specificity (S3, S2, S1, S2 and S3 ) of Oligopeptidase B from Trypanosoma cruzi and Trypanosoma brucei using Fluorescent-Quenched Peptides: A comparative study and identification of specific carboxypeptidase activity. Biochemical Journal (London), Inglaterra, v. 373, p. 933-938, 2003.
137. SOUZA, D G ; PINHO, V ; PESQUERO, J L ; LOMEZ, e S ; POOLE, S ; JULIANO, L ; CORREA, A ; CASTRO, M S ; TEIXEIRA, Mm . Role of the bradykinin B(2) receptor for the local and systemic inflammatory response that follows severe reperfusion injury. British Journal of Pharmacology, Inglaterra, v. 139, p. 129-139, 2003.
138. MARQUEZIN, C A ; HIRATA, I Y ; JULIANO, L ; ITO, As . Tryptophan as a probe for acid-base equilibria in peptides. Biopolymers (New York), Brasil, v. 71, p. 569-576, 2003.
139. SONG, e S ; JULIANO, M A ; JULIANO, L ; HERSH, L B . Substrate activation of insulin degrading enzyme (Insulysin): A potential target for drug development.. The Journal of Biological Chemistry, USA, v. 278, p. 49789-49794, 2003.
140. SZELTNER, Z ; REA, D ; RENNER, V ; JULIANO, L ; POLGAR, L . Electrostatic environment at the active site of prolyl oligopeptidase is highly influential during substrate binding. The Journal of Biological Chemistry, USA, v. 278, p. 48786-48793, 2003.
141. PERPETUO, e A ; JULIANO, L ; LEBRUN, I . Biochemical and pharmacological aspects of two bradykinin-potentiating peptides obtained from tryptic hydrolysis of casein. . Journal of Protein Chemistry, USA, v. 22, p. 601-606, 2003.
142. IWAI, L K ; YOSHIDA, M ; SIDNEY, J ; YASUDA, M A S ; GOLDBERG, A C ; JULIANO, M A ; HAMMER, J ; JULIANO, L ; SETTE, A ; KALIL, J ; TRAVASSOS, L R ; CUNHANETO, e . In Silico Prediction of Peptides Binding to Multiple HLA-DR Molecules Accurately Identifies Immunodominant Epitopes from gp43 of Paracoccidioides brasiliensis Frequently Recognized in Primary Peripheral Blood Mononuclear Cell Responses from Sensitized Individuals . Molecular Medicine (Cambridge), USA, v. 9, p. 209-219, 2003.
143. KONNO, K. ; PALMA, M. S. ; HIRATA, I Y ; JULIANO, M A ; JULIANO, L ; YASUHARA, T. . Identification of bradykinins in solitary wasp venoms. Toxicon, USA, v. 40, p. 309-312, 2002.
144. LIMA, A P ; ALMEIDA, P C ; TERSARIOL, I L ; SCHMITZ, V. ; SCHMAIER, A. H. ; JULIANO, L ; HIRATA, I Y ; STERL, W. M. ; CHAGAS, J. R. ; SCARFSTEIN, J. . Heparan sulfate modulates kinin release by Trypanosoma cruzi through the activity of cruzipain. The Journal of Biological Chemistry, USA, v. 277, p. 5875-5881, 2002.
145. MARANA, S R ; LOPES, A R ; JULIANO, L ; JULIANO, M A ; FERREIRA, C. ; TERRA, W R . Subsites of trypsin active site favor catalysis or substrate binding. . Biochemical and Biophysical Research Communications, USA, v. 290, p. 494-497, 2002.
146. BRILLARD-BOURDET, M. ; REHAULT, S. ; JULIANO, L ; FERRER, M. ; MOREAU, T ; GAUTHIER, F . Amidolytic activity of prostatic acid phosphatase on human semenogelins and semenogelin-derived synthetic substrates. European Journal of Biochemistry, Belgica, v. 269, p. 309-395, 2002.
147. COSTA, S. K. ; MORENO, R. A. ; ESQUISATTO, L. C. ; JULIANO, L ; BRAIN, S. D. ; NUCCI, G. ; ANTUNES, E. . Role of kinins and sensory neurons in the rat pleural leukocyte migration induced by Phoneutria nigriventer spider venom. Neuroscience Letters, USA, v. 318, p. 158-162, 2002.
148. HILAIRE, P. M. ; ALVES, L. ; HERRERA, F. ; RENIL, M. ; SANDERSON, S. J. ; MOTTRAM, J C ; COOMBS, J. C. ; JULIANO, M A ; JULIANO, L ; AREVALO, J. ; MELDAL, M . Solid-Phase Library Synthesis, Screening, and Selection of Tight-Binding Reduced Peptide Bond Inhibitors of a Recombinant Leishmania mexicana Cysteine Protease B.. Journal of Medicinal Chemistry, USA, v. 45, p. 1971-1982, 2002.
149. BIANCHINI, E. P. ; LOUVAIN, V. B. ; MARQUE, P. E. ; JULIANO, M A ; JULIANO, L ; LEBONIEC, B. F. . Mapping of the catalytic groove preferences of factor Xa reveals an inadequate selectivity for its macromolecule substrates. The Journal of Biological Chemistry, USA, v. 277, p. 20527-20534, 2002.
150. REHAULT, S. ; BRILLARDBOURDET, M. ; BOURGEOIS, L. ; FRENETTE, G. ; JULIANO, L ; GAUTHIER, F ; MOREAU, T . Design of new and sensitive fluorogenic substrates for human kallikrein hK3 (prostate-specific antigen) derived from semenogelin sequences. Biochimica et Biophysica Acta, v. 1596, p. 55-62, 2002.
151. PIMENTA, D C ; NANTES, I L ; SOUZA, E. S. ; BONNIEC, B Le ; ITO, A S ; TERSARIOL, I L ; OLIVEIRA, V ; JULIANO, M A ; JULIANO, L . Interaction of heparin with internally quenched fluorogenic peptides derived from heparin-binding consensus sequences, kallistatin and anti-thrombin III. Biochemical Journal (London), Inglateraa, v. 366, p. 435-446, 2002.
152. PIMENTA, D C ; MELO, R L ; CALIENDO, G ; SANTAGADA, V ; FIORINO, F ; SEVERINO, B ; NUCCI, G ; JULIANO, L ; JULIANO, M A . Design of inhibitors for human tissue kallikrein using non-natural aromatic and basic amino acids. Biological Chemistry, Alemanha, v. 383, p. 853-857, 2002.
153. ATTUCCI, S ; KORKMAZ, B ; JULIANO, L ; HAZOUARD, e ; GIRARDIN, C ; BRILLARDBOURDET, M. ; REHAULT, S. ; ANTHONIOZ, P ; GAUTIER, F . Measurement of free and membrane-bound cathepsin G in human neutrophils using new sensitive fluorogenic substrates.. Biochemical Journal (London), Inglaterra, v. 366, p. 965-970, 2002.
154. KORKMAZ, B ; ATTUCCI, S ; HAZOUARD, e ; FERRANDIERE, M ; JOURDAN, M L ; BRILLARBOURDET, M ; JULIANO, L ; GAUTHIER, F . Discriminating between the activities of human neutrophil elastase and proteinase 3 using serpin-derived fluorogenic substrates.. The Journal of Biological Chemistry, USA, v. 277, p. 39074-39081, 2002.
155. OLIVEIRA, V ; GATTI, R ; RIOLI, V ; FERRO, e S ; SPISNI, A ; CAMARGO, A C ; JULIANO, M A ; JULIANO, L . Temperature and salts effects on the peptidase activities of the recombinant metallooligopeptidases neurolysin and thimet oligopeptidase. . European Journal of Biochemistry, Inglaterra, v. 269, p. 4326-4334, 2002.
156. TURCHIELO, R F ; FREUND, M T L ; HIRATA, I Y ; JULIANO, L ; ITO, A S . Ortho-aminobenzoic acid-labeled bradykinins in interaction with lipid vesicles. Biopolymers (New York), USA, v. 65, p. 336-346, 2002.
157. CEZARI, M H S ; PUZER, L ; JULIANO, M A ; CARMONA, A K ; JULIANO, L . Cathepsin B carboxydipeptidase specificity analysis using internally quenched fluorescent peptides. Biochemical Journal (London), Inglaterra, v. 368, p. 365-369, 2002.
158. PERPETUO, e A ; JULIANO, L ; PRADO, S M ; FRATELLI, F ; FERNANDES, I ; LEBRUN, I . Development of an operational synaptobrevin-based fluorescent substrate for tetanus neurotoxin quantification. . Biotechnology and Applied Biochemistry, USA, v. 36, p. 155-161, 2002.
159. SONG, e S ; MUKHERJEE, A. ; JULIANO, M A ; PYREK, J S ; GOODMAN, J. P. ; JULIANO, L ; HERSH, L B . Analysis of the subsite specificity of rat insulysin using fluorogenic peptide substrates. The Journal of Biological Chemistry, USA, v. 276, p. 1152-1155, 2001.
160. CHEN, V ; CHAO, L ; PIMENTA, D C ; BLEDSOE, G. ; JULIANO, L ; CHAO, J. . Identification of a major heparin-binding site in kallistatin. The Journal of Biological Chemistry, USA, v. 276, p. 1276-1284, 2001.
161. ALMEIDA, P C ; NANTES, I L ; CHAGAS, J. R. ; RIZZI, C C ; FALJONIALARIO, A. ; CARMONA, E. ; JULIANO, L ; NADER, H B ; TERSARIOL, I L . Cathepsin B activity regulation heparin-like glycosaminoglycans protect human cathepsin B from alkaline pH-induced inactivation.. The Journal of Biological Chemistry, USA, v. 276, p. 944-951, 2001.
