David Hughes Walker

  • Endereço para acessar este CV: http://lattes.cnpq.br/5585019490289230
  • Última atualização do currículo em 27/03/2007


David Hughes Walker, MD Professor and Chairman, The Carmage and Martha Walls Distinguished Chair in Tropical Diseases, Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA. Executive Director, UTMB Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas, USA. (Texto informado pelo autor)


Identificação


Nome
David Hughes Walker
Nome em citações bibliográficas
WALKER, D.


Formação acadêmica/titulação


1972 - 1973
Especialização - Residência médica.
Harvard University, School of Medicine. Residência médica em: Pathology, Clinical Fellow
Número do registro: .
1971 - 1973
Especialização - Residência médica.
Peter Bent Brigham Hospital. Residência médica em: Clinical Pathology, Senior Assistant Resident
Número do registro: .
1971 - 1972
Especialização - Residência médica.
Harvard University, School of Medicine. Residência médica em: Pathology, Research Fellow
Número do registro: .
1971 - 1971
Especialização - Residência médica.
Gorgas Memorial Laboratory. Residência médica em: Tropical Pathology, Research
Número do registro: .
1971 - 1971
Especialização - Residência médica.
Peter Bent Brigham Hospital. Residência médica em: Pathology, Chief Resident
Número do registro: .
1970 - 1971
Especialização - Residência médica.
Peter Bent Brigham Hospital. Residência médica em: Pathology, Junior Assistant Resident
Número do registro: .
1969 - 1970
Especialização - Residência médica.
Peter Bent Brigham Hospital. Residência médica em: Pathology, Intern
Número do registro: .
1965 - 1969
Graduação em Professional Curriculum, M.D..
Vanderbilt University, School of Medicine.
1961 - 1965
Graduação em History, B.A. (Valedictorian).
Davidson College, D.C, Estados Unidos.


Atuação Profissional



UTMB Center for Biodefense and Emerging Infectious Diseases, UTMB, Estados Unidos.
Vínculo institucional

2002 - Atual
Vínculo: Servidor Público, Enquadramento Funcional: Diretor, Regime: Dedicação exclusiva.


WHO Collaborating Center for Tropical Diseases, WHO, Estados Unidos.
Vínculo institucional

1994 - Atual
Vínculo: Servidor Público, Enquadramento Funcional: Diretor, Regime: Dedicação exclusiva.


University of Texas Medical Branch, UTMB, Estados Unidos.
Vínculo institucional

1987 - Atual
Vínculo: Servidor Público, Enquadramento Funcional: Professor e Chefe, Regime: Dedicação exclusiva.



Áreas de atuação


1.
Grande área: Ciências Biológicas / Área: Microbiologia / Subárea: Biologia e Fisiologia dos Microorganismos.
2.
Grande área: Ciências Biológicas / Área: Bioquímica / Subárea: Biologia Molecular.
3.
Grande área: Ciências Biológicas / Área: Parasitologia / Subárea: Entomologia e Malacologia de Parasitos e Vetores.


Produções



Produção bibliográfica
Artigos completos publicados em periódicos

1.
LABRUNA, M. B.2007LABRUNA, M. B. ; MCBRIDE, J. ; WALKER, D. . A preliminary investigation of Ehrlichia species in ticks, humans, dogs, and capybaras from Brazil.. Veterinary Parasitology, v. 143, p. 189-195, 2007.

2.
zhang, j.g.2007zhang, j.g. ; popov, v.l. ; gao, s. ; WALKER, D. ; yu, x.j. . The developmental cycle of Ehrlichia chaffeensis in vertebrate cells. Cellular Microbiology, v. 9, p. 610-618, 2007.

3.
Cardenas, A.M.2007Cardenas, A.M. ; DOYLE, C.K. ; zhang, j.g. ; WALKER, D. ; MCBRIDE, J. . Glycoproteins gp36 and gp19 has enhanced sensitivity and provides species-specific immunodiagnosis of Ehrlichia canis infection.. Clinical and Vaccine Immunology, v. 14, p. 123-128, 2007.

4.
Stevenson, H.L.2006Stevenson, H.L. ; Jordan, J.M. ; Peerwani, Z. ; Wang, H.Q. ; WALKER, D. ; Ismail, N. . An intradermal environment promotes a protective type-1 response against systemic monocytotropic ehrlichial infection.. Infection and Immunity, v. 74, p. 4856-4864, 2006.

