Isaias Raw

  • Endereço para acessar este CV: http://lattes.cnpq.br/4908464869643876
  • Última atualização do currículo em 21/09/2015


Possui graduação em Medicina pela Universidade de São Paulo (1950). Atualmente é pesquisador do Instituto Butantan e pesquisador aposentado da Universidade de São Paulo. Tem experiência na área de Bioquímica de Macromoléculas com ênfase em Proteínas. Sua atuação principal atualmente é no desenvolvimento de vacinas e biofármacos. (Texto informado pelo autor)


Identificação


Nome
Isaias Raw
Nome em citações bibliográficas
RAW, I.;RAW, ISAÍAS;RAW, ISAIAS

Endereço


Endereço Profissional
Instituto Butantan, Secretaria da Saude Esp.
Av. Dr. Vital Brasil 1500
Butantan
05503900 - São Paulo, SP - Brasil
Telefone: (11) 26279367
Ramal: 9367
Fax: (11) 37261505


Formação acadêmica/titulação


1945 - 1950
Graduação em Medicina.
Universidade de São Paulo, USP, Brasil.


Livre-docência


1957
Livre-docência.
Universidade de São Paulo, USP, Brasil.
Título: Oxidação de ácido betahidroxibutírico, Ano de obtenção: 1957.
Palavras-chave: ácidos graxos; metabolismo; enzimas.
Grande área: Ciências da Saúde
Setores de atividade: Produtos e Processos Biotecnológicos.


Atuação Profissional



Instituto Butantan, IBU, Brasil.
Vínculo institucional

1984 - Atual
Vínculo: Servidor público ou celetista, Enquadramento Funcional: Pesquisador, Carga horária: 0

Atividades

4/1951 - Atual
Pesquisa e desenvolvimento , Instituto Butantan, .

Linhas de pesquisa
Imunobiologicos
4/1993 - 4/1997
Direção e administração, Instituto Butantan, .

Cargo ou função
Diretor.

Universidade de São Paulo, USP, Brasil.
Vínculo institucional

1984 - Atual
Vínculo: Servidor Público, Enquadramento Funcional: Pesquisador, Carga horária: 0

Vínculo institucional

1951 - 1969
Vínculo: Servidor Público, Enquadramento Funcional: Professor titular, Carga horária: 0
Outras informações
Aposentado.

Atividades

4/1951 - Atual
Pesquisa e desenvolvimento , Universidade de São Paulo, .

Linhas de pesquisa
Bioquimica


Linhas de pesquisa


1.
Bioquimica
2.
Imunobiologicos


Áreas de atuação


1.
Grande área: Ciências Biológicas / Área: Bioquímica / Subárea: Química de Macromoléculas/Especialidade: Proteínas.
2.
Grande área: Ciências Biológicas / Área: Bioquímica / Subárea: Bioquímica dos Microorganismos.
3.
Grande área: Ciências Biológicas / Área: Bioquímica / Subárea: Química de Macromoléculas.


Idiomas


Inglês
Compreende Bem, Fala Bem, Lê Bem, Escreve Bem.
Francês
Compreende Razoavelmente, Fala Pouco, Lê Bem, Escreve Pouco.
Espanhol
Compreende Bem, Fala Bem, Lê Bem, Escreve Razoavelmente.


Prêmios e títulos


2010
Prêmio Fundação Bungue - 2010 - Saúde Pública/Medicina Preventiva, BUNGUE FUNDAÇÃO.
2004
Conrado Wessel de Arte, Ciência e Cultura, Fundação Conrado Wessel.
2000
Medalha do Instituto Butantan, Governo do Estado de S.Paulo.
1995
Ordem Nacional do Merito Cientifico, Governo Federal.
1982
Academico, Academia Brasileira de Ciencias.
1975
professor emerito, Faculdade de Medicina, USP.
1964
Professor catedratico, USP.


Produções



Produção bibliográfica
Artigos completos publicados em periódicos

1.
SALCEDO-RIVILLAS, C.2014SALCEDO-RIVILLAS, C. ; DEBRIE, A.-S. ; MIYAJI, E. N. ; FERREIRA, J. M. C. ; RAW, I. ; LOCHT, C. ; HO, P. L. ; MIELCAREK, N. ; OLIVEIRA, M. L. S. . Pertussis toxin improves the immune responses to a combined pneumococcal antigen and lead to enhanced protection against Streptococcus pneumoniae. Clinical and Vaccine Immunology, v. 21(7), p. 972-981, 2014.

2.
VICENTIN, E. C.2014VICENTIN, E. C. ; FRANCOSO, K. S. ; ROCHA, M. V. ; IOURTOV, D. ; DOS SANTOS, F. L. ; KUBRUSLY, F. S. ; SAKAUCHI, M. A. ; RAW, I. ; NOSTEN, F. ; RENIA, L. ; RODRIGUES, M. M. ; RUSSELL, B. ; SOARES, I. S. . Invasion-Inhibitory Antibodies Elicited by Immunization with Plasmodium vivax Apical Membrane Antigen-1 Expressed in Pichia pastoris Yeast. Infection and Immunity (Print), v. 82, p. 1296-1307, 2014.

3.
RODRIGUES, ESTELA S.2014RODRIGUES, ESTELA S. ; VERINAUD, CLAUDIA I. ; OLIVEIRA, DOUGLAS S. ; RAW, ISAÍAS ; LOPES, ALEXANDRE P. Y. ; MARTINS, ELIZABETH A. L. ; CHENG, ELISABETH . Purification of Coagulation Factor Viii By Immobilized Metal Affinity Chromatography. Biotechnology and Applied Biochemistry, v. n/a, p. n/a-n/a, 2014.

4.
LUNA, EXPEDITO J.A.2013LUNA, EXPEDITO J.A. ; FRAZATTI-GALLINA, NEUZA M. ; TIMENETSKY, MARIA C.S.T. ; CARDOSO, MARIA R.A. ; VERAS, MARIA A.S.M. ; MIRAGLIA, JOÃO L. ; ESCOBAR, ANA M.U. ; GRISI, SANDRA J.F.E. ; RAW, ISAIAS ; PRECIOSO, ALEXANDER R. . A phase I clinical trial of a new 5-valent rotavirus vaccine. Vaccine (Guildford), v. 31, p. 1100-1105, 2013.

5.
LIMA, FERNANDA A.2013LIMA, FERNANDA A. ; MIYAJI, ELIANE N. ; QUINTILIO, WAGNER ; RAW, ISAIAS ; HO, PAULO L. ; OLIVEIRA, MARIA LEONOR S. . Pneumococcal Surface Protein A does not affect the immune responses to a combined diphtheria tetanus and pertussis vaccine in mice. Vaccine (Guildford), v. 31, p. 2465-2470, 2013.

6.
CARICATI, C. P.2013CARICATI, C. P. ; OLIVEIRA-NASCIMENTO, L. ; YOSHIDA, J. T. ; STEPHANO, M. A. ; CARICATI, A. T. P. ; RAW, I. . Safety of snake antivenom immunoglobulins: Efficacy of viral inactivation in a complete downstream process. Biotechnology Progress (Print), v. 29, p. 972-979, 2013.

7.
DIAS, WALDELY OLIVEIRA2013DIAS, WALDELY OLIVEIRA ; VAN DER ARK, ARNO A.J. ; SAKAUCHI, MARIA APARECIDA ; KUBRUSLY, FLÁVIA SALDANHA ; PRESTES, ANA FABÍOLA R.O. ; BORGES, MONAMARIS MARQUES ; FURUYAMA, NOEMI ; HORTON, DENISE S.P.Q. ; QUINTILIO, WAGNER ; ANTONIAZI, MARTA ; KUIPERS, BETSY ; VAN DER ZEIJST, BERNARD A.M. ; RAW, ISAIAS . An improved whole cell pertussis vaccine with reduced content of endotoxin. Human Vaccines & Immunotherapeutics, v. 9, p. 339-348, 2013.

8.
MAHONEY, R.T.2012MAHONEY, R.T. ; FRANCIS, D.P. ; FRAZATTI-GALLINA, N.M. ; PRECIOSO, A.R. ; RAW, I. ; WATLER, P. ; WHITEHEAD, P. ; WHITEHEAD, S.S. . Cost of production of live attenuated dengue vaccines: A case study of the Instituto Butantan, Sao Paulo, Brazil. Vaccine (Guildford), v. 30, p. 4892-4896, 2012.

9.
NOVO, JULIANA BRANCO2012NOVO, JULIANA BRANCO ; MORGANTI, LIGIA ; MORO, ANA MARIA ; PAES LEME, ADRIANA FRANCO ; SERRANO, SOLANGE MARIA DE TOLEDO ; RAW, ISAIAS ; HO, PAULO LEE . Generation of a Chinese Hamster Ovary Cell Line Producing Recombinant Human Glucocerebrosidase. Journal of Biomedicine and Biotechnology (Print), v. 2012, p. 1-10, 2012.