162. PIMENTA, D C ; OLIVEIRA, A. ; JULIANO, M A ; JULIANO, L . Substrate specificity of human cathepsin D using internally quenched fluorescent peptides derived from reactive site loop of kallistatin.. Biochimica and Biophysica Acta, Holanda, v. 1544, p. 113-122, 2001.
163. ALVES, L. C. ; MELO, R L ; SANDERSON, S. J. ; MORTTRAM, J. C. ; COOMBS, G H ; CALIENDO, G ; SANTAGADA, V ; JULIANO, L ; JULIANO, M A . S1 subsite specificity of a recombinant cysteine proteinase, CPB, of Leishmania mexicana compared with cruzain, human cathepsin L and papain using substrates containing non-natural basic amino acids.. European Journal of Biochemistry, Belgica, v. 268, p. 1206-1212, 2001.
164.   OLIVEIRA, V ; CAMPOS, M ; MELO, R L ; FERRO, e S ; CAMARGO, A C ; JULIANO, M A ; JULIANO, L . Substrate Specificity Characterization of Recombinant Metallo Oligo-Peptidases: Thimet Oligopeptidase and Neurolysin. . Biochemistry (Easton), USA, v. 40, p. 4417-4425, 2001.
165. MELO, R L ; POSO, R. C. B. ; ALVES, L. C. ; PERISSUTI, E. ; CALIENDO, G ; SANTAGADA, V ; JULIANO, L ; JULIANO, M A . Synthesis and hydrolysis by cathepsin B of fuorogenic substrates with the general structure benzoyl-X-ARG-MCA containing non-natural basic amino acids at position X.. Biochimica and Biophysica Acta, Holanda, v. 1547, p. 82-94, 2001.
166. KONNO, K. ; HISADA, M. ; NAOKI, H. ; ITAGAKI, Y. ; YASUHARA, T. ; JULIANO, M A ; JULIANO, L ; PALMA, M. S. ; YAMANE, T. ; NAKAJIMA, T. . Isolation and sequence determination of peptides in the venom of the spider wasp (Cyphononyx dorsalis) guided by matrix-assisted laser desorption/ionization time of flight (MALDI-TOF) mass spectrometry. Toxicon, USA, v. 39, p. 1257-1260, 2001.
167. MELO, R L ; POZZO, R C ; PIMENTA, D C ; PERISSUTTI, E. ; CALIENDO, G ; SANTAGADA, V ; JULIANO, L ; JULIANO, M A . Human tissue kallikrein S(1) subsite recognition of non-natural basic amino acids.. Biochemistry (Easton), USA, v. 40, p. 5226-5232, 2001.
168. MAGDESIAN, M H ; GIORDANO, R. ; ULRICH, H ; JULIANO, M A ; JULIANO, L ; SCHUMACHER, R. I. ; COLLI, W ; ALVES, M J . Infection by Trypanosoma cruzi: identification of a parasite ligand and its host-cell receptor. The Journal of Biological Chemistry, USA, v. 276, p. 19382-19389, 2001.
169. OLIVEIRA, V ; CAMPOS, M ; HEMERLY, J P ; FERRO, e S ; CAMARGO, A C M ; JULIANO, L ; JULIANO, M A . Selective neurotensin-derived internally quenched fluorogenic substrates for neurolysin (ec 3.4.24.16): comparison with thimet oligopeptidase (ec 3.4.24.15) and neprilysin (E.C. 3.4.24.11). . Analytical Biochemistry, U.S.A, v. 292, p. 257-265, 2001.
170. LIMA, A P ; REIS, F C ; SERVEAU, C. ; LALMANACH, G. ; JULIANO, L ; MENARD, R. ; VERNET, T. ; THOMAS, D. Y. ; STORER, A. C. ; SCHARFSTEIN, J . Cysteine protease isoforms from Trypanosoma cruzi, cruzipain 2 and cruzain, present different substrate preference and susceptibility to inhibitors. Molecular and Biochemical Parasitology, Holanda, v. 114, p. 41-52, 2001.
171. ALVES, L. C. ; HIILARE, P. M. S. ; MELDAL, M ; SANDERSON, S. J. ; MOTTRAM, J C ; COOMBS, G H ; JULIANO, L ; JULIANO, M A . Identification of peptides inhibitory to recombinant cysteine proteinase, CPB, of Leishmania mexicana. Molecular and Biochemical Parasitology, Holanda, v. 114, p. 81-88, 2001.
172. MELO, R L ; ALVES, L. C. ; NERY, e Del ; JULIANO, L ; JULIANO, M A . Synthesis and hydrolysis by cysteine and serine proteases of short internally quenched fluorogenic peptides. Analytical Biochemistry, USA, v. 293, p. 71-77, 2001.
173. IWAI, L K ; DURANTI, M. A. ; JULIANO, L ; JULIANO, M A ; ABEL, L C ; KALIL, J ; CUNHA NETO, e . Retro-inverso peptide analogues of Trypanosoma cruzi B13 protein epitopes fail to be recognized by human sera and peripheral blood mononuclear cells. Peptides (New York), USA, v. 22, p. 853-860, 2001.
174. ALVES, L. C. ; JUDICE, W A ; HILARE, P. M. ; MELDAL, M ; SANDERSON, S. J. ; MOTTRAM, J C ; COOMBS, J. C. ; JULIANO, L ; JULIANO, M A . Substrate specificity of recombinant cysteine proteinase, CPB, of Leishmania mexicana. Molecular and Biochemical Parasitology, Holanda, v. 116, p. 1-9, 2001.
175. ZANI, M. ; BRILLARD-BOURDET, M. ; LAZURE, C. ; JULIANO, L ; COURTY, Y. ; GAUTHIER, F ; MOREAU, T . Purification and characterization of active recombinant rat kallikrein rK9.. Biochimica et Biophysica Acta, Holanda, v. 1547, p. 387-396, 2001.
176. CORDOVA, M. ; JARA, J. ; NERY, e Del ; HIRATA, I Y ; ARAUJO, M S ; CARMONA, A K ; JULIANO, M A ; JULIANO, L . Characterization of two cysteine proteinases secreted by Fasciola hepatica and demonstration of their kininogenase activity.. Molecular and Biochemical Parasitology, Holanda, v. 116, p. 109-115, 2001.
177. ALVES, L. C. ; MELO, R L ; CEZARI, M H S ; SANDERSON, S. J. ; MOTTRAM, J C ; COOMS, G. H. ; JULIANO, L ; JULIANO, M A . Analysis of the S(2) subsite specificities of the recombinant cysteine proteinases CPB of Leishmania mexicana, and cruzain of Trypanosoma cruzi, using fluorescent substrates containing non-natural basic amino acids. Molecular and Biochemical Parasitology, Holanda, v. 117, p. 137-143, 2001.
178. CORDEIRO, Y. ; MACHADO, F. ; JULIANO, L ; JULIANO, M A ; BRENTANI, R. R. ; FOLGUEL, D. ; SILVA, J L . DNA converts cellular prion protein into the beta-sheet conformation and inhibits prion peptide aggregation. The Journal of Biological Chemistry, USA, v. 276, p. 49400-49409, 2001.
179. ANEAS, M. A. ; PORTARO, F C ; LEBRUN, I ; JULIANO, L ; PALMA, M. S. ; FERNANDES, B. L. . ZapA, a possible virulence factor from Proteus mirabilis exhibits broad protease substrate specificity. . Brazilian Journal of Medical and Biological Research, Brasil, v. 34, p. 397-403, 2001.
180. JUDICE, W A ; CEZARI, M H S ; LIMA, A P ; SCHARFSTEIN, J ; CHAGAS, J. R. ; TERSARIOL, I L ; JULIANO, M A ; JULIANO, L . Comparison of the specificity, stability and individual rate constants with respective activation parameters for the peptidase activity of cruzipain and its recombinant form, cruzain, from Trypanosoma cruzi.. European Journal of Biochemistry, Belgica, v. 268, p. 6578-6586, 2001.
181. MANQUE, P. M. ; EICHINGER, D. ; JULIANO, M A ; JULIANO, L ; ARAYA, J. E. ; YOSHIDA, N. . Characterization of the Cell Adhesion Site of Trypanosoma cruzi Metacyclic Stage Surface Glycoprotein gp82. Infection and Immunity, Estados Unidos, v. 68, p. 478-484, 2000.
182. MARQUE, P. E. ; SPUNTARELLI, R. ; JULIANO, L ; AIACH, M. ; BONNIEC, B. F. L. . The Role of Glu(192) in the Allosteric Control of the S(2)'and S(3)'Subsites of Thrombin. The Journal of Biological Chemistry, Estados Unidos, v. 275, p. 809-816, 2000.
183. APLETALINA, e V . ; JULIANO, M A ; JULIANO, L ; LINDBERG, I . Structure-function analysis of the 7B2 CT peptide.. Biochemical and Biophysical Research Communications, Inglaterra, v. 267, p. 940-942, 2000.
184. OLIVEIRA, V. ; FERRO, e S ; GOMES, M. D. ; OSHIRO, M. E. ; ALMEIDA, P C ; JULIANO, M A ; JULIANO, L . Characterization of thiol-, aspartyl-, and thiol-metallo-peptidase activities in Madin-Darby Canine Kidney cells. Journal of Cellular Biochemistry, Estados Unidos, v. 76, p. 478-488, 2000.
185. PORTARO, F. C. V. ; SANTOS, A. B. F. ; CEZARI, M H S ; JULIANO, M A ; JULIANO, L ; CARMONA, E. . Probing the specificity of cysteine proteinases at subsites remote from the active site: analysis of P4, P3, P2', and P3'variations in extended substrates. Biochemical Journal (London), Inglaterra, v. 347, p. 123-129, 2000.
186. GUNCAR, G ; KLEMENCIC, I. ; TURK, B ; TURK, V. ; CARMONA, A K ; JULIANO, L ; TURK, D . Crystal structure of cathepsin X: a flip-flop of the ring of His23 allows carboxy-monopeptidase and carboxy-dipeptidase activity of the protease. Structure (London), Inglaterra, v. 8, p. 305-313, 2000.
