Lucas Felipe Bastos Horta

  • Endereço para acessar este CV: http://lattes.cnpq.br/0654575342300019
  • Última atualização do currículo em 01/11/2013


Graduando em Medicina pela Universidade Federal do Rio de Janeiro e aluno de Iniciação Científica do Laboratório de Investigação Pulmonar. Focado em estudos sobre ventilação mecânica. (Texto informado pelo autor)


Identificação


Nome
Lucas Felipe Bastos Horta
Nome em citações bibliográficas
HORTA, L. F. B.


Formação acadêmica/titulação


2011
Graduação em andamento em Medicina.
Universidade Federal do Rio de Janeiro, UFRJ, Brasil.
2007 - 2009
Ensino Médio (2º grau).
Colégio Cristo Redentor Academia de Comércio.




Atuação Profissional



Universidade Federal do Rio de Janeiro, UFRJ, Brasil.
Vínculo institucional

2013 - Atual
Vínculo: , Enquadramento Funcional:



Projetos de pesquisa


2013 - Atual
THERAPY WITH DASATINIB IN A MURINE MODEL OF SILICOSIS
Descrição: Introduction/Objectives: Dasatinib is a tyrosine kinase inhibitor, described to reduce the proinflammatory functions of mature neutrophils. Thus, we hypothesized that therapy with dasatinib would present beneficial effects in silicosis, a lung disease whose progression depends on neutrophil activation. Methods: 40 female C57BL/6 mice were randomly assigned into two groups. In control (C) group, saline was once intratracheally injected (50μl), whereas silicotic (S) mice received silica (20mg/50 μl). In day 14, C and S groups were further randomized into subgroups receiving DMSO 1% (100μl, DMSO) or Dasatinib (1mg/Kg/dose, 100 μl, DAS) through gavage administration, twice a day, for 14 days. In day 28, in vivo (resistive and viscoelastic pressures, and static elastance) lung mechanics; fraction of granuloma; granuloma and tissue cellularity; fraction area of normal and collapsed alveoli; collagen fiber content; TGF-b, IL1-b and TNF-a protein levels in the tissue were assessed. Ethics Committee's protocol IBCCF 019. Results: At day 28, higher resistive (915%) and viscoelastic pressures (19%), lung elastance (27%), tissue polymorphonuclear (8.7%) and mononuclear cells (10.6%), fraction of collapse (43%), parenchyma fibrosis (22%), and levels of TGF-b (69%), IL1-b (501%) and TNF-a (53%) were observed in S-DMSO group. Dasatinib reduced resistive (67%) and viscoelastic pressures (3.9%), lung elastance (18%) and led to a reduction of granuloma fraction (5.6%), inflammatory cells in parenchyma (14%) and granuloma (2.7%), fraction of collapsed alveoli (22.5%), parenchyma collagen content (18.1%) and the protein levels of profibrogenic (48%) and proinflammatory mediators (37%, 48%, respectively). Conclusions: Therapy with Dasatinib in silicosis was effective at modulating the inflammatory and fibrotic processes thus improving lung mechanics, through the modulation of profibrotic and proinflammatory mediators, and it might be an alternative to silicosis treatment. .
Situação: Em andamento; Natureza: Pesquisa.
2012 - Atual
EFFECTS OF RAPID VS. SLOW RECRUITMENT MANEUVERS ASSOCIATED A DECREMENTAL PEEP TITRATION IN EXPERIMENTAL ACUTE RESPIRATORY DISTRESS SYNDROME
Descrição: Introduction/Objective: Recent studies have shown that the pattern of airway pressure increase (fast vs. slow) during a recruitment maneuver (RM) may yield different biological effects in acute respiratory distress syndrome (ARDS). However, these studies compared RMs using a fixed PEEP which may hinder RM beneficial effects. We aimed to compare the effects of different RMs associated with a decremental PEEP trial in experimental ARDS. Methods: Wistar rats were submitted to cecal ligation and puncture surgery. After 48h, animals were mechanically ventilated. Baseline functional data were collected, and rats were assigned to 2 different RMs (n=8/each), targeted to maximal inspiratory pressure of 30cmH2O, as follows: 1) sustained continuous positive airway pressure for 30s (CPAP) and 2) RM with stepwise airway pressure increase (STEP, 5 cmH2O/step, 8.5s each) within 51s. The third group was non-recruited (NR), but submitted to PEEP titration similar to the previous two groups. PEEP titration was performed reducing PEEP=2cmH2O every 2 minutes, starting at PEEP=11cmH2O. PEEP level was adjusted to the lowest respiratory system elastance (ERS). After RM, all animals were ventilated for 1h. Results: Functional data were similar among the groups at baseline. Although CPAP and STEP maneuvers presented similar pressure-time product, STEP presented lower mean airway pressure compared to CPAP (p<0.05). All animals reduced lung static elastance (Est,L, 40-50% after RM), which was sustained for 1-hour (p<0.05). PEEP median level was 5 cmH2O in all groups but presented higher variation in NR (26%). Alveolar collapse was also higher in NR group. Conclusion: In the present model, oxygenation and lung mechanics improved despite RM strategy. Titrated PEEP level was similar in all groups, although its variability was higher in NR, suggesting the need for RM to open the different lung units reducing alveolar heterogeneities. Supported by: PRONEX-FAPERJ, FAPERJ, CNPq, CAPES, INCT-INOFAR..
Situação: Em andamento; Natureza: Pesquisa.


Áreas de atuação


1.
Grande área: Ciências da Saúde / Área: Medicina.
2.
Grande área: Ciências Biológicas / Área: Fisiologia / Subárea: Fisiologia de Órgãos e Sistemas/Especialidade: Fisiologia da Respiração.


Idiomas


Português
Compreende Bem, Fala Bem, Lê Bem, Escreve Bem.
Inglês
Compreende Bem, Fala Bem, Lê Bem, Escreve Bem.


Produções



Produção bibliográfica
Apresentações de Trabalho
1.
Cruz F ; HORTA, L. F. B. . O tratamento com dasatinib em um modelo murino de silicose. 2013. (Apresentação de Trabalho/Congresso).



Eventos



Participação em eventos, congressos, exposições e feiras
1.
Congresso Brasileiro de Fisiologia. O tratamento com dasatinib em um modelo murino de silicose. 2013. (Congresso).



Inovação



Projetos de pesquisa



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