10.
LIMA, F. A.2012LIMA, F. A. ; FERREIRA, D. M. ; MORENO, A. T. ; FERREIRA, P. C. D. ; PALMA, G. M. P. ; FERREIRA, J. M. C. ; RAW, I. ; MIYAJI, E. N. ; HO, P. L. ; OLIVEIRA, M. L. S. . Controlled Inflammatory Responses in the Lungs Are Associated with Protection Elicited by a Pneumococcal Surface Protein A-Based Vaccine against a Lethal Respiratory Challenge with Streptococcus pneumoniae in Mice. Clinical and Vaccine Immunology, v. 19, p. 1382-1392, 2012.

11.
KASHINO, S. S.2012KASHINO, S. S. ; ABEIJON, C. ; QIN, L. ; KANUNFRE, K. A. ; KUBRUSLY, F. S. ; SILVA, F. O. ; COSTA, D. L. ; CAMPOS, D. ; COSTA, C. H. N. ; RAW, I. ; CAMPOS-NETO, A. . Identification of Leishmania infantum chagasi proteins in urine of patients with visceral leishmaniasis: a promising antigen discovery approach of vaccine candidates. Parasite Immunology (Print), v. 34, p. 360-371, 2012.

12.
MIYAKI, COSUE2011MIYAKI, COSUE ; MEROS, MAURICIO ; PRECIOSO, ALEXANDER R. ; RAW, ISAIAS . Influenza vaccine production for Brazil: A classic example of successful North-South bilateral technology transfer. Vaccine (Guildford), v. 29, p. A12-A15, 2011.

13.
PRECIOSO, ALEXANDER R.2011PRECIOSO, ALEXANDER R. ; MIRAGLIA, JOÃO L. ; CAMPOS, LÚCIA MARIA A. ; GOULART, ALESSANDRA C. ; TIMENETSKY, MARIA DO CARMO S.T. ; CARDOSO, MARIA REGINA A. ; LUNA, EXPEDITO ; MONDINI, GABRIELLA ; GUEDES, JOSÉ DA S. ; RAW, ISAIAS . A phase I randomized, double-blind, controlled trial of 2009 influenza A (H1N1) inactivated monovalent vaccines with different adjuvant systems. Vaccine (Guildford), v. 29, p. 8974-8981, 2011.

14.
HO, PAULO LEE2011HO, PAULO LEE ; MIYAJI, ELIANE NAMIE ; OLIVEIRA, MARIA LEONOR SARNO ; DIAS, WALDELY DE OLIVEIRA ; KUBRUSLY, FLAVIA SALDANHA ; TANIZAKI, MARTHA MASSAKO ; MARTINS, ELIZABETH ANGÉLICA LEME ; RAW, ISAIAS . Economical Value of Vaccines for the Developing Countries-The Case of Instituto Butantan, a Public Institution in Brazil. PLoS Neglected Tropical Diseases (Online), v. 5, p. e1300, 2011.

15.
MIRAGLIA, JOÃO L.2011MIRAGLIA, JOÃO L. ; ABDALA, EDSON ; HOFF, PAULO M. ; LUIZ, ANDRÉ M. ; OLIVEIRA, DANISE S. ; SAAD, CARLA G. S. ; LAURINDO, IEDA M. M. ; VISO, ANA T. R. ; TAYRA, ANGELA ; PIERROTTI, LÍGIA C. ; AZEVEDO, LUIZ S. ; CAMPOS, LÚCIA MARIA A. ; AIKAWA, NÁDIA E. ; TIMENETSKY, MARIA DO CARMO S. T. ; LUNA, EXPEDITO ; CARDOSO, MARIA REGINA A. ; GUEDES, JOSÉ DA S. ; RAW, ISAIAS ; KALIL, JORGE ; PRECIOSO, ALEXANDER R. . Immunogenicity and Reactogenicity of 2009 Influenza A (H1N1) Inactivated Monovalent Non-Adjuvanted Vaccine in Elderly and Immunocompromised Patients. Plos One, v. 6, p. e27214, 2011.

16.
MIYAKI, C2010MIYAKI, C ; QUINTILLLO, W. ; MIYAJI, e N ; BOTOSSO VF ; KUBRUSLY, F S ; SANTOS FL ; IOURTOV, D ; HG, H. ; RAW, I. . Production of H5N1 (NIBRG-14) inactivated whole virus and split virion influenza vaccines and analysis of immunogenicity in mice using different adjuvant formulations.. Vaccine (Guildford), v. 16, p. 2505-2509, 2010.

17.
CHENG, ELISABETH2010CHENG, ELISABETH ; JINZENJI, DANIELA ; LORTHIOIS, ANA PAULA ALMEIDA ARANHA ; CARVALHO, ROBERTA RODRIGUES ; TANAKA-AZEVEDO, ANITA MITIKO ; RAW, ISAÍAS ; MARTINS, ELIZABETH ANGÉLICA LEME . Purification of coagulation factor VIII using chromatographic methods. Direct chromatography of plasma in anion exchange resins. Biotechnology Letters, v. 32, p. 1207-1214, 2010.

18.
NOVO, JULIANA BRANCO2010NOVO, JULIANA BRANCO ; OLIVEIRA, MARIA LEONOR SARNO ; MAGALHÃES, GERALDO SANTANA ; MORGANTI, LIGIA ; RAW, ISAÍAS ; HO, PAULO LEE . Generation of Polyclonal Antibodies Against Recombinant Human Glucocerebrosidase Produced in Escherichia coli. Molecular Biotechnology, v. 46, p. 279-286, 2010.

19.
OLIVEIRA, MARIA LEONOR S.2010OLIVEIRA, MARIA LEONOR S. ; MIYAJI, ELIANE N. ; FERREIRA, DANIELA M. ; MORENO, ADRIANA T. ; FERREIRA, PATRICIA C. D. ; LIMA, FERNANDA A. ; SANTOS, FERNANDA L. ; SAKAUCHI, MARIA APARECIDA ; TAKATA, CÉLIA S. ; HIGASHI, HISAKO G. ; RAW, ISAÍAS ; KUBRUSLY, FLAVIA S. ; HO, PAULO L. . Combination of Pneumococcal Surface Protein A (PspA) with Whole Cell Pertussis Vaccine Increases Protection Against Pneumococcal Challenge in Mice. Plos One, v. 5, p. e10863, 2010.

20.
ZORZETO TQ2009ZORZETO TQ ; HG, H. ; Da Silva, MT ; Carniel, EF ; DIAS, Wo ; RAMALHO VD ; Mazzola, TN ; Lima, SC ; Morcillo AM ; MA, S. ; ANTONIO MA ; ZANOLLI M de L ; ESTEVES, M. ; RAW, I. ; Vilela, M.M . Immunogenicity of a whole-cell pertussis vaccine with low lipopolysaccharide content in infants.. Clinical and Vaccine Immunology, v. 16, p. 544-550, 2009.

21.
QUINTILO, W.2009QUINTILO, W. ; KOBRUSLY, F. ; IOURTOV, D ; MIYAKI, C ; SAKAUCHI, D ; Dias S de C ; TAKATE CS ; MIYAJI, e N ; HG, H. ; LEITE, L C ; RAW, I. . Bordetella pertussis monophosphoryl lipid A as adjuvant for inactivated split virion influenza vaccine in mice.. Vaccine (Guildford), v. 27, p. 4219-4224, 2009.

22.
HIGASHI, H G2009HIGASHI, H G ; LUNA E ; PRECIOSO, A R ; Vilela, M.M ; KUBRUSKY, F. ; DIAS, Wo ; RAW, I. . Acellular and "low" pertussis vaccines: adverse events and the role of mutations.. Revista do Instituto de Medicina Tropical de São Paulo (Impresso), v. 51, p. 131-134, 2009.

23.
QUINTILO, W.2009QUINTILO, W. ; TAKATA CS ; OA, S. ; da Costa MH ; RAW, I. . Evaluation of a diphtheria and tetanus PLGA microencapsulated vaccine formulation without stabilizers.. Current Drug Delivery, v. 6, p. 297-04, 2009.

24.
de Cássia Dias S2008de Cássia Dias S ; SAKAUCHI, D ; ABREU, P. ; de Lima Netto S ; IOURTOV, D ; RAW, I. ; KUBRUSKY, F. . Purification and characterization of aprotinin from porcine lungs.. Biotechnology Letters, v. 30, p. 807-812, 2008.