187. SOUZA, E. S. ; HIRATA, I Y ; JULIANO, L ; ITO, A S . End-to-end distance distribution in bradykinin observed by Forster resonance energy transfer. Biochimica and Biophysica Acta, Holanda, v. 1474, p. 251-261, 2000.
188. SANDERSON, S. J. ; POLLOK, K. G. ; HILLEY, K. G. ; MELDAL, M ; HILAIRE, P S ; JULIANO, M A ; JULIANO, L ; MOTTRAM, J C ; COOMBS, G H . Expression and characterization of a recombinant cysteine proteinase of Leishmania mexicana. Biochemical Journal (London), Inglaterra, v. 347, p. 383-388, 2000.
189. LUKE, C. ; SCHICK, C. ; TSU, C. ; WHISSTOCK, J. C. ; IRVING, J. A. ; BROMME, D ; JULIANO, L ; GHI, G. P. ; SILVERMAN, G. A. . Simple modifications of the serpin reactive site loop convert SCCA2 into a cysteine proteinase inhibitor: a critical role for the P3'proline in facilitating RSL cleavage. Biochemistry (Easton), USA, v. 39, p. 7081-7091, 2000.
190. CHOW, K M ; CSUHAI, E. ; JULIANO, M A ; PYREK, J. S. ; JULIANO, L ; HERSCH, L. B. . Studies on the subsite specificity of rat nardilysin (N-arginine dibasic convertase) . The Journal of Biological Chemistry, USA, v. 275, p. 19545-19551, 2000.
191. ALMEIDA, P C ; OLIVEIRA, V ; CHAGAS, J. R. ; MELDAL, M ; JULIANO, M A ; JULIANO, L . Hydrolysis by cathepsin B of fluorescent peptides derived from human prorenin. Hypertension (Dallas), USA, v. 35, p. 1278-1283, 2000.
192. NERY, e Del ; ALVES, L. C. ; MELO, R L ; CEZARI, M H S ; JULIANO, L ; JULIANO, M A . Specificity of cathepsin B to fluorescent substrates containing benzyl side-chain-substituted amino acids at P1 subsite. Journal of Protein Chemistry, USA, v. 19, p. 33-38, 2000.
193. ALMEIDA, P C ; CHAGAS, J. R. ; CEZARI, M H S ; JULIANO, M A ; JULIANO, L . Hydrolysis by plasma kallikrein of fluorogenic peptides derived from prorenin processing site . Biochimica et Biophysica Acta, Holanda, v. 1479, p. 83-90, 2000.
194. TURCHIELLO, R. F. ; JULIANO, L ; ITO, A S ; LAMYFREUND, M. T. . How bradykinin alters the lipid membrane structure: A spin label comparative study with bradykinin fragments and other cations. Biopolymers (New York), USA, v. 54, p. 211-221, 2000.
195. FERNANDES, B. L. ; ANEAS, M. A. ; JULIANO, L ; PALMA, M. S. ; LEBRUN, I ; PORTARO, F C . Development of an operational substrate for ZapA, a metalloprotease secreted by the bacterium Proteus mirabilis. Brazilian Journal of Medical and Biological Research, Brasil, v. 33, p. 765-770, 2000.
196. EMIN, J A ; SUCCAR, C. ; CASTRO, M. S. A. ; GODINHO, R. O. ; CEZARI, M H S ; JULIANO, L ; LAPA, A J . Evidence for activation of the tissue kallikrein-kinin system in nociceptive transmission and inflammatory responses of mice using a specific enzyme inhibitor. British Journal of Pharmacology, In glaterra, v. 130, p. 1099-1107, 2000.
197. SORGINE, M. H. ; LOGULLO, C. ; ZINGALI, R. B. ; SILVA, G. O. P. ; JULIANO, L ; OLIVEIRA, P. L. . A heme-binding aspartic proteinase from the eggs of the hard tick Boophilus microplus.. The Journal of Biological Chemistry, USA, v. 275, p. 28659-28665, 2000.
198. YOUNG, V. ; SCHMITZ, V. ; SANTOS, M. A. V. ; LIMA, A. P. C. D. ; LALMANACH, G. ; JULIANO, L ; GAUTHIER, F . Altered expression of cruzipain and a cathepsin B-like target in a Trypanosoma cruzi cell line displaying resistance to synthetic inhibitors of cysteine-proteinases . Molecular and Biochemical Parasitology, Holanda, v. 109, p. 47-59, 2000.
199. ARAUJO, M C ; MELO, R L ; CEZARI, M H S ; JULIANO, M A ; JULIANO, L ; CARMONA, A K . Peptidase specificity characterization of C- and N-terminal catalytic sites of angiotensin I-converting enzyme.. Biochemistry (Easton), USA, v. 39, p. 8519-8525, 2000.
200. KLEMENCIC, I. ; CARMONA, A K ; CEZARI, M H S ; JULIANO, M A ; JULIANO, L ; GUNCAR, G ; TURK, D ; KRIZAJ, I. ; TURK, V. ; TURK, B . Biochemical characterization of human cathepsin X revealed that the enzyme is an exopeptidase, acting as carboxymonopeptidase or carboxydipeptidase . European Journal of Biochemistry, Belgica, v. 267, p. 5404-5412, 2000.
201. HILARI, P M ; ALVES, L. C. ; SANDERSON, S. J. ; MOTTRAM, J C ; JULIANO, M A ; JULIANO, L ; COOMBS, G H ; MELDAL, M . The substrate specificity of a recombinant cysteine protease from Leishmania mexicana: Application of a combinatorial peptide library approach.. ChemBioChem, Alemanha, v. 1, p. 115-121, 2000.
202. LOFTI, C. F. ; LEPIQUE, A. P. ; FORTI, F L ; SCHWIND, T. T. ; EICHLER, C. B. ; SANTOS, M. O. ; REBUSTINI, I. T. ; HAJJ, G. N. ; JULIANO, L ; ARMELIN, H A . Proliferative signaling initiated in ACTH receptors.. Brazilian Journal of Medical and Biological Research, Brasil, v. 33, p. 1133-1140, 2000.
203. SCHARFSTEIN, J ; SCHMITZ, V. ; MORANDI, V. ; CAPELA, M. M. ; LIMA, A P ; MORROT, A. ; JULIANO, L ; MULLERESTERL, W. . Host cell invasion by Trypanosoma cruzi is potentiated by activation of bradykinin B(2) receptors. . Journal of Experimental Medicine, USA, v. 192, p. 1289-1300, 2000.
204. PIMENTA, D C ; CHEN, V. C. ; CHAO, J. ; JULIANO, M A ; JULIANO, L . alpha(1)-antichymotrypsin and kallistatin hydrolysis by human cathepsin D. Journal of Protein Chemistry, USA, v. 19, p. 411-418, 2000.
205. QUINTO, B. M. ; JULIANO, M A ; HIRATA, I Y ; CARMONA, A K ; JULIANO, L ; CASARINI, D e . Characterization of a prolyl endopeptidase (kininase) from human urine using fluorogenic quenched substrates . International Journal of Biochemistry & Cell Biology, USA, v. 32, p. 1161-1172, 2000.
206. PUCCIA, R. ; JULIANO, M. A. ; JULIANO, L ; CARMONA, A. K. ; TRAVASOS, L. R. . Characterization of an exocellular serine-thiol proteinase activity in Paracoccidioides brasilensis.. Brazilian Journal of Medical and Biological Research, Brasil, v. 32, p. 645-649, 1999.
207. JULIANO, M. A. ; FILIRA, F. ; GOBBO, M. ; ROCCHI, R. ; NERY, E. ; JULIANO, L . Chromogenic and fluorogenic glycosylated and acetylglycosylated peptides as substrates for serine, thiol and aspartyl proteases.. Journal of Peptide Research, USA, v. 53, p. 51-54, 1999.
208. Carvalho KM ; Nava RA ; Franca MSF ; Camarao GC ; JULIANO, L . A liver metalloendopeptidase which degrades the circulating hypotensive peptide hormones bradykinin and atrial natriuretic peptide.. Brazilian Journal of Medical and Biological Research, Brasil, v. 32, p. 51-54, 1999.
209. PIMENTA, D. C. ; CHAO, J. ; CHAO, L. ; JULIANO, M. A. ; JULIANO, L . Specificity of human tissue kallikrein towards substrates containing Phe-Phe pair of amino acids.. Biochemical Journal (London), U.K., v. 339, p. 473-479, 1999.
210. MAURICIO, M C. ; MELO, R I ; NERY, e Del ; ALVES, M F ; JULIANO, M A ; CASARINI, D e ; JULIANO L. ; Carmona AK . Internally quenched fluorogenic substrates for angiotensin I-converting enzyme. Journal of Hypertension, Holanda, v. 17, p. 665-672, 1999.
211. CSUHAI, E. ; JULIANO, M. A. ; HARMS, A. ; JULIANO, L ; LB, H. . New fluorogenic substrates for N-arginine dibasic convertase.. Analytical Biochemistry, USA, v. 269, p. 149-154, 1999.
212. RÉHAULT, S. S. ; BRILLARD-BOURDET, M. ; JULIANO, M A ; JULIANO, L ; GAUTHIER, F. ; MOREAU, T. . New, sensitive fluorogenic substrates for human cathepsin G based on the sequence of serpin-reactive site loops.. The Journal of Biological Chemistry, USA, v. 274, p. 13810-13817, 1999.
213. CSUHAI, E. ; JULIANO, M. A. ; JULIANO, L ; HERSH, L. B. . Kinetic analysis of spermine binding to NRD convertase.. Archives of Biochemistry and Biophysics, USA, v. 362, p. 291-300, 1999.