5.
de Souza, R.2006de Souza, R. ; Barata, C. ; Santos-Silva, M. ; WALKER, D. ; Bacellar, F. . Rickettsia sibirica isolation from a patient and detection in ticks, Portugal.. Emerging Infectious Diseases, v. 12, p. 1102-1108, 2006.

6.
MAVROMATIS, k2006MAVROMATIS, k ; DOYLE, C.K. ; Lykidis, A. ; Ivanova, N. ; Francino, M.P. ; Chain, P. ; WALKER, D. ; MCBRIDE, J. . The genome of the obligately intracellular bacterium Ehrlichia canis reveals themes of complex membrane structure and immune evasion strategies.. Journal of Bacteriology, v. 188, p. 4015-4023, 2006.

7.
Cardoso, L.D.2006Cardoso, L.D. ; Freitas, R.N. ; Mafra, C.L. ; LABRUNA, M. B. ; Gennari, S.M. ; WALKER, D. ; Galvao, M.A.M. . 237. Cardoso LD, Freitas RN, Mafra CL, Neves CVB, Figueira FCB, Labruna MB, Gennari SM, WALKER DH, Galvao MAM.. Cadernos de Saúde Pública (FIOCRUZ), v. 22, p. 495-501, 2006.

8.
Zavalla-Castro, J.E.2006Zavalla-Castro, J.E. ; Zavalla-Velazquez, J.E. ; WALKER, D. ; Olano, J.P. . Fatal human infection with Rickettsia rickettsii in Yucatán, Mexico. Emerging Infectious Diseases, v. 12, p. 672-674, 2006.

9.
zhang, j.g.2006zhang, j.g. ; HAO, J-F ; WALKER, D. ; yu, x.j. . A mutation inactivating the methyltransferase gene in avirulent Madrid E strain Rickettsia prowazekii reverted to wild type in the virulent revertant strain Evir.. Vaccine (Guildford), v. 24, p. 2317-2323, 2006.

10.
Zavalla-Velazquez, J.E.2006Zavalla-Velazquez, J.E. ; Laviada-Molina, H ; Zavalla-Castro, J.E. ; Peres-Osorio, C. ; Becerra-Carmona, G. ; Ruiz-Sosa, JA ; Bouyer, D. ; WALKER, D. . Rickettsia felis, the agent of an emerging infectious disease: report of a new case in Mexico. Archives of Medical Research, v. 37, p. 419-422, 2006.

11.
Ismail, N.2006Ismail, N. ; Stevenson, H.L. ; WALKER, D. . The role of TNF- and IL-10 in the pathogenesis of severe murine monocytotropic ehrlichiosis: increased resistance of TNF receptor p55- and p75- deficient mice to fatal ehrlichial infection.. Infection and Immunity, v. 74, p. 1846-1856, 2006.

12.
Guedes, E.2005Guedes, E. ; Leite, R.C. ; Prata, M.C.A. ; Pacheco, R.C. ; WALKER, D. ; LABRUNA, M. B. . Detection of the tick Rickettsia rickettsii in Amblyomma cajennense in a new Brazilian spotted fever-endemic area in the state of Minas Gerais. Memórias do Instituto Oswaldo Cruz, v. 100, p. 841-845, 2005.

13.
Ndip, L.M.2005Ndip, L.M. ; Ndip, R.N. ; Esemu SN ; Dickmu VL ; Fokam EB ; WALKER, D. ; MCBRIDE, J. . Ehrlichial infection in Cameroonian canines by Ehrlichia canis and Ehrlichia ewingii. Veterinary Microbiology (Amsterdam), v. 111, p. 59-66, 2005.

14.
DOYLE, C.K.2005DOYLE, C.K. ; LABRUNA, M. B. ; Breitschwerdt EB ; Tang Y ; Corstvet RE ; Hegarty B ; Bloch KC ; Li P ; WALKER, D. ; MCBRIDE, J. . Detection of medically important Ehrlichia by quantitative multicolor Taqman real-time PCR of the dsb gene.. The Journal of Molecular Diagnostics, v. 7, p. 504-510, 2005.