25.
NASCIMENTO, I.2008NASCIMENTO, I. ; DIAS, W O ; QUINTILLLO, W. ; Christ AP ; MORAES JF ; VANCETTO MD ; RIBEIRO-DOS-SANTOS G ; RAW, I. ; LEITE, L C . Immunogenicity and safety of combined intradermal recombinant Hepatitis B with BCG vaccines at birth.. Microbes and Infection, v. 10, p. 198-202, 2008.

26.
NASCIMENTO, I.2008NASCIMENTO, I. ; DIAS, W O ; WQUINTILO ; Christ AP ; MORAES JF ; MDC, V. ; RIBEIRO-DOS-SANTOS G ; RAW, I. ; LEITE, L C . Neonatal immunization with a single dose of recombinant BCG expressing subunit S1 from pertussis toxin induces complete protection against Bordetella pertussis intracerebral challenge.. Microbes and Infection, v. 10, p. 198-202, 2008.

27.
GEBARA, Vc2007 GEBARA, Vc ; Risoléo, L ; LOPES, A. ; Ferreira, VR ; QUINTILO, W. ; Lépine, L ; SILVA, W. ; RAW, I. . Adjuvant and immunogenic activities of the 73kDa N-terminal alpha-domain of BrkA autotransporter and Cpn60/60kDa chaperonin of Bordetella pertussis.. Vaccine (Guildford), v. 25, p. 621-629, 2007.

28.
Mazzola, TN2007 Mazzola, TN ; Da Silva, MT ; Moreno, YM ; Lima, SC ; Carniel, EF ; Morcillo AM ; Antonio, MA ; Zenoli, ML ; Neto, A A ; Blotta, MH ; RAW, I. ; Vilela, M.M . Robust gammadelta+ T cell expansion in infants immunized at birth with BCG vaccine.. Vaccine (Guildford), v. 25, p. 6313-6320, 2007.

29.
RAW, I.;RAW, ISAÍAS;RAW, ISAIAS2006RAW, I.; BARUQUE-RAMOS, J ; HISS, H ; CONVERTI, A ; GONÇALVES, V M . Accumulation of organic acids in cultivations of Neisseria meningitidis C.. Journal of Industrial Microbiology and Biotechnology, Inglaterra, 2006.

30.
PRECIOSO, A R2006PRECIOSO, A R ; SAKAE, P P ; MASCARETTI, R S ; KUBRUSLY, F S ; GEBARA, V C ; IOURTOV, D ; REBELLO, C M ; VAZ, F A ; RAW, I. . Analysis of the immunogenicity and stability of a porcine pulmonary surfactant preparation administered in rabbits.. Clinics, São Paulo - Brasil., v. 61, p. 153-160, 2006.

31.
FRAZATTI-GALLINA, N M2004FRAZATTI-GALLINA, N M ; MOURAO-FUCHES, R M ; PAOLI, R L ; SILVA, M L ; MIYAKI, C ; VALENTINI, e J ; RAW, I. ; HIGASHI, H G . Vero-cell rabies vaccine produced using serum-free medium.. Vaccine (Guildford), Holanda, v. 23, p. 511-517, 2004.

32.
FUKASAWA, L O2004FUKASAWA, L O ; DIAS, W O ; SCHENKMAN, R P ; RAW, I. ; TANIZAKI, M M . Adjuvant can improve protection induced by OMV vaccine against Neisseria meningitidis serogroups B/C in neonatal mice.. FEMS Immunology and Medical Microbiology, Holanda, v. 41, p. 205-210, 2004.

33.
NEVES, F O2004NEVES, F O ; HO, P L ; RAW, I. ; PEREIRA, C A ; MOREIRA, C ; NASCIMENTO, A L . Overexpression of a synthetic gene encoding human alpha interferon in Escherichia coli.. Protein Expression and Purification, USA, v. 35, p. 353-359, 2004.

34.
MAZZANTINI, R P2004MAZZANTINI, R P ; MIYAJI, e N ; DIAS, W O ; SAKAUCHI, D ; NASCIMENTO, A L ; RAW, I. ; WINTER, N ; GICQUEL, B ; RAPPUOLI, R ; LEITE, L C . Adjuvant activity of Mycobacterium bovis BCG expressing CRM197 on the immune response induced by BCG expressing tetanus toxin fragment C.. Vaccine (Guildford), Holanda, v. 22, p. 740-746, 2004.

35.
KUBRUSLY, F S2004KUBRUSLY, F S ; IOURTOV, D ; LEME, e ; RAW, I. . Pulmonary surfactant protein A isolation as a by-product of porcine pulmonary surfactant production.. Biotechnology and Applied Biochemistry, Inglaterra, v. 40, p. 173-179, 2004.

36.
LO, Fukasawa2003LO, Fukasawa ; O, Gorla M C ; S, Lemos A P ; SCHENKMAN, R. P. F. ; BRANDILEONE, M. C. C. ; FOX, J. W. ; RAW, I. ; FRASH, C. ; TANIZAKI, M M . Immune response to native NadA from Neisseria meningitidis and its expression in clinical isolates in Brazil. Journal Medical Microbiology, Inglaterra, v. 52, p. 121-125, 2003.

37.
Beny Spira2003Beny Spira ; RAW, I. . Differentially expressed genes in liver of thioacertmide treated rats. Comparative Biochemistry and Physiology, Inglaterra, v. 135, p. 129-135, 2003.

38.
F, Paz M2003F, Paz M ; BARUQUE-RAMOS, J ; H, H. ; A, Vicentin M ; MBB, L. ; RAW, I. . Polyssacharuide production in bath process of Neisseria Meningities Serotype C compáring Frankz, modified Frank and Catlib cultivation media. Bras.J.Microbiol, Brasil, v. 34, p. 27-32, 2003.

39.
TAKAGI, M2003TAKAGI, M ; CABRERA-CRESPO, J ; BARUQUE-RAMOS, J ; ZANGIROLAMI, Tc ; RAW, I. ; TANIZAKI, M M . Characterization of polysaccharide production of haemophilus influenzae Type b and its relationship to bacterial cell growth.. Applied Biochemistry and Biotechnology, USA, v. 110, p. 91-100, 2003.

40.
WU, Y Z2003WU, Y Z ; MEDJANE, S ; CHABOT, S ; KUBRUSLY, F S ; RAW, I. ; CHIGNARD, M ; TOUQUI, L . Surfactant protein-A and phosphatidylglycerol suppress type IIA phospholipase A2 synthesis via nuclear factor-kappaB.. American Jorunal of Respiratory and Critical Care Medicine, USA, v. 168, p. 692-699, 2003.

41.
RAMOS, C R2003RAMOS, C R ; FIGUEREDO, R C ; PERTINHEZ, T A ; VILAR, M M ; NASCIMENTO, A L Do ; TENDLER, M ; RAW, I. ; SPISNI, A ; HO, P L . Gene structure and M20T polymorphism of the Schistosoma mansoni Sm14 fatty acid-binding protein. Molecular, functioanl, and immunoprotection analysis.. The Journal of Biological Chemistry, USA, v. 278, p. 12745-12751, 2003.

42.
RAW, I.;RAW, ISAÍAS;RAW, ISAIAS2002RAW, I.; DSPQ, H. ; GEBRARA, V. ; SILVA, W. . Vitamin A adjuvant to mouse immune response to pertussis, tetanus, diphteria vaccines. Biotechnology Letters, USA, v. 24, p. 1515-1518, 2002.

43.
APM, A.2002APM, A. ; Oliveira, ML ; RAMOS, C R ; ME Sbrogio-Almeida ; RAW, I. ; HO, Pl . Synthesis of cholera toxin B subunit gene:cloning and expressiopn of a functional 6XHis-taggget protein in Escherichia coli. Protein expression & purification, USA., v. 25, p. 481-487, 2002.

44.
RAW, I.;RAW, ISAÍAS;RAW, ISAIAS2001RAW, I.; MIIYAI, e N ; MANZZANINI, R P ; DIAS, W O ; NASCIMENTO, A L ; MARCOWITSTZ, R. ; MATOS, R. ; WINTER, N ; GUICAQUET, B. ; RAPUOLI, R. ; LEITE, L. . Induction of neurtralizing antibodies against diphteria toxin by priming with recombinant Mycobacterium bovis BCG expressing CRM 197, a mutant diphteria ttoxin. Infection and Immunity, USA, v. 69, p. 967-874, 2001.

45.
RAW, I.;RAW, ISAÍAS;RAW, ISAIAS2001RAW, I.; SILVA, R B Pietro da ; HO, P L . Cross reactivity of different Micrusrus an tivenom with homologous and theterologous snake venoms. Toxicon, USA, v. 39, p. 940-953, 2001.