214. PORTARO, F. C. V. ; GOMES, M. D. ; CABRERA, A ; FERNANDEZ, B. L. ; SILVA, C. L. ; FERRO, E. S. ; JULIANO, L ; CAMARGO, A. C. M. . Thimet oligopeptidase and the stability of MHC class I epitopes in macrophage cytosol.. Biochemical and Biophysical Research Communications, USA, v. 255, p. 596-601, 1999.
215. BERMAN, Y. ; JULIANO, L ; DEVI, L. A. . Specificity of the dynorphin-processing endoprotease: comparison with prohormone convertases.. Journal of Neurochemistry, USA, v. 72, p. 2120-2126, 1999.
216.   MULLER, L. ; ZHU, P. ; JULIANO, M. A. ; JULIANO, L ; LINDBERG, I. . A 36-residue peptide contains all of the information required for 7B2-mediated activation of prohormone convertase 2.. The Journal of Biological Chemistry, USA, v. 274, p. 21471-21477, 1999.
217. HENKEL, M. ; POTT, G. ; HENKEL, A. W. ; JULIANO, L ; KAM, C. M. ; POWERS, J. C. ; FRANZUSOFF, A. . Endocytic delivery of intramolecularly quenched substrates and inhibitors to the intracellular yeast Kex2 protease1.. Biochemical Journal (London), Ingaterra, v. 341, p. 445-452, 1999.
218. Puccia R ; Juliano MA ; JULIANO, L ; Travassos LR ; Carmona AK . Detection of the basement membrane-degrading proteolytic activity of Paracoccidioides brasiliensis after SDS-PAGE using agarose overlays containing Abz-MKALTLQ-EDDnp . Brazilian Journal of Medical and Biological Research, Brasil, v. 32, p. 645-649, 1999.
219. ALMEIDA, P. C. ; NANTES, P. C. ; NANTES, I L ; JUDICE, W. A. S. ; CHAGAS, J. R. ; JULIANO, L ; NADER, H B ; TERSARIOL, I. L. S. . Cysteine proteinase activity regulation: A possible role of heparin and heparin-like glycosaminoglycans. The Journal of Biological Chemistry, USA, v. 274, p. 30433-30438, 1999.
220. HILAIRE, P. M. S. ; WILLERT, P. M. ; JULIANO, M. A. ; JULIANO, L ; MELDAL, M. . Fluorescence-quenched solid phase combinatorial libraries in the characterization of cysteine proteases substrate specificity.. Journal of Combinatorial Chemistry, USA, v. 1, p. 509-523, 1999.
221. NERY, E. ; CHAGAS, J. R. ; JULIANO, M. A. ; JULIANO, L ; PRADO, e S . Comparison of human and porcine tissue kallikrein substrate specificities. Immunopharmacology, Holanda, v. 45, p. 151-157, 1999.
222. MELDAL, M. ; SVENDSEN, I. ; JULIANO, L ; JULIANO, M. A. ; NERY, E. ; SCHARFSTEIN, J. . Inhibition of cruzipain visualized in a fluorescence quenched solid-phase inhibitor library assay. D-amino acid inhibitors for cruzipain, cathepsin B and cathepsin L.. Journal of Peptide Science, Holanda, v. 4, p. 83-91, 1998.
223. TURCHIELLO, R. F. ; LAMY-FREUND, M. T. ; HIRATA, I. Y. ; JULIANO, L ; ITO, A. S. . Ortho-aminobenzoic acid as a fluorescent probe for the interaction between peptides and micelles.. Biophysical Chemistry, USA, v. 73, p. 217-225, 1998.
224. JACCHIERI, S. C. ; GOMES, M. D. ; JULIANO, L ; CAMARGO, A. C. M. . A comparative conformational analysis of Thimet Oligopeptidase (EC 3.4.24.15) substrates.. European Journal of Biochemistry, USA, v. 51, p. 452-459, 1998.
225. JOHANNING, K. ; JULIANO, M. A. ; JULIANO, L ; LAZURE, C. ; LOMANGO, N. S. ; STEINER, D. F. ; LINDBERG, I. . Specificity of prohormone convertase 2 on proenkephalin and proenkephalin-related substrates.. The Journal of Biological Chemistry, USA, v. 273, p. 22672-22680, 1998.
226. ITO, A. S. ; TURCHIELLO, R. F. ; HIRATA, I. Y. ; CEZARI, M. H. S. ; MELDAL, M. ; JULIANO, L . Fluorescent properties of amino acids labeled with ortho-aminobenzoic acid. Biospectroscopy, USA, v. 4, p. 395-402, 1998.
227. CARVALHO, W. S. ; LOPES, C. T. ; JULIANO, L ; COELHO, P. M. Z. ; MELO, J. R. C. ; BERALDO, W. T. ; PESQUERO, J. L. . Purification and partial characterization of kininogenase activity from Schistosoma mansoni adult worms.. Parasitology (London), USA, v. 117, p. 311-319, 1998.
228. NERY, E. M. A. ; JULIANO, M. A. ; MORTEN, I. ; SVENDSEN, J. ; SHARFSTEIN, A. R. ; WALMSLEY, L. ; JULIANO, L . Characterization of the substrate specificity of the major cysteine protease (cruzipain) from Trypanosoma cruzi using a portion-mixing combinatorial library and fluorogenic peptides.. Biochemical Journal (London), U.K., v. 323, p. 427-433, 1997.
229. CAMARGO, A. C. M. ; GOMES, M. D. ; REICHL, A. P. ; FERRO, E. S. ; JACCHIERI, S. ; HIRATA, I. Y. ; JULIANO, L . Structural features that make oligopeptides susceptible substrates for hydrolysis by recombinant thimet oligopeptidase.. Biochemical Journal (London), Inglaterra, v. 324, p. 517-522, 1997.
230. PORTARO, F. C. V. ; CEZARI, M. H. S. ; JULIANO, M. A. ; JULIANO L. ; WALMSLEY, A R ; PRADO, E. S. . Design of kallidin-releasing tissue kallikrein inhibitors based on the specificities of the enzyme's binding subsites.. Biochemical Journal (London), Inglaterra, v. 323, p. 167-171, 1997.
231. HIRATA, I. Y. ; SEDENHO, M. H. C. ; BOSCHCOV, P. ; GARRATT, R. C. ; OLIVA, G. G. ; ITO, A. S. ; SPISNI, A. ; FRANZONI, L. ; JULIANO, L . Reduction of ortho-aminobenzoyl-proline fluorescence and formation of pyrrolobenzodiazepine-5,11-Dione. Letters in Peptide Science, Holanda, v. 5, p. 19-28, 1997.
232. CHAGAS, J. R. ; AUTHIE, E. ; SERVEAU, C. ; LALMANACH, G. ; JULIANO, L ; GAUTHIER, F. . A comparison of the enzymatic properties of the major cysteine proteinases from Trypanosoma congolense and Trypanosoma cruzi.. Molecular and Biochemical Parasitology, USA, v. 88, p. 85-94, 1997.
233. GOMES, R. A. ; JULIANO, L ; CHAGAS, J. R. ; HIAL, V. . Characterization of kininogenase activity of an acidic proteinase isolated from human kidney.. Canadian Journal of Physiology and Pharmacology, Canada, v. 75, p. 757-761, 1997.
234. LOPES, E. S. ; JULIANO L. ; SUMITANI, M. ; JULIANO, L ; BERALDO, W. T. ; PESQUERO, J. L. . Distribution of tonin- and kallikrein-like activities in rat brain. Brain Research, USA, v. 769, p. 152-157, 1997.
235. MEDEIROS, M. A. ; FRANCA, M. S. ; BOILEAU, G. ; JULIANO, L ; CARVALHO, K. M. . Specific fluorogenic substrates for neprilysin (neutral endopeptidase, EC 3.4.24.11) which are highly resistant to serine- and metalloproteases.. Brazilian Journal of Medical and Biological Research, Brasil, v. 30, p. 1157-1162, 1997.
236. NAGLER, D. K. ; STORER, A. C. ; PORTARO, F. C. ; CARMONA, E. ; JULIANO, L ; MENARD, R. . Major increase in endopeptidase activity of human cathepsin B upon removal of occluding loop contacts.. Biochemistry (Easton), USA, v. 36, p. 12609-12615, 1997.
237. BOURGEOIS, L. ; DEPERTHES, D. B. ; JULIANO, M. A. ; JULIANO, L ; TREMBLAY, R. R. ; DUBÉ, J. Y. ; GAUTHIER, F. . Serpin-derived peptide substrates for investigating the substrate specificity of human tissue kallikreins hK1 and hK2.. The Journal of Biological Chemistry, USA, v. 272, p. 29590-29595, 1997.
238. PIMENTA, C. D. ; JULIANO, M. A. ; JULIANO, L . Hydrolysis of somatostatin by human tissue kallikrein after the amino acid pairPhe-Phe. Biochemical Journal (London), U.K., v. 327, p. 27-30, 1997.
239. NERY, E. ; JULIANO, M. A. ; LIMA, A. P. C. A. ; SCHARFSTEIN, J. ; JULIANO, L . Kininogenase activity by the major cysteinyl proteinase (cruzipain) from Trypanosoma cruzi. The Journal of Biological Chemistry, USA, v. 272, p. 25713-25718, 1997.
240. VANHOOF, G. ; GOOSSENS, F. ; JULIANO, M A ; JULIANO, L ; HENDRIKS, D. ; SCHATTEMAN, K. ; SCHARPE, S. L. A. . Isolation and sequence analysis of a human cDNA clone (XPNPEPL) homologous to X-prolyl aminopeptidase (aminopeptidase P). Cytogenetics and Cell Genetics, Holanda, v. 78, p. 275-280, 1997.