15.
Zavalla-Castro, J.E.2005Zavalla-Castro, J.E. ; Small, M ; Keng, C. ; Bouyer, D. ; Zavalla-Velazquez, J.E. ; WALKER, D. . Transcription of the Rickettsia felis ompA gene in naturally infected fleas. American Journal of Tropical Medicine and Hygiene, v. 73, p. 662-666, 2005.

16.
Whitworth T2005Whitworth T ; popov, v.l. ; yu, x.j. ; WALKER, D. ; Bouyer, D. . Expression of Rickettsia prowazekii pld or tlyC gene in Salmonella enterica serovar typhimurium mediates phagosomal escape. Infection and Immunity, v. 73, p. 6668-6673, 2005.

17.
Valbuena, G.2005Valbuena, G. ; WALKER, D. . Changes in the adherens junctions of human endothelial cells infected with spotted fever group rickettsiae.. Virchows Archiv, v. 446, p. 379-382, 2005.

18.
Mattner J2005Mattner J ; DeBord KL ; Ismail N ; Goff RD ; Cantu C ; Zhou D ; Saint-Mezard P ; Wang V ; Gao Y ; Yin N ; Hoebe K ; Schneewind O ; WALKER, D. ; Beutler B . Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections. Nature (London), v. 434, p. 525-529, 2005.

19.
Stevenson, H.L.2005Stevenson, H.L. ; LABRUNA, M. B. ; Montenieri JA ; Kosoy MY ; Gage KL ; WALKER, D. . Detection of Rickettsia felis in a New World Flea species, Anomiopsyllus nudata (Siphonaptera: Ctenophthalmidae). Journal of Medical Entomology, v. 42, p. 163-167, 2005.

20.
Lai S2005Lai S ; WALKER, D. ; Elghetany MT . Catastrophic antiphospholipid syndrome: a rare cause of disseminated microvascular thrombotic injury a case report with pathological and molecular correlative studies.. Pathology International, v. 55, p. 144-149, 2005.

21.
LABRUNA, M. B.2005LABRUNA, M. B. ; Camargo LMA ; Camargo EP ; WALKER, D. . Detection of a spotted fever group Rickettsia in the tick Haemaphysalis juxtakochi in Rondonia, Brazil.. Veterinary Parasitology, v. 127, p. 169-174, 2005.

22.
LABRUNA, M. B.2004LABRUNA, M. B. ; Whitworth T ; Bouyer, D. ; MCBRIDE, J. ; Camargo EP ; Camargo LMA ; popov, v.l. ; WALKER, D. . Rickettsia bellii and Rickettsia amblyommii in Amblyomma ticks from the state of Rondônia, Western Amazon, Brazil.. Journal of Medical Entomology, v. 41, p. 1073-1081, 2004.

23.
Valbuena, G.2004Valbuena, G. ; WALKER, D. . Effect of blocking the CXCL9/10-CXCR3 chemokine system in the outcome of endothelial-target rickettsial infections.. American Journal of Tropical Medicine and Hygiene, v. 71, p. 393-399, 2004.

24.
Calic S2004Calic S ; Galvao, M.A.M. ; Bacellar, F. ; Mafra, C.L. ; Rocha CMBM ; Chamone CB ; Leite, R.C. ; WALKER, D. . Human ehrlichioses in Brazil: first suspect cases.. The Brazilian Journal of Infectious Diseases, v. 8, p. 256-262, 2004.

25.
Valbuena, G.2004Valbuena, G. ; WALKER, D. . Expression of CX3CL1 (fractalkine) in mice with endothelial-target rickettsial infection of the spotted fever group.. Virchows Archiv, v. 446, p. 21-27, 2004.

26.
Ndip, L.M.2004Ndip, L.M. ; Fokam EB ; Bouyer, D. ; Ndip, R.N. ; Titanji PK ; WALKER, D. ; MCBRIDE, J. . Detection of Rickettsia africae in patients and ticks along the coastal region of Cameroon. American Journal of Tropical Medicine and Hygiene, v. 71, p. 363-366, 2004.

27.
McLeod MP2004McLeod MP ; Qin X ; Karpathy SE ; Gioia J ; Highlander SK ; Fox GE ; McNeill TZ ; Jiang H ; Muzny D ; Yu XJ ; WALKER, D. ; Weinstock GM . Complete genome sequence of Rickettsia typhi and comparison with sequences of other rickettsiae.. Journal of Bacteriology, v. 186, p. 5842-5855, 2004.