46.
CIANCIARULLO, A.2001CIANCIARULLO, A. ; LEME, e ; BEÇAK, W. ; RAW, I. ; KUBRUSLY, Fs . Ultrastructural chemical reaction to detect saturated phospholipids of a natural lung surfactant. Biotechnology Letters, USA, v. 23, p. 1202-1206, 2001.

47.
GRELLET, S.2001GRELLET, S. ; MARTINS, E. ; GNÇALVES, V. ; LOPES, A. ; RAW, I. ; CABEROCRESPO, J. . An Associated process for the purificastion of immunoglobulin F, catalase, superoxide dismutase and albumin from haemolyzed human plancental blood. Biotechnology and Applied Biochemistry, Canadá., v. 34, p. 135-142, 2001.

48.
RAW, I.;RAW, ISAÍAS;RAW, ISAIAS2001RAW, I.; HO, P L . Site-directed mutagenesdis of bovine FGF-2 cDNA alllow for the production of the human form of FGF-2 in E.coli. Biotechnology Letters, USA, v. 23, p. 1151-1157, 2001.

49.
RAW, I.;RAW, ISAÍAS;RAW, ISAIAS2000RAW, I.; CABRERACRESPO, J. ; GONÇLAVES, V. M. ; MARTINS, E. A. L. ; GRELLET, S. ; LOPES, A. P. Y. . Albumin purification from human placenta. Biotechnology and Applied Biochemistry, Inglaterra, v. 31, p. 101-106, 2000.

50.
RAW, I.;RAW, ISAÍAS;RAW, ISAIAS2000RAW, I.; TANAKA, A. M. ; TANAKA, A. ; LOPES, A. P. Y. ; TAKAGI, M ; CAARERACRESPO, J. . Purification ofporcine plasma factor VIII using chromatography. Biotechnology Letters, Holanda, v. 22, p. 257-260, 2000.

51.
RAW, I.;RAW, ISAÍAS;RAW, ISAIAS2000RAW, I.; OLIVEIRA, J. S. ; SILVA, A. R. B. ; SOARES, M B ; DIAS, W O ; HO, P L ; ATEPHANO, M. . Cloning and characterization of an alpha neurotoxin type protein specific for the coral snake Micrurus corallinus. Biochemistry and Molecular Biology International, USA, v. 267, p. 887-891, 2000.

52.
RAW, I.;RAW, ISAÍAS;RAW, ISAIAS2000RAW, I.; QUINTIÇOP, W. ; SDATO, W. ; SRAUJO, P. ; COSTA, M. H. B. . Estabilization of immunoconjugates by threalose. Biotechnology Letters, Inglaterra, v. 22, p. 417-420, 2000.

53.
RAW, I.;RAW, ISAÍAS;RAW, ISAIAS2000RAW, I.; ESTEVES, M. ; WQUINTILO ; RASATO ; ARAUJO, P. ; COSTA, M. B. . Stabilization of mmunoconjugates by threalose. Biotechnology Letters, v. 22, p. 257-261, 2000.

54.
RAW, I.;RAW, ISAÍAS;RAW, ISAIAS2000RAW, I.; IURTOV, D. ; KUBRUSLY, Fs ; TENORIO, E. ; HIGASHI, Hg . Tween 20 , birih35 and triton X-100 detrmination exploring the properties of oxyethylene groups in the presence of proteins. Brazilian Journal of Medical and Biological Research, Brasil, v. 35, p. 245-247, 2000.

55.
RAW, I.;RAW, ISAÍAS;RAW, ISAIAS2000RAW, I.; NASCIMENTO, I. ; DIAS, Wo ; MEZZANITINI, R. ; MIYAKI, E. ; GAMBERINI, M. ; QUINTILO, W. ; GUEBARA, V. ; CARODOS, C. ; HO, L. ; WINTER, N ; GUIUQEL, B. ; RAPPUOLI, R ; LEITE, L. . Recombinant Mycobterium bovis BCG expressing pertussis toxin S1 induces the protectiiob against intracerebral challenge with live Bordetella pertussis in mice. Infection and Immunity, v. 68, p. 4877-4883, 2000.

56.
RAW, I.;RAW, ISAÍAS;RAW, ISAIAS2000RAW, I.; MYIAI, E. ; MAZZANTINI, Rp ; DIAS, Wo ; NASCIMENTO, A. ; MARCOWITZ, R. ; MATOS, D. ; WINTER, N ; GICQUET, B. ; RAPPUOLI, R ; LEITE, L. . Induction of neutralizing antibodies agains diphteria toxin by priming with recombinant Mycobacteria bovis BCG expressing CRM 197, a mutant diphteria toxin. Infection and Immunity, USA, v. 69, p. 869-874, 2000.

57.
RAW, I.;RAW, ISAÍAS;RAW, ISAIAS2000RAW, I.; RIBAS, A. ; HO, Pl ; TANIZAKI, M. ; NASCIMENTO, A. . High level expression of tetanus toxin fragment C thioredoxin fussion protein in E.coli. Biotechnology and Applied Biochemistry, USA, v. 31, p. 94-98, 2000.

58.
RAW, I.;RAW, ISAÍAS;RAW, ISAIAS2000 RAW, I.; KUBRUSKY, F S ; LIMA NETTO, S. ; IURTOV, D. ; ARAUJO, O S de . A natural surfactant from pig lungs. Biotechnology Letters, USA, v. 22, p. 1251-1253, 2000.

59.
RAW, I.;RAW, ISAÍAS;RAW, ISAIAS1999RAW, I.; HIGASHI, H G . Vaccination and self suffiency. Revista do Instituto de Medicina Tropical de São Paulo, São Paulo - Brasil, v. 4, p. 1-2, 1999.

60.
RAW, I.;RAW, ISAÍAS;RAW, ISAIAS1999RAW, I.; FUKSAWA, L. O. ; GLORIA, M. C. O. ; SCHENKAM, P. P. F. ; GARCIA, G. T. ; CARNEIRO, S. M. ; TANIXAKI, M. M. . Meningites neissera serogroup C poyssacharide and serogroup B outer membrane vesicle conjugateas bivalent meningococcus vaccine candidate. Vaccine (Guildford), USA, v. 17, p. 2951-2953, 1999.

61.
RAW, I.;RAW, ISAÍAS;RAW, ISAIAS1999RAW, I.; IOSHIMOTO, L. M. ; RISSATO, M. I. ; BONUIKLHA, V S J ; MIYAKI, C ; GRANOVSKI, M. . Safety and immunogenicity of hepatitis B vaccine Butang in adults. Revista do Instituto de Medicina Tropical de São Paulo, Brasil, v. 41, p. 191-195, 1999.

62.
RAW, I.;RAW, ISAÍAS;RAW, ISAIAS1999RAW, I.; GONÇALVES, V M ; LEITE, L C ; CRESPO, J C . Purification of catalase dfrom human placenta. Biotechnol Appl Biochemistry, Inglaterra, v. 29, p. 73-79, 1999.

63.
RAW, I.;RAW, ISAÍAS;RAW, ISAIAS1997RAW, I.. Clinical trials on adults of a recombinant yeast-derived hepatitis B vaccine manufactured by Instituto Butantan. Revista do Instituto de Medicina Tropical de São Paulo, Brasil, v. 39, p. 39-42, 1997.

64.
RAW, I.;RAW, ISAÍAS;RAW, ISAIAS1997RAW, I.; WOLF ; TRONCONI, J R ; LEBRUN, I. ; HO, I. M. . Further biochemical and pharmacological characterization of PF3, a neurotoxic peptide from armader sopice Phoneutrai nigriverter. Journal Nat Toxins, USA, v. 6, p. 211-219, 1997.

65.
RAW, I.;RAW, ISAÍAS;RAW, ISAIAS1997RAW, I.; SATO, R. ; QUINTINLIO, Q. ; SILVEIRA, A N ; FATTAL, G. B. ; BUENODACOSTA, M H . Alternative method to deter,mine microquantitation of protein with low chromophobic content. Biochem Technology, Inglaterra, v. 11, p. 617-620, 1997.

66.
RAW, I.;RAW, ISAÍAS;RAW, ISAIAS1997RAW, I.; HO, P L ; SOARES, M B ; MAAK, T. ; GIMENEAS, K. ; PURPTP, G. ; FURTADO, M D F D . Cloning an unusual natriuretic peptide from South American snale Micrurus crallinus. Eur J Bicchemistry, França, v. 250, p. 144-148, 1997.

67.
RAW, I.;RAW, ISAÍAS;RAW, ISAIAS1996RAW, I.. Batch cultivation kinetics of Neisseria meningitis seromgrpoup C in Franz medium I. Growth and polyssacaride production. Arq Biol Tecnol, Brasil, v. 30, p. 215-220, 1996.