241. VANHOOF, G. ; GOOSSENS, F. ; JULIANO, M. A. ; JULIANO, L ; HENDRIKS, I. D. ; SCHATTEMAN, K. ; SCHARPE, S. . Human lymphocyte X-prolyl aminopeptidase (aminopeptidase P)-like protein. A new member of the proline peptidase family? . Advances in Experimental Medicine and Biology, Holanda, v. 421, p. 25-29, 1997.
242. MOLINA, H. M. ; JULIANO L. ; CARMONA, A. K. ; KOUYOUMDJIAN, M. ; BORGES, D. R. ; JULIANO, L. . Liver bradykinin-inactivating-endopeptidase is similar to the metalloendopeptidase (EC 3.4.24.15).. Immunopharmacology, USA, v. 32, p. 176-179, 1996.
243. BIZETO, L. ; ANTUNES, E. ; PORTARO, F C. V. ; JULIANO, M. A. ; JULIANO, L ; PRADO, E. S. ; NUCCI, G. . Pharmacological characterization of novel tissue kallikrein inhibitors in vivo.. Immunopharmacology, USA, v. 32, p. 111-114, 1996.
244. GOMES-SILVA, R. A. ; CHAGAS, J. R. ; JULIANO, L ; HIAL, V. . Met-Lys-bradykinin-Ser, the kinin released from human kininogen by human pepsin.. Immunopharmacology, USA, v. 32, p. 73-75, 1996.
245. SANTORI, F. R. ; DORTA, M. L. ; JULIANO, L ; SILVEIRA, J. S. ; CRUZ, R. C. ; YOSHIDA, N. . Identification of a domain of Trypanosoma cruzi metacyclic trypomastigote surface molecule gp82 required for attachment and invasion of mammalian cells.. Molecular and Biochemical Parasitology, USA, v. 78, p. 209-216, 1996.
246. ALVES, L. C. ; ALMEIDA, P. C. ; FRANZONI, L. ; JULIANO, L ; JULIANO, M A . Synthesis of N alpha-protected aminoacyl 7-amino-4-methyl-coumarin amide by phosphorous oxychloride and preparation of specific fluorogenic substrates for papain.. Peptide Research, USA, v. 9, p. 92-96, 1996.
247. CEZARI, M. H. S. ; JULIANO, L . Studies on lactam formation during coupling procedures of N alpha-N omega-protected arginine derivatives.. Peptide Research, USA, v. 9, p. 88-91, 1996.
248. SERVEAU, C. ; LALMANACH, G. ; JULIANO, M. A. ; SCHARFSTEIN, J. ; JULIANO, L ; GAUTHIER, F. . Investigation of the substrate specificity of cruzipain, the major cysteine proteinase of Trypanosoma cruzi, through the use of cystatin-derived substrates and inhibitors.. Biochemical Journal (London), Inglaterra, v. 313, p. 951-956, 1996.
249. CARMONA, A. K. ; JULIANO, L . Inhibition of angiotensin converting enzyme and potentiation of bradykinin by retro-inverso analogues of short peptides and sequences related to angiotensin I and bradykinin. Biochemical Pharmacology, USA, v. 51, p. 1051-1060, 1996.
250. CARVALHO, K. M. ; BOILEAU, G. ; CAMARGO, A. C. M. ; JULIANO, L . A highly selective assay for neutral endopeptidase based on the cleavage of a fluorogenic substrate related to Leu-enkephalin.. Analytical Biochemistry, USA, v. 237, p. 167-173, 1996.
251. CARVALHO, K. M. ; BOILEAU, G. ; FRANÇA, M. S. F. ; MEDEIROS, M. A. S. ; CAMARGO, A. C. M. ; JULIANO, L . A new fluorometric assay for neutral endopeptidase (EC 3.4.24.11).. Brazilian Journal of Medical and Biological Research, Brasil, v. 28, p. 1055-1059, 1995.
252. SANCHEZ, E. F. ; JULIANO L. ; CORDEIRO, M. N. ; OLIVEIRA, E. B. ; JULIANO, L. ; PRADO, E. S. ; DINIZ, C. R. . Proteolytic Specificity Of Two Hemorragic Factors, Lhf-I And Lhf-Ii Isolated From Bushmaster Snake (Lachesis Muta Muta).. Toxicon, v. 33, p. 1061-1069, 1995.
253. CASARINI, D. E. ; CARMONA, A. K. ; PLAVNIK, F. L. ; ZANELLA, M. T. ; JULIANO, L ; RIBEIRO, A. B. . Calcium channel blockers as inhibitors of angiotensin I-converting enzyme.. Hypertension (Dallas), USA, v. 26, p. 1145-1148, 1995.
254. LALMANACH, G. ; SERVEAU, C. ; BRILLARD-BOURDET, M. ; CHAGAS, J. R. ; MEYER, R. ; JULIANO, L ; GAUTHIER, F. . Conserved cystatin segments as models for designing specific substrates and inhibitors of cysteine proteinases. Journal of Protein Chemistry, USA, v. 14, p. 645-653, 1995.
255. BERMAN, Y. L. ; JULIANO, L ; DEVI, L. A. . Purification and characterization of a dynorphin-processing endopeptidase.. The Journal of Biological Chemistry, USA, v. 270, p. 23845-23850, 1995.
256. NERY, E. ; CHAGAS, J. R. ; JULIANO, M A ; PRADO, e S ; JULIANO, L . Evaluation of the extent of the binding site in human tissue kallikrein by synthetic substrates with sequences of human kininogen fragments.. Biochemical Journal (London), Inlaterra, v. 312, p. 233-238, 1995.
257. BRENNAN, J. D. ; CLARK, I. D. ; HOGUE, C. W. V. ; ITO, A. S. ; JULIANO, L ; PAIVA, A. C. M. ; RAJENDRAN, B. ; SZABO, A. G. . Interaction of enantiomers of Lysyl-7-azatryptophanyl-lysine with acidic phospholipid vesicles: A fluorescence study. Applied Spectroscopy, USA, v. 49, p. 51-59, 1995.
258. LEBRUN, I. ; LEBRUN, F L ; HENRIQUES, O. B. ; CARMONA, A. K. ; JULIANO, L ; CAMARGO, A. C. M. . Isolation and characterization of a new bradykinin potentiating octapeptide from gamma-casein.. Canadian Journal of Physiologogy and Pharmacology, Canada, v. 73, p. 85-91, 1995.
259. CARMONA, A. K. ; PUCCIA, R. ; OLIVEIRA, M. C. F. ; RODRIGUES, E. G. ; JULIANO, L ; TRAVASSOS, L. R. . Characterization of an exocellular serine-thiol proteinase activity in Paracoccidioides brasiliensis.. Biochemical Journal (London), Inglaterra, v. 309, p. 209-214, 1995.
260. CHAGAS, J. R. ; PORTARO, F. F. C. V. ; HIRATA, I. Y. ; ALMEIDA, P. C. ; JULIANO, M. A. ; JULIANO, L ; PRADO, E. S. . Determinants of the unusual cleavage specificity of lysyl-bradykinin-releasing kallikreins.. Biochemical Journal (London), Inglaterra, v. 306, p. 63-69, 1995.
261. CAMARGO, A. C. ; GOMES, M. D. ; TOFFOLETTO, O. ; RIBEIRO, M. J. L. ; FERRO, E. S. ; FERNANDES, B. L. ; SUZUKI, K. ; SASAKI, L. ; JULIANO, L . Structural requirements of bioactive peptides for interaction with endopeptidase 22.19.. Neuropeptides (Edinburgh), USA, v. 26, p. 281-287, 1994.
262. HIRATA, Y. ; CEZARI, M. H. S. ; NAKAIE, C. R. ; BOSCHCOV, P. ; ITO, A. S. ; JULIANO, A. M. ; JULIANO, L . Internally quenched fluorogenic protease substrates: solid-phase synthesis and fluorescence spectroscopy of peptides containing ortho-aminobenzoyl / dinitrophenyl groups as donor-acceptor pairs.. Letters in peptide science, USA, v. 1, p. 299-308, 1994.
263. SERVEAU, C. ; JULIANO, L ; BERNARD, P. ; MOREAU, T. ; MAYAER, R. ; GAUTHIER, F. . New substrates of papain, based on the conserved sequence of natural inhibitors of the cystatin family. . Biochimie (Paris), França, v. 76, p. 153-158, 1994.
264. GAUTHIER, F. ; MOREAU, T. ; LALMANACH, G. ; BRILLARD-BOUDET, M. ; FERRERDIMARTINO, M ; JULIANO, L . A new, sensitive fluorogenic substrate for papain based on the sequence of the cystatin inhibitory site.. Archives of Biochemistry and Biophysics, USA, v. 306, p. 304-308, 1993.
265. CARMONA, E. ; PORTARO, F. C. V. ; JULIANO, L ; PICARELLI, Z P ; PRADO, E. S. . Further characterization of bothropain, a cysteine peptidase from the plasma of the snake Bothrops Jararaca. Comparative Biochemistry and Physiology, USA, v. 104, p. 599-606, 1993.
266. GOMES, M. D. ; JULIANO, L ; FERRO, E. S. ; MATSUEDA, R. ; CAMARGO, A. C. M. . Dynorphin-derived peptides reveal the presence of a critical cysteine for the activity of brain endo-oligopeptidase A.. Biochemical and Biophysical Research Communications, USA, v. 197, p. 501-507, 1993.
267. PRADO, E. S. ; CHAO, J. ; CHAGAS, J. R. ; JULIANO, M. A. ; JULIANO, L . Determinants of tissue kallikrein cleavage specificity in the limited proteolysis of kininogens. . Agents and Actions, USA, v. 38, p. 74-81, 1992.
268. CHAGAS, J. R. ; HIRATA, I. Y. ; JULIANO, M. A. ; XIONG, W. ; WANG, C. ; CHAO, J. ; JULIANO, L ; PRADO, E. S. . Substrate specificities of tissue kallikrein and T-kininogenase: their possible role in kininogen processing. . Biochemistry (Easton), USA, v. 31, p. 4969-4974, 1992.