28.
Valbuena, G.2004Valbuena, G. ; Jordan JM ; WALKER, D. . T cells mediate cross-protective immunity between spotted group rickettsiae and spotted fever group rickettsiae.. The Journal of Infectious Diseases, v. 190, p. 1221-1227, 2004.

29.
Olano, J.P.2004Olano, J.P. ; Feng HM ; Wen G ; MCBRIDE, J. ; WALKER, D. . Histologic, serologic, and molecular analysis of persistent ehrlichiosis in a murine model. American Journal of Cinical Pathology, v. 195, p. 997-1016, 2004.

30.
LABRUNA, M. B.2004LABRUNA, M. B. ; Gennari, S.M. ; Galvao, M.A.M. ; Mafra, C.L. ; Vidotto O ; Schumaker T ; WALKER, D. . Prevalence of antibodies to spotted fever group rickettsiae in humans and domestic animals in a Brazilian spotted fever-endemic area in the State of São Paulo, Brazil: serologic evidence for infection by Rickettsia rickettsii and another spotted fever group rickettsia.. American Journal of Tropical Medicine and Hygiene, v. 71, p. 93-97, 2004.

31.
LABRUNA, M. B.2004LABRUNA, M. B. ; Bouyer, D. ; MCBRIDE, J. ; Camargo EP ; Camargo LMA ; WALKER, D. . Molecular evidence for a spotted fever group Rickettsia species in the tick Amblyomma longirostre in Brazil. Journal of Medical Entomology, v. 41, p. 533-537, 2004.

32.
Feng HM2004Feng HM ; Whitworth T ; popov, v.l. ; WALKER, D. . Effect of antibody on the rickettsia-host cell interaction. Infection and Immunity, v. 72, p. 3524-3530, 2004.

33.
Jang W-J2004Jang W-J ; Kim J-H ; Jung K-D ; Lee S-H ; Choi M-S ; Kim I-S ; WALKER, D. ; Park K-H . First serologic evidence of human spotted fever group rickettsiosis in Korea. Journal of Clinical Microbiology, v. 42, p. 2310-2313, 2004.

34.
Alcantara VE2004Alcantara VE ; Gallardo EG ; WALKER, D. . Typhus group rickettsiae antibodies in rural Mexico. Emerging Infectious Diseases, v. 10, p. 549-550, 2004.

35.
Feng HM2004Feng HM ; Whitworth T ; Olano, J.P. ; WALKER, D. . Fc-dependent polyclonal antibodies and antibodies to outer membrane proteins A and B, but not to lipopolysaccharide protect SCID mice against fatal Rickettsia conorii infection.. Infection and Immunity, v. 72, p. 2222-2228, 2004.

36.
Ndip, L.M.2004Ndip, L.M. ; Bouyer, D. ; Travassos da Rosa APA ; Titan J ; Tesh RB ; WALKER, D. . Acute spotted fever rickettsiosis among febrile patients, Cameroon. Emerging Infectious Diseases, v. 10, p. 432-436, 2004.

37.
Feng HM2004Feng HM ; WALKER, D. . Mechanisms of immunity to Ehrlichia muris: a model of human monocytotropic ehrlichiosis. Infection and Immunity, v. 72, p. 996-998, 2004.

38.
Ismail, N.2004Ismail, N. ; Soong L ; Valbuena, G. ; MCBRIDE, J. ; Olano, J.P. ; WALKER, D. . Overproduction of TNF- by CD8+ type-1 cells and downregulation of IFN- production by CD4+ Th1 cells contribute to toxic shock-like syndrome in an animal model of fatal monocytotropic ehrlichioses.. Journal of Immunology (Baltimore), v. 172, p. 1786-1800, 2004.

39.
LABRUNA, M. B.2004LABRUNA, M. B. ; Whitworth T ; Horta MC ; Bouyer, D. ; MCBRIDE, J. ; Pinter A ; popov, v.l. ; Gennari, S.M. ; WALKER, D. . Rickettsia species infecting Amblyomma cooperi ticks from an area in the State of Sao Paulo, Brazil, where Brazilian spotted fever is endemic.. Journal of Clinical Microbiology, v. 42, p. 90-98, 2004.




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