68.
RAW, I.;RAW, ISAÍAS;RAW, ISAIAS1996RAW, I.; WOLF, P. ; HO, P L . Purification of fibroblast growth factor I from human placenta using tri(n-butyl) phospahte and sodium cholate. Bichimie, França, v. 78, p. 190-198, 1996.

69.
RAW, I.;RAW, ISAÍAS;RAW, ISAIAS1996RAW, I.. Batch cultivation kinetics of Neisseria meningitis. Arquivos Biol Tecnologia, Brasil, v. 39, p. 215-230, 1996.

70.
RAW, I.;RAW, ISAÍAS;RAW, ISAIAS1996RAW, I.; TANIZAKI, M M ; GARCIA, M. M. ; GARCIA, J. B. ; LEITE, L C C ; HISS, H ; CRESPO, J C V . Purification of meningococcal group C polyssacharide by a producedfure suitable for scale-up. Journal of Microbiological Methods, USA, v. 27, p. 19-25, 1996.

71.
RAW, I.;RAW, ISAÍAS;RAW, ISAIAS1995RAW, I.; SOARES, M B ; HO, P L ; YAMANET . Reverse biology applied to Micrurus corlinus , a South American snake. Journal Of Toxicology Reviews, USA, v. 14, p. 327-337, 1995.

72.
RAW, I.;RAW, ISAÍAS;RAW, ISAIAS1995RAW, I.; FERRO, e S ; ABREU, P. ; MENDONÇA, R. Z. ; FRANCO, M. ; VALENTIN, E. J. G. ; BEÇAK, W. ; PEREIRA, P. A. E. ; TANMBOURGI, D. V. ; CAMARGO, A. C. M. ; HO, P L . Presence of endooligopeptidase A (EC 3.4.22.19) like protein in PC12 cells: activity miodulation by cAMP analogs but no basic fibroblasst growth factor. Journal Cell Biochemistry, USA, v. 57, p. 311-320, 1995.

73.
RAW, I.;RAW, ISAÍAS;RAW, ISAIAS1995RAW, I.. Procedures for scaling up the recombinant 18kD hsp lepra protein production. Biotechnolgy Letters, Inglaterra, v. 9, p. 527-532, 1995.

74.
RAW, I.;RAW, ISAÍAS;RAW, ISAIAS1995RAW, I.; GEBRA, V. C. B. ; PETRICHEVICH, V. ; SILVA, W D . Efect of saponin from Quiullaja sapnoaria (molina) on anitbody, tumor necrotic factor and itnerferon gama production. Biochem Appl Biochem, Inglaterra, v. 21, p. 31-37, 1995.

75.
RAW, I.;RAW, ISAÍAS;RAW, ISAIAS1995RAW, I.. The use of frozen inocullum and 0,2% formaldehyde for inactivation of pertussis vaccine production. Rev Farmacia Bioquimica Usp, Brasil, v. 31, p. 85-88, 1995.

76.
MORO, A.1994MORO, A. ; MT, R. ; MN, G. ; ML, S. ; JE, K. ; RAW, I. . Multiparametric analyses of hybridoma growth on glass cylinders in a packed-bed bioreactors system with internal aeration. Serum-supplemented and serum-free media comparison for MAb. Journal of Immunological Methods, v. 176, p. 67-77, 1994.

77.
COSTA, M. H. B.1994COSTA, M. H. B. ; Arisi, A.C ; Matos, CR ; Silva, LV ; RAW, I. . Kinetic Studies on the membrane form of intestinal alkaline phosphatase. Brazilian Journal of Medical and Biological Research, v. 27, p. 2859-2862, 1994.

78.
DIAS, W O1994DIAS, W O ; Horton, DS ; Takahashi, CM ; RAW, I. . A Bordetella pertussis acellular vaccine candidate: autigenic characterization and antibody induction. Brazilian Journal of Medical and Biological Research, v. 27, p. 2607-2611, 1994.

79.
COSTA, M. H. B.1994COSTA, M. H. B. ; Arisi, A.C ; Matos, CR ; Silva, LV ; RAW, I. . Characterization of different membrane forms of placental alkaline phosphatases. Brazilian Journal of Medical and Biological Research, v. 27, p. 445-451, 1994.

80.
MENDONÇA, R. Z.1993MENDONÇA, R. Z. ; IOSHIMOTO, L. M. ; MENDONÇA, RM ; FRANCO, M. ; VALENTINI, Ej ; BEÇAK, W. ; RAW, I. ; PEREIRA, C A . Preparation of human rabies vaccine in VERO cell culture using a microcarrier system.. Brazilian Journal of Medical and Biological Research, v. 26, p. 1305-1317, 1993.

81.
BATARELLO, YM1993BATARELLO, YM ; CABRERA-CRESPO, J ; HO, P L ; CARVALHO, A ; RAW, I. . Purification of superoxide dismutase from placental halmolisate blood: a simple and efficient method.. Biochemistry and Molecular Biology International, v. 30, p. 45-51, 1993.

82.
LEITE, L C1992LEITE, L C ; FURTADO, M. F. D. ; CORREA TC ; RAW, I. . Characterization of the snake venoms from seven Brazilian species of Bothrops by FPLC arion-exchange chromatography.. Comparative Biochemistry and Physiology, v. 102, p. 515-520, 1992.

83.
HO, P. L.1992HO, P. L. ; RAW, I. . Cyclic AMP potentiates bFGF-induced neurite autgrowth in PC12 cells.. Journal of Cellular Physiology, v. 150, p. 647-656, 1992.

84.
BELIZARIO, JE1991BELIZARIO, JE ; KATZ, M ; CHENKER, E ; RAW, I. . Bioactivity of skeletal muscle proteolysis-inducing factors in the plasma proteins from cancer patients with weight loss.. British Journal of Cancer, v. 63, p. 705-710, 1991.

85.
RAW, I.;RAW, ISAÍAS;RAW, ISAIAS1986RAW, I.; ROCHA, MC ; ESTEVES, M. I. ; KAMIGUTI, AS . Isolation and characterization of a thrombin-like enzyme from the venom of crotalus durissus.. Brazilian Journal of Medical and Biological Research, v. 19, p. 333-338, 1986.

86.
RAW, I.;RAW, ISAÍAS;RAW, ISAIAS1985RAW, I.; JULIANI, MH ; ROCHA, MC ; MAIA, JC . Effect of insulin on the synthesis of rat liver ribosomal and endoplasmic reticulum proteins.. Brazilian Journal of Medical and Biological Research, v. 18, p. 421-426, 1985.

87.
RAW, I.;RAW, ISAÍAS;RAW, ISAIAS1984RAW, I.; SCHMIDT, BJ ; MERZEL, J. . Catecholamines and congenital pain insensitivity.. Brazilian Journal of Medical and Biological Research, v. 17, p. 271-279, 1984.

88.
RAW, I.;RAW, ISAÍAS;RAW, ISAIAS1983RAW, I.. Effect of extra-hepatic Walker sarcoma 256 on the synthesis and degradation of liver cytochromes P-450 and b5.. Brazilian Journal of Medical and Biological Research, v. 16, p. 291-295, 1983.

89.
RAW, I.;RAW, ISAÍAS;RAW, ISAIAS1983RAW, I.; DiFini, F. . The possible role of ATP-dependent proteolysis on the solubilization of methemoglobin reductase during reticulocyte maturation.. Biochemical and Biophysical Research Communications, v. 116, p. 357-359, 1983.

90.
de-Araujo,PS.1982de-Araujo,PS. ; de-Andrade-Silva, E. ; RAW, I. . Effect of drugs and hormones on rat liver dimethylaminoazobenzene reductase activity.. Brazilian Journal of Medical and Biological Research, v. 15, p. 17-28, 1982.

91.
RAW, I.;RAW, ISAÍAS;RAW, ISAIAS1979RAW, I.; ROCKWELL, P. . Effect of a single dose of inducers and inhibitors on the rate of synthesis of cytochromes and reductases in liver organelles.. Molecular and Cellular Biochemistry, v. 28, p. 7-16, 1979.

92.
RAW, I.;RAW, ISAÍAS;RAW, ISAIAS1978RAW, I.; STERN JR, ; A., D. C. . Cytochrome P450 in the liver mitochondrial outer membrane of 20-methyl cholanthrene or Aroclor treated rabbits.. Biochemical and Biophysical Research Communications (Print), v. 81, p. 1294-1297, 1978.

93.
RAW, I.;RAW, ISAÍAS;RAW, ISAIAS1977RAW, I.. The integration of nutrition education in the basic biomedical sciences.. Medical Education (Oxford. Print), v. 52, p. 654-657, 1977.