269. MEIRELLES, M. N. L. ; JULIANO, L ; CARMONA, E. ; SILVA, S. G. ; COSTA, E. M. ; MUTA, A. C. M. ; SCHARFSTEIN, J. . Inhibitors of the major cysteinyl proteinase (GP57/51) impair host cell invasion and arrest the intracellular development of Trypanosoma cruzi in vitro.. Molecular and Biochemical Parasitology, USA, v. 52, p. 175-184, 1992.
270. OLIVEIRA, M. C. F. ; HIRATA, I. ; CHAGAS, J. R. ; BOSCHCOV, P. ; GOMES, A. R. ; FIGUEIREDO, A. F. S. ; JULIANO, L . Intramolecularly quenched fluorogenic peptide substrates for human renin.. Analytical Biochemistry, USA, v. 230, p. 39-46, 1992.
271. WANG, J. ; CHAO, J. ; JULIANO, L ; CHAO, L . Comparative studies on P2 specificity of wild-type rat tissue kallikrein, Y99H:W215G mutant and tonin.. Agents and Actions, USA, v. 38, p. 59-65, 1992.
272. CEZARI, M. H. S. ; JULIANO, L . Studies on lactam formation during coupling procedures of N alpha- N omega protected-arginine derivatives. Peptide Research, USA, v. 9, n. 88, p. 88-91, 1991.
273. HIRATA, I. Y. ; BOSCHCOV, P. ; OLIVEIRA, M. C. F. ; JULIANO, M. A. ; MIRANDA, A. ; CHAGAS, J. R. ; TSUBOI, S. ; OKADA, Y. ; JULIANO, L . Synthesis of human angiotensinogen (1-17) containing one of the putative glycosylation binding sites and its hydrolysis by human renin and porcine pepsin. . International Journal of Peptide and Protein Research, v. 38, p. 298-307, 1991.
274. CHAGAS, J. R. ; JULIANO, L ; PRADO, E. S. . Intramolecularly quenched fluorogenic tetrapeptide substrates for tissue and plasma kallikreins.. Analytical Biochemistry, USA, v. 192, p. 419-425, 1991.
275. MEIRELLES, M. N. L. ; JULIANO, L ; CARMONA, E. ; COSTA, E. M. ; SILVA, S. G. ; LIMA, A. T. V. C. ; ARNHOLDT, A. V. ; LEME, V. M. C. ; GUIMARAES, E. S. P. ; BERRO, O. J. ; SCHARFSTEIN, J. . Functional and antigenic properties of the major cysteine proteinase (GP57/51) of Trypanosoma cruzi. . Memórias do Instituto Oswaldo Cruz, v. 85, p. 533-538, 1990.
276. JULIANO, L ; CHAGAS, J. R. ; HIRATA, I. Y. ; CARMONA, E. ; SUCUPIRA, M. ; OLIVEIRA, E. S. ; CAMARGO, A. C. M. . A selective assay for endooligopeptidase A based on the cleavage of fluorogenic substrate structurally related to enkephalin. . Biochemical and Biophysical Research Communications, USA, v. 173, p. 647-652, 1990.
277. RAMAZEILLES, C. ; JULIANO, L ; CHAGAS, J. R. ; RABINOVITCH, M. . The anti-leishmanial activity of dipeptide esters on Leishmania amazonensis amastigotes. Parasitology (London), USA, v. 100, p. 201-207, 1990.
278. LIMA, R S ; JULIANO, L ; FIGUEIREDO, A S F ; SIQUEIRA, G R . Human urinary kallikreins A, B and D: isolation, purification and properties.. Advances in Experimental Medicine and Biology, USA, v. 247A, p. 507-511, 1989.
279. OKADA, Y. ; JULIANO, L ; TSUBOI, S. ; MIRANDA, A. ; JULIANO, M. A. . Formation and degradation of lactam derivatives of Ng-tosylarginine during peptides synthesis.. Anais da Academia Brasileira de Ciências, Brasil, v. 60, p. 281-286, 1988.
280. SALGADO, A H ; SIQUEIRA, H A ; JULIANO, L ; FIGUEIREDO, A S F . Rat submandibular gland kallikreins A and B: isolation, purification and properties. Advances in Experimental Medicine and Biology, USA, v. 247B, p. 163-168, 1988.
281. MIRANDA, A. ; JULIANO, L . Conformationally restricted analogs of angiotensin II: titration and biological activity.. Brazilian Journal of Medical and Biological Research, Brasil, v. 21, p. 903-914, 1988.
282. RABIONOVITCH, M. ; ALFIERI, S. C. ; RAMAZEILLES, C. ; QUINTANO, L. G. ; ANTOINE, J C ; RYTER, A ; ZIBERFART, V ; SHAW, Elliot ; JULIANO, L . Leishmanicidal activity of amino acid and peptide esters: an update. . Memórias do Instituto Oswaldo Cruz, Brasil, v. 1, p. 378-382, 1988.
283. OLIVEIRA, L. ; ARAUJO-VIEL, M S ; LJULIANO ; PRADO, Eline S . Substrate activation of porcine pancreatic kallikrein by N alpha derivatives of arginine 4-nitroanilides.. Biochemistry (Easton), USA, v. 26, p. 5032-5035, 1987.
284. JULIANO, L ; JULIANO, M A ; MIRANDA, A ; TSUBOI, Y. ; OKADA, Y . Amino acids and peptides. XVI. Synthesis of NG-tosylarginyl peptide derivatives-observation of lactam formation of arginyl residue. . Chemical and Pharmaceutical Bulletin, Japão, v. 35, p. 2550-2553, 1987.
285. PRADO, e S ; JULIANO, L ; ARAUJO-VIEL, M S ; JULIANO, M A . Tissue kallikreins and related enzymes: characterization by model oligopeptides.. Advances in Experimental Medicine and Biology, v. 241, p. 241-246, 1986.
286. PRADO, Eline S ; ARAUJO-VIEL, M S ; JULIANO, L ; JULIANO, M A ; STELLA, R C R ; SAMPAIO, C A . Tetrapeptide substrates for the discrimination among kallikreins and other trypsin-like serine proteinases.. Biol. Chem. Hoppe-Seyler, v. 367, p. 199-205, 1986.
287. JULIANO, M A ; JULIANO, L . Synthesis and kinetic parameters of hydrolysis by trypsin of some acyl-arginyl-p-nitroanilides and peptides containing arginyl-p-nitroanilide.. Brazilian Journal of Medical and Biological Research, Brasil, v. 8, p. 435-445, 1985.
288. BOSCHCOV, P. ; SEIDEL, W. ; MURADIN, J. ; TOMINAGA, M. ; PAIVA, A C M ; JULIANO, L . Ionization constants and thermodynamic parameters of histidine and derivatives.. Bioorganic Chemistry, USA, v. 12, p. 34-44, 1983.
289. BOSCHCOV, P. ; JULIANO, L ; SEIDEL, W. ; MURADIN, J. ; TOMINAGA, M. ; PAIVA, A C M . Reactivity with p-nitrophenyl acetate and interaction between the amino and imidazole groups of histidine and related compounds . Bioorganic Chemistry, v. 11, p. 383-393, 1982.
290. NAKAIE, C R ; OLIVEIRA, M C F ; JULIANO, L ; PAIVA, A C M . Inhibition of renin by conformationally restricted analogues of angiotensinogen.. Biochemical Journal (London), Inglaterra, v. 205, p. 43-47, 1982.
291. VIEL, M S A ; JULIANO, L ; PRADO, e S . The cleavage of the Met-Lys bond in a bradykinin derivative by glandular kallikreins.. Biol. Chem. Hoppe-Seyler, Alemanha, v. 362, p. 337-345, 1981.
292. JULIANO, L ; LALUCE, C. ; OLIVEIRA, M C F ; PAIVA, A C M . Titration and fluorimetric studies of the tyrosine side chain of angiotesin II and related peptides.. Biopolymers (New York), v. 18, p. 1793-1807, 1979.
293. PAIVA, T B ; MIYAMOTO, M e ; JULIANO, L ; PAIVA, A C M . Requirements for angiotensin tachyphylaxis in smooth muscles. . Journal of Pharmacology and Experimental Therapeutics, v. 202, p. 294-300, 1977.
294. OLIVEIRA, M C F ; JULIANO, L ; PAIVA, A C M . Conformations of synthetic tetradecapeptide renin substrate and of angiotensin I in aqueous solution.. Biochemistry (Easton), USA, v. 16, p. 2606-2610, 1977.
295. NOUAILHETAS, V. L. A. ; JULIANO, L ; NAKAIE, C R ; PAIVA, A C M . Effect of lipophilic character on the biological activity of synthetic angiotensin peptides. . Biochemical Journal (London), Inglaterra, v. 165, p. 547-551, 1977.
296. PAIVA, A C M ; JULIANO, L ; BOSCHCOV, L. . Ionization of methyl derivatives of imidazole, histidine, thyreotropin releasing factor, and related compounds.. Journal of the American Chemical Society, v. 98, p. 7645-7648, 1976.
297. PAIVA, T B ; JULIANO, L ; GOISSIS, G. ; MIYAMOTO, M. E. ; PAIVA, A C M . Angiotensin-like and antagonistic activities of N-terminal modified (8-leucine)angiotensin II peptides. . Journal of Medicinal Chemistry, v. 17, p. 238-241, 1974.
298. PAIVA, T B ; JULIANO, L ; NOUAILLETAS, V L ; PAIVA, A C M . The Effect of pH on tachyphylaxys to angiotensin peptides in isolated ginea-pig ileum and rat uterus.. European Journal of Pharmacology, Holanda, v. 25, p. 191-196, 1974.