94.
LAU,T.1977LAU,T. ; RAW, I. ; SCHMIDT, BJ ; PIVA, A. . Pain insensitivity a metabolic disease.. Lancet, v. 1, p. 598-599, 1977.

95.
Da COSTA MAIA, JC1974Da COSTA MAIA, JC ; PUDLES, J. ; RAW, I. ; SCHMIDT, BJ . Isolation of a new urine metabolite excreted in generalized congenital analgesia.. Clinica Chimica Acta, v. 54, p. 225-234, 1974.

96.
RAW, I.;RAW, ISAÍAS;RAW, ISAIAS1974RAW, I.. An inter-American effort to innovate medical education.. Medical Education (Oxford. Print), v. 49, p. 451-453, 1974.

97.
Nobrega, FG1969Nobrega, FG ; Araujo, PS ; Pasetto, M ; RAW, I. . Some properties of cytochrome b5 from liver microsomes of man, monkey, pig and chicken.. Biochemical Journal (London. 1984), v. 115, p. 849-856, 1969.

98.
R, B.1965R, B. ; RAW, ISAIAS . SEXUAL DIFFERENCE IN RAT LIVER MICROSOMAL CYTOCHROME B5.. Experimental Cell Research, v. 38, p. 213-215, 1965.

99.
M., B.1964M., B. ; R., B. ; RAW, ISAIAS . ROLE OF NUCLEOLAR RIBONUCLEIC ACID IN INCORPORATION OF RIBOSOMAL AMINO ACID.. Nature, v. 201, p. 1130, 1964.

100.
RAW, I.1961RAW, I.; OC., N. ; JB., M. F. . Isolation of a DPNH-diaphorase from pig liver mitochondria.. Isolation of a DPNH-diaphorase from pig liver mitochondria., v. 23, p. 123-128, 1961.

101.
RAW, ISAÍAS1960RAW, ISAÍAS; OC., N. ; PETRAGNANI N, . Studies of electron transport enzymes. IV. Oxidation and reduction of cytochrome b5 by rat liver mitochondria.. Journal of Biological Chemistry (Online), v. 235, p. 1517-20, 1960.

102.
RAW, I.1960RAW, I.; BJ, S. . [Isocitric dehydrogenase in the serum as test of hepatic function].. Revista Paulista de Medicina (Cessou em 1993. Cont. ISSN 1516-3180 São Paulo Medical Journal (Impresso)), v. 57, p. 340-344, 1960.

103.
PETRAGNANI N,1959PETRAGNANI N, ; NOGUEIRA OC, ; RAW, ISAÍAS . Methaemoglobin reduction through cytochrome B5.. Nature, v. 184, p. 1651, 1959.

104.
RAW, I.1959RAW, I.; W., C. . Crystalline cytochrome b5.. Nature, v. 184, p. 1798-23, 1959.

105.
RAW, ISAIAS1959RAW, ISAIAS; HR, M. . Studies of electron transport enzymes. III. Cytochrome b5 of pig liver mitochondria.. Biochemical and Biophysical Research Communications (Print), v. 234, p. 1867-73, 1959.

106.
RAW, ISAIAS1958RAW, ISAIAS; MOLINARI R, ; DO AMARAL DF, ; HL., M. . Isolation of a cytochrome of the antimycin A sensitive pathway for DPNH oxidation.. Biochemical and Biophysical Research Communications (Print), v. 233, p. 225, 1958.

107.
RAW, ISAIAS1956RAW, ISAIAS. Isolation of a cytochrome of the antimycin A sensitive pathway for DPNH oxidation.. Person-Centered and Experiential Psychotherapies, v. 12, p. 348, 1956.

108.
RAW, ISAÍAS1953RAW, ISAÍAS. The inhibitory action of hydroxylamine on biological oxidations.. Science, v. 118, p. 159, 1953.

Livros publicados/organizados ou edições
1.
RAW, I.; MARTINS, E. . Medicina Molecular.. 2A. ed. São Paulo: Editora Roca, 2005. v. 1. 396p .

2.
RAW, I.; HO, P. L. . Integração e sinais.. São Paulo.: EDUSP., 2000. v. 1. 260p .

3.
RAW, I.; MENUCCI, L. ; KRASICHIL, M. . A Biologia e o Homem.. São Paulo: EDUSP., 2000. 400p .

4.
RAW, I.; MORA, A. M. . Medicina Molecular.. São Paulo.: Editora Rocca., 1999. v. 1. 226p .

5.
RAW, I.; BRENTANI, M. ; BRENTANI, R. ; MENUCCI, L. . Bases moleculares da medicina-cancer. Rio de Janeiro: Areneu + EDUSP, 1992. v. 1. 124p .

Capítulos de livros publicados
1.
RAW, I.; MTARODRIGUES ; GARBUIO, A. ; NAGAO, L. ; MORO, A. . Cell growth rate estimation in packed-bed and hollow fibber reactor: metabolism and productivity. In: F Wurm; A Bernard. (Org.). Animal cell technology: products from cell, cell as products. Amsterdham: Kluwer Academic Press, 1999, v. , p. 159-161.

2.
RAW, I.; |Isaias Raw ; Isaias Raw . Residual DNA content of hybridoma cultures: decorrece of apoptosis?. In: MJT Carrondo; JB Griffiths; JL Moreira. (Org.). Amsterdham: Kluwer Academic Press, 1997, v. 1, p. 467-472.

Trabalhos completos publicados em anais de congressos
1.
RAW, I.; FS, K. ; AM, T. ; PS, A. ; D, I. . Purification of swine pulmonary surfactant protein A to use as purified antigen into inject animals. In: XXIX Reunião Anual da SBBq, 2000, Minas Gerais, 2000.

2.
RAW, I.; AP, A. ; AP, B. ; CMPM, U. ; WO, D. ; MM, T. ; RPF, S. . Studies on protocol formulation of a meningococui serogroup B vaccine. In: XXIX Reunião Anual da SBBq, 2000, Minas Gerais, 2000.

3.
RAW, I.; LO, Fukasawa ; MCO, G. ; CE, F. ; MM, T. . Identification of a 190Kd protein with epitope that shares homology with protein of different Neisseria meningitidis. In: XXIX Reunião Anual da SBBq, 2000, Minas Gerais, 2000.

4.
RAW, I.; MM, V. ; CRR, R. ; ALTO, N. ; H, T. ; WO, D. ; N, T. ; PAE, A. ; R, E. ; PL, H. ; M, T. . Development of na anti-helmint vaccine: effact of 6X-His-taget SM14 fatty acid binding protein characteristic from Schistosoma mansoni in experimental animals. In: XXIX Reunião Anual da SBBq, 2000, Minas Gerais, 2000.

5.
RAW, I.; S, G. ; APA, L. ; EAL, M. . Purification of human and swine pro-coagulant factor VIII. Concomitant purification of other proteins of human plasma. In: XXIX reunião Anual da SBBq, 2000, Minas Gerais, 2000.

6.
RAW, I.; PAE, A. ; PL, H. ; M, T. ; ALTO, N. . Expression of fragment C of tetanus toxin in fusion and in tanden with the 14 KDA Schistossoma mansoni protein (SM). In: XXIX Reunião Anual da SBBq, 2000, Minas Gerais, 2000.

7.
RAW, I.; M, G. ; CG, P. ; RPF, S. ; LCC, L. . Development of recombinant pneumococcal vaccines based on psaA.. In: XXIX Reunião Anual da SBBq, 2000, Minas Gerais, 2000.

8.
RAW, I.; IP, N. ; WO, D. ; RP, M. ; EN, M. ; M, G. ; W, Q. ; VCC, G. ; DF, C. ; PL, H. ; N, W. ; B, G. ; R, R. ; LCC, L. . Recombinant BCG expressing S1 pertussis toxin induces protection against intracerebral chalange with live Bordetella pertussis in mice. In: XXIX Reunião Anual da SBBq, 2000, Minas Gerais, 2000.

9.
RAW, I.; APM, A. ; MIE, O. ; PL, H. . Sintesis and molecular cloning of cholera toxin subunit B gene (E.coli). In: XXIX Reunião Anual da SBBq, 2000, Minas Gerais, 2000.

10.
RAW, I.; MTA, R. ; A, G. ; AM, M. . Hybridoma metabolism in continuos perfussion bioreactors. In: XXIX Reunião Anual da SBBq, 2000, Minas Gerais, 2000.

11.
RAW, I.; M, T. ; NM, G. ; JB, R. ; MM, T. . Batch cultivation of Haemophilus influenzae B. In: XXIX Reunião Anual da SBBq, 2000, Minas Gerais, 2000.

12.
RAW, I.; UC, O. ; ARBP, S. ; JS, O. ; PL, H. . Expression of a potential pre-synaptic neurotoxin phospholipase A2 from the venom gland of micrurus corallinus. In: XXVIII Reunião Anual da SBBq, 1999, Minas Gerais, 1999.

13.
RAW, I.; WO, D. ; DSPQ, H. ; N, F. ; ACB, S. ; VRF, F. . The use of vitamina A a immunologic adjuvant for Bordetella pertussis antigens. In: XXVIII Reunião Anual da SBBq, 1999, Minas Gerais, 1999.

14.
RAW, I.; DC, F. ; MM, T. . Chemical modifications of Neisseria meningitidis lypopolyssacharide. In: XXVIII Reunião Anual da SBBq, 1999, Minas Gerais, 1999.

15.
RAW, I.; FS, K. ; SL, N. ; D, I. ; PS, A. . Purification of the collegiobn SP-A using a column of immobilized d-amanose. In: XXVIII Reunião Anual da SBBq, 1999, Minas Gerais, 1999.

16.
RAW, I.; PAE, A. ; M, T. ; MM, V. ; PL, H. ; CRR, R. ; ALTO, N. . Cloning of fragment C of tetanus toxin in fusion and in tandem with the 14KFDA Shistossoma mansoni Protein (SM14). In: XXVIII Reunião Anual da SBBq, 1999, Minas Gerais, 1999.

17.
RAW, I.; M, G. ; RPF, S. ; CG, P. ; VM, G. ; MM, T. ; LCC, L. . Three different proposal for the recombinant pneumococcal vaccines. In: XXVIII Reunião Anual da SBBq, 1999, Minas Gerais, 1999.

18.
RAW, I.; VM, G. ; NM, G. ; MM, T. . Influence of ratio carbon/nitrogen sources on capsular polyssacharide production by Staphilococcus pneumoniae. In: XXVIII Reunião Anual da SBBq, 1999, Minas Gerais, 1999.

19.
RAW, I.; ALTO, N. ; AV, R. ; AI, G. ; WO, D. . High-level expression of tetanus toxin fragment C-thioredoxin fusion protein in e.coli. In: XXVIII Reunião Anual da SBBq, 1999, Minas Gerais, 1999.

20.
RAW, I.; D, C. ; J, C. ; A, C. ; A, T. ; APY, L. ; S, G. ; EAL, M. . The viability of capturing Factor VIII directly from umprecessed and unclarified suine plasma, comparison of expanded bed adsorption and fast flow chromatography and tangential filtration. In: XXVIII Reunião Anual da SBBq, 1999, Minas Gerais, 1999.

21.
RAW, I.; NM, G. ; M, T. ; VM, G. ; MM, T. . Influence of glucose and dissolved oxygen on capsular polysacharide production of Haemophilus influenzae. In: XXVIII Reunião Anual da SBBq, 1999, Minas Gerais, 1999.

22.
RAW, I.. Vaccine developments: new chalanges/Viability of production. In: Proceedings of the Inter. Workshop on Vaccine Development & Production - Fiocruz, 1999, Rio de Janeiro, 1999.

23.
RAW, I.; PAE, A. ; PL, H. . Expression and purification of the extracellular domains of fibroblast factor receptor 1 in E.coli. In: XXVII Reunião Anual da SBBq, 1998, Minas Gerais, 1998.

24.
RAW, I.; WO, D. ; DSPQ, H. ; VRF, F. . Effect of vitamin A on mice humoral response to Bordetella pertussis extracts. In: XXVII Reunião Anual da SBBq, 1998, Minas Gerais, 1998.

25.
RAW, I.; J, C. ; VM, G. ; EAL, M. ; S, G. . Purification of albumin from human placenta in a pilot plant. In: XXVII Reunião Anual da SBBq, 1998, Minas Gerais, 1998.

26.
RAW, I.; EAL, M. ; VM, G. ; APY, L. ; A, C. ; J, C. . Co-purification of superoxide dismutase and transferrin with albumin from hemolyzate from human placenta. In: XXVII Reunião Anual da SBBq, 1998, Minas Gerais, 1998.

27.
RAW, I.; JB, R. ; UM, V. ; R, M. . Influence of glucose concentration on the formation kinetics. In: XXVII Reunião Anual da SBBq, 1998, Minas Gerais, 1998.

28.
RAW, I.; FO, F. ; MCO, G. ; RPF, S. ; DC, F. ; NM, G. ; MM, T. . PSC-OVM conjugate as a candidate vaccine agains Neisseriameningitidis serogroup B and C. In: XXVII Reunião Anual da SBBq, 1998, Minas Gerais, 1998.

29.
RAW, I.; PA, M. ; A, G. ; AM, M. . Production of recombinant erythropoetin in CHO cells. In: XXVI Reunião Anual da SBBq, 1997, Minas Gerais, 1997.

30.
RAW, I.; E, Y. ; C, L. ; WO, D. . Antibodies mice leve produced by bordetella pertussis outerm membrane proteins. In: XXVI Reunião Anual da SBBq, 1997, Minas Gerais, 1997.

31.
RAW, I.; LR, G. ; RPF, S. ; MM, T. . An imporved process for neisseria meningitidis serogroup C vaccine production. In: XXVI Reunião Anual da SBBq, 1997, Minas Gerais, 1997.

32.
RAW, I.; A, G. ; MTA, R. ; AM, M. . A simple method to avoid bovine IgG contamination in monoclonal antibodies production. In: XXVI Reunião Anaul da SBBq, 1997, Minas Gerais, 1997.

33.
RAW, I.; AM, T. ; M, T. ; J, C. ; APY, L. . Porcine factor VIII purification: purification using classic chromatography methods. In: XXVI Reunião Anual da SBBq, 1997, Minas Gerais, 1997.

34.
RAW, I.; VM, G. ; S, G. ; J, C. ; LCC, L. . Purification of catalase from human placenta. In: XXVI Reunião Anual da SBBq, 1997, Minas Gerais, 1997.

35.
RAW, I.; WO, D. ; DSPQ, H. ; N, F. ; VRF, F. . Effect of vitamin A on mice humoral response to bordetella pertussis cells. In: XXVI Reunião Anual da SBBq, 1997, Minas Gerais, 1997.

36.
RAW, I.; ARBP, S. ; JS, O. ; PL, H. . Expression of a potential alpha neurotoxin from the venom gland of micrurus corallinus in a soluble form in E.coli. In: XXVI Reunião Anual da SBBq, 1997, Minas Gerais, 1997.

37.
RAW, I.; MHB, C. ; OA, S. ; RA, S. . Biodegradable microspheres as antigen carrer. In: Fesbe, 1996, 1996.

38.
RAW, I.; C, L. ; A, C. ; MHB, C. ; WO, D. . Outer membrane vesicle: an alternative pertussis vaccine. In: Fesbe, 1996, 1996.

39.
RAW, I.; E, C. ; M, A. ; PAE, A. ; PL, H. . Expression of a potental neurotoxinphospholipase A-2 type from micrurus corallinus a South American Coral Snake. In: XXV Reunião Anual da SBBq, 1996, Minas Gerais, 1996.

40.
RAW, I.; ARBP, S. ; PL, H. . Expression of a protein homologous to alfa-neurotoxins from the South American Coral Snake. In: XXV Reunião Anual da SBBq, 1996, Minas Gerais, 1996.

41.
RAW, I.; Z, P. ; I, L. ; AP, R. ; MDC, P. ; MDC, V. ; F, F. . Increase tetanus toxin product by pepetides isolated from casein hydrolyzate and changes in free aminoacids from media during growth. In: XXV Reunião Anual da SBBq, 1996, Minas Gerais, 1996.

42.
RAW, I.; AM, T. ; M, T. ; J, C. ; APY, L. . Choise of the best conditions for the purification of FVIII from porcine plasma. In: XXV Reunião Anual da SBBq, 1996, Minas Gerais, 1996.

43.
RAW, I.; MTA, R. ; A, G. ; LP, A. ; AM, M. . Reisdual mouse DNA content in monoclonal antibody for human use. In: XXV Reunião Anual da SBBq, 1996, Minas Gerais, 1996.

44.
RAW, I.; DSPQ, H. ; WO, D. ; N, F. ; MA, F. ; MA, S. ; E, M. ; E, S. . Use os histamine se nistizing factor test to evaluate detoxification procedure of pertussis vaccine. In: XXV Reunião Anual da SBBq, 1996, Minas Gerais, 1996.

45.
RAW, I.; C, L. ; PA, A. ; WO, D. ; MHB, C. ; E, Y. . Bordetella pertussis outer membrane vesicles: biochemical, morfological and immunological evaluation. In: XXV Reunião Anual da SBBq, 1996, Minas Gerais, 1996.