299. JULIANO, L ; PAIVA, A. . Conformation of angiotensin II in aqueous solution. Titration of several peptide analogs and homologs. . Biochemistry (Easton), USA, v. 13, p. 2445-2450, 1974.
300. JULIANO, L ; BOSCHCOV, P. ; PAIVA, A C M . Interaction of angiotensin peptides and of amino acids with p-nitrophenyl acetate. Biochemistry (Easton), v. 13, p. 4263-4267, 1974.
Livros publicados/organizados ou edições
1. JULIANO, L. ; JULIANO L. . Sistemas Nervosos - (Traducao) Autor: P.N.R. Ushewood. SAO PAULO: ED. NACIONAL E USP, 1977. 00344 p.
2. MIKAL, S. ; JULIANO L. ; TRADUTORES, L. ; JULIANO, J. R. . Homeostase No Homem: Fluidos, Eletrolitos, Proteinas e Minerais Em Clinica - (Traducao).. SAO PAULO: EDART ED USP, 1976. 00344 p.
3. MAGALHAES, J. R. ; JULIANO L. ; CACERES, O. ; ALVES, J. M. ; MENUCCI, L. ; JULIANO, L. . Introducao A Bioquimica - Traducao- Autores: E.E. Conn e D.K. Stumpf.. SAO PAULO: EDGARD BUCHER, 1975. 00344 p.
Artigos aceitos para publicação
1. Andrade, Douglas ; Assis, Diego M. ; Santos, Jorge A.N. ; Alves, Fabiana M. ; Hirata, Izaura Y. ; Araujo, Mariana S. ; Blaber, Sachiko I. ; Blaber, Michael ; Juliano, Maria A. ; Juliano, Luiz . Substrate specificity of kallikrein-related peptidase 13 activated by salts or glycosaminoglycans and a search for natural substrate candidates. Biochimie (Paris. Print), 2011.
Produção técnica
Produtos tecnológicos
1. JULIANO L. ; CARMONA, A K ; JULIANO, M A . Substratos para enzima conversora da angiotensina I. 2005.
2. JULIANO, M A ; JULIANO, L ; CARMONA, A K . Substratos para detecção e quantificação da enzima conversora da angiotensina I. 2004.
3. JULIANO L. ; CARMONA, A K ; JULIANO, M A . Substrato para enzima conversora. 2004.
4. JULIANO L. . Desenvolvimento de Substratos Para Enzimas Proteociclicas Envolvidas Na Coagulacao Sanguinea.. 1989.
5. JULIANO L. . Desenvolvimento da Sintese Desamino-Darginina-Vassopressina Em Solucao.. 1986.
6. JULIANO L. . Desenvolvimento da Sintese da Vasopressina Em Solucao.. 1985.
7. JULIANO L. . Desenvolvimento da Sintese da Ocitocitocina Em Solucao.. 1982.
Processos ou técnicas
1. JULIANO L. . Purificacao de Ocitocina, Vasopressina e Analogos Por Cromatografia, Em Larga Escala.. 1986.

Orientações
Orientações em andamento
Dissertação de mestrado
1. Lilian Caroline Gonçalves de Oliveira. Caracterização das propriedades hidrolíticas de cisteíno peptidases derivadas de vírus e protozoários.. Início: 2009. Dissertação (Mestrado em Pós -doutorado em bioquímica) - Departamento de Biofísica, Conselho Nacional de Desenvolvimento Científico e Tecnológico. (Orientador).
Tese de doutorado
1. Fernanda Montiel Dalio. Desenvolvimento de Novos Inibidores para a Thimet oligopeptidase e Neurolisina. Início: 2009. Tese (Doutorado em Ciências Biológicas (Biologia Molecular)) - Universidade Federal de São Paulo. (Orientador).
2. Joyce Meire Gilio. Produção e Caracterização da Metacaspase (YCA1) de Saccharomyces cerevisiae. Início: 2009. Tese (Doutorado em Ciências Biológicas (Biologia Molecular)) - Universidade Federal de São Paulo. (Orientador).
3. Marcia Y. Kondoa. Caracterização do Mecanismo Catalítico das Glutamil Peptidases. Início: 2008. Tese (Doutorado em Ciências Biológicas (Biologia Molecular)) - Universidade Federal de São Paulo, Conselho Nacional de Desenvolvimento Científico e Tecnológico. (Orientador).
4. Débora N. Okamotoa. KINETIC ANALYSIS OF SALTING ACTIVATION OF A SUBTILISIN-LIKE HALOPHILIC PROTEASE. Início: 2007. Tese (Doutorado em Ciências Biológicas (Biologia Molecular)) - Universidade Federal de São Paulo, Conselho Nacional de Desenvolvimento Científico e Tecnológico. (Orientador).
Supervisão de pós-doutorado
1. Maurico Ferreira Marcondes Machado. Início: 2009. Universidade Federal de São Paulo.
2. Mario Augusto Izidoro. Início: 2009. Universidade Federal de São Paulo.
3. Iuri Estrada Gouvea. Início: 2008. Universidade Federal de São Paulo, Fundação de Amparo à Pesquisa do Estado de São Paulo.
4. Thaysa Paschoalin. Início: 2007. Universidade Federal de São Paulo, Fundação de Amparo à Pesquisa do Estado de São Paulo.
Supervisões e orientações concluídas
Dissertação de mestrado
1. Geovana Prado Vaz Feitosa. ORGANOTELURANAS COMO INIBIDORES IRREVERSÍVEIS PARA AS CATEPSINAS HUMANAS B, L S.. 2008. Dissertação (Mestrado em Ciências Biológicas (Biologia Molecular)) - Universidade Federal de São Paulo, Conselho Nacional de Desenvolvimento Científico e Tecnológico. Orientador: Luiz Juliano Neto.
2. Iuri Estrada Gouveia. PROPRIEDADES HIDROLÍTICAS DA CISTEÍNO-PEPTIDASE 3C DE PICORNAVÍRUS . 2005. 90 f. Dissertação (Mestrado em Ciências Biológicas (Biologia Molecular)) - Universidade Federal de São Paulo, Fundação de Amparo à Pesquisa do Estado de São Paulo. Orientador: Luiz Juliano Neto.
3. Andreza de Oliveira. Estudo de especificidade da catepsina D humana. 2001. 70 f. Dissertação (Mestrado em Ciências Biológicas (Biologia Molecular)) - Universidade Federal de São Paulo, Fundação de Amparo à Pesquisa do Estado de São Paulo. Orientador: Luiz Juliano Neto.
4. Leo Kei Iwai. Sintese e caracterizacao de peptideos antigenicos . Teste de funcao biologica de analogos retro-invertidos dos peptideos antigenicos de B13. 1999. 0 f. Dissertação (Mestrado em Ciências Biológicas (Biologia Molecular)) - Universidade Federal de São Paulo, Fundação de Amparo à Pesquisa do Estado de São Paulo. Orientador: Luiz Juliano Neto.
5. Vitor Marcelo Bueno Brandão de Oliveira. Ferramentas para o estudo de enzimas proteolíticas em células de cultura. 1998. 0 f. Dissertação (Mestrado em Ciências Biológicas (Biologia Molecular)) - Universidade Federal de São Paulo, Fundação de Amparo à Pesquisa do Estado de São Paulo. Orientador: Luiz Juliano Neto.
6. Mauricio Campos Araujo. Desenvolvimento de substratos de fluorescência apagada para enzima conversora da angiotensina-I. 1998. 0 f. Dissertação (Mestrado em Ciências Biológicas (Biologia Molecular)) - Universidade Federal de São Paulo, Fundação de Amparo à Pesquisa do Estado de São Paulo. Orientador: Luiz Juliano Neto.
7. Daniel Carvalho Pimenta. Síntese e Determinação das Cinéticas Para A Hidrólise de Peptídeos Relacionados À Calistatina Pela Calicreína Tissular Humana.. 1997. Dissertação (Mestrado em Ciências Biológicas (Biologia Molecular)) - Universidade Federal de São Paulo, . Orientador: Luiz Juliano Neto.
8. Elaine Del Nery Santos. Estudo da Atividade Cininogenásica das Calicreínas Tissulares, Humana e Porcina, Utilizando Substratos Fluorogênicos.. 1997. Dissertação (Mestrado em Ciências Biológicas (Biologia Molecular)) - Universidade Federal de São Paulo, . Orientador: Luiz Juliano Neto.
9. Maria Helena Saldenho Cezari. Estudo de Reações Colaterais Na Síntese de Peptídeos: Formação de Alfa-Lactamas Derivados de Arginina.. 1995. Dissertação (Mestrado em Ciências Biológicas (Biologia Molecular)) - Universidade Federal de São Paulo, . Orientador: Luiz Juliano Neto.
10. Paulo Cézar de Almeida. Substratos Fluorescentes Para Enzimas Proteoliticas Capazes de Realizar A Conversão de Pró-Renina Em Renina Ativa No Rato. 1994. Dissertação (Mestrado em Ciências Biológicas (Biologia Molecular)) - Universidade Federal de São Paulo, . Orientador: Luiz Juliano Neto.
11. Lira Celeste Alves. Síntese e Estudo Cinético da Hidrólise de Substratos Fluorescentes Para Proteases.. 1994. Dissertação (Mestrado em Ciências Biológicas (Biologia Molecular)) - Universidade Federal de São Paulo, . Orientador: Luiz Juliano Neto.
12. I. Y. Hirata. Sintese do Fragmento do Angiotensinogenio H(1-17)-Nh2 e Hidrolise Pela Renina Humana e Pesina de Porco. 1992. Dissertação (Mestrado em Ciências Biológicas (Biologia Molecular)) - Universidade Federal de São Paulo, . Orientador: Luiz Juliano Neto.
13. J. R. CHAGAS. Substratos Fluorogenicos Com Apagamento Intramolecular Para Calicreinas e Outras Arginil Hidrlases.. 1991. Dissertação (Mestrado em Ciências Biológicas (Biologia Molecular)) - Universidade Federal de São Paulo, . Orientador: Luiz Juliano Neto.