46.
RAW, I.; MM, T. ; WO, D. ; C, L. ; MHB, C. . Meningococcal polysacharide 18KDa-HPS M. leprae protein conjugated vaccine. In: XXV Reunião Anual da SBBq, 1996, Minas Gerais, 1996.

47.
RAW, I.; D, I. ; FS, K. ; ECN, T. ; HG, H. . Determination of tween 10 in bulk samples os recombinant hepatites B vaccine during itsbproduction. In: VII Encontro Nacional de Virologia, 1996, São Lourenço, 1996.

48.
RAW, I.; MM, T. . An improved method for meningococcus C polysacharide purification. In: 10th Neisseria Congress, 1996, Baltimore, 1996.

49.
RAW, I.; PL, H. ; MB, S. ; TP, M. ; MFD, F. . Clonagem e caracterização de toxinas da cobra coral micrurus corallinus. In: IV Simpósio da Sociedade Brasileira de Toxinologia, 1996, Recife, 1996.

50.
RAW, I.; ARBP, S. ; PL, H. . Expression of a recombinant protein homologous to alfa-neurotoxin from South American Coral Snake micrurus corallinus. In: IV Simposium da Sociedade Brasileira de Toxinologia, 1996, Recife, 1996.

51.
RAW, I.. Recoverng a traditional institution through biotechnology. In: Simposia of Biotechnology - VIII PABMMB, 1996, 1996.

52.
RAW, I.; MH, M. ; ARBP, S. ; MF, F. ; PL, H. ; YAMANET . Cloning and characterization of a repetitie 1.7 kb hind II DNA fragment from Crotalus durissus terrificus genome. In: XXIV Reunião Anual da SBBq, 1995, Minas Gerais, 1995.

53.
RAW, I.; AJVP, S. ; MB, S. ; L, S. ; I, R. ; T, Y. ; PL, H. . Expression of a potencia alfa-neurotoxin from venom gland of micrurus corallinus in e.coli. In: XXIV Reunião Anual da SBBq, 1995, Minas Gerais, 1995.

54.
RAW, I.; DSPQ, H. . Effect of trehalose on the stability of urease and immunoconjugates. In: XXIV Reunião Anual da SBBq, 1995, Minas Gerasi, 1995.

55.
RAW, I.; CMPM, U. ; D, O. ; VI, P. ; VLA, R. ; RC, B. ; MA, S. ; WS, S. . Secreted proteins by BCG cultivated in different media. In: XXIV Reunião Anual da SBBq, 1995, Minas Gerais, 1995.

56.
RAW, I.; Z, P. ; I, L. ; SMA, P. ; MDC, V. ; F, F. . Increase of tetanus toxin production after media enrichment with gel filtration and ion exchange chromatography casein hydrolysate fractions. In: XXIV Reunião Anual da SBBq, 1995, Minas Gerais, 1995.

57.
RAW, I.; AM, T. ; M, T. ; J, C. ; APY, L. . Purification of factor VIII from porcine plasma. In: XXIV Reunião Anual da SBBq, 1995, Minas Gerais, 1995.

58.
RAW, I.; M, K. ; LP, S. . Alfa-1-antitrypsin: purification from human placenta and characterization. In: XXIV Reunião Anual da SBBq, 1995, Minas Gerais, 1995.

59.
RAW, I.; VM, G. ; APY, L. ; J, C. ; LCC, L. . Development of an industrial method for catalase purification from human placenta. In: XXIV Reunião Anual SBBq, 1995, Minas Gerais, 1995.

60.
RAW, I.; CY, L. ; MI, E. ; NM, E. ; F, F. ; MDC, V. ; SMA, P. . A simple method for large scale purification of tetanus toxin. In: XXIV Reunião Anual da SBBq, 1995, Minas Gerais, 1995.

61.
RAW, I.; WO, D. ; DSPQ, H. ; CM, T. . Production of a bordetella pertussis acellular vaccine candidate: attempt to an antige recovery enchancement. In: XXIV Reunião Anual da SBBq, 1995, Minas Gerais, 1995.

62.
RAW, I.; C, L. ; MHB, C. ; WO, D. . Outer membrane vesicle of bordetella pertussis as pertussis vaccine candidate. In: XXIV Reunião Anual da SBBq, 1995, Minas Gerais, 1995.

63.
RAW, I.; LR, G. ; MM, T. ; A, P. ; PS, G. ; JB, R. ; H, H. . Purification of meningococcal group C polysaccharide by a procedure suitable for large scale. In: XXIX Reunião da SBBq, 1995, Minas Gerais, 1995.

64.
RAW, I.; MM, T. ; LJ, D. ; RA, S. ; MHB, C. . Meningococcal group C polysacharide conjugate vaccine. In: XXIX Reunião Anual da SBBq, 1995, Minas Gerais, 1995.

65.
RAW, I.; LVN, S. ; MHB, C. . Preparation of liposes an entrapoment of antigens. In: XXIX Reunião Anual da SBBq, 1995, Minas Gerais, 1995.

66.
RAW, I.; CRT, M. ; MHB, C. . Conjugation of protein to fatty acids incorporation in liposomes. In: XXIX Reunião Anual da SBBq, 1995, Minas Gerais, 1995.

67.
RAW, I.; RA, S. ; MHB, C. . Protein microsphere on the in vitro study os controlle resase system. In: XXIX Reunião Anual da SBBq, 1995, Minas Gerais, 1995.

68.
RAW, I.; LVN, S. ; MI, E. ; PS, A. ; MHB, C. . Thermoprotective effect of immunoconjugate components. In: XXIX Reunião Anual da SBBq, 1995, Minas Gerais, 1995.

69.
RAW, I.; CRT, M. ; MI, E. ; PS, A. ; MHB, C. . The stabilization of immunoconjugate components by threalose. In: XXIX Reunião Anual da SBBq, 1995, Minas Gerais, 1995.

70.
RAW, I.; P, W. ; LRP, T. ; I, L. ; F, M. ; ARBP, S. ; T, Y. ; PL, H. . PC12 cells as modl to study neurotoxins. In: XXIX Reunião Anual da SBBq, 1995, Minas Gerais, 1995.

71.
RAW, I.; C, L. ; WO, D. ; MHB, C. . Pertussis vaccine: an alternative proposal. In: !º Seminário Internacional de Farmaceuticos, 1995, 1995.

72.
RAW, I.. Programe brésilein du traitment des envenimations. In: 1º Congress Inter. sur Evenimations et leurs treaitments, 1995, Paris, 1995.

73.
RAW, I.; C, L. ; WO, D. ; MHB, C. . Pertussis vaccine: an alternative approach. In: Simpósio Nipo-Brasileiro de Ciência e Tecnologia, 1995, 1995.

74.
RAW, I.; MN, G. ; EK, K. ; E, Y. ; ML, G. ; P, L. ; AM, M. . Utilização de um anticorpo monoclocal alfa-FVIII na purificação de uma proteina coagulante ativa. In: Fesbe, 1995, 1995.

75.
RAW, I.; AM, T. ; M, T. ; J, C. ; APY, L. . Desenvolvimento e comparação de métodos para purificação de fator VIII a partir de plasma suíno.. In: Fesbe, 1995, 1995.

76.
RAW, I.; MHB, C. ; OA, S. ; RA, S. ; LVN, S. . Liposome as carrier system of vaccine antigene. In: Fesbe, 1995, 1995.

77.
RAW, I.; MHB, C. ; OA, S. ; RA, S. ; CRT, M. . Antibody response to external lyposome associated antigen. In: Fesbe, 1995, 1995.

78.
RAW, I.; RA, S. ; MHB, C. . Bioprocess design: a study case. In: Simpósio Nipo-Brasileiro de Ciência e Tecnologia, 1995, 1995.

Artigos aceitos para publicação
1.
CHENG E ; JINZENJI D ; LORTHIOIS AP ; de CARVALHO RR ; TANAKA, A. M. ; RAW, I. . Purification of coagulation factor VIII using chromatographic methods. Direct chromatography of plasma in anion exchange resins.. Biotechnology Letters, 2010.



Orientações



Orientações e supervisões concluídas
Dissertação de mestrado
1.
Celia Liberman. Membrana externa da Bordetela pertussis. 1998. 0 f. Dissertação (Mestrado em Biotecnologia) - Universidade de São Paulo, . Orientador: Isaias Raw.

2.
Zenaldo Porfíro. Isolamento e caracterização de peptidios derivados do digesto pancreático da caseia e sua utilização para produção de toxina tetânica. 1996. 0 f. Dissertação (Mestrado em Bioquímica) - Universidade de São Paulo, . Orientador: Isaias Raw.




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