14. A. MIRANDA. Sintese e Propriedades de Analogos da Angiotensina Ii de Conformacao Restrita.. 1984. Dissertação (Mestrado em Ciências Biológicas (Biologia Molecular)) - Universidade Federal de São Paulo, . Orientador: Luiz Juliano Neto.
15. Maria Aparecida Juliano. Sintese e Estudos Cineticos de Novos Substratos Cromogenicos Para Algumas Serino-Proteases.. 1983. Dissertação (Mestrado em Ciências Biológicas (Biologia Molecular)) - Universidade Federal de São Paulo, . Orientador: Luiz Juliano Neto.
16. VINIBALDA FURTNER. Protecao do Grupo Sulfidrila Na Sintese da Ocitocina.. 1982. Dissertação (Mestrado em Ciências Biológicas (Biologia Molecular)) - Universidade Federal de São Paulo, . Orientador: Luiz Juliano Neto.
17. A K Carmona. Enzima Conservadora da Angiotensina Ii: Acao Inibidora de Analogs e Homologos da Angiotensina Ii.. 1979. Dissertação (Mestrado em Ciências Biológicas (Biologia Molecular)) - Universidade Federal de São Paulo, . Orientador: Luiz Juliano Neto.
18. P. BOSCHCOV. Contribuicao Para Estudo Conformacional de Peptideos Contendo Histidina.. 1978. Dissertação (Mestrado em Ciências Biológicas (Biologia Molecular)) - Universidade Federal de São Paulo, . Orientador: Luiz Juliano Neto.
Tese de doutorado
1. JORGE ALEXANDRE NOGUEIRA SANTOS. Propriedades e especificidade da protease leader da febre aftosa. 2009. Tese (Doutorado em Ciências Biológicas (Biologia Molecular)) - Universidade Federal de São Paulo, Conselho Nacional de Desenvolvimento Científico e Tecnológico. Orientador: Luiz Juliano Neto.
2. IURI ESTRADA GOUVÊA. ENZIMAS PROTEOLÍTICAS VIRAIS:DENGUE NS3 E POLIOVÍRUS 3C. 2008. Tese (Doutorado em Ciências Biológicas (Biologia Molecular)) - Universidade Federal de São Paulo, Conselho Nacional de Desenvolvimento Científico e Tecnológico. Orientador: Luiz Juliano Neto.
3. Mario Augusto Izidoro. Human furin hydrolytic specificity on synthetic peptides derived from processing sites in virus polyproteins and cellular proproteins: effects of potassium and magnesium ions. 2008. Tese (Doutorado em Ciências Biológicas (Biologia Molecular)) - Universidade Federal de São Paulo, Conselho Nacional de Desenvolvimento Científico e Tecnológico. Orientador: Luiz Juliano Neto.
4. Silvia dos Santos Gorrão. Estudo da Especificidade da oligopeptidase B recombinante de Escherichia coli e obtenção de anticorpos monoclonais contra a oligopeptidase B recombinante de Trypanosoma cruzi e E. col. 2007. Tese (Doutorado em Ciências Biológicas (Biologia Molecular)) - Universidade Federal de São Paulo, Fundação de Amparo à Pesquisa do Estado de São Paulo. Orientador: Luiz Juliano Neto.
5. Jefferson Pessoa Hemerly. Estudo da especificidade da Prolil Oligopeptidase recombinante de cérebro de porco e variante e produção de anticorpos monoclonais. 2006. 200 f. Tese (Doutorado em Ciências Biológicas (Biologia Molecular)) - Universidade Federal de São Paulo, Fundação de Amparo à Pesquisa do Estado de São Paulo. Orientador: Luiz Juliano Neto.
6. Shirley Leite de Almeida Farias. ATIVIDADE PROTEOLÍTICA RELACIONADA À SINALIZAÇÃO POR CÁLCIO EM PLASMODIUM. 2005. 0 f. Tese (Doutorado em Ciências Biológicas (Biologia Molecular)) - Universidade Federal de São Paulo, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior. Orientador: Luiz Juliano Neto.
7. Wagner Alves de Souza Judice. Abordagem termodinamica da atividade de cisteino proteases. 2004. 110 f. Tese (Doutorado em Ciências Biológicas (Biologia Molecular)) - Universidade Federal de São Paulo, Fundação de Amparo à Pesquisa do Estado de São Paulo. Orientador: Luiz Juliano Neto.
8. Maria Helena S Cezari. COMPARAÇÃO DA ESPECIFICIDADE DA CATEPSINA B PARA SUAS ATIVIDADES ENDO E EXOPEPTIDÁSICAS UTILIZANDO SUBSTRATOS PEPTÍDICOS DE FLUORESCÊNCIA APAGADA INTERNAMENTE. 2002. 120 f. Tese (Doutorado em Ciências Biológicas (Biologia Molecular)) - Universidade Federal de São Paulo, . Orientador: Luiz Juliano Neto.
9. Daniel C Pimenta. Substratos e inibidores para a calicreina tissular humana. 2001. 110 f. Tese (Doutorado em Ciências Biológicas (Biologia Molecular)) - Universidade Federal de São Paulo, Fundação de Amparo à Pesquisa do Estado de São Paulo. Orientador: Luiz Juliano Neto.
10. Vitor Marcelo Bueno Brandão de Oliveira. Estudo das endooligopeptidases e conformação de peptídeos . 2001. 105 f. Tese (Doutorado em Ciências Biológicas (Biologia Molecular)) - Universidade Federal de São Paulo, Fundação de Amparo à Pesquisa do Estado de São Paulo. Orientador: Luiz Juliano Neto.
11. E. Nery. Estudo da atividade cininogenasica e da especificidade primaria da cruzipaina, a principal cisteino peptidase do T cruzi. 2000. 0 f. Tese (Doutorado em Ciências Biológicas (Biologia Molecular)) - Universidade Federal de São Paulo, Fundação de Amparo à Pesquisa do Estado de São Paulo. Orientador: Luiz Juliano Neto.
12. Henrique Pimenta Barroso Magalhães. Avanços na caracterização biológica da protease trombica de Lachesis muta muta. 2000. 0 f. Tese (Doutorado em Ciências Biológicas (Biologia Molecular)) - Universidade Federal de São Paulo, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior. Orientador: Luiz Juliano Neto.
13. Fernanda Calheta Vieira Portaro. Caracterização dos Subsítios S4 e S'3 das Cisteíno-Proteases Papaína e Catepsinas L, B e Catepsinas B Mutantes.. 1997. Tese (Doutorado em Ciências Biológicas (Biologia Molecular)) - Universidade Federal de São Paulo, . Orientador: Luiz Juliano Neto.
14. Paulo Cézar de Almeida. Estudos Relativos Ao Processamento da Pró-Renina Com A Utilização de Substratos Fluorogênicos.. 1997. Tese (Doutorado em Ciências Biológicas (Biologia Molecular)) - Universidade Federal de São Paulo, . Orientador: Luiz Juliano Neto.
15. Izaura Yoshico Hirata. Síntese Em Fase Sólida de Peptídeos Fluorescentes Com Apagamento Intramolecular e Estudos da Lactamização de Derivados de Abz-Prolina. 1997. Tese (Doutorado em Ciências Biológicas (Biologia Molecular)) - Universidade Federal de São Paulo, . Orientador: Luiz Juliano Neto.
16. Fernanda Portaro. Estudo de Especificidade da Catepsina B Nativa e Modificada Por Mutações Puntuais Na Alça de Oclusão. Comaparação Com Catepsina L e Papaina. 1997. Tese (Doutorado em Ciências Biológicas (Biologia Molecular)) - Universidade Federal de São Paulo, Conselho Nacional de Desenvolvimento Científico e Tecnológico. Orientador: Luiz Juliano Neto.
17. J. R. CHAGAS. Estudo dos Determinantes da Especificidade de Calicreinas Tissulares Atraves de Substratos Especificos.. 1993. Tese (Doutorado em Ciências Biológicas (Biologia Molecular)) - Universidade Federal de São Paulo, . Orientador: Luiz Juliano Neto.
18. Maria Aparecida Juliano. Estuda Comparativo da Especificidade Entre Tonina,Calicreina e Tripsi-Na Com Substratos Cromogenicos.. 1992. Tese (Doutorado em Ciências Biológicas (Biologia Molecular)) - Universidade Federal de São Paulo, . Orientador: Luiz Juliano Neto.
19. A. MIRANDA. Reatividade de Grupos Nucleofilicos Nas Angiotensinas I e Ii.. 1989. Tese (Doutorado em Ciências Biológicas (Biologia Molecular)) - Universidade Federal de São Paulo, . Orientador: Luiz Juliano Neto.
20. A. K. CARMONA. Enzima Conversora da Angiotensina I: Requisitos Estruturais de Substratos e Inibidores.. 1988. Tese (Doutorado em Ciências Biológicas (Biologia Molecular)) - Universidade Federal de São Paulo, . Orientador: Luiz Juliano Neto.
21. P. BOSCHCOV. Histidina e Derivados: Equilibrio Com Protons e Cinetica de Reacao Com Acetato de P-Nitrofenila.. 1980. Tese (Doutorado em Ciências Biológicas (Biologia Molecular)) - Universidade Federal de São Paulo, . Orientador: Luiz Juliano Neto.
Supervisão de pós-doutorado
1. Fabiana Madureira Alves. 2007. Universidade Federal de São Paulo, Fundação de Amparo à Pesquisa do Estado de São Paulo. Luiz Juliano Neto.
2. Rodrigo L. O. R. Cunha. 2006. Universidade Federal de São Paulo, Fundação de Amparo à Pesquisa do Estado de São Paulo. Luiz Juliano Neto